Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1176 - 1176
Опубликована: Дек. 4, 2024
Antibiotics,
widely
used
medications
that
have
significantly
increased
life
expectancy,
possess
a
broad
range
of
effects
beyond
their
primary
antibacterial
activity.
While
some
are
recognized
as
adverse
events,
others
demonstrated
unexpected
benefits.
These
adjunctive
effects,
which
been
defined
"pleiotropic"
in
the
case
other
pharmacological
classes,
include
immunomodulatory
properties
and
modulation
microbiota.
Specifically,
macrolides,
tetracyclines,
fluoroquinolones
shown
to
modulate
immune
system
both
acute
chronic
conditions,
including
autoimmune
disorders
(e.g.,
rheumatoid
arthritis,
spondyloarthritis)
inflammatory
pulmonary
diseases
asthma,
obstructive
disease).
Azithromycin,
particular,
is
recommended
for
long-term
treatment
due
its
well-established
effects.
Furthermore,
antibiotics
influence
human
Rifaximin,
example,
exerts
eubiotic
effect
enhances
balance
between
gut
microbiota
host
cells
epithelial
cells.
pleiotropic
offer
new
therapeutic
opportunities
by
interacting
with
cells,
signaling
molecules,
bacteria
involved
non-infectious
like
spondyloarthritis
bowel
diseases.
The
aim
this
review
explore
potential
antibiotics,
from
molecular
cellular
evidence
clinical
application,
order
optimize
use.
Understanding
these
essential
ensure
careful
use,
particularly
consideration
threat
antimicrobial
resistance.
Current Neuropharmacology,
Год журнала:
2023,
Номер
22(6), С. 1080 - 1109
Опубликована: Окт. 19, 2023
Neurodegenerative
disease
(ND)
incidence
has
recently
increased
due
to
improved
life
expectancy.
Alzheimer's
(AD)
or
Parkinson's
(PD)
are
the
most
prevalent
NDs.
Both
diseases
poly
genetic,
multifactorial
and
heterogenous.
Preventive
medicine,
a
healthy
diet,
exercise,
controlling
comorbidities
may
delay
onset.
After
diagnosed,
therapy
is
needed
slow
progression.
Recent
studies
show
that
local,
peripheral
age-related
inflammation
accelerates
NDs'
onset
Patients
with
autoimmune
disorders
like
inflammatory
bowel
(IBD)
could
be
at
higher
risk
of
developing
AD
PD.
However,
no
increase
in
ND
been
reported
if
patients
adequately
diagnosed
treated.
Autoantibodies
against
abnormal
tau,
β
amyloid
α-
synuclein
have
encountered
PD
protective.
This
discovery
led
proposal
immune-based
therapies
for
involving
monoclonal
antibodies,
immunization/
vaccines,
pro-inflammatory
cytokine
inhibition
anti-inflammatory
addition.
All
different
approaches
analysed
here.
Future
perspectives
on
new
therapeutic
strategies
both
concisely
examined.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 22, 2023
Age-related
hearing
loss
is
the
most
common
sensory
disorder
worldwide
that
contributes
to
numerous
health
conditions
in
aging
population.
Despite
its
prevalence,
current
treatments,
including
aids,
are
unsatisfactory
improving
deficits
or
slowing
reversing
pathophysiology.
Immunosenescence
a
key
driver
of
neurodegenerative
disease,
and
similar
mechanism
has
recently
come
attention
age-related
loss.
Imbalanced
levels
cytokines
chemokines
contribute
aberrant
immune
cell
activity
chronic
pro-inflammatory
microenvironment
may
lead
degradation
inner
ear
structure
function.
Macrophages,
typically
guardians
organ
homeostasis,
found
develop
dysregulated
with
due
unidentified
factors,
they
interact
other
components
innate
system
damage
hair
cells,
synapses,
neurons,
structures
critical
signal
transmission.
They
also
increasingly
trigger
inflammasome,
protein
complex
involved
inflammatory
death,
complement
cascade,
perpetuate
cycle
inflammation
cellular
cochlea,
resulting
Senescence
certain
T
populations
have
indicated
role
adaptive
immunity
as
well.
Deciphering
mechanisms
dysregulation
first
step
producing
targeted
therapies
for
This
brief
review
describes
emerging
research
surrounding
systems
parallels
diseases.
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1682 - 1682
Опубликована: Окт. 14, 2024
Parkinson's
disease
(PD)
is
a
pathological
state
characterized
by
combined
set
of
abnormal
movements
including
slow
motion,
resting
tremors,
profound
stiffness
skeletal
muscles,
or
obvious
abnormalities
in
posture
and
gait,
together
with
significant
behavioral
changes.
Until
now,
no
single
therapeutic
modality
was
able
to
provide
complete
cure
for
PD.
This
work
trial
assess
the
immunomodulatory
effects
canagliflozin
without
levodopa/carbidopa
on
rotenone-induced
parkinsonism
Balb/c
mice.
Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1176 - 1176
Опубликована: Дек. 4, 2024
Antibiotics,
widely
used
medications
that
have
significantly
increased
life
expectancy,
possess
a
broad
range
of
effects
beyond
their
primary
antibacterial
activity.
While
some
are
recognized
as
adverse
events,
others
demonstrated
unexpected
benefits.
These
adjunctive
effects,
which
been
defined
"pleiotropic"
in
the
case
other
pharmacological
classes,
include
immunomodulatory
properties
and
modulation
microbiota.
Specifically,
macrolides,
tetracyclines,
fluoroquinolones
shown
to
modulate
immune
system
both
acute
chronic
conditions,
including
autoimmune
disorders
(e.g.,
rheumatoid
arthritis,
spondyloarthritis)
inflammatory
pulmonary
diseases
asthma,
obstructive
disease).
Azithromycin,
particular,
is
recommended
for
long-term
treatment
due
its
well-established
effects.
Furthermore,
antibiotics
influence
human
Rifaximin,
example,
exerts
eubiotic
effect
enhances
balance
between
gut
microbiota
host
cells
epithelial
cells.
pleiotropic
offer
new
therapeutic
opportunities
by
interacting
with
cells,
signaling
molecules,
bacteria
involved
non-infectious
like
spondyloarthritis
bowel
diseases.
The
aim
this
review
explore
potential
antibiotics,
from
molecular
cellular
evidence
clinical
application,
order
optimize
use.
Understanding
these
essential
ensure
careful
use,
particularly
consideration
threat
antimicrobial
resistance.
