Hidden hearing loss: Fifteen years at a glance

Hearing Research, Год журнала: 2024, Номер 443, С. 108967 - 108967

Опубликована: Янв. 30, 2024

Hearing loss affects approximately 18% of the population worldwide. difficulties in noisy environments without accompanying audiometric threshold shifts likely affect an even larger percentage global population. One potential causes hidden hearing is cochlear synaptopathy, synapses between inner hair cells (IHC) and auditory nerve fibers (ANF). These are most vulnerable structures cochlea to noise exposure or aging. The deafferentation, i.e., afferent information, whose downstream effect information that sent higher-order processing stages. Understanding physiological perceptual effects this early deafferentation might inform interventions prevent later, more severe loss. In past decade, a large body work has been devoted better understand loss, including their corresponding impact on pathway, use measures for clinical diagnosis deafferentation. This review synthesizes findings from studies humans animals answer some key questions field, it points gaps knowledge warrant investigation. Specifically, recent suggest electrophysiological have function as indicators humans, but research needed these be included part test battery.

Язык: Английский

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Better speech-in-noise comprehension is associated with enhanced neural speech tracking in older adults with hearing impairment

Cortex, Год журнала: 2022, Номер 151, С. 133 - 146

Опубликована: Март 19, 2022

The alignment between low-frequency activity in the brain and slow acoustic modulations speech signal depicts a core principle present theories of perception—a process referred to as 'neural tracking'. While most older adults, particularly those with highly prevalent age-related hearing loss, have difficulties perception comprehension, impact loss on neural tracking is still unclear. In this study we investigated effects pure-tone different types background noise response large sample adults (N = 101). Furthermore, examined whether was predictive for comprehension. For purpose, obtained scalp EEG from our participants who had varying degrees (7.5–59.6 dB HL .5–8 kHz pure tones) while they listened sentences quiet, pink multi-talker babble noise. Speech quantified by computing cross-correlation amplitude envelope heard. A higher degree associated greater (i.e., cross-correlation). Additionally, showed positive association This relationship modulated hearing-impaired benefitting more tracking. Our results highlight potential an objective measure comprehension possible target mechanism clinical interventions such neurofeedback. interaction suggests compensatory which rely signal.

Язык: Английский

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Adaptation in auditory processing

Physiological Reviews, Год журнала: 2022, Номер 103(2), С. 1025 - 1058

Опубликована: Сен. 1, 2022

Adaptation is an essential feature of auditory neurons, which reduces their responses to unchanging and recurring sounds allows response properties be matched the constantly changing statistics that reach ears. As a consequence, processing in system highlights novel or unpredictable produces efficient representation vast range animals can perceive by continually adjusting sensitivity and, lesser extent, tuning neurons most commonly encountered stimulus values. Together with attentional modulation, adaptation sound also helps generate neural representations are tolerant background noise therefore plays vital role scene analysis. In this review, we consider diverse forms found terms levels at they arise, underlying mechanisms, impact on coding perception. We ask what dynamics adaptation, occur over multiple timescales, reveal about statistical environment. Finally, examine how influenced learning experience changes as result aging hearing loss.

Язык: Английский

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Tinnitus und beeinflussende Komorbiditäten

Laryngo-Rhino-Otologie, Год журнала: 2023, Номер 102(S 01), С. S50 - S58

Опубликована: Май 1, 2023

Numerous studies show that impairments in chronic tinnitus are closely connected with psychosomatic and other concomitant symptoms. This overview summarizes some of these studies. Beyond hearing loss, individual interactions medical psychosocial stress factors as well resources central importance. Tinnitus related distress reflects a large number intercorrelated, influences - such personality traits, reactivity depression or anxiety which can be accompanied by cognitive difficulties should conceptualized assessed within vulnerability-stress-reaction model. Superordinate age, gender education level increase vulnerability to stress. Therefore, diagnosis therapy individualised, multidimensional interdisciplinary. Multimodal approaches aim address individually constellated medical, audiological psychological order sustainably the quality life those affected. Counselling first contact is also indispensable for therapy.

Язык: Английский

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Somatostatin and the pathophysiology of Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102270 - 102270

Опубликована: Март 13, 2024

Язык: Английский

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Cortical Responses to the Amplitude Envelopes of Sounds Change with Age

Journal of Neuroscience, Год журнала: 2021, Номер 41(23), С. 5045 - 5055

Опубликована: Апрель 26, 2021

Many older listeners have difficulty understanding speech in noise, when cues to speech-sound identity are less redundant. The amplitude envelope of fluctuates dramatically over time, and features such as the rate change at onsets (attack) offsets (decay), signal critical information about sounds. Aging is also thought be accompanied by increases cortical excitability, which may differentially alter sensitivity dynamics. Here, we recorded electroencephalography younger human adults (of both sexes) investigate how aging affects neural synchronization 4 Hz amplitude-modulated noises with different shapes (ramped: slow attack sharp decay; damped: decay). We observed that subcortical responses did not differ between age groups, whereas compared exhibited larger sound onsets, consistent an increase auditory excitability. Neural activity synchronized more strongly rapid-onset, slow-offset (damped) envelopes, was sinusoidal, peaked. Younger demonstrated opposite pattern, showing stronger slow-onset, rapid-offset (ramped) well a sinusoidal response shape. current results suggest age-related changes excitability cortex This part reason why experience noise.

