Sleep Medicine, Год журнала: 2023, Номер 111, С. 1 - 1
Опубликована: Сен. 8, 2023
Язык: Английский
Cell Death and Disease, Год журнала: 2024, Номер 15(8)
Опубликована: Авг. 27, 2024
Язык: Английский
Процитировано
3
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 10, 2024
The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal accumulation phosphorylated α-synuclein (αSyn), as well a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike αSyn aggregates, relationship between NM and PD pathogenesis is not understood. In this study, we engineered an E. coli MG1655 strain to produce exosomes containing melanin (E.melanin), investigated its potential neuroprotective effects on DaNs context PD. By employing combination cell cultures, biochemical studies, single nuclear RNA sequencing (snRNA seq), various vivo validations, found that administration E.melanin effectively alleviated loss improved motor behavior impairments observed both pharmacological transgenic mouse models. Mechanistically, snRNA seq data suggested activated PSAP-GPR37L1 signaling pathway specifically astrocytes, leading reduction astrocytic engulfment synapses. Notably, activation GPR37L1 receptor using Tx14(A) peptide successfully rescued defects protected against degeneration mice with Overall, our findings provide novel insights into understanding molecular mechanisms underlying melanin's protective while offering strategies for manipulating treating pathophysiological progression.
Язык: Английский
Процитировано
2
Journal of Functional Foods, Год журнала: 2024, Номер 116, С. 106220 - 106220
Опубликована: Май 1, 2024
Neurodegenerative disorders such as Parkinson's disease, present a global health concern with limited therapeutic options. In this context, dietary interventions have emerged potential strategy to counteract the oxidative stress and inflammation underlying these conditions. Rice bran enzymatic extract (RBEE), rich in bioactive compounds, has shown ability modulating neuroinflammatory responses improving mitochondrial function. This study investigates neuroprotective of RBEE murine model PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The results reveal that supplementation effectively preserves dopaminergic population reduces MPTP-induced gliosis Substantia Nigra (SN). Moreover, enhances Complex I activity mouse brains. These findings underscore supplement mitigate neuronal loss, neuroinflammation, dysfunction associated PD. is promising novel candidate strategies, offering hope quest for effective preventive measures
Язык: Английский
Процитировано
1
Brain and Behavior, Год журнала: 2024, Номер 14(10)
Опубликована: Окт. 1, 2024
Parkinson's disease (PD) is a prevalent neurodegenerative disorder with poor prognosis. Observational studies have demonstrated significant correlation between serum galectin-3 and PD, suggesting potential role of as biomarker for PD. However, it still unclear whether contributes to the risk disease.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15516 - 15516
Опубликована: Окт. 24, 2023
Galectin-3 is the most studied member of Galectin family, with a large range mediation in biological activities such as cell growth, proliferation, apoptosis, differentiation, adhesion, and tissue repair, well pathological processes inflammation, fibrosis, angiogenesis. As known to all, aberrant neovascularization are main pathophysiological retinal degeneration many ocular diseases. Therefore, review aims conclude role Gal3 various diseases occurrence development discuss its molecular mechanisms according research systemic At same time, we summarized predictive biomarker clinical application inhibitors possibility novel target for treatment
Язык: Английский
Процитировано
3
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 8207 - 8214
Опубликована: Ноя. 1, 2024
Background: Parkinson's disease (PD) is a movement disorder that lacks proven biomarkers. Case–control genome-wide association studies revealed the potential effect of galectin‑3 (GAL3) on motor progression in PD patients. Based this finding, our study aimed to explore correlation between serum GAL3 levels and performance Methods: Five hundred patients 200 healthy controls were recruited. The measured participants by enzyme linked immunosorbent assay (ELISA). baseline characteristics collected, associated scale scores obtained. Results: Compared with controls, greatly increased These could distinguish sensitivity 0.798 specificity 0.815 (AUC = 0.795, 95% CI 0.757– 0.834, P < 0.001). Patients age > 60 years tended have higher levels, duration, Hoehn-Yahr stage, MDS-UPDRS III total score, tremor subscores, rigid bradykinesia subscores than those ≤ years. When adjusting for confounders, level was significantly correlated score subscores. In men PD, score; but found women. Moreover, associations significant Conclusion: Higher related more severe years, it may be predictive biomarker Keywords: disease, Galectin‑3, Motor performance, Biomarker
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Ноя. 15, 2023
ABSTRACT The glycoprotein Galectin-3 (Gal-3) is a multifunctional molecule that plays pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although involvement Gal-3 tumour progression, resistance to treatment immunosuppression has long been studied different cancer types, mainly outside system, its elevated expression myeloid glial cells underscores profound impact on brain’s immune response. In this context, microglia infiltrating macrophages, predominant non-cancerous within microenvironment, assume critical roles establishing an immunosuppressive milieu diverse brain tumours. Through utilisation primary cell cultures immortalised microglial lines, we have elucidated promoting migration, invasion, phenotypic activation. Furthermore, employing two distinct vivo models encompassing (glioblastoma) secondary tumours (breast metastasis), our histological transcriptomic analysis show depletion triggers robust pro-inflammatory response notably based interferon-related pathways. Interestingly, prominently observed tumour-associated macrophages (TAMs), resulting suppression growth.
Язык: Английский
Процитировано
0
Sleep Medicine, Год журнала: 2023, Номер 111, С. 1 - 1
Опубликована: Сен. 8, 2023
Язык: Английский
Процитировано
0