Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 434 - 434

Published: Feb. 11, 2025

Background and Objectives: Orofacial pain corresponds to sensitization originating from the facial oral regions, often accompanied by diagnostic complexity due a multitude of contributory factors, leading significant patient distress impairment. Here, we have reviewed current mechanistic pathways biochemical aspects complex orofacial pathology, highlighting recent advancements in understanding its multifactorial regulation signaling thus providing holistic approach challenging it. Materials Methods: Studies were identified an online search PubMed database without any time range. Results: We discussed neuron–glia interactions glial cell activation terms immunomodulatory effects, metabolism reprogramming effects epigenetic modulatory response comprising different factors. highlighted fundamental role oxidative stress affecting cellular as well machinery, which renders pathology intricate multidimensional. Emerging research on modulation regulatory genes molecular environmental factors is also discussed, alongside updates novel treatment approaches. Conclusions: This review deliberates integrative perspectives implications immune system, glucose metabolism, lipid redox homeostasis mitochondrial dysfunction accommodating effect dysregulated non-coding RNAs for interdisciplinary at level, aiming improve outcomes with precise diagnosis offering improved management treatment.

Language: Английский

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Role of MicroRNAs in Acute Myeloid Leukemia

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 446 - 446

Published: April 11, 2025

MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping human transcriptome. So far, genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to malignant clonal disorder hematopoietic stem cells and is characterized by uncontrolled proliferation abnormal progenitor bone marrow blood. For past several years, scientific attention has attracted role AML, since alterations levels may contribute AML development. This review describes main functions classes presents biogenesis. study aims recent reports altered microRNA their influence on cell survival, cycle, apoptotic potential. Additionally, it summarizes correlations between target mRNAs outlines particular subtypes according ELN recommendations.

Language: Английский

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IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 17, 2025

Abstract Ovarian cancer (OC) is often detected at an advanced stage and has a high recurrence rate after surgery or chemotherapy. Thus, it essential to develop new strategies for OC treatment. This study tended investigate the effects of endothelial cell-specific molecule 1 (ESM1) in OC. The impact ESM1 on lipid metabolism was investigated through regulation expression. Differential genes regulated by were screened mRNA sequencing. role autophagy explored using inhibitor chloroquine (CQ). Co-IP, dual-luciferase reporter assay, actinomycin D treatment others used analyze mechanism metabolism. xenograft mouse model constructed explore development. regulatory patient samples verified microarray analysis Log-rank (Mantel-Cox) test. After silencing, cholesterol synthesis decreased lipolysis increased. sequencing revealed that related Beclin (BECN1). In vitro experiments, inhibited suppressing BECN1-mediated autophagy. BECN1 expression transcription factor Kruppel-like 10 (KLF10). competitive binding between HSPA5 promoted ubiquitination degradation HMGCR, thereby inhibiting production. intervention experiment with exogenous showed positive correlation m6A reader IGF2BP3 content. Mechanistically, stability mRNA. vivo modified methylation lipolysis. High predicted poor prognosis patients. IGF2BP3/ESM1/KLF10/BECN1 feedback, which promising target

Language: Английский

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Transcriptomic biomarkers in biomedicine

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 329

Published: Jan. 1, 2025

Language: Английский

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Long non-coding RNAs: recent insights, remaining challenges, and exciting new directions

Human Genetics, Journal Year: 2024, Volume and Issue: 143(7), P. 797 - 799

Published: July 1, 2024

Language: Английский

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Molecular pathway approach in biology and fundamental medicine

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 353 - 383

Published: Dec. 6, 2024

Language: Английский

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