Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

Science, Год журнала: 2024, Номер 383(6682)

Опубликована: Фев. 1, 2024

The transmission of the heartbeat through cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, elicited correlated local field oscillations in olfactory bulb mitral cell layer. These did not require synaptic but reflected baroreceptive transduction cells. This was mediated by fast excitatory mechanosensitive ion channel and modulated spiking awake animals, entrained activity subset neurons within ~20 milliseconds. Thus, we propose this fast, intrinsic interoceptive mechanism perception-for example, during arousal-within possibly across various other areas.

Язык: Английский

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Common principles for odour coding across vertebrates and invertebrates

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(7), С. 453 - 472

Опубликована: Май 28, 2024

Язык: Английский

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Principles of odor coding in vertebrates and artificial chemosensory systems

Physiological Reviews, Год журнала: 2021, Номер 102(1), С. 61 - 154

Опубликована: Июль 13, 2021

The biological olfactory system is the sensory responsible for detection of chemical composition environment. Several attempts to mimic systems have led various artificial using different technical approaches. Here we provide a parallel description and their counterparts. We start with presentation input systems, stimuli, treat interface between external world environment where receptor neurons or chemosensors reside. then delineate functions as well overall input-output (I/O) relationships. Up this point, our accounts go along similar lines. next processing steps differ considerably: whereas in biology step following “integration” “processing” neuron outputs bulb, has realizations electronic noses. For long period time, signal stages beyond i.e., higher centers, were little studied. Only recently there been marked growth studies tackling information these centers. In noses, third stage virtually never considered. review, an up-to-date overview current knowledge both fields and, first attempt tie them together. hope it will be breeding ground better information, communication, data exchange very related but so far little-connected fields.

Язык: Английский

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Development of the mammalian main olfactory bulb

Development, Год журнала: 2022, Номер 149(3)

Опубликована: Фев. 1, 2022

ABSTRACT The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. forms early during development and functional from birth. However, system continues to mature change throughout life as target constitutive adult neurogenesis. Our Review synthesises current knowledge prenatal, postnatal development, focusing on maturation, morphology, functions interactions its diverse constituent glutamatergic GABAergic cell types. We highlight not only great advances in understanding made recent years, but also gaps our present that most urgently require addressing.

Язык: Английский

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The olfactory bulb: A neuroendocrine spotlight on feeding and metabolism

Journal of Neuroendocrinology, Год журнала: 2024, Номер 36(6)

Опубликована: Март 11, 2024

Abstract Olfaction is the most ancient sense and needed for food‐seeking, danger protection, mating survival. It often first sensory modality to perceive changes in external environment, before sight, taste or sound. Odour molecules activate olfactory neurons that reside on epithelium nasal cavity, which transmits this odour‐specific information bulb (OB), where it relayed higher brain regions involved perception behaviour. Besides odour processing, recent studies suggest OB extends its function into regulation of food intake energy balance. Furthermore, numerous hormone receptors associated with appetite metabolism are expressed within OB, suggesting a neuroendocrine role outside hypothalamus. Olfactory cues important promote preparatory behaviours consumption, such as enhancing salivation. In addition, altered state (fasting, satiety overnutrition) can change processing perception. Similarly, various animal models human pathologies indicate strong link between impairment metabolic dysfunction. Therefore, understanding nature reciprocal relationship critical understand how disorders arise. This present review elaborates connection olfaction, feeding behaviour will shed light an interface internal environments. Elucidating specific mechanisms by signals integrated translated responses holds promise development targeted therapeutic strategies interventions aimed at modulating promoting health.

Язык: Английский

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Modulation of the sex pheromone detection by nutritional and hormonal signals in a male insect

Journal of Experimental Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

As in other animals, insects can modulate their odor-guided behaviors, especially sexual behavior, according to environmental and physiological factors such as the individual's nutritional state. This behavioral flexibility results from modifications of olfactory pathways under control hormones. Most studies have focused on central modulation system less attention has been paid peripheral system. To understand how inputs influence detection sex pheromones insects, we turned male moth Agrotis ipsilon for which responsiveness is dependent diet reproductive hormones, juvenile hormone (JH) 20-hydroxyecdysone (20E). We demonstrated that a sugar-rich with sodium increases sensitivity receptor neurons (Z)-7-dodecen-1-yl acetate, major pheromone compound, antennal expression binding protein (PBP2) (OR3). Such also induces overexpression Methoprene-tolerant JH underexpression ecdysone 20E antennae. The diet-induced responses were maintained by treatment Cucurbitacin B, antagonist, but suppressed topic application Precocene, biosynthesis inhibitor. These findings reveal positive state enhances through actions actors moths. More broadly our study provides, first time, neuronal molecular basis dietary-dependent endocrine

