Human Genetics, Journal Year: 2023, Volume and Issue: 142(8), P. 997 - 999
Published: July 21, 2023
Language: Английский
Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(4)
Published: Sept. 18, 2024
SUMMARYSARS-CoV-2 can not only cause respiratory symptoms but also lead to neurological complications. Research has shown that more than 30% of SARS-CoV-2 patients present neurologic during COVID-19 (A. Pezzini and A. Padovani, Nat Rev Neurol 16:636-644, 2020, https://doi.org/10.1038/s41582-020-0398-3). Increasing evidence suggests invade both the central nervous system (CNS) (M.S. Xydakis, M.W. Albers, E.H. Holbrook, et al. Lancet 20: 753-761, 2021 https://doi.org/10.1016/S1474-4422(21)00182-4 ) peripheral (PNS) (M.N. Soares, M. Eggelbusch, E. Naddaf, J Cachexia Sarcopenia Muscle 13:11-22, 2022, https://doi.org/10.1002/jcsm.12896), resulting in a variety disorders. This review summarized CNS complications caused by infection, including encephalopathy, neurodegenerative diseases, delirium. Additionally, some PNS disorders such as skeletal muscle damage inflammation, anosmia, smell or taste impairment, myasthenia gravis, Guillain-Barré syndrome, ICU-acquired weakness, post-acute sequelae were described. Furthermore, mechanisms underlying SARS-CoV-2-induced discussed, entering brain through retrograde neuronal hematogenous routes, disrupting normal function cytokine storms, inducing cerebral ischemia hypoxia, thus leading Moreover, an overview long-COVID-19 is provided, along with recommendations for care therapeutic approaches experiencing
Language: Английский
Citations
6
Allergology International, Journal Year: 2023, Volume and Issue: 73(2), P. 206 - 213
Published: Nov. 22, 2023
Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue frequently with COVID during and post-acute phases. This study aimed to identify the specific risk factors for general
Language: Английский
Citations
12
Published: July 30, 2024
Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading
Language: Английский
Citations
4
Ukrainian Journal of Military Medicine, Journal Year: 2025, Volume and Issue: 6(1), P. 147 - 158
Published: March 31, 2025
Мета: дослідити зв’язок показників церебральної гемодинаміки і мікроциркуляції з прогресуванням серцевої недостатності у хворих на ішемічною хворобою серця (ІХС) та COVID-19. Методи: З січня 2020 року по грудень 2022 було проведено дослідження, в якому взяли участь 79 пацієнтів ІХС без ознак COVID-19, а також 127 осіб хронічною поєднанні COVID-19 180 пацієнтів, які мали ІХС. Дослідження проходило клінічних базах Національного медичного університету імені ОО Богомольця, зокрема 18 клінічній лікарні Києва медичному центрі «Медбуд». Проводили: емболодетекцію визначенням кількості мікроемболічних сигналів (МЕС), ультразвукове дослідження судин голови шиї: вимірювали комплекс інтіма-медіа (КІМ), пікову систолічну швидкість правій лівій середній мозковій артерії (СМАп, СМАл), задніх мозкових артеріях (ЗМАп, ЗМАл), базилярній (БА), Д-димер, Феритин, за даними лазерної доплерівської флоуметрії: тип МКЦ, амплітуду ендотеліальних флаксмоцій (АЕФ), дихальних (АДФ), цифрової капіляроскопії: довжину артеріальної частини капіляру (ДА), венозної (ДВ), швидіксть кровотоку артеріальній частині (ША), розмір перехідної зони (ПЗ), ангіорезистометрії кількість петехій після проби (АРМ1), через 5 хв. (АРМ2), Результати. У із супутнім спостерігаються найбільше зниження церебрального кровотоку, виражене погіршення мікроциркуляції, більші значення феритину Д-димеру. В однофакторній моделі логістичної регресії виявлено слабкий ризику фракції викиду лівого шлуночку показниками МЕС, КІМ, СМАп, СМАл, ЗМАп, ЗМАл, БА, ПЗ, типу АРМ1, АРМ2, АЕФ, АДФ, ДА, ДВ, ША. багатофакторної зростання прогресування при ВШ=10.5 (95% 2.27 – 48.2), умов врахування пікової швидкості обох середніх артерія, сегменті Р2 правої задньої мозкової артерії, рівня феритину, довжини капіляру, площа під кривою операційних характеристик AUC = 0.80 ВІ 0.75 0.83). Висновки. Запропоновано використовувати індекс оцінки для IF відповідною шкалою широкого використання практиці. Існує потреба методах неінвазивної властивостей мікросудинної реактивності метою визначення прогнозу перебігу хронічну
Citations
0
Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 659 - 684
Published: Oct. 21, 2024
Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.
Language: Английский
Citations
3
Journal of Medical Microbiology, Journal Year: 2024, Volume and Issue: 73(10)
Published: Oct. 10, 2024
The Coronavirus Disease 2019 (COVID-19) pandemic has had a significant impact on global healthcare, with high mortality and severe complications remaining major concern. Understanding the predictors of COVID-19 severity may improve patient management outcomes. While considerable research focused pathogenesis virus vaccine development, identification reliable demographic, clinical laboratory disease remains critical.
Language: Английский
Citations
2
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Oct. 21, 2024
Language: Английский
Citations
2
Science Insights, Journal Year: 2024, Volume and Issue: 44(6), P. 1397 - 1402
Published: June 29, 2024
Four years after the emergence of long COVID, science is little closer to understanding its cause, pathogenesis, prevention or treatment than it was at outset. This due in part lack an explanatory hypothesis that fits scattergram data emerging from basic, clinical and epidemiological research. We propose a unifying connects triggering viral infection pathogenesis plethora 200 symptoms: COVID central nervous system disorder biologic origin, provisionally named “Post-COVID CNS dysfunction (PCCD)”. As neuroscience develops, has become increasingly evident much mental illness cognitive impairment basis brain structure, chemistry function. Applying this we symptoms are mediated through virus-induced biological mechanisms acting on within CNS. Both past future research should be combined test PCCD hypothesis. can open pathway significant progress prevention, care therapeutics. A multi-sector collaborative platform—with leadership federal government’s Office Long Research Practice—could, for example, assist testing, improving, implementing
Language: Английский
Citations
1
Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1076 - 1076
Published: Aug. 28, 2024
Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused (PPVR). Both ML hemodynamic decrease (HD) incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading
Language: Английский
Citations
1
Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2511 - 2511
Published: Oct. 8, 2023
Respiratory viral infections have been found to a negative impact on neurological functions, potentially leading significant impairment. The SARS-CoV-2 virus has precipitated worldwide pandemic, posing substantial threat human lives. Growing evidence suggests that may severely affect the CNS and respiratory system. current prevalence of clinical issues associated with raised concerns. However, there needs be more comprehensive understanding specific pathways by which enters nervous Based available evidence, this review focuses manifestations possible mechanisms invades brain.
Language: Английский
Citations
2