The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells DOI Creative Commons
Yating Li, Xing Wang, Xiaolong Liu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0316476 - e0316476

Published: Dec. 31, 2024

Background Gastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. Therefore, it imperative to explore potential therapeutic targets for gastric cancer. PARP9 abnormally expressed in variety of tumors associated with cell apoptosis DNA damage. However, its relationship GC has not been fully studied. Methods The expression prognostic significance were examined using bioinformatics approaches. Cell lines either knockdown or overexpression established through lentiviral transduction, the role phenotypes cells was validated via CCK8 assays, wound healing clonogenic Transwell migration experiments. Finally, alterations downstream signaling pathways following changes analyzed RNA sequencing. Results tissues can significantly inhibit proliferation, invasion cells, increase damage cells. process may be realized synergistic interaction SOX6 MAPK pathway. Conclusions Our study reveals link between GC, providing new target treatment GC.

Language: Английский

Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches DOI Creative Commons

Saad Bakrim,

Meriem El Fessikh, Hamza Elhrech

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 26, 2025

Abstract Inflammation is a complex and finely tuned component of the host defense mechanism, responding sensitively to range physical, chemical, biological stressors. Current research advancing our grasp both cellular molecular mechanisms that initiate regulate interactions within inflammatory pathways. Substantial evidence now indicates profound link between inflammation, innate immunity, cancer. Dysregulation pathways known be pivotal factor in induction, growth, metastasis tumors through multiple mechanistic Basically, tumor microenvironment (TME), characterized by dynamic interplay cancerous cells surrounding stromal cells, plays central role these processes. Increasingly, controlled acute inflammation being explored as promising therapeutic tool certain types However, TME exhibit remarkable plasticity, with shifting phenotypic functional roles facilitate cancer cell survival, proliferation, migration, especially under chronic conditions. Additionally, signaling molecules associated immune system, like chemokines, are co-opted malignant support invasion, metastasis. These findings underscore need for deeper insights into connecting pathology, which could pave way innovative diagnostic approaches targeted anti-inflammatory therapies counter development. The current review underlines critical involvement development, examining connection key mediators, biomarkers, their We also discuss impact inflammation-targeted on anticancer Furthermore, we major drugs potential applications oncology, assessing how modulated management. Lastly, outline an overview ongoing discoveries field, highlighting challenges promise targeting therapy.

Language: Английский

Citations

0
Neurobiology of cancer: Adrenergic signaling and drug repurposing DOI
Zi-Kai Dong, Yongfei Wang,

Weiping Li

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 264, P. 108750 - 108750

Published: Nov. 10, 2024

Language: Английский

Citations

2
Chitosan and hyaluronic acid in colorectal cancer therapy: A review on EMT regulation, metastasis, and overcoming drug resistance DOI

Mingming Han,

Xi Zhou,

Cheng Hang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138800 - 138800

Published: Dec. 16, 2024

Language: Английский

Citations

2
Breast Cancer DOI
Boris Mravec

Published: Jan. 1, 2024

Citations

1
Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways DOI Creative Commons

Thirukumaran Kandasamy,

Shilpi Sarkar, Siddhartha Sankar Ghosh

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(12), P. 3780 - 3794

Published: Oct. 31, 2024

Breast cancer remains one of the most prevalent and challenging cancers to treat due its complexity heterogenicity. Cellular processes such as metabolic reprogramming epithelial-to-mesenchymal transition (EMT) contribute breast by driving uncontrolled cell division, metastasis, resistance therapies. Strategically targeting these intricate pathways can effectively impede progression, thereby revealing significant potential for therapeutic interventions. Among various emerging approaches, drug repurposing offers a promising avenue enhancing clinical outcomes. In recent years, high-throughput screening, QSAR, network pharmacology have been widely employed identify repurposed drugs. As an outcome, several drugs, Metformin, Itraconazole, Pimozide, Disulfiram, were regulate EMT pathways. Moreover, strategies combination therapy, targeted delivery, personalized medicine utilized enhance efficacy specificity This review focuses on altered metabolism in through repurposing. It also highlights advancements screening techniques, associated limitations, overcome challenges.

Language: Английский

Citations

0
The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells DOI Creative Commons
Yating Li, Xing Wang, Xiaolong Liu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0316476 - e0316476

Published: Dec. 31, 2024

Background Gastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. Therefore, it imperative to explore potential therapeutic targets for gastric cancer. PARP9 abnormally expressed in variety of tumors associated with cell apoptosis DNA damage. However, its relationship GC has not been fully studied. Methods The expression prognostic significance were examined using bioinformatics approaches. Cell lines either knockdown or overexpression established through lentiviral transduction, the role phenotypes cells was validated via CCK8 assays, wound healing clonogenic Transwell migration experiments. Finally, alterations downstream signaling pathways following changes analyzed RNA sequencing. Results tissues can significantly inhibit proliferation, invasion cells, increase damage cells. process may be realized synergistic interaction SOX6 MAPK pathway. Conclusions Our study reveals link between GC, providing new target treatment GC.

Language: Английский

Citations

0