Chemotherapy‑induced
nausea
and
vomiting
(CINV)
is
a
common
distressing
adverse
effect
in
elderly
patients
with
gynecological
cancer
undergoing
paclitaxel
carboplatin
therapy.
The
present
study
aimed
to
identify
predictors
of
CINV
this
population.
A
retrospective
analysis
was
conducted
209
treated
chemotherapy
at
Affiliated
Hospital,
Southwest
Medical
University
(Luzhou,
China)
between
May
2019
July
2023.
Multinational
Association
Supportive
Care
Cancer
Antiemesis
Tool
(MAT)
used
assess
the
presence,
frequency,
severity
CINV.
Patients
were
categorized
into
group
(n=76)
non‑CINV
(n=133)
based
on
MAT
results.
Age,
hypertension,
pre‑chemotherapy
sleep
duration
anxiety
level
identified
as
significant
univariate
analysis.
In
multivariate
analysis,
age,
remained
predictors.
conclusion,
are
These
findings
could
help
tailoring
preventative
strategies
for
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 27, 2025
Advanced
hepatocellular
carcinoma
(HCC)
poses
treatment
challenges,
especially
where
access
to
multi-kinase
inhibitors
and
ICIs
is
limited
by
high
costs
lack
of
insurance.
This
study
evaluates
the
effectiveness
5-fluorouracil
(5-FU)
plus
platinum-based
chemotherapy
as
an
alternative
systemic
for
advanced
HCC.
A
retrospective
analysis
HCC
patients
treated
with
5-FU
was
conducted.
The
Kaplan-Meier
method
determined
median
progression-free
survival
(PFS)
overall
(OS).
From
April
2009
October
2023,
48
were
included
in
study.
Nearly
all
(97.9%)
had
extrahepatic
metastasis
stable
liver
function,
three-quarters
previously
sorafenib.
At
a
follow-up
7.8
months,
PFS
4.2
months
(95%
CI,
1.3–7.1),
OS
8.2
2.5–13.9).
pretreatment
neutrophil-to-lymphocyte
ratio
(≥
3.0)
adversely
affected
both
(HR
=
1.79;
95%
0.99–3.25;
p
0.034)
2.02;
1.10–3.69;
0.011).
Hematologic
toxicities
related
substantial,
62.5%
experiencing
grade
3
or
4
events,
primarily
neutropenia,
which
60.4%
them.
Our
findings
suggest
that
combined
viable,
cost-effective
resource-limited
settings,
particularly
compared
inhibitors,
significant
implications
developing
countries.
Journal of Hepatocellular Carcinoma,
Год журнала:
2025,
Номер
Volume 12, С. 193 - 203
Опубликована: Янв. 1, 2025
To
develop
and
validate
a
predictive
model
for
predicting
six-month
outcome
by
integrating
pretreatment
MRI
features
one-month
treatment
response
after
TACE.
A
total
of
108
patients
with
160
hCCs
from
single-arm,
multicenter
clinical
trial
(NCT03113955)
were
analyzed
served
as
the
training
cohort.
An
external
dataset
(ChiCTR2100046020)
consisting
63
99
test
dataset.
Radiomics
was
constructed
based
on
selected
MR
images.
Univariate
multivariate
logistic
regression
analysis
radiological
factors
used
to
identify
independent
predictors
6-month
response.
combined
further
incorporating
response,
radiomics
signature.
Among
all
features,
only
corona
enhancement
selected.
The
model,
named
TRACE
(Treatment
at
1
month,
RAdiomics
Corona
Enhancement),
AUCs
0.91
(training
cohort)
0.84
(test
cohort).
demonstrated
significantly
higher
AUC
than
(P
=
0.001).
High-risk
low-risk
groups
stratified
using
also
exhibited
significant
differences
in
overall
survival
(OS)
<
In
contrast,
none
published
scoring
systems,
including
ART,
SNACOR
or
ABCR
score,
between
risk
OS
prediction.
favorable
capability
TACE
holds
potential
marker
long-term
outcomes.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 31, 2025
Pancreatic
cysts,
particularly
intraductal
papillary
mucinous
neoplasms
(IPMNs),
pose
a
potential
risk
for
progressing
to
pancreatic
cancer
(PC).
This
study
investigates
the
genetic
architecture
of
benign
cysts
and
its
connection
PC
using
genome-wide
association
studies
(GWAS).
The
discovery
GWAS
identified
significant
variants
associated
with
specifically
rs142409042
variant
near
OPCML
gene.
A
pairwise
comparing
revealed
rs7190458
BCAR1
CTRB1
genes.
Further
analysis
genes
highlighted
Actin
Related
Protein
(Arp)
2/3
complex
as
potentially
important
molecular
mechanism
connecting
PC.
Arp2/3
complex-associated
were
significantly
upregulated
in
PC,
suggesting
their
role
malignant
transformation
cysts.
Differential
expression
these
was
observed
across
various
cell
types
indicating
involvement
tumor
microenvironment.