Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 26, 2025
Abstract
Inflammation
is
a
complex
and
finely
tuned
component
of
the
host
defense
mechanism,
responding
sensitively
to
range
physical,
chemical,
biological
stressors.
Current
research
advancing
our
grasp
both
cellular
molecular
mechanisms
that
initiate
regulate
interactions
within
inflammatory
pathways.
Substantial
evidence
now
indicates
profound
link
between
inflammation,
innate
immunity,
cancer.
Dysregulation
pathways
known
be
pivotal
factor
in
induction,
growth,
metastasis
tumors
through
multiple
mechanistic
Basically,
tumor
microenvironment
(TME),
characterized
by
dynamic
interplay
cancerous
cells
surrounding
stromal
cells,
plays
central
role
these
processes.
Increasingly,
controlled
acute
inflammation
being
explored
as
promising
therapeutic
tool
certain
types
However,
TME
exhibit
remarkable
plasticity,
with
shifting
phenotypic
functional
roles
facilitate
cancer
cell
survival,
proliferation,
migration,
especially
under
chronic
conditions.
Additionally,
signaling
molecules
associated
immune
system,
like
chemokines,
are
co-opted
malignant
support
invasion,
metastasis.
These
findings
underscore
need
for
deeper
insights
into
connecting
pathology,
which
could
pave
way
innovative
diagnostic
approaches
targeted
anti-inflammatory
therapies
counter
development.
The
current
review
underlines
critical
involvement
development,
examining
connection
key
mediators,
biomarkers,
their
We
also
discuss
impact
inflammation-targeted
on
anticancer
Furthermore,
we
major
drugs
potential
applications
oncology,
assessing
how
modulated
management.
Lastly,
outline
an
overview
ongoing
discoveries
field,
highlighting
challenges
promise
targeting
therapy.
Язык: Английский
Neurobiology of cancer: Adrenergic signaling and drug repurposing
Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
264, С. 108750 - 108750
Опубликована: Ноя. 10, 2024
Язык: Английский
Chitosan and hyaluronic acid in colorectal cancer therapy: A review on EMT regulation, metastasis, and overcoming drug resistance
Mingming Han,
Xi Zhou,
Cheng Hang
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
289, С. 138800 - 138800
Опубликована: Дек. 16, 2024
Язык: Английский
Breast Cancer
Опубликована: Янв. 1, 2024
Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(12), С. 3780 - 3794
Опубликована: Окт. 31, 2024
Breast
cancer
remains
one
of
the
most
prevalent
and
challenging
cancers
to
treat
due
its
complexity
heterogenicity.
Cellular
processes
such
as
metabolic
reprogramming
epithelial-to-mesenchymal
transition
(EMT)
contribute
breast
by
driving
uncontrolled
cell
division,
metastasis,
resistance
therapies.
Strategically
targeting
these
intricate
pathways
can
effectively
impede
progression,
thereby
revealing
significant
potential
for
therapeutic
interventions.
Among
various
emerging
approaches,
drug
repurposing
offers
a
promising
avenue
enhancing
clinical
outcomes.
In
recent
years,
high-throughput
screening,
QSAR,
network
pharmacology
have
been
widely
employed
identify
repurposed
drugs.
As
an
outcome,
several
drugs,
Metformin,
Itraconazole,
Pimozide,
Disulfiram,
were
regulate
EMT
pathways.
Moreover,
strategies
combination
therapy,
targeted
delivery,
personalized
medicine
utilized
enhance
efficacy
specificity
This
review
focuses
on
altered
metabolism
in
through
repurposing.
It
also
highlights
advancements
screening
techniques,
associated
limitations,
overcome
challenges.
Язык: Английский
The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0316476 - e0316476
Опубликована: Дек. 31, 2024
Background
Gastric
cancer
(GC)
is
a
highly
malignant
gastrointestinal
tumor
characterized
by
difficult
early
diagnosis
and
poor
prognosis.
Therefore,
it
imperative
to
explore
potential
therapeutic
targets
for
gastric
cancer.
PARP9
abnormally
expressed
in
variety
of
tumors
associated
with
cell
apoptosis
DNA
damage.
However,
its
relationship
GC
has
not
been
fully
studied.
Methods
The
expression
prognostic
significance
were
examined
using
bioinformatics
approaches.
Cell
lines
either
knockdown
or
overexpression
established
through
lentiviral
transduction,
the
role
phenotypes
cells
was
validated
via
CCK8
assays,
wound
healing
clonogenic
Transwell
migration
experiments.
Finally,
alterations
downstream
signaling
pathways
following
changes
analyzed
RNA
sequencing.
Results
tissues
can
significantly
inhibit
proliferation,
invasion
cells,
increase
damage
cells.
process
may
be
realized
synergistic
interaction
SOX6
MAPK
pathway.
Conclusions
Our
study
reveals
link
between
GC,
providing
new
target
treatment
GC.
Язык: Английский