eNeuro,
Год журнала:
2024,
Номер
11(3), С. ENEURO.0272 - 23.2024
Опубликована: Фев. 12, 2024
Human
and
animal
imaging
studies
demonstrated
that
chronic
pain
profoundly
alters
the
structure
functionality
of
several
brain
regions
even
causes
mental
dysfunctions
such
as
depression
anxiety
disorders.
In
this
article,
we
conducted
a
multimodal
study
cross-sectionally
longitudinally,
to
evaluate
how
neuropathic
affects
brain.
Using
spared
nerve
injury
(SNI)
model
which
promotes
long-lasting
mechanical
allodynia,
results
showed
deeply
modified
intrinsic
organization
functional
network
2
weeks
after
injury.
There
are
significant
changes
in
activity
left
thalamus
(Th_L)
olfactory
bulb
(OB_L)
SNI,
evidenced
by
both
blood
oxygen
level-dependent
(BOLD)
signal
c-Fos
expression.
Importantly,
these
were
closely
related
behavior
rats.
However,
it
is
worth
noting
morphine
administration
for
analgesia,
only
increased
TH
region
reversed,
while
decreased
OB
becomes
more
prominent.
Functional
connectivity
(FC)
correlation
analysis
further
two
interest
(ROIs)
exhibit
different
FC
patterns
with
other
regions.
Our
comprehensively
revealed
adaptive
neural
networks
induced
cross-sectional
longitudinal
dimensions
emphasized
abnormal
Th_L
OB_L
pathological
condition.
It
provides
reliable
assistance
exploring
intricate
mechanisms
diseases.
The
transmission
of
the
heartbeat
through
cerebral
vascular
system
causes
intracranial
pressure
pulsations.
We
discovered
that
arterial
pulsations
can
directly
modulate
central
neuronal
activity.
In
a
semi-intact
rat
brain
preparation,
elicited
correlated
local
field
oscillations
in
olfactory
bulb
mitral
cell
layer.
These
did
not
require
synaptic
but
reflected
baroreceptive
transduction
cells.
This
was
mediated
by
fast
excitatory
mechanosensitive
ion
channel
and
modulated
spiking
awake
animals,
entrained
activity
subset
neurons
within
~20
milliseconds.
Thus,
we
propose
this
fast,
intrinsic
interoceptive
mechanism
perception-for
example,
during
arousal-within
possibly
across
various
other
areas.
Physiological Reviews,
Год журнала:
2021,
Номер
102(1), С. 61 - 154
Опубликована: Июль 13, 2021
The
biological
olfactory
system
is
the
sensory
responsible
for
detection
of
chemical
composition
environment.
Several
attempts
to
mimic
systems
have
led
various
artificial
using
different
technical
approaches.
Here
we
provide
a
parallel
description
and
their
counterparts.
We
start
with
presentation
input
systems,
stimuli,
treat
interface
between
external
world
environment
where
receptor
neurons
or
chemosensors
reside.
then
delineate
functions
as
well
overall
input-output
(I/O)
relationships.
Up
this
point,
our
accounts
go
along
similar
lines.
next
processing
steps
differ
considerably:
whereas
in
biology
step
following
“integration”
“processing”
neuron
outputs
bulb,
has
realizations
electronic
noses.
For
long
period
time,
signal
stages
beyond
i.e.,
higher
centers,
were
little
studied.
Only
recently
there
been
marked
growth
studies
tackling
information
these
centers.
In
noses,
third
stage
virtually
never
considered.
review,
an
up-to-date
overview
current
knowledge
both
fields
and,
first
attempt
tie
them
together.
hope
it
will
be
breeding
ground
better
information,
communication,
data
exchange
very
related
but
so
far
little-connected
fields.
ABSTRACT
The
mammalian
main
olfactory
bulb
is
a
crucial
processing
centre
for
the
sense
of
smell.
forms
early
during
development
and
functional
from
birth.
However,
system
continues
to
mature
change
throughout
life
as
target
constitutive
adult
neurogenesis.
Our
Review
synthesises
current
knowledge
prenatal,
postnatal
development,
focusing
on
maturation,
morphology,
functions
interactions
its
diverse
constituent
glutamatergic
GABAergic
cell
types.
We
highlight
not
only
great
advances
in
understanding
made
recent
years,
but
also
gaps
our
present
that
most
urgently
require
addressing.
