Maternal
choline
supplementation
(MCS)
improves
cognition
in
Alzheimer’s
disease
(AD)
models.
However,
effects
of
MCS
on
neuronal
hyperexcitability
AD
are
unknown.
We
investigated
a
well-established
mouse
model
with
hyperexcitability,
the
Tg2576
mouse.
The
most
common
type
mice,
and
many
other
models
patients,
generalized
EEG
spikes
(interictal
spikes;
IIS).
Hyperexcitability
is
also
reflected
by
elevated
expression
transcription
factor
ΔFosB
granule
cells
(GCs)
dentate
gyrus
(DG),
which
principal
cell
type.
studied
hilus
DG
because
hilar
neurons
regulate
GC
excitability.
found
reduced
marker
NeuN
within
studies
have
shown
sign
oxidative
stress
or
pathology.Tg2576
breeding
pairs
received
diet
relatively
low,
intermediate
high
concentration
choline.
After
weaning,
all
mice
diet.
In
offspring
fed
diet,
IIS
frequency
declined,
was
reduced,
restored.
Spatial
memory
improved
using
novel
object
location
task.
contrast,
exposed
to
low
had
several
adverse
effects,
such
as
increased
mortality.
They
weakest
immunoreactivity
greatest
ΔFosB.
their
surprising.
results
provide
new
evidence
that
early
life
can
improve
outcomes
AD,
mixed
effects.
This
first
study
showing
dietary
neurons,
spatial
an
animal
AD.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 4, 2025
Acute
lung
injury
(ALI)
is
a
severe
respiratory
disease
accompanied
by
diffuse
inflammatory
responses
induced
various
clinical
causes.
Many
fresh
medicinal
plants
have
shown
better
efficacy
than
their
dried
forms
in
preventing
and
treating
diseases
like
inflammation.
As
classical
Chinese
herb,
platycodon
grandiflorum
(PG)
has
been
demonstrated
effective
pneumonia,
but
most
of
previous
studies
focused
on
the
processed
or
PG
formats,
while
specific
benefits
its
form
are
still
underexplored.
Exosome-like
nanoparticles
derived
from
expected
to
point
out
an
important
direction
for
exploring
material
basis
mechanism
this
herbal
medicine.
The
could
effectively
improve
ALI
lipopolysaccharide
(LPS),
relieve
histopathological
weight
loss,
reduce
levels
factors
mice,
exhibiting
treatment
ALI.
Further
extraction
purification
exosome-like
(PGLNs)
that
PGLNs
had
good
biocompatibility,
with
characteristics
consistent
general
nanoparticles.
Besides,
proteomic
analysis
indicated
were
rich
variety
proteins.
Animal
experiments
showed
improved
pathological
changes
LPS-induced
tissues,
inhibited
expression
promoted
anti-inflammatory
factors,
exerted
regulatory
effect
polarization
macrophages.
Cell
further
confirmed
be
taken
up
RAW264.7
cells
repolarize
M1
macrophages
into
M2
type,
therefore
reducing
secretion
harmful
cytokines.
Moreover,
non-targeted
metabolomics
reveals
inflammation
control
macrophage
manner
closely
linked
pathways
including
glycolysis
lipid
metabolism,
highlighting
potential
which
protect
lungs
damage
Fresh
repair
effects
form.
one
active
substances
PG,
may
regulate
regulating
metabolic
metabolism
glycolysis,
so
as
injury.
Biomolecules,
Год журнала:
2024,
Номер
14(4), С. 392 - 392
Опубликована: Март 25, 2024
Inflammation
is
a
physiological
condition
characterized
by
complex
interplay
between
different
cells
handled
metabolites
and
specific
inflammatory-related
molecules.
In
some
pathological
situations,
inflammation
persists
underlying
worsening
the
state.
Over
years,
two
membrane
transporters
namely
OCTN1
(SLC22A4)
OCTN2
(SLC22A5)
have
been
shown
to
play
roles
in
inflammation.
These
form
OCTN
subfamily
within
larger
SLC22
family.
The
link
these
proteins
has
proposed
based
on
their
chronic
inflammatory
diseases
such
as
asthma,
Crohn’s
disease
(CD),
rheumatoid
arthritis
(RA).
Moreover,
show
ability
mediate
transport
of
several
compounds
including
carnitine,
carnitine
derivatives,
acetylcholine,
ergothioneine,
gut
microbiota
by-products,
which
specifically
associated
with
for
anti-
or
proinflammatory
action.
Therefore,
absorption
distribution
molecules
rely
presence
OCTN2,
whose
expression
modulated
cytokines
transcription
factors
typically
activated
present
review,
we
wish
provide
state
art
function
regulation
relationships
focusing
metabolic
signature
collected
body
districts
gene
polymorphisms
related
diseases.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15732 - 15732
Опубликована: Окт. 29, 2023
Macrophages
serve
as
vital
defenders,
protecting
the
body
by
exhibiting
remarkable
cellular
adaptability
in
response
to
invading
pathogens
and
various
stimuli.
These
cells
express
nicotinic
acetylcholine
receptors,
with
α7-nAChR
being
extensively
studied
due
its
involvement
activating
cholinergic
anti-inflammatory
pathway.