Язык: Английский

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Olfactory bulb tracks breathing rhythms and place in freely behaving mice

Опубликована: Март 11, 2025

Vertebrates sniff to control the odor samples that enter their nose. These can not only help identify odorous objects, but also locations and events. However, there is no receptor for place or time. Therefore, take full advantage of olfactory information, an animal’s brain must contextualize odor-driven activity with information about when, where, how they sniffed. To better understand contextual in system, we captured breathing movements mice while recording from bulb. In stimulus- task-free experiments, structure into persistent rhythmic states which are synchronous statelike ongoing neuronal population activity. reflect a strong dependence individual neuron on variation frequency, display using “sniff fields” quantify generalized linear models. addition, many bulb neurons have “place significant firing allocentric location, were comparable hippocampal recorded under same conditions. At level, mouse’s location be decoded similar accuracy hippocampus. Olfactory sensitivity cannot explained by rhythms scent marks. Taken together, show mouse tracks self-location, may unite internal models self environment as soon enters brain.

Язык: Английский

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Bio-inspired approaches for explosives detection

TrAC Trends in Analytical Chemistry, Год журнала: 2021, Номер 142, С. 116330 - 116330

Опубликована: Май 14, 2021

Due to unique abilities of the animals regarding analysis complex gas substances, they still remain a gold standard in explosives. Unusual capabilities biological chemosensory systems, including both vertebrates and invertebrates, stimulate elaboration devices mimicking their activity operation parameters as precisely possible. The electronic analogues are subject investigation many research centres, which brings successful commercialization closer. They believed substitute or complement explosive hazardous ones. limitations classic sensors can be overcome using strategies inspired by solutions known from systems. Apart high selectivity sensitivity desired for explosives, systems allows overcoming other problems connected mainly with effective sampling odour localization. Presented review is focused on biomimetic devices, mimic sense smell direct way inspiration design used detection Potential biosensors bioelectronic noses (B-ENs) incredibly accurate versatile "biological noses" was evaluated. A summary olfactory should facilitate approach problem artificial instruments development strategy aimed at explosives these

Язык: Английский

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Reciprocal processes of sensory perception and social bonding: an integrated social‐sensory framework of social behavior

Genes Brain & Behavior, Год журнала: 2021, Номер 21(3)

Опубликована: Дек. 14, 2021

Abstract Organisms filter the complexity of natural stimuli through their individual sensory and perceptual systems. Such filtering is particularly important for social stimuli. A shared “social umwelt” allows individuals to respond appropriately expected diversity cues signals during interactions. In this way, behavioral neurobiological mechanisms sociality bonding cannot be disentangled from processing. While a degree embeddedness between processes clear, our dominant theoretical frameworks favor treating as distinct. An integrated social‐sensory framework has potential greatly expand understanding underlying variation in more broadly. Here we leverage what known about processing pair two common study systems with significant species differences umwelt (rodent chemosensation avian acoustic communication). We primarily highlight that (1) communication essential bond formation maintenance, (2) neural circuits perception, are integrated, (3) candidate neuromodulatory regulate also impact perception. Finally, propose approaches fully integrate processing, communication, across levels analysis: behavioral, neurobiological, genomic. This perspective raises key questions: how shaped by processing?, extent saliency interactions emerging relationships?

Язык: Английский

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Olfactory‐driven beta band entrainment of limbic circuitry during neonatal development

The Journal of Physiology, Год журнала: 2023, Номер 601(16), С. 3605 - 3630

Опубликована: Июль 11, 2023

Cognitive processing relies on the functional refinement of limbic circuitry during first two weeks life. During this developmental period, when auditory, somatosensory and visual systems are still largely immature, sense olfaction acts as 'door to world', providing an important source environmental inputs. However, it is unknown whether early olfactory shapes activity in neonatal development. Here, we address question by combining simultaneous vivo recordings from bulb (OB), lateral entorhinal cortex (LEC), hippocampus (HP) prefrontal (PFC) with stimulation well opto- chemogenetic manipulations mitral/tufted cells OB non-anaesthetized mice both sexes. We show that synchronizes circuity beta frequency range. Moreover, drives neuronal network LEC, subsequently, HP PFC via long-range projections mitral HP-projecting LEC neurons. Thus, communication within circuits KEY POINTS: postnatal development, oscillatory circuit. Olfactory boosts firing synchronization along bulb-lateral cortex-hippocampal-prefrontal pathway. Mitral drive Inhibition vesicle release targeting cell axons reveals direct involvement bulb-driven entrainment circuitry.

Язык: Английский

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