bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 15, 2023
ABSTRACT
The
glycoprotein
Galectin-3
(Gal-3)
is
a
multifunctional
molecule
that
plays
pivotal
role
in
the
initiation
and
progression
of
various
central
nervous
system
diseases,
including
cancer.
Although
involvement
Gal-3
tumour
progression,
resistance
to
treatment
immunosuppression
has
long
been
studied
different
cancer
types,
mainly
outside
system,
its
elevated
expression
myeloid
glial
cells
underscores
profound
impact
on
brain’s
immune
response.
In
this
context,
microglia
infiltrating
macrophages,
predominant
non-cancerous
within
microenvironment,
assume
critical
roles
establishing
an
immunosuppressive
milieu
diverse
brain
tumours.
Through
utilisation
primary
cell
cultures
immortalised
microglial
lines,
we
have
elucidated
promoting
migration,
invasion,
phenotypic
activation.
Furthermore,
employing
two
distinct
vivo
models
encompassing
(glioblastoma)
secondary
tumours
(breast
metastasis),
our
histological
transcriptomic
analysis
show
depletion
triggers
robust
pro-inflammatory
response
notably
based
interferon-related
pathways.
Interestingly,
prominently
observed
tumour-associated
macrophages
(TAMs),
resulting
suppression
growth.
Neural Regeneration Research,
Год журнала:
2023,
Номер
19(9), С. 2004 - 2009
Опубликована: Дек. 21, 2023
Neuroinflammation
and
neurodegeneration
are
key
processes
that
mediate
the
development
progression
of
neurological
diseases.
However,
mechanisms
modulating
these
in
different
diseases
remain
incompletely
understood.
Advances
single
cell
based
multi-omic
analyses
have
helped
to
identify
distinct
molecular
signatures
such
as
Lgals3
is
associated
with
neuroinflammation
central
nervous
system
(CNS).
encodes
galectin-3
(Gal3),
a
β-galactoside
glycan
binding
glycoprotein
frequently
upregulated
by
reactive
microglia/macrophages
CNS
during
various
While
Gal3
has
previously
been
non-CNS
inflammatory
fibrotic
diseases,
recent
studies
highlight
prominent
regulator
inflammation
neuroaxonal
damage
multiple
sclerosis,
Alzheimer's
disease,
Parkinson's
disease.
In
this
review,
we
summarize
pleiotropic
functions
discuss
evidence
demonstrates
its
detrimental
role
We
also
consider
challenges
translating
preclinical
observations
into
targeting
human
CNS.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 10, 2024
The
characteristic
neuropathology
of
Parkinson's
disease
(PD)
involves
the
abnormal
accumulation
phosphorylated
α-synuclein
(αSyn),
as
well
a
significant
decrease
in
neuromelanin
(NM)
levels
within
dopamine
neurons
(DaNs).
Unlike
αSyn
aggregates,
relationship
between
NM
and
PD
pathogenesis
is
not
understood.
In
this
study,
we
engineered
an
E.
coli
MG1655
strain
to
produce
exosomes
containing
melanin
(E.melanin),
investigated
its
potential
neuroprotective
effects
on
DaNs
context
PD.
By
employing
combination
cell
cultures,
biochemical
studies,
single
nuclear
RNA
sequencing
(snRNA
seq),
various
vivo
validations,
found
that
administration
E.melanin
effectively
alleviated
loss
improved
motor
behavior
impairments
observed
both
pharmacological
transgenic
mouse
models.
Mechanistically,
snRNA
seq
data
suggested
activated
PSAP-GPR37L1
signaling
pathway
specifically
astrocytes,
leading
reduction
astrocytic
engulfment
synapses.
Notably,
activation
GPR37L1
receptor
using
Tx14(A)
peptide
successfully
rescued
defects
protected
against
degeneration
mice
with
Overall,
our
findings
provide
novel
insights
into
understanding
molecular
mechanisms
underlying
melanin's
protective
while
offering
strategies
for
manipulating
treating
pathophysiological
progression.
Journal of Functional Foods,
Год журнала:
2024,
Номер
116, С. 106220 - 106220
Опубликована: Май 1, 2024
Neurodegenerative
disorders
such
as
Parkinson's
disease,
present
a
global
health
concern
with
limited
therapeutic
options.
In
this
context,
dietary
interventions
have
emerged
potential
strategy
to
counteract
the
oxidative
stress
and
inflammation
underlying
these
conditions.
Rice
bran
enzymatic
extract
(RBEE),
rich
in
bioactive
compounds,
has
shown
ability
modulating
neuroinflammatory
responses
improving
mitochondrial
function.
