IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(5), С. 488 - 488

Опубликована: Май 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Язык: Английский

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Long-Covid in Children and Adolescents: Clinical Challenges and Treatment Perspectives

Journal of Education Health and Sport, Год журнала: 2025, Номер 77, С. 56640 - 56640

Опубликована: Янв. 3, 2025

Wprowadzenie: Długi COVID jest powikłaniem choroby koronawirusowej. Jako nowy stan medyczny, stwarzający zagrożenie w ustaleniu spójnych zasad klasyfikacji, diagnozy i leczenia. Cel: Celem artykułu przegląd aktualnej wiedzy na temat nowego tematu znanego jako długiego u dzieci. Materiały metody: Przegląd dodatkowych prac latach 2020–2024, dostępne szczegółowych danych PubMed, zidentyfikowane za pomocą słów kluczowych, a także publikacja WHO „Światowa Organizacja Zdrowia. Definicja stanu chorobowego po COVID-19 dzieci młodzieży według konsensusu ekspertów, 16 lutego 2023 r.” Wyniki: literatury ogólnej, że długi powszechnym problemem, dotykającym 25,24% nastolatków. Zidentyfikowane pojęcie obejmuje wiek powyżej 10 lat, infekcja pierwotna, MIS-C, płeć żeńska, choroba alergiczna, otyłość, zamieszkiwanie zanieczyszczonych, współistniejąca, zły fizyczny wcześniejszy przebieg prowadzący. Spektrum występowania LC ogólne zawiera wiele niespecyficznych manifestacji. Różnorodność objawów komplikuje diagnozę wymaga bardziej holistycznego leczenia do opieki nad pacjentem. Leczenie również stanowi wyzwanie. Informacje o badaniach podłączonych osoby dorosłej, raporty włączeniu laktoferyny języku angielskim, są wersji żołądkowo-jelitowej Aktywność fizyczna wymagana skuteczna metoda celu uzyskania sobie ze zmniejszoną wydolnością koniecznością stosowania. Wnioski: Jest pilna potrzeba szeroko zakrojonych badań przyczyną, objawami leczeniem młodzieży. Opracowanie wyników poprawiło jakość życia pacjentów, pomogło diagnozować usprawniło procesy

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Measuring Post-Exertional Malaise with DePaul Symptom Questionnaires: Challenges and Opportunities

OBM Neurobiology, Год журнала: 2025, Номер 09(01), С. 1 - 30

Опубликована: Фев. 5, 2025

Following mental or physical exertion, patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience Post-Exertional Malaise (PEM). Although self-report questions represent less expensive and invasive procedures to assess PEM, variability in the wording of symptom can cause reliability validity problems. If different PEM measures are used studies, this could create difficulties replicating findings, identifying biomarkers, determining effective treatments for patients. The objective article is describe challenges opportunities DePaul Symptom Questionnaires (DSQ) specific. five DSQ items identify 97% ME/CFS. A brief DSQ-PEM instrument has now been constructed that consists supplementary such as duration how quickly would recover from activities. more comprehensive called Questionnaire assesses a list triggers length recovery time PEM. In article, we show DSQ’s provide clues ME/CFS pathophysiology well these be outcome measures. Future research should focus on contrasting comparing ways eliciting assessing relationships between questionnaires examining impact treatment trials

Язык: Английский

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Post-COVID bei jungen Menschen

Nervenheilkunde, Год журнала: 2025, Номер 44(01/02), С. 16 - 23

Опубликована: Фев. 1, 2025

Zusammenfassung Nach aktuellen Schätzungen leiden ca. 5–10 % aller symptomatisch Infizierten nach Abklingen der akuten COVID-19-Erkrankung unter länger anhaltenden gesundheitlichen Beeinträchtigungen. Psychische Symptome und kognitive Beeinträchtigungen zählen zu häufigen Symptomen von Long- insbesondere Post-COVID. Während sich für Erwachsene zahlreiche Publikationen Post-COVID finden, ist die Datenlage Kinder Adoleszente verhältnismäßig dünn uneinheitlich. Angesichts weniger dramatischer Akutverläufe in dieser Gruppe Assoziation Schwere des Akutverlaufs zur Wahrscheinlichkeit Auftretens war nicht mit einem bedeutsamen Auftreten gerechnet worden. Insbesondere hinsichtlich ihrer psychischen kognitiven Entwicklungen sind aber besonders durch störende Einflüsse gefährdet. Diese Gefährdungen können Coronavirus-Erkrankung direkt ausgehen. Auch Maßnahmen Eindämmung Pandemie haben wesentlich Entwicklung Kindern Adoleszenten eingegriffen. Für das Verständnis bei Therapieansätzen Kenntnis vorliegenden Forschungsergebnisse relevant. Dieser Artikel fasst daher aktuelle Wissen um Long-COVID psychischer kognitiver zusammen.

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Age differences in prevalence and symptoms of post-COVID-19 condition among children: a prospective cohort study

European Journal of Pediatrics, Год журнала: 2025, Номер 184(3)

Опубликована: Март 5, 2025

Язык: Английский

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The COVID-19 pandemic in children and young people during 2022–24: what new did we learn?

