Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Май 26, 2023
Neurodegenerative
diseases
have
reached
alarming
numbers
in
the
past
decade.
Unfortunately,
clinical
trials
testing
potential
therapeutics
proven
futile.
In
absence
of
disease-modifying
therapies,
physical
activity
has
emerged
as
single
most
accessible
lifestyle
modification
with
to
fight
off
cognitive
decline
and
neurodegeneration.
this
review,
we
discuss
findings
from
epidemiological,
clinical,
molecular
studies
investigating
modifications
promoting
brain
health.
We
propose
an
evidence-based
multidomain
approach
that
includes
activity,
diet,
training,
sleep
hygiene
treat
prevent
neurodegenerative
diseases.
Frontiers in Neurology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 20, 2025
Background
Recent
scientific
interest
has
focused
on
exploring
the
potential
relationships
between
fatigue,
respiratory
function
and
balance
in
multiple
sclerosis
(MS)
subjects.
While
some
studies
suggest
that
fatigue
may
impact
postural
stability,
exact
nature
of
these
associations
remains
under
investigation.
Ultrasound
imaging
is
increasingly
being
used
to
examine
structural
functional
characteristics
core
muscles,
aiming
better
understand
how
variables
might
be
interconnected.
Understanding
crucial
for
developing
targeted
interventions
enhance
overall
physical
performance
this
population.
This
study
examines
relationship
function,
balance,
ultrasound
abdominal
musculature
MS.
Methods
A
cross-sectional
was
conducted
involving
27
subjects
diagnosed
with
MS,
comprising
17
females
10
males.
Study
were:
(Modified
Fatigue
Impact
Scale—MFIS);
(Forced
Vital
Capacity—FVC
Forced
Expiratory
Volume
first
second—FEV1);
(Berg
Balance
Scale—BBS
Trunk
Impairment
Scale
Dynamic—TIS
DYN);
measurements
diaphragmatic
musculature.
Correlations
were
analyzed
using
Spearman’s
correlation,
a
statistical
significance
level
p
<
0.05.
Results
Significant
correlations
found
scores.
FVC
showed
moderate
correlation
BBS
(
r
=
0.443),
while
FEV1
had
high
0.500)
TIS
DYN
0.427).
MFIS
negative
−0.402).
The
strength
central
musculature,
particularly
internal
oblique,
trunk
stability
control.
Conclusion
These
findings
highlight
interplay
muscle
morphology
emphasizing
benefits
targeting
improve
reduce
ultimately
enhancing
quality
life
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(3), С. 839 - 839
Опубликована: Янв. 27, 2025
Background:
The
prognosis
of
people
with
multiple
sclerosis
(MS)
has
improved
substantially
in
recent
decades
due
to
advances
diagnosis
and
treatment.
Due
the
unpredictable
course
heterogenous
treatment
response
MS,
there
is
a
clear
need
for
biomarkers
that
reflect
disease
activity
clinical
follow-up
these
patients.
We
conducted
systematic
review
Bayesian
network
meta-analysis
aim
analyzing
effects
physical
exercise
on
neurofilaments
(NfL)
glial
fibrillary
acidic
protein
(GFAP)
levels
patients
MS.
Methods:
A
was
following
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines,
starting
PICO
(patient/population,
intervention,
comparison,
outcome)
question:
what
are
(with
independence
type)
NfL
and/or
GFAP
MS
compared
other
interventions
or
no
intervention
whatsoever?
systematically
comprehensive
literature
search
from
January
March
2024
identify
original
studies
answered
question,
using
main
data
sources.
quality
included
assessed
Quality
Index
Downs
&
Black.
For
followed
randomized
controlled
trial
(RCT)
design,
methodological
each
paper
Physiotherapy
Evidence
Database
(PEDro)
Scale.
Risk
bias
also
explored
by
two
independent
reviewers.
Finally,
all
articles
were
classified
according
evidence
grades
recommendation
established
Oxford
Center
Evidence-Based
Medicine.
continuous
outcome
measures
enough
comparisons
greater
than
equal
good
PEDro
scale,
(NMA)
applied.
statistical
analyses
performed
R
(version
4.1.3,
Core
Team
2023)
“BUGSnet”
“gemtc”
packages.
NMA
can
be
used
obtain
posterior
probability
distribution
relative
effects,
which
allows
us
quantify
uncertainty
parameter
estimates
rank
treatments
network.
