Drugs, Год журнала: 2024, Номер 84(8), С. 909 - 932
Опубликована: Июль 2, 2024
Язык: Английский
Journal of Clinical Oncology, Год журнала: 2024, Номер 42(16), С. 1975 - 1996
Опубликована: Май 1, 2024
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use providers should be used conjunction independent professional judgment. Guidance may applicable all patients, interventions, diseases, stages diseases. based on analysis statement standard care. does endorse third-party drugs, devices, services, therapies assumes no responsibility any harm arising from related this information. See complete disclaimer Appendix 1 2 (online only) more. PURPOSE To evidence-based prevention management osteoradionecrosis (ORN) jaw secondary head neck radiation therapy patients cancer. METHODS The International Society Oral Oncology-Multinational Association Supportive Care Cancer (ISOO-MASCC) convened multidisciplinary Expert Panel evaluate evidence formulate recommendations. PubMed, EMBASE, Cochrane Library databases were searched randomized controlled trials observational studies, published between January 1, 2009, December 2023. also incorporated systematic reviews conducted ISOO-MASCC, which included studies 1990, through 31, 2008. RESULTS A total 1,539 publications initially identified. There 487 duplicate publications, resulting 1,052 screened abstract, 104 full text, 80 evaluation. RECOMMENDATIONS Due limitations available evidence, relied informal consensus some Recommendations that deemed strong those pertaining best practices ORN surgical management. No recommendation was possible utilization leukocyte- platelet-rich fibrin photobiomodulation ORN. hyperbaric oxygen remains largely unjustified, limited support its practice. Additional information at www.asco.org/head-neck-cancer-guidelines
Язык: Английский
Процитировано
26
Otolaryngology, Год журнала: 2023, Номер 168(4), С. 571 - 592
Опубликована: Март 25, 2023
Abstract Objective To develop an expert consensus statement (ECS) on the management of dysphagia in head and neck cancer (HNC) patients to address controversies offer opportunities for quality improvement. Dysphagia HNC was defined as swallowing impairment with cancers nasal cavity, paranasal sinuses, nasopharynx, oral oropharynx, larynx, or hypopharynx. Methods Development group members expertise followed established guidelines developing ECS. A professional search strategist systematically reviewed literature, best available evidence used compose statements targeted at providers managing adult populations. The development prioritized topics where there significant practice variation that would improve patient care if were possible. Results identified 60 candidate statements, based 75 initial proposed questions, focused addressing following high yield topics: (1) risk factors, (2) screening, (3) evaluation, (4) prevention, (5) interventions, (6) surveillance. After 2 iterations Delphi survey removal duplicative 48 met standardized definition consensus; 12 designated no consensus. Conclusion Expert achieved pertaining intervention, surveillance patients. Clinicians can use these care, inform policy protocols, appreciate areas is Future research, ideally randomized controlled trials, warranted additional related
Язык: Английский
Процитировано
28
Oral Oncology, Год журнала: 2025, Номер 164, С. 107252 - 107252
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
1
Head & Neck, Год журнала: 2024, Номер unknown
Опубликована: Авг. 1, 2024
Abstract Background Radiation‐induced dysphagia and restricted mouth opening are common problems among patients with head neck cancer. The aim of the present randomized controlled trial was to determine if an exercise protocol could prevent swallowing impairment. Methods Eighty‐nine participants were randomly assigned either active group performing preventive exercises ( n = 45) or a control 44). Outcome measures collected at baseline before radiotherapy approximately 1‐month post‐treatment. Primary endpoints changes in function according Penetration Aspiration Scale ability measured millimeters. Intention‐to‐treat analysis used. Results Swallowing deteriorated both groups, no statistically significant positive effect detected follow‐up. Among who completed >75% exercises, there trend toward better outcomes. Conclusions Preventive did not improve short‐term after radiotherapy.
Язык: Английский
Процитировано
6
The journal of nutrition health & aging, Год журнала: 2023, Номер 27(8), С. 597 - 606
Опубликована: Июль 28, 2023
Oropharyngeal dysphagia (OD) is an underdiagnosed medical condition with a high prevalence in populations such as patients frailty, neurological disease, or head and neck pathology. Potential barriers to its diagnosis include lack of (or low) awareness the existence severity condition, hidden nature within 'normal ageing' process, clinical limitations, socioeconomic reasons. Consequently, effective treatment not systematically offered timely manner, complications, dehydration respiratory infections aspiration pneumonia, can arise. To overcome this issue, early use screening questionnaires identify people at risk swallowing disorders represents cornerstone preventive medicine. Several tools have been created but few are widely used practice. The Eating Assessment Tool-10 (EAT-10) was developed quick, easy-to-understand, self-administered tool for OD.