Язык: Английский

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Afferent Loss, GABA, and Central Gain in Older Adults: Associations with Speech Recognition in Noise

Journal of Neuroscience, Год журнала: 2022, Номер 42(38), С. 7201 - 7212

Опубликована: Авг. 22, 2022

Deficits in auditory nerve (AN) function for older adults reduce afferent input to the cortex. The extent which cortex adapts this loss of and mechanisms underlying adaptation are not well understood. We took a neural systems approach measuring AN cortical evoked responses within 50 27 younger human (59 female) estimate central gain or increased activity despite reduced activity. Relative adults, adults9 response amplitudes were smaller, but not. used relationship between predict from their responses. Central was thus defined as difference observed those predicted parameter estimates adults. In decreased contributed lower GABA levels, greater gain, poorer speech recognition noise (SIN). These effects on SIN occur addition to, independent from, attributed elevated hearing thresholds. Our results consistent with animal models suggest that some may result changes encoding inhibitory neurotransmission, contribute SIN. An advancement our understanding throughout system gradual increasing age provide potential therapeutic targets intervention. SIGNIFICANCE STATEMENT Age-related is one most common chronic conditions aging, yet little known about how sensory input. measured same stimulus we found hyperexcitability relative concomitant declines gain. Lower levels GABA, an neurotransmitter, associated adapt attenuated by reducing inhibition amplify response, amplification lead

Язык: Английский

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Neural signatures of auditory hypersensitivity following acoustic trauma

eLife, Год журнала: 2022, Номер 11

Опубликована: Сен. 16, 2022

Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations afferent activity levels. However, sudden peripheral deafferentation adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptual disorders including hypersensitivity, phantom limb pain, and tinnitus. Here, we show mice with noise-induced damage of the high-frequency cochlear base were behaviorally hypersensitive spared mid-frequency tones direct optogenetic stimulation auditory thalamocortical neurons. Chronic two-photon calcium imaging from ACtx pyramidal neurons (PyrNs) revealed initial stage spatially diffuse hyperactivity, hyper-correlation, hyperresponsivity consolidated around deafferented map regions three or more days after acoustic trauma. Deafferented PyrN ensembles also displayed decoding mirrored behavioral suggesting regulation sound intensity coding following sensorineural loss be underlying source hypersensitivity. Excess gain trauma was expressed heterogeneously among individual PyrNs, yet 40% this variability could accounted for by each cell’s baseline properties prior PyrNs initially high spontaneous gradual monotonic growth functions likely excess This suggests while changes are triggered reduced bottom-up input, their subsequent stabilization is shaped local circuit milieu, where indicators inhibition presage pathological hyperactivity hearing loss.

Язык: Английский

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Effects of aging on cortical representations of continuous speech

Journal of Neurophysiology, Год журнала: 2023, Номер 129(6), С. 1359 - 1377

Опубликована: Апрель 25, 2023

We observed age-related changes in cortical temporal processing of continuous speech that may be related to older adults’ difficulty understanding noise. These occur both timing and strength the representations at different stages depend on noise condition selective attention. Critically, their dependence dramatically among early, middle, late stages, underscoring how aging differentially affects these stages.

Язык: Английский

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Electrocochleographic frequency-following responses as a potential marker of age-related cochlear neural degeneration

Hearing Research, Год журнала: 2024, Номер 446, С. 109005 - 109005

Опубликована: Апрель 5, 2024

Auditory nerve (AN) fibers that innervate inner hair cells in the cochlea degenerate with advancing age. It has been proposed age-related reductions brainstem frequency-following responses (FFR) to carrier of low-frequency, high-intensity pure tones may partially reflect this neural loss (Märcher-Rørsted et al., 2022). If AN is primary factor contributing changes FFR, then FFR could serve as an indicator cochlear degeneration. In study, we employed electrocochleography (ECochG) investigate effects age on neurophonic potentials, i.e., phase-locked frequency tone stimulus. We compared these findings brainstem-generated FFRs obtained simultaneously using same stimulation. conducted recordings young and older individuals normal hearing. Responses (250 ms, 516 1086 Hz, 85 dB SPL) clicks were recorded both ECochG at tympanic membrane traditional scalp electroencephalographic (EEG) FFR. Distortion product otoacoustic emissions (DPOAE) also collected. recordings, sustained (ANN) tonal stimulation, well click-evoked compound action potential (CAP) AN, significantly reduced listeners controls, despite audiometric thresholds. EEG stimulation diminished participants. Unlike CAP response, transient-evoked wave-V remained unaffected. These indicate a decreased number contributes response The results suggest scalp-recorded opposed clinical standard auditory more reliable

Язык: Английский

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