Results:
Eight
this
six
NMA,
they
appraised
quality.
characteristics
studies,
types
training
described
protocols,
quality,
risk
bias,
studied
outlined.
Qualitative
synthesis,
different
modalities
selection
final
model
assessment,
ranking
shown.
Conclusions:
Our
findings
indicated
moderate-intensity
more
likely
reduce
concentration
high-intensity
exercise,
and,
turn,
low-intensity
exercise.
However,
inconclusive.
Degenerative Neurological and Neuromuscular Disease,
Год журнала:
2023,
Номер
Volume 13, С. 55 - 68
Опубликована: Сен. 1, 2023
Background:
Today,
living
well
with
multiple
sclerosis
(MS)
is
often
measured
by
a
person's
overall
quality
of
life
rather
than
being
limited
to
the
more
traditional
metrics
reduced
frequency
relapses
or
progression
disability.
This
change
in
focus,
holistic
view
health,
such
as
life,
has
shifted
views
what
both
providers
and
people
essential
for
MS.
Purpose:
narrative
review
aims
examine
relevant
literature
on
existing
emerging
non-pharmacological
interventions
shown
improve
across
all
health
domains.
Methods:
A
search
was
conducted
MEDLINE,
CINAHL,
Scopus
electronic
databases
using
following
terms:
health-related
quality,
satisfaction,
intervention,
non-drug,
intervention.
After
screening
abstracts,
24
were
selected
this
review.
Results:
Common
used
fatigue
sleep,
mental
emotional
cognition,
physical
chronic
pain.
Several
included
positively
improved
sclerosis.
These
exercise,
cognitive
behavior
therapy,
rehabilitation.
Conclusion:
Non-pharmacological
exercise
behavioral
therapy
should
be
prescribed
during
routine
medical
care.
Translating
research
into
standard
clinical
practice
one
area
focus.
In
addition,
higher
studies,
randomized
control
trials,
need
nonpharmacological
assess
effectiveness.
Keywords:
sclerosis,
wellness,
Abstract
Background
Physical
fatigue
is
one
of
the
most
disabling
symptoms
in
people
with
Multiple
Sclerosis
(PwMS).
Several
factors
might
influence
development
fatigue,
such
as
gender,
education,
body
mass
index
(BMI),
Expanded
Disability
Status
Scale
(EDSS),
disease
duration,
working
status
(Ws),
physiotherapy
(Ph),
and
disease-modifying
therapies
(DMTs).
Fatigue
Symptoms
Impacts
Questionnaire-Relapsing
(FSIQ-RMS)
a
patient-reported
outcome
(PRO)
that
allows
to
define
impact
PwMS
clearly.
This
study
aimed
assess
on
by
using
FSIQ-RMS.
Methods
The
participants
were
enrolled
from
May
July
2021
MS
Centers
Sant’Andrea
Hospital
Policlinico
Umberto
I
Rome.
was
evaluated
FSIQ-RMS,
validated,
culturally
adapted
Italian.
Clinical
demographic
data
collected
at
same
time.
Results
We
178
[Female
74.16%;
RMS
82.58%,
SPMS
17.52%].
FSIQ-RMS
scores
significantly
correlated
EDSS
(p-value
<
0.01).
Analysis
variance
between
means
showed
statistically
significant
difference
BMI
groups
24hours_FSIQ-RMS
score
7days_FSIQ-RMS
(
p
0.01),
lower
group
having
highest
scores.
Furthermore,
perceived
improved
both
subjects
performing
Ph
0.05)
those
who
actively
work
Conclusions
use
real-world
setting
confirmed
underweight
high
levels
disability
are
closely
related
fatigue.
In
addition,
active
Ws
strongly
PwMS.
JMIR Rehabilitation and Assistive Technologies,
Год журнала:
2024,
Номер
11, С. e52733 - e52733
Опубликована: Фев. 2, 2024
Physical
activity
(PA)
represents
a
low-cost
and
readily
available
means
of
mitigating
multiple
sclerosis
(MS)
symptoms
alleviating
the
disease
course.
Nevertheless,
persons
with
MS
engage
in
lower
levels
PA
than
general
population.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 25, 2024
Multiple
sclerosis
(MS)
is
a
progressively
debilitating
disorder
that
has
seen
notable
rise
in
prevalence
recent
years.
This
study
examines
the
burden
of
MS
from
1990
to
2019,
providing
detailed
analysis
by
age,
sex,
and
sociodemographic
index
(SDI)
across
204
countries
territories.
