Role of disulfide death in cancer (Review) DOI Open Access
Xue Li, Danxia Zhu

Oncology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Ноя. 12, 2024

The research field of regulated cell death is growing extensively. Following the recognition ferroptosis, other unique and distinct forms death, including cuproptosis disulfide have been identified. Disulfide occurs due to abnormal accumulation disulfides within cells in environments lacking glucose, leading contraction actin cytoskeleton, which ultimately triggers various signaling pathways death. induction treatment cancer may exhibit significant therapeutic potential. Therefore, present review, a comprehensive critical analysis current understanding molecular mechanisms regulatory networks presented. In addition, potential physiological functions tumor suppression immune surveillance as well its pathological roles are described. core focus areas for future into this form also explored. Given lack extensive clinical findings well-defined key concepts, these be regarded pivotal points interest studies.

Язык: Английский

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions DOI Creative Commons
Jinyu Chen,

Boyuan Ma,

Yubiao Yang

и другие.

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Апрель 29, 2024

Abstract Cell death is an important part of the life cycle, serving as a foundation for both orderly development and maintenance physiological equilibrium within organisms. This process fundamental, it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration immunological responses. A novel paradigm programmed cell death, known disulfidptosis, has recently emerged in scientific circle. Disulfidptosis defined accumulation cystine by cancer with high expression solute carrier family 7 member 11 (SLC7A11) during glucose starvation. causes extensive disulfide linkages between F-actins, resulting their contraction subsequent detachment from cellular membrane, triggering death. The RAC1-WRC axis involved this phenomenon. sparked growing interest due to its potential applications variety pathologies, particularly oncology, neurodegenerative disorders, metabolic anomalies. Nonetheless, complexities regulatory pathways remain elusive, precise molecular targets have yet be definitively identified. manuscript aims meticulously dissect historical evolution, underpinnings, frameworks, implications disulfidptosis various disease contexts, illuminating promise groundbreaking therapeutic pathway target.

Язык: Английский

Процитировано

11
Bioinformatics analysis of genes associated with disulfidptosis in spinal cord injury DOI Creative Commons
Shuang Wang, Xinhua Liu,

Jun Tian

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0318016 - e0318016

Опубликована: Фев. 14, 2025

Research findings indicate that programmed cell death (PCD) plays a pivotal role in the pathophysiology of spinal cord injury (SCI), and recently discovered form death, disulfidptosis, has emerged as novel phenomenon. However, characterization disulfidptosis-related genes SCI remains insufficiently explored. We retrieved SCI-related data from Gene Expression Omnibus (GEO) database identified three key associated with disulfidptosis human (CAPZB, SLC3A2, TLN1), whose mediated signaling pathways are closely intertwined SCI. Subsequent functional enrichment analysis suggested these may regulate multiple exert corresponding roles pathology. Moreover, we predicted potential targeted drugs for along their transcription factors constructed an intricate regulatory network. CIBERSORT revealed CAPZB, TLN1 might be implicated modulating changes within immune microenvironment individuals Our study provides compelling evidence confirming significant involvement following while offering valuable insights into its underlying pathological mechanisms.

Язык: Английский

Процитировано

1
Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis DOI
Zelin Tian,

Junbo Song,

Jiang She

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1632 - 1647

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

5
Machine learning-driven prognostic analysis of cuproptosis and disulfidptosis-related lncRNAs in clear cell renal cell carcinoma: a step towards precision oncology DOI Creative Commons

Ronghui Chen,

Jun Wu,

Yinwei Che

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Март 16, 2024

Cuproptosis and disulfidptosis, recently discovered mechanisms of cell death, have demonstrated that differential expression key genes long non-coding RNAs (lncRNAs) profoundly influences tumor development affects their drug sensitivity. Clear renal carcinoma (ccRCC), the most common subtype kidney cancer, presently lacks research utilizing cuproptosis disulfidptosis-related lncRNAs (CDRLRs) as prognostic markers. In this study, we analyzed RNA-seq data, clinical information, mutation data from The Cancer Genome Atlas (TCGA) on ccRCC cross-referenced it with known (CDRGs). Using LASSO machine learning algorithm, identified four CDRLRs-ACVR2B-AS1, AC095055.1, AL161782.1, MANEA-DT-that are strongly associated prognosis used them to construct a risk model. To verify model's reliability validate these CDRLRs significant factors, performed dataset grouping validation, followed by RT-qPCR external database validation for in ccRCC. Gene function pathway analysis were conducted using Ontology (GO) Set Enrichment Analysis (GSEA) high- low-risk groups. Additionally, burden (TMB) immune microenvironment (TME), employing oncoPredict Immunophenoscore (IPS) algorithms assess sensitivity diverse categories targeted therapeutics immunosuppressants. Our predominant objective is refine predictions patients inform treatment decisions conducting an exhaustive study disulfidptosis.

Язык: Английский

Процитировано

4
Comprehensive identification of a disulfidptosis-associated long non-coding RNA signature to predict the prognosis and treatment options in ovarian cancer DOI Creative Commons
Shouze Liu, Rulan Jiang, Xinxin Wang

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

Distinguished from cuproptosis and ferroptosis, disulfidptosis has been described as a newly discovered form of non-programmed cell death tightly associated with glucose metabolism. However, the prognostic profile disulfidptosis-related lncRNAs (DRLRs) in ovarian cancer (OC) their biological mechanisms need to be further elucidated.