Journal of Neuroendocrinology,
Год журнала:
2024,
Номер
36(6)
Опубликована: Март 11, 2024
Abstract
Olfaction
is
the
most
ancient
sense
and
needed
for
food‐seeking,
danger
protection,
mating
survival.
It
often
first
sensory
modality
to
perceive
changes
in
external
environment,
before
sight,
taste
or
sound.
Odour
molecules
activate
olfactory
neurons
that
reside
on
epithelium
nasal
cavity,
which
transmits
this
odour‐specific
information
bulb
(OB),
where
it
relayed
higher
brain
regions
involved
perception
behaviour.
Besides
odour
processing,
recent
studies
suggest
OB
extends
its
function
into
regulation
of
food
intake
energy
balance.
Furthermore,
numerous
hormone
receptors
associated
with
appetite
metabolism
are
expressed
within
OB,
suggesting
a
neuroendocrine
role
outside
hypothalamus.
Olfactory
cues
important
promote
preparatory
behaviours
consumption,
such
as
enhancing
salivation.
In
addition,
altered
state
(fasting,
satiety
overnutrition)
can
change
processing
perception.
Similarly,
various
animal
models
human
pathologies
indicate
strong
link
between
impairment
metabolic
dysfunction.
Therefore,
understanding
nature
reciprocal
relationship
critical
understand
how
disorders
arise.
This
present
review
elaborates
connection
olfaction,
feeding
behaviour
will
shed
light
an
interface
internal
environments.
Elucidating
specific
mechanisms
by
signals
integrated
translated
responses
holds
promise
development
targeted
therapeutic
strategies
interventions
aimed
at
modulating
promoting
health.
Journal of Experimental Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
As
in
other
animals,
insects
can
modulate
their
odor-guided
behaviors,
especially
sexual
behavior,
according
to
environmental
and
physiological
factors
such
as
the
individual's
nutritional
state.
This
behavioral
flexibility
results
from
modifications
of
olfactory
pathways
under
control
hormones.
Most
studies
have
focused
on
central
modulation
system
less
attention
has
been
paid
peripheral
system.
To
understand
how
inputs
influence
detection
sex
pheromones
insects,
we
turned
male
moth
Agrotis
ipsilon
for
which
responsiveness
is
dependent
diet
reproductive
hormones,
juvenile
hormone
(JH)
20-hydroxyecdysone
(20E).
We
demonstrated
that
a
sugar-rich
with
sodium
increases
sensitivity
receptor
neurons
(Z)-7-dodecen-1-yl
acetate,
major
pheromone
compound,
antennal
expression
binding
protein
(PBP2)
(OR3).
Such
also
induces
overexpression
Methoprene-tolerant
JH
underexpression
ecdysone
20E
antennae.
The
diet-induced
responses
were
maintained
by
treatment
Cucurbitacin
B,
antagonist,
but
suppressed
topic
application
Precocene,
biosynthesis
inhibitor.
These
findings
reveal
positive
state
enhances
through
actions
actors
moths.
More
broadly
our
study
provides,
first
time,
neuronal
molecular
basis
dietary-dependent
endocrine
Vertebrates
sniff
to
control
the
odor
samples
that
enter
their
nose.
These
can
not
only
help
identify
odorous
objects,
but
also
locations
and
events.
However,
there
is
no
receptor
for
place
or
time.
Therefore,
take
full
advantage
of
olfactory
information,
an
animal’s
brain
must
contextualize
odor-driven
activity
with
information
about
when,
where,
how
they
sniffed.
To
better
understand
contextual
in
system,
we
captured
breathing
movements
mice
while
recording
from
bulb.
In
stimulus-
task-free
experiments,
structure
into
persistent
rhythmic
states
which
are
synchronous
statelike
ongoing
neuronal
population
activity.
reflect
a
strong
dependence
individual
neuron
on
variation
frequency,
display
using
“sniff
fields”
quantify
generalized
linear
models.
addition,
many
bulb
neurons
have
“place
significant
firing
allocentric
location,
were
comparable
hippocampal
recorded
under
same
conditions.
At
level,
mouse’s
location
be
decoded
similar
accuracy
hippocampus.
Olfactory
sensitivity
cannot
explained
by
rhythms
scent
marks.
Taken
together,
show
mouse
tracks
self-location,
may
unite
internal
models
self
environment
as
soon
enters
brain.
