Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Апрель 25, 2024

Язык: Английский

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Perioperative esketamine administration for prevention of postpartum depression after the cesarean section: A systematic review and meta-analysis

Journal of Affective Disorders, Год журнала: 2024, Номер 361, С. 564 - 580

Опубликована: Июнь 24, 2024

Язык: Английский

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Effects of perioperative application of esketamine on postpartum depression in cesarean section: A systematic review and meta-analysis

Medicine, Год журнала: 2024, Номер 103(27), С. e38821 - e38821

Опубликована: Июль 5, 2024

Background: To evaluate the effect of perioperative esketamine administration on postpartum depression in pregnant women undergoing cesarean section. Methods: Data sources was PubMed, Embase, Web Science, and Cochrane Library from inception to February 1, 2024. Randomized controlled trials section were selected compared use period. The primary outcome measure incidence maternal depression. Preferred reporting items for systematic reviews meta-analyses used. pooled by random-effects models are presented as risk ratios (RR) (95% confidence intervals, 95% CI) or mean differences CI). This review registered PROSPERO (ID: CRD42023431197). Results: We included 8 studies with a total 1655 participants. quality rated high unclear. Seven involving 1485 participants reported Compared without esketamine, those using period showed 48% decreased developing (RR: 0.52, CI: 0.35–0.79) 1.43-point reduction EPDS (Edinburgh Postnatal Depression Scale) (mean difference: −1.43, −2.32 −0.54). For immediate intraoperative adverse reactions, application caused nausea vomiting 2.16, 1.22–3.81), dizziness 6.11, 1.49–24.98), hallucinations 6.83, 1.57–29.68) no use. Conclusions: Perioperative may reduce increase but has significant postoperative reactions.

Язык: Английский

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Comparing the adverse effects of ketamine and esketamine between genders using FAERS data

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 12, 2024

Background Ketamine was developed as an anesthetic. Esketamine is the isolated S-enantiomer of racemic ketamine. They provide new avenues for treatment depression, especially treatment-resistant depression. Considering differences in pharmacokinetics and hormonal status ketamine patients different genders, sex-based esketamine adverse drug events (ADE) may also be observed. This study presents data mining safety analysis between promoting individualization clinical practice. Methods Adverse reactions to reported first quarter 2004 second 2023 U.S. Food Drug Administration on Event Reporting System (FAERS) were extracted. Thereafter, reporting odds ratio (ROR) with 95% confidence interval (CI) calculated. Results A total 2907 female reports 1634 male included analysis. ROR showed that completed suicide, decreased therapeutic product effects, urinary retention, hypertension common men. Additionally, 552 653 recorded. revealed toxicity various agents, bradycardia, cystitis agitation, more likely occur men, whereas women develop suicidal ideation, increased transaminase levels, sclerosing cholangitis, sterile pyuria. Conclusion The differ across which should considered practice individualized treatment.

Язык: Английский

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Comment on “Efficacy of racemic ketamine or esketamine monotherapy for reducing suicidal ideation in uni- or bipolar depression: a systematic review and meta-analysis”

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Chronic, combinatorial targeting of NMDARs and 5-HT4Rs exerts extended behavioral effects against stress-induced perseverative behavior and hyponeophagia

Neuropsychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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Efficacy of ketamine versus esketamine in the treatment of perioperative depression: A review

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 242, С. 173773 - 173773

Опубликована: Май 26, 2024

Язык: Английский

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The association between ketamine and esketamine and suicidality: reports to the Food And Drug Administration Adverse Event Reporting System (FAERS)

Expert Opinion on Drug Safety, Год журнала: 2024, Номер unknown, С. 1 - 6

Опубликована: Июнь 17, 2024

Introduction Replicated evidence indicates that ketamine and esketamine reduces measures of suicidality in persons with treatment resistant depression (TRD). It remains uncertain whether susceptible individuals may experience worsening pre-existing either agent.

Язык: Английский

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Is there evidence for using ketamine among individuals with dementia?

Journal of International Medical Research, Год журнала: 2024, Номер 52(6)

Опубликована: Июнь 1, 2024

The aim of this short narrative review was to evaluate the existing literature regarding clinical use ketamine among individuals with dementia, especially those behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, MEDLINE) databases were searched for abstracts using search terms “ketamine” AND “dementia.” Only articles describing in dementia included. Articles that did not include ketamine, published a non-English language, primarily described animal studies, or reviews excluded. Three case reports met inclusion criteria. One subcutaneous depression, one intramuscular acute agitation, S-ketamine as anesthesia during electroconvulsive therapy depression catatonia. No significant adverse effects reported any cases. Although treatment agitation associated has potential, current evidence remains limited. High-quality prospective studies are needed confirm observations these before can be used treat disturbances dementia.

Язык: Английский

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The effect and mechanism of low-dose esketamine in neuropathic pain-related depression-like behavior in rats

Brain Research, Год журнала: 2024, Номер 1843, С. 149117 - 149117

Опубликована: Июль 6, 2024

Язык: Английский

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