Journal of Global Health, Год журнала: 2025, Номер 15

Опубликована: Апрель 1, 2025

The research conducted between 2022 and 2024 has advanced our understanding of COVID-19 in children young people (CYP), particularly with the emergence Omicron variant its subvariants. findings have reinforced that, while infections are often milder compared to earlier variants, overall seroprevalence SARS-CoV-2 increased, notable regional demographic disparities. COVID-19-related hospitalisation rates rose during waves, especially among infants, unvaccinated individuals, CYP at higher risk, i.e. comorbidities such as obesity, diabetes, neurological or cardiac conditions. Despite this, severe disease mortality remained very low. observed increases type 1 diabetes incidence multisystem inflammatory syndrome (MIS-C) also highlighted broader systemic effects paediatric populations. Evidence underscored protective effect vaccination preventing MIS-C vaccine safety, emphasising need for targeted immunisation strategies, who may be risk. Studies estimated that a significant proportion experienced persistent post-COVID-19 infection symptoms fatigue, mood disturbances, sleep disorders, respiratory difficulties, but reported prevalence varied widely, from low 1.6% high 70%, due differences study methodologies, case definitions, populations studied. Standardised definitions measurement tools, those developed through international consensus processes, required improve diagnosis, treatment, into this persisting condition. Ethnic disparities uptake persist, implying hesitancy accessibility, alongside approaches countering disinformation, important areas future research.

Язык: Английский

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Characterisation and Management of Children and Young People Referred to a Paediatric Tertiary Post-COVID Service

Journal of Adolescent Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Post-COVID condition (PCC) emerged following the 2020 coronavirus pandemic and required rapid service development to manage affected patients. This evaluation describes demographics, medical background, management six-month outcomes of children young people with PCC-related symptoms referred one specialist tertiary between June August 2022. Data were retrospectively collected from referral information notes. 176 patients (61% female) aged 6-18 years referred, a mean 8.2 impacting on functioning (97%) school attendance (86%). 10% had an autistic spectrum disorder diagnosis, above ∼2% national prevalence, while rates atopy mental health similar prevalence. 59% managed in clinics by clinicians input allied professionals. At 6 month review, 40/73 reported improvement their daily functioning, 30/73 reporting no change 3/73 functional deterioration. School increased over months for 43/67 patients, 12/67 4/67 reduced attendance. Patients have significant impairment challenges accessing education. More than half those seen showed months, subgroup persistent symptoms. suggests that model is beneficial this complex patient group overall, although needs be resourced longer some. Further work needed understand variability presentation symptom course.

Язык: Английский

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Experiences of physiotherapists working with adults living with Long COVID in Canada: a qualitative study

BMJ Open, Год журнала: 2024, Номер 14(11), С. e086357 - e086357

Опубликована: Ноя. 1, 2024

To explore experiences of physiotherapists working with adults living Long COVID in Canada.

Язык: Английский

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Post-Acute Cardiovascular Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Project

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

Abstract Background The risk of cardiovascular outcomes in the post-acute phase SARS-CoV-2 infection has been quantified among adults and children. This paper aimed to assess a multitude cardiac signs, symptoms, conditions, as well focused on patients with without congenital heart defects (CHDs), provide more comprehensive assessment children adolescents after COVID-19. Methods retrospective cohort study used data from RECOVER consortium comprising 19 US children’s hospitals health institutions between March 2020 September 2023. Every participant had at least six-month follow-up entry. Absolute risks incident COVID-19 sequelae were reported. Relative (RRs) calculated by contrasting COVID-19-positive COVID-19-negative groups using Poisson regression model, adjusting for demographic, clinical, healthcare utilization factors through propensity scoring stratification. Results A total 1,213,322 individuals under 21 years old (mean[SD] age, 7.75[6.11] years; 623,806 male [51.4%]) included. absolute rate any outcome this was 2.32% positive 1.38% negative groups. Patients CHD post-SARS-CoV-2 showed increased (RR, 1.63; 95% confidence interval (CI), 1.47-1.80), including 11 18 hypertension, arrhythmias (atrial fibrillation ventricular arrhythmias), myocarditis, other disorders (heart failure, cardiomyopathy, arrest), thrombotic (thrombophlebitis thromboembolism), cardiovascular-related symptoms (chest pain palpitations). Those CHDs also experienced heightened CI, 1.57-1.69), covering 14 conditions (ventricular premature atrial or contractions), inflammatory disease (pericarditis myocarditis), arrest, cardiogenic shock), (pulmonary embolism pain, palpitations, syncope). Conclusions Both variety infection, underscoring need targeted monitoring management phase. Clinical Perspective section What is new? We investigated pediatric population Multisystem Inflammatory Syndrome Children (MIS-C) over 1 million patients, stratified (CHD) status. extended period beyond previous studies, ensuring every included cross-section across various settings primary, specialty, emergency care, testing inpatient facilities. are clinical implications? Within phase, previously infected statistically significant outcomes, arrhythmias, thromboembolism, chest palpitations. These findings consistent CHDs. Awareness can lead timely referral, investigations, these adolescents.

Язык: Английский

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Long/post-COVID in children and adolescents: symptom onset and recovery after one year based on healthcare records in Germany

Infection, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Abstract Purpose Evidence on the incidence and persistence of post-acute sequelae COVID-19 (PASC) among children adolescents is still limited. Methods In this retrospective cohort study, 59,339 with laboratory-confirmed in 2020 170,940 matched controls were followed until 2021-09-30 using German routine healthcare data. Incidence rate differences (ΔIR) ratios (IRR) 96 potential PASC estimated Poisson regression. Analyses stratified according to age (0–11, 12–17 years), sex. At individual level, diagnoses patients onset symptoms was tracked starting from first quarter post-infection. Results 0–3 month follow-up, a previous SARS-CoV-2 infection showed 34% increased risk adverse health outcome, approximately 6% suffered association COVID-19. The attributable higher (≥ 12 years) than children. For most common symptoms, IRRs largely persisted at 9–12 follow-up. IRR highest for rare conditions strongly associated COVID-19, particularly inflammatory 0–11 years, chronic fatigue respiratory insufficiency adolescents. Tracking level revealed similar rates decline control cohorts, generally leaving less 10% persistent after months. Conclusion Although very few presented longer months, excess morbidity and, particularly, history means relevant burden pediatric care.

Язык: Английский

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