Neurological complications caused by SARS-CoV-2

Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(4)

Опубликована: Сен. 18, 2024

SUMMARYSARS-CoV-2 can not only cause respiratory symptoms but also lead to neurological complications. Research has shown that more than 30% of SARS-CoV-2 patients present neurologic during COVID-19 (A. Pezzini and A. Padovani, Nat Rev Neurol 16:636-644, 2020, https://doi.org/10.1038/s41582-020-0398-3). Increasing evidence suggests invade both the central nervous system (CNS) (M.S. Xydakis, M.W. Albers, E.H. Holbrook, et al. Lancet 20: 753-761, 2021 https://doi.org/10.1016/S1474-4422(21)00182-4 ) peripheral (PNS) (M.N. Soares, M. Eggelbusch, E. Naddaf, J Cachexia Sarcopenia Muscle 13:11-22, 2022, https://doi.org/10.1002/jcsm.12896), resulting in a variety disorders. This review summarized CNS complications caused by infection, including encephalopathy, neurodegenerative diseases, delirium. Additionally, some PNS disorders such as skeletal muscle damage inflammation, anosmia, smell or taste impairment, myasthenia gravis, Guillain-Barré syndrome, ICU-acquired weakness, post-acute sequelae were described. Furthermore, mechanisms underlying SARS-CoV-2-induced discussed, entering brain through retrograde neuronal hematogenous routes, disrupting normal function cytokine storms, inducing cerebral ischemia hypoxia, thus leading Moreover, an overview long-COVID-19 is provided, along with recommendations for care therapeutic approaches experiencing

Язык: Английский

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Asthma is a risk factor for general fatigue of long COVID in Japanese nation-wide cohort study

Allergology International, Год журнала: 2023, Номер 73(2), С. 206 - 213

Опубликована: Ноя. 22, 2023

Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue frequently with COVID during and post-acute phases. This study aimed to identify the specific risk factors for general

Язык: Английский

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A blood supply pathophysiological microcirculatory mechanism for the Long COVID

Опубликована: Июль 30, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Язык: Английский

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Предиктори прогресування серцевої недостатності у хворих на ІХС у поєднанні з COVID-19

Ukrainian Journal of Military Medicine, Год журнала: 2025, Номер 6(1), С. 147 - 158

Опубликована: Март 31, 2025

Мета: дослідити зв’язок показників церебральної гемодинаміки і мікроциркуляції з прогресуванням серцевої недостатності у хворих на ішемічною хворобою серця (ІХС) та COVID-19. Методи: З січня 2020 року по грудень 2022 було проведено дослідження, в якому взяли участь 79 пацієнтів ІХС без ознак COVID-19, а також 127 осіб хронічною поєднанні COVID-19 180 пацієнтів, які мали ІХС. Дослідження проходило клінічних базах Національного медичного університету імені ОО Богомольця, зокрема 18 клінічній лікарні Києва медичному центрі «Медбуд». Проводили: емболодетекцію визначенням кількості мікроемболічних сигналів (МЕС), ультразвукове дослідження судин голови шиї: вимірювали комплекс інтіма-медіа (КІМ), пікову систолічну швидкість правій лівій середній мозковій артерії (СМАп, СМАл), задніх мозкових артеріях (ЗМАп, ЗМАл), базилярній (БА), Д-димер, Феритин, за даними лазерної доплерівської флоуметрії: тип МКЦ, амплітуду ендотеліальних флаксмоцій (АЕФ), дихальних (АДФ), цифрової капіляроскопії: довжину артеріальної частини капіляру (ДА), венозної (ДВ), швидіксть кровотоку артеріальній частині (ША), розмір перехідної зони (ПЗ), ангіорезистометрії кількість петехій після проби (АРМ1), через 5 хв. (АРМ2), Результати. У із супутнім спостерігаються найбільше зниження церебрального кровотоку, виражене погіршення мікроциркуляції, більші значення феритину Д-димеру. В однофакторній моделі логістичної регресії виявлено слабкий ризику фракції викиду лівого шлуночку показниками МЕС, КІМ, СМАп, СМАл, ЗМАп, ЗМАл, БА, ПЗ, типу АРМ1, АРМ2, АЕФ, АДФ, ДА, ДВ, ША. багатофакторної зростання прогресування при ВШ=10.5 (95% 2.27 – 48.2), умов врахування пікової швидкості обох середніх артерія, сегменті Р2 правої задньої мозкової артерії, рівня феритину, довжини капіляру, площа під кривою операційних характеристик AUC = 0.80 ВІ 0.75 0.83). Висновки. Запропоновано використовувати індекс оцінки для IF відповідною шкалою широкого використання практиці. Існує потреба методах неінвазивної властивостей мікросудинної реактивності метою визначення прогнозу перебігу хронічну

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Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine

Biomolecules & Therapeutics, Год журнала: 2024, Номер 32(6), С. 659 - 684

Опубликована: Окт. 21, 2024

Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.

Язык: Английский

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Predictors of the severity of the course of COVID-19: demographic factors, clinical signs and laboratory markers

Journal of Medical Microbiology, Год журнала: 2024, Номер 73(10)

Опубликована: Окт. 10, 2024

The Coronavirus Disease 2019 (COVID-19) pandemic has had a significant impact on global healthcare, with high mortality and severe complications remaining major concern. Understanding the predictors of COVID-19 severity may improve patient management outcomes. While considerable research focused pathogenesis virus vaccine development, identification reliable demographic, clinical laboratory disease remains critical.

Язык: Английский

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Potential hypothesis for the increased risk of Parkinson´s disease following COVID-19

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Окт. 21, 2024

Язык: Английский

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Re-Framing Long COVID as Central Nervous System Dysfunction

Science Insights, Год журнала: 2024, Номер 44(6), С. 1397 - 1402

Опубликована: Июнь 29, 2024

Four years after the emergence of long COVID, science is little closer to understanding its cause, pathogenesis, prevention or treatment than it was at outset. This due in part lack an explanatory hypothesis that fits scattergram data emerging from basic, clinical and epidemiological research. We propose a unifying connects triggering viral infection pathogenesis plethora 200 symptoms: COVID central nervous system disorder biologic origin, provisionally named “Post-COVID CNS dysfunction (PCCD)”. As neuroscience develops, has become increasingly evident much mental illness cognitive impairment basis brain structure, chemistry function. Applying this we symptoms are mediated through virus-induced biological mechanisms acting on within CNS. Both past future research should be combined test PCCD hypothesis. can open pathway significant progress prevention, care therapeutics. A multi-sector collaborative platform—with leadership federal government’s Office Long Research Practice—could, for example, assist testing, improving, implementing

Язык: Английский

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A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

Life, Год журнала: 2024, Номер 14(9), С. 1076 - 1076

Опубликована: Авг. 28, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused (PPVR). Both ML hemodynamic decrease (HD) incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Язык: Английский

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SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic

Microorganisms, Год журнала: 2023, Номер 11(10), С. 2511 - 2511

Опубликована: Окт. 8, 2023

Respiratory viral infections have been found to a negative impact on neurological functions, potentially leading significant impairment. The SARS-CoV-2 virus has precipitated worldwide pandemic, posing substantial threat human lives. Growing evidence suggests that may severely affect the CNS and respiratory system. current prevalence of clinical issues associated with raised concerns. However, there needs be more comprehensive understanding specific pathways by which enters nervous Based available evidence, this review focuses manifestations possible mechanisms invades brain.

Язык: Английский

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