Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 353 - 383
Опубликована: Дек. 6, 2024
Язык: Английский
Biomedicines, Год журнала: 2025, Номер 13(2), С. 434 - 434
Опубликована: Фев. 11, 2025
Background and Objectives: Orofacial pain corresponds to sensitization originating from the facial oral regions, often accompanied by diagnostic complexity due a multitude of contributory factors, leading significant patient distress impairment. Here, we have reviewed current mechanistic pathways biochemical aspects complex orofacial pathology, highlighting recent advancements in understanding its multifactorial regulation signaling thus providing holistic approach challenging it. Materials Methods: Studies were identified an online search PubMed database without any time range. Results: We discussed neuron–glia interactions glial cell activation terms immunomodulatory effects, metabolism reprogramming effects epigenetic modulatory response comprising different factors. highlighted fundamental role oxidative stress affecting cellular as well machinery, which renders pathology intricate multidimensional. Emerging research on modulation regulatory genes molecular environmental factors is also discussed, alongside updates novel treatment approaches. Conclusions: This review deliberates integrative perspectives implications immune system, glucose metabolism, lipid redox homeostasis mitochondrial dysfunction accommodating effect dysregulated non-coding RNAs for interdisciplinary at level, aiming improve outcomes with precise diagnosis offering improved management treatment.
Язык: Английский
Процитировано
1
Genes, Год журнала: 2025, Номер 16(4), С. 446 - 446
Опубликована: Апрель 11, 2025
MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping human transcriptome. So far, genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to malignant clonal disorder hematopoietic stem cells and is characterized by uncontrolled proliferation abnormal progenitor bone marrow blood. For past several years, scientific attention has attracted role AML, since alterations levels may contribute AML development. This review describes main functions classes presents biogenesis. study aims recent reports altered microRNA their influence on cell survival, cycle, apoptotic potential. Additionally, it summarizes correlations between target mRNAs outlines particular subtypes according ELN recommendations.
Язык: Английский
Процитировано
0
Cell Death and Disease, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 17, 2025
Abstract Ovarian cancer (OC) is often detected at an advanced stage and has a high recurrence rate after surgery or chemotherapy. Thus, it essential to develop new strategies for OC treatment. This study tended investigate the effects of endothelial cell-specific molecule 1 (ESM1) in OC. The impact ESM1 on lipid metabolism was investigated through regulation expression. Differential genes regulated by were screened mRNA sequencing. role autophagy explored using inhibitor chloroquine (CQ). Co-IP, dual-luciferase reporter assay, actinomycin D treatment others used analyze mechanism metabolism. xenograft mouse model constructed explore development. regulatory patient samples verified microarray analysis Log-rank (Mantel-Cox) test. After silencing, cholesterol synthesis decreased lipolysis increased. sequencing revealed that related Beclin (BECN1). In vitro experiments, inhibited suppressing BECN1-mediated autophagy. BECN1 expression transcription factor Kruppel-like 10 (KLF10). competitive binding between HSPA5 promoted ubiquitination degradation HMGCR, thereby inhibiting production. intervention experiment with exogenous showed positive correlation m6A reader IGF2BP3 content. Mechanistically, stability mRNA. vivo modified methylation lipolysis. High predicted poor prognosis patients. IGF2BP3/ESM1/KLF10/BECN1 feedback, which promising target
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 299 - 329
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Gynecologic Oncology Reports, Год журнала: 2025, Номер unknown, С. 101776 - 101776
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Human Genetics, Год журнала: 2024, Номер 143(7), С. 797 - 799
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 353 - 383
Опубликована: Дек. 6, 2024
Язык: Английский
Процитировано
0