This
study
investigates
neuroprotective
of
RBEE
murine
model
PD
induced
by
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP).
The
results
reveal
that
supplementation
effectively
preserves
dopaminergic
population
reduces
MPTP-induced
gliosis
Substantia
Nigra
(SN).
Moreover,
enhances
Complex
I
activity
mouse
brains.
These
findings
underscore
supplement
mitigate
neuronal
loss,
neuroinflammation,
dysfunction
associated
PD.
is
promising
novel
candidate
strategies,
offering
hope
quest
for
effective
preventive
measures
Brain and Behavior,
Год журнала:
2024,
Номер
14(10)
Опубликована: Окт. 1, 2024
Parkinson's
disease
(PD)
is
a
prevalent
neurodegenerative
disorder
with
poor
prognosis.
Observational
studies
have
demonstrated
significant
correlation
between
serum
galectin-3
and
PD,
suggesting
potential
role
of
as
biomarker
for
PD.
However,
it
still
unclear
whether
contributes
to
the
risk
disease.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15516 - 15516
Опубликована: Окт. 24, 2023
Galectin-3
is
the
most
studied
member
of
Galectin
family,
with
a
large
range
mediation
in
biological
activities
such
as
cell
growth,
proliferation,
apoptosis,
differentiation,
adhesion,
and
tissue
repair,
well
pathological
processes
inflammation,
fibrosis,
angiogenesis.
As
known
to
all,
aberrant
neovascularization
are
main
pathophysiological
retinal
degeneration
many
ocular
diseases.
Therefore,
review
aims
conclude
role
Gal3
various
diseases
occurrence
development
discuss
its
molecular
mechanisms
according
research
systemic
At
same
time,
we
summarized
predictive
biomarker
clinical
application
inhibitors
possibility
novel
target
for
treatment
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 8207 - 8214
Опубликована: Ноя. 1, 2024
Background:
Parkinson's
disease
(PD)
is
a
movement
disorder
that
lacks
proven
biomarkers.
Case–control
genome-wide
association
studies
revealed
the
potential
effect
of
galectin‑3
(GAL3)
on
motor
progression
in
PD
patients.
Based
this
finding,
our
study
aimed
to
explore
correlation
between
serum
GAL3
levels
and
performance
Methods:
Five
hundred
patients
200
healthy
controls
were
recruited.
The
measured
participants
by
enzyme
linked
immunosorbent
assay
(ELISA).
baseline
characteristics
collected,
associated
scale
scores
obtained.
Results:
Compared
with
controls,
greatly
increased
These
could
distinguish
sensitivity
0.798
specificity
0.815
(AUC
=
0.795,
95%
CI
0.757–
0.834,
P
<
0.001).
Patients
age
>
60
years
tended
have
higher
levels,
duration,
Hoehn-Yahr
stage,
MDS-UPDRS
III
total
score,
tremor
subscores,
rigid
bradykinesia
subscores
than
those
≤
years.
When
adjusting
for
confounders,
level
was
significantly
correlated
score
subscores.
In
men
PD,
score;
but
found
women.
Moreover,
associations
significant
Conclusion:
Higher
related
more
severe
years,
it
may
be
predictive
biomarker
Keywords:
disease,
Galectin‑3,
Motor
performance,
Biomarker
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 15, 2023
ABSTRACT
The
glycoprotein
Galectin-3
(Gal-3)
is
a
multifunctional
molecule
that
plays
pivotal
role
in
the
initiation
and
progression
of
various
central
nervous
system
diseases,
including
cancer.
Although
involvement
Gal-3
tumour
progression,
resistance
to
treatment
immunosuppression
has
long
been
studied
different
cancer
types,
mainly
outside
system,
its
elevated
expression
myeloid
glial
cells
underscores
profound
impact
on
brain’s
immune
response.
In
this
context,
microglia
infiltrating
macrophages,
predominant
non-cancerous
within
microenvironment,
assume
critical
roles
establishing
an
immunosuppressive
milieu
diverse
brain
tumours.
Through
utilisation
primary
cell
cultures
immortalised
microglial
lines,
we
have
elucidated
promoting
migration,
invasion,
phenotypic
activation.
Furthermore,
employing
two
distinct
vivo
models
encompassing
(glioblastoma)
secondary
tumours
(breast
metastasis),
our
histological
transcriptomic
analysis
show
depletion
triggers
robust
pro-inflammatory
response
notably
based
interferon-related
pathways.
Interestingly,
prominently
observed
tumour-associated
macrophages
(TAMs),
resulting
suppression
growth.