Activation
of
this
pathway
plays
a
crucial
role
suppressing
macrophages'
production
proinflammatory
cytokines,
thus
mitigating
excessive
inflammation
maintaining
host
homeostasis.
Macrophage
polarization,
which
occurs
specific
or
insults,
is
process
that
has
received
limited
attention
concerning
activation
contributions
context.
This
review
aims
present
evidence
highlighting
how
constituents
macrophages,
led
α7-nAChR,
facilitate
polarization
macrophages
towards
phenotypes.
Additionally,
we
explore
influence
viral
infections
on
macrophage
inflammatory
phenotypes,
taking
into
account
mechanisms.
We
also
current
understanding
these
infections.
Finally,
provide
insights
relatively
unexplored
partial
duplication
known
dup
α7,
emerging
significant
factor
scenarios.
Current Alzheimer Research,
Год журнала:
2024,
Номер
21(2), С. 141 - 154
Опубликована: Фев. 1, 2024
Background:
As
individuals
age,
they
may
develop
Alzheimer's
disease
(AD),
which
is
characterized
by
difficulties
in
speech,
memory
loss,
and
other
issues
related
to
neural
function.
Cycloastragenol
an
active
ingredient
of
Astragalus
trojanus
has
been
used
treat
inflammation,
aging,
heart
disease,
cancer.
Objectives:
This
study
aimed
explore
the
potential
therapeutic
benefits
cycloastragenol
rats
with
experimentally
induced
AD.
Moreover,
underlying
molecular
mechanisms
were
also
evaluated
measuring
Nrf2
HO-1,
are
involved
oxidative
stress,
NFκB
TNF-α,
BCL2,
BAX,
caspase-3,
apoptosis.
Methods:
Sprague-Dawley
given
70
mg/kg
aluminum
chloride
intraperitoneally
daily
for
six
weeks
induce
Following
AD
induction,
25
oral
gavage
three
weeks.
Hippocampal
sections
stained
hematoxylin/
eosin
anti-caspase-3
antibodies.
The
Nrf2,
NFκB,
caspase-3
gene
expressions
protein
levels
samples
analyzed.
Results:
significantly
improved
rats'
behavioral
test
performance.
It
strengthened
organization
hippocampus.
performance
hippocampal
structure
rats.
caused
a
marked
decrease
expression
was
associated
increase
HO-1.
Conclusion:
hippocampus
enhanced
outcomes
tests,
decreased
concentration
AChE
brain,
exerted
antioxidant
anti-inflammatory
effects.
Antiapoptotic
effects
noted,
leading
significant
improvements
cognitive
function,
memory,
behavior
treated
Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 470 - 487
Опубликована: Окт. 23, 2024
Alzheimer's
disease
(AD)
is
one
kind
of
devasting
neurodegenerative
disorders
affecting
over
50
million
people
worldwide.
Multi-targeted
therapy
has
emerged
as
a
new
treatment
for
diagnosing
and
alleviating
the
pathogenesis
process
AD;
however,
current
strategy
limited
by
its
unsatisfactory
efficiency.
In
our
study,
engineered
activated
neutrophil-derived
exosomes
(MP@Cur-MExo)
were
developed
to
improve
mitochondrial
function
in
neurons
targeting
Aβ-induced
neurotoxicity.
MP@Cur-MExo
are
derived
from
IL-8-stimulated
neutrophils
decorated
with
mitochondria
ligand
Aβ
targeted
modified
SPION.
Engineered
can
be
cleaved
matrix
metallopeptidase-2,
which
overexpressed
AD
brain.
Consequently,
released
SPION
Curcumin-loaded
collaboratively
protected
neuron
cells
against
deficiency.
addition,
effectively
accumulated
inflamed
region
brain
at
an
early
stage,
allowing
diagnosis
through
bimodal
(MRI/IVIS)
imaging.
Importantly,
mouse
model
stage
AD,
intravenously
injected
restored
reduced
damage,
thereby
attenuating
progression.
conclusion,
designed
demonstrated
that
omnidirectional
improvement
serve
novel
practical
approach
diseases.
This
study
also
reveals
promising
therapeutic
agent
impeding
progression
future
clinical
applications.
Ageing Research Reviews,
Год журнала:
2024,
Номер
unknown, С. 102637 - 102637
Опубликована: Дек. 1, 2024
Alzheimer's
disease
(AD)
is
a
progressive,
degenerative
disorder
of
the
central
nervous
system.
Despite
extensive
research
conducted
on
this
disorder,
its
precise
pathogenesis
remains
unclear.
In
recent
years,
microbiota-gut-brain
axis
has
attracted
considerable
attention
within
field
AD.
The
gut
microbiota
communicates
bidirectionally
with
system
through
gut-brain
axis,
and
alterations
in
structure
function
can
influence
progression
Consequently,
regulating
to
mitigate
AD
emerged
as
novel
therapeutic
approach.
Currently,
numerous
studies
concentrate
intrinsic
relationship
between
paper,
we
summarize
multifaceted
role
present
detailed
strategies
targeting
microbiota,
including
treatment
Traditional
Chinese
Medicine
(TCM),
which
garnered
increasing
years.
Finally,
discuss
potential
for
modulating
alleviate
AD,
current
challenges
area
research,
provide
an
outlook
future
directions
field.