Язык: Английский
Процитировано
15
Revista de Logopedia Foniatría y Audiología, Год журнала: 2025, Номер 45(2), С. 100518 - 100518
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
Dysphagia, Год журнала: 2022, Номер 38(1), С. 127 - 144
Опубликована: Июль 7, 2022
Abstract Oropharyngeal dysphagia (OD) is a high impact morbidity in head-and-neck cancer (HNC) patients. A wide variety of instruments are developed to screen for affective symptoms and OD. The current paper aims systematically review appraise the literature obtain insight into prevalence, strength, causal direction relationship between OD HNC This was conducted accordance with PRISMA statement. systematic search performed using PubMed, PsycINFO, Cochrane, Embase. All available publications reporting on conditions swallowing function patients were included. Conference papers, tutorials, reviews, studies less than 5 excluded. Fifteen met inclusion criteria. level evidence methodological quality assessed ABC-rating scale QualSyst critical appraisal tool. Eleven reported positive findings this highlight importance symptom screening dysphagic as clinically relevant seems be prevalent coincident population. Considering patients’ daily life, early detection an integrated interdisciplinary approach recommended. However, due heterogeneity study designs, outcomes, outcome measures, generalization results limited.
Язык: Английский
Процитировано
20
Neurogastroenterology & Motility, Год журнала: 2022, Номер 35(1)
Опубликована: Сен. 19, 2022
Abstract Background Oro‐pharyngeal pathophysiology, including upper esophageal sphincter (UES) and pharyngeal disorders, can be assessed by high‐resolution manometry impedance (P‐HRM‐I). We aimed to establish methodology diagnose disorders utilizing P‐HRM‐I, hypothesizing that the objective measures could used disordered deglutition evidenced greater aspiration scores. Methods Patients ( n = 509, 18–91 years) were compared controls 120, 20–94 years). Variables measuring UES relaxation, opening extent, intrabolus pressure, contractile strength derived for 10 ml liquid swallows. Three associated pressurization patterns, which may indicative of obstructed flow, characterized: pan‐pressurization (Type 1), distal compartmentalized 2), transient 3). Deglutitive was determined from video fluoroscopy. Results relaxation pressure best able differentiate patients T 6.528, p < 0.0001). with abnormal (>8 mmHg) more frequently exhibited patterns had adjunct evidence reduced luminal distensibility (high and/or opening). Utilizing this information, a diagnostic scheme devised identifying 138 disorder. A further 96 without disorder abnormally weak pressures, confirming propulsive Amongst sub‐sample 320 undergoing fluoroscopy, those pressurizations higher scores (Chi‐square 60.169, Conclusion P‐HRM‐I provide based on findings opening, pressure. Measuring contractility requires optimization.
Язык: Английский
Процитировано
19
International Journal of Language & Communication Disorders, Год журнала: 2024, Номер 59(4), С. 1538 - 1552
Опубликована: Фев. 1, 2024
Evidence shows that 20%-30% of patients who aspirate do so silently. Research to date has not demonstrated clear evidence indicate which are at higher risk silent aspiration. Our aim was use univariate logistic regression analysis retrospective case review determine potential patterns
Язык: Английский
Процитировано
4
ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(11), С. 3394 - 3418
Опубликована: Окт. 14, 2024
Head and neck cancers (HNC) are aggressive, difficult-to-treat tumors that can be caused by genetic factors but mainly lifestyle or infection the human papillomavirus. As sixth most common malignancy, it presents a formidable therapeutic challenge with limited modalities. Curcumin, natural polyphenol, is appearing as promising multitarget anticancer antimetastatic agent. Numerous studies have shown curcumin its derivatives potential to affect signaling pathways (NF-κB, JAK/STAT, EGFR) molecular mechanisms crucial for growth migration of head tumors. Furthermore, ability interact tumor microenvironment trigger immune system may significantly influence organism's response tumor. Combining conventional therapies such chemotherapy radiotherapy improve efficacy treatment reduce side effects treatment, thereby increasing potential. This review comprehensive overview discusses both benefits limitations in context biology, an emphasis on HNC. also includes possibilities limiting properties terms development new derivatives, formulations, combinations type therapy HNC subsequent use clinical practice.
Язык: Английский
Процитировано
4