Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: May 26, 2023

Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potential therapeutics proven futile. In absence of disease-modifying therapies, physical activity has emerged as single most accessible lifestyle modification with to fight off cognitive decline and neurodegeneration. this review, we discuss findings from epidemiological, clinical, molecular studies investigating modifications promoting brain health. We propose an evidence-based multidomain approach that includes activity, diet, training, sleep hygiene treat prevent neurodegenerative diseases.

Language: Английский

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Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points

Degenerative Neurological and Neuromuscular Disease, Journal Year: 2023, Volume and Issue: Volume 13, P. 55 - 68

Published: Sept. 1, 2023

Background: Today, living well with multiple sclerosis (MS) is often measured by a person's overall quality of life rather than being limited to the more traditional metrics reduced frequency relapses or progression disability. This change in focus, holistic view health, such as life, has shifted views what both providers and people essential for MS. Purpose: narrative review aims examine relevant literature on existing emerging non-pharmacological interventions shown improve across all health domains. Methods: A search was conducted MEDLINE, CINAHL, Scopus electronic databases using following terms: health-related quality, satisfaction, intervention, non-drug, intervention. After screening abstracts, 24 were selected this review. Results: Common used fatigue sleep, mental emotional cognition, physical chronic pain. Several included positively improved sclerosis. These exercise, cognitive behavior therapy, rehabilitation. Conclusion: Non-pharmacological exercise behavioral therapy should be prescribed during routine medical care. Translating research into standard clinical practice one area focus. In addition, higher studies, randomized control trials, need nonpharmacological assess effectiveness. Keywords: sclerosis, wellness,

Language: Английский

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Exploring the Major Barriers to Physical Activity in Persons With Multiple Sclerosis: Observational Longitudinal Study

JMIR Rehabilitation and Assistive Technologies, Journal Year: 2024, Volume and Issue: 11, P. e52733 - e52733

Published: Feb. 2, 2024

Physical activity (PA) represents a low-cost and readily available means of mitigating multiple sclerosis (MS) symptoms alleviating the disease course. Nevertheless, persons with MS engage in lower levels PA than general population.

Language: Английский

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Correlations among fatigue, respiratory function, balance and core muscle morphology in multiple sclerosis: a comprehensive observational study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Background Recent scientific interest has focused on exploring the potential relationships between fatigue, respiratory function and balance in multiple sclerosis (MS) subjects. While some studies suggest that fatigue may impact postural stability, exact nature of these associations remains under investigation. Ultrasound imaging is increasingly being used to examine structural functional characteristics core muscles, aiming better understand how variables might be interconnected. Understanding crucial for developing targeted interventions enhance overall physical performance this population. This study examines relationship function, balance, ultrasound abdominal musculature MS. Methods A cross-sectional was conducted involving 27 subjects diagnosed with MS, comprising 17 females 10 males. Study were: (Modified Fatigue Impact Scale—MFIS); (Forced Vital Capacity—FVC Forced Expiratory Volume first second—FEV1); (Berg Balance Scale—BBS Trunk Impairment Scale Dynamic—TIS DYN); measurements diaphragmatic musculature. Correlations were analyzed using Spearman’s correlation, a statistical significance level p < 0.05. Results Significant correlations found scores. FVC showed moderate correlation BBS ( r = 0.443), while FEV1 had high 0.500) TIS DYN 0.427). MFIS negative −0.402). The strength central musculature, particularly internal oblique, trunk stability control. Conclusion These findings highlight interplay muscle morphology emphasizing benefits targeting improve reduce ultimately enhancing quality life

Language: Английский

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Identification of lipid metabolism-related gene markers and construction of a diagnostic model for multiple sclerosis: an integrated analysis by bioinformatics and machine learning

Analytical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 115781 - 115781

Published: Jan. 1, 2025

Language: Английский

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Effects of Physical Exercise on Neurofilament Light Chain and Glial Fibrillary Acidic Protein Level in Patients with Multiple Sclerosis: A Systematic Review and Bayesian Network Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 839 - 839

Published: Jan. 27, 2025

Background: The prognosis of people with multiple sclerosis (MS) has improved substantially in recent decades due to advances diagnosis and treatment. Due the unpredictable course heterogenous treatment response MS, there is a clear need for biomarkers that reflect disease activity clinical follow-up these patients. We conducted systematic review Bayesian network meta-analysis aim analyzing effects physical exercise on neurofilaments (NfL) glial fibrillary acidic protein (GFAP) levels patients MS. Methods: A was following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, starting PICO (patient/population, intervention, comparison, outcome) question: what are (with independence type) NfL and/or GFAP MS compared other interventions or no intervention whatsoever? systematically comprehensive literature search from January March 2024 identify original studies answered question, using main data sources. quality included assessed Quality Index Downs & Black. For followed randomized controlled trial (RCT) design, methodological each paper Physiotherapy Evidence Database (PEDro) Scale. Risk bias also explored by two independent reviewers. Finally, all articles were classified according evidence grades recommendation established Oxford Center Evidence-Based Medicine. continuous outcome measures enough comparisons greater than equal good PEDro scale, (NMA) applied. statistical analyses performed R (version 4.1.3, Core Team 2023) “BUGSnet” “gemtc” packages. NMA can be used obtain posterior probability distribution relative effects, which allows us quantify uncertainty parameter estimates rank treatments network. Results: Eight this six NMA, they appraised quality. characteristics studies, types training described protocols, quality, risk bias, studied outlined. Qualitative synthesis, different modalities selection final model assessment, ranking shown. Conclusions: Our findings indicated moderate-intensity more likely reduce concentration high-intensity exercise, and, turn, low-intensity exercise. However, inconclusive.