TrAC Trends in Analytical Chemistry,
Год журнала:
2021,
Номер
142, С. 116330 - 116330
Опубликована: Май 14, 2021
Due
to
unique
abilities
of
the
animals
regarding
analysis
complex
gas
substances,
they
still
remain
a
gold
standard
in
explosives.
Unusual
capabilities
biological
chemosensory
systems,
including
both
vertebrates
and
invertebrates,
stimulate
elaboration
devices
mimicking
their
activity
operation
parameters
as
precisely
possible.
The
electronic
analogues
are
subject
investigation
many
research
centres,
which
brings
successful
commercialization
closer.
They
believed
substitute
or
complement
explosive
hazardous
ones.
limitations
classic
sensors
can
be
overcome
using
strategies
inspired
by
solutions
known
from
systems.
Apart
high
selectivity
sensitivity
desired
for
explosives,
systems
allows
overcoming
other
problems
connected
mainly
with
effective
sampling
odour
localization.
Presented
review
is
focused
on
biomimetic
devices,
mimic
sense
smell
direct
way
inspiration
design
used
detection
Potential
biosensors
bioelectronic
noses
(B-ENs)
incredibly
accurate
versatile
"biological
noses"
was
evaluated.
A
summary
olfactory
should
facilitate
approach
problem
artificial
instruments
development
strategy
aimed
at
explosives
these
Genes Brain & Behavior,
Год журнала:
2021,
Номер
21(3)
Опубликована: Дек. 14, 2021
Abstract
Organisms
filter
the
complexity
of
natural
stimuli
through
their
individual
sensory
and
perceptual
systems.
Such
filtering
is
particularly
important
for
social
stimuli.
A
shared
“social
umwelt”
allows
individuals
to
respond
appropriately
expected
diversity
cues
signals
during
interactions.
In
this
way,
behavioral
neurobiological
mechanisms
sociality
bonding
cannot
be
disentangled
from
processing.
While
a
degree
embeddedness
between
processes
clear,
our
dominant
theoretical
frameworks
favor
treating
as
distinct.
An
integrated
social‐sensory
framework
has
potential
greatly
expand
understanding
underlying
variation
in
more
broadly.
Here
we
leverage
what
known
about
processing
pair
two
common
study
systems
with
significant
species
differences
umwelt
(rodent
chemosensation
avian
acoustic
communication).
We
primarily
highlight
that
(1)
communication
essential
bond
formation
maintenance,
(2)
neural
circuits
perception,
are
integrated,
(3)
candidate
neuromodulatory
regulate
also
impact
perception.
Finally,
propose
approaches
fully
integrate
processing,
communication,
across
levels
analysis:
behavioral,
neurobiological,
genomic.
This
perspective
raises
key
questions:
how
shaped
by
processing?,
extent
saliency
interactions
emerging
relationships?
The Journal of Physiology,
Год журнала:
2023,
Номер
601(16), С. 3605 - 3630
Опубликована: Июль 11, 2023
Cognitive
processing
relies
on
the
functional
refinement
of
limbic
circuitry
during
first
two
weeks
life.
During
this
developmental
period,
when
auditory,
somatosensory
and
visual
systems
are
still
largely
immature,
sense
olfaction
acts
as
'door
to
world',
providing
an
important
source
environmental
inputs.
However,
it
is
unknown
whether
early
olfactory
shapes
activity
in
neonatal
development.
Here,
we
address
question
by
combining
simultaneous
vivo
recordings
from
bulb
(OB),
lateral
entorhinal
cortex
(LEC),
hippocampus
(HP)
prefrontal
(PFC)
with
stimulation
well
opto-
chemogenetic
manipulations
mitral/tufted
cells
OB
non-anaesthetized
mice
both
sexes.
We
show
that
synchronizes
circuity
beta
frequency
range.
Moreover,
drives
neuronal
network
LEC,
subsequently,
HP
PFC
via
long-range
projections
mitral
HP-projecting
LEC
neurons.
Thus,
communication
within
circuits
KEY
POINTS:
postnatal
development,
oscillatory
circuit.
Olfactory
boosts
firing
synchronization
along
bulb-lateral
cortex-hippocampal-prefrontal
pathway.
Mitral
drive
Inhibition
vesicle
release
targeting
cell
axons
reveals
direct
involvement
bulb-driven
entrainment
circuitry.