Язык: Английский

Процитировано

1
Signature Construction and Disulfidptosis-Related Molecular Cluster Identification for Better Prediction of Prognosis in Glioma DOI
Y. G. Zhuang, Jiewen Chen,

Zhuohao Mai

и другие.

Journal of Molecular Neuroscience, Год журнала: 2024, Номер 74(2)

Опубликована: Апрель 4, 2024

Язык: Английский

Процитировано

0
A disulfidptosis-related classification and risk signature identifies immunotherapy biomarkers and predicts prognosis in gastric cancer: An observational study DOI Creative Commons

Ruyue Chen,

Lixin Jiang

Medicine, Год журнала: 2024, Номер 103(22), С. e38398 - e38398

Опубликована: Май 31, 2024

Gastric cancer (GC) is one of the most prevalent types globally, often detected at advanced stages. However, its prognosis remains poor, necessitating exploration new biomarkers. Disulfidptosis, a recently identified form programmed cell death, has not yet been investigated in relation to GC and associated mechanisms. We analyzed potential associations between disulfidptosis genes clinical risk using TCGA (The Cancer Genome Atlas)-STAD (stomach adenocarcinoma) as training set GSE84433 validation set. In addition, we explored prognostic value biological mechanisms disulfide by consensus clustering, enrichment analysis, mutation histology analysis immune infiltration analysis. Finally, constructed disulfidptosis-related signature (DRRS) assess association class, survival prognosis, infiltration. By utilizing data from 19 genes, successfully subgroups C1 C2 patients through clustering. Notably, 2 groups exhibited significant variations terms rates, scores, Subsequently, developed DRRS via LASSO (least absolute shrinkage selection operator) regression incorporating PRICKLE1, NRP1, APOD, MISP3, SERPINE1. This scoring system effectively distinguished individuals with high low risks, verified These findings strongly indicate close microenvironment tumors. Moreover, demonstrated commendable predictive capabilities for outcomes patients. this study, have different subtypes alterations immunotumour microenvironment. Furthermore, accuracy DRRS, valuable tool predicting survival, function, GC. contribute better comprehension offer opportunities innovative approaches treatment.

Язык: Английский

Процитировано

0
A novel disulfidptosis-related biomarker for assessing the therapeutic efficacy of a machine learning-based observational study in colon adenocarcinoma DOI

Xinwei Ji,

Lixin Wang,

Pengbo Luan

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

Abstract Background This study investigated colon adenocarcinoma (COAD), one of the most common types cancer globally. In recent years, a novel cell death pathway, hydrogen sulfide poisoning, has been identified, and targeting disulfide reductase may emerge as new strategy for treatment. However, predictive potential disulfidptosis-related gene (DRGs) in COAD its characteristics tumor immune microenvironment (TIME) remain to be further elucidated. Methods obtained DRGs transcriptome mutation data colorectal samples from Tissue Cancer Genome Atlas (TCGA) database. Pearson differential expression correlation analysis were used identify COAD-related DRGs, risk prognosis model was constructed using univariate least absolute shrinkage selection operator (LASSO) Cox regression analysis. Enrichment then conducted explore biological functions signal transduction differentially expressed genes associated with model. The reliability validated through various statistical analyses such survival analysis, receiver operating characteristic (ROC) curves, calibration plots, bar graphs. relationship between prognostic model, microenvironment, drug sensitivity examined. Finally, specimens patients extracted human protein atlas (HPA) database Yantaishan hospital, compared normal tissues verify level DRGs. Results We have successfully established containing 6 (RPA2, TIMP1, WDR1, POLR3K, KTI12, RTKN). performs well predicting overall COAD. Validation this clinical indicators shows considerable Furthermore, there is significant (TME), infiltrating cells, (p < 0.05). HPA experimental results verified that levels RPA2, KTI12 RTKN tumors higher than those tissues, while WDR1 opposite 0.01). Conclusion identified molecular therapeutic targets response are related targeted therapy provide research direction diagnosis treatment

Язык: Английский

Процитировано

0
Role of disulfide death in cancer (Review) DOI Open Access
Xue Li, Danxia Zhu

Oncology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Ноя. 12, 2024

The research field of regulated cell death is growing extensively. Following the recognition ferroptosis, other unique and distinct forms death, including cuproptosis disulfide have been identified. Disulfide occurs due to abnormal accumulation disulfides within cells in environments lacking glucose, leading contraction actin cytoskeleton, which ultimately triggers various signaling pathways death. induction treatment cancer may exhibit significant therapeutic potential. Therefore, present review, a comprehensive critical analysis current understanding molecular mechanisms regulatory networks presented. In addition, potential physiological functions tumor suppression immune surveillance as well its pathological roles are described. core focus areas for future into this form also explored. Given lack extensive clinical findings well-defined key concepts, these be regarded pivotal points interest studies.

Язык: Английский

Процитировано

0