Language: Английский

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Physical Activity in Multiple Sclerosis: Real-World Data From Saskatchewan, Canada

International Journal of MS Care, Journal Year: 2025, Volume and Issue: 27(Q1), P. 42 - 49

Published: Feb. 10, 2025

ABSTRACT BACKGROUND: Physical activity guidelines for multiple sclerosis (MS) were first published in 2013. is safe and beneficial MS, yet it unclear if physical levels are changing real-world settings. METHODS: The primary objective of this study to determine the people with MS changing. Between September 1, 2014, February 22, 2022, when accessed a provincial drugs program Saskatchewan, Canada, they invited complete Godin Leisure-Time Exercise Questionnaire by mail. Scatter plots total (TPA) health contribution (HC) scores generated from each person's questionnaire. Multivariable linear regression explored associations interactions between disease-modifying treatment (DMT), sex, age, age at onset, disease duration on level. RESULTS: response rate was 50.8% (505 responses 993 requests). Of respondents, 69.7% female; mean 42.8 (± 11.5) years; median 6.0 years (IQR, 2.0-14.0); 47.4% had prior DMT exposure. There no significant change new registrants over 7 (regression slopes TPA: 0.71, P = .26; HC: 0.61, .21). Men reported higher than women (TPA: β 11.95; < .001; 6.65; .001). 0.03; .003; exposure not associated activity. CONCLUSIONS: remained suboptimal benefits 7-year period. Future research should include how use impact levels.

Language: Английский

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Aerobic capacity moderates the association between cervical cord atrophy and clinical disability in mildly disabled multiple sclerosis patients

Multiple Sclerosis Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Background: Spinal cord volume loss is associated with clinical disability in multiple sclerosis (MS). Aerobic capacity may mitigate the impact of central nervous system (CNS) damage accumulation, exerting beneficial effects on MS-related disability. Objectives: We investigated whether aerobic could moderate association between spinal atrophy and MS. Methods: In this cross-sectional analysis, expanded status scale (EDSS), peak oxygen consumption (VO 2 peak), brain volumetric measures, normalized mean upper cervical area (nMUCCA) were collected from 51 MS patients 33 healthy controls (HCs). Low was defined as having a VO z-score less than –1.64 standard deviations. patients, we explored nMUCCA EDSS moderated by level capacity. Results: The relationship capacity, significant × interaction (β = −0.099, 95% bootstrapped confidence interval [CI] [−0.172; −0.014], p 0.012). Lower significantly higher score low −0.073, < 0.001), but not those high 0.026, 0.417). Conclusions: mild disability, can potentially negative

Language: Английский

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Medical comorbidities in adults newly diagnosed with multiple sclerosis and clinically isolated syndrome: An observational study exploring prevalence, risk factors, and outcomes

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106390 - 106390

Published: March 1, 2025

Language: Английский

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The effect of proprioceptive neuromuscular facilitation techniques on pain, motor functions, fatigue and health related quality of life in individuals with multiple sclerosis: a randomized, single-blind study

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 7, 2025

This study aimed to evaluate the effects of PNF on pain, motor function, fatigue, and quality life in MS patients. A randomized, controlled, single-blind was conducted. Forty-four patients were randomly assigned either Group (PNFG, n = 22, 16 female) or Control (CG, female). PNFG underwent supervised combined aerobic training thrice weekly for 8 weeks, while CG followed a home exercise regimen. Various measures employed, including Visual Analogue Scale (VAS) Timed Up Go (TUG) test, Functional Reach Test (FRT), Six-Minute Walk (6-MWT), Fatigue Severity (FSS), Impact (FIS), Dexterity Questionnaire-24 (DextQ-24) Multiple Sclerosis Quality Life-54 (MSQoL-54). exhibited significant improvements VAS (p 0.000), FRT 0.001), TUG 6-MWT FIS 0.007), DextQ-24 0.033), MSQoL-54 scores (Physical Health Composite, Mental p 0.005, 0.002, respectively) < 0.05). also showed 0.018), FSS 0.006), psychosocial function 0.017, 0.001, respectively), ADL 0.045) outperformed (Dressing, 0.038) subscales (emotional well-being, energy, health perception, 0.007, 0.037, 0.044, is first randomized controlled trial show that improves upper limb (skill) physiotherapy effectively improved fatigue life, with group achieving better outcomes. Both modalities offered accessible rehabilitation options.

Language: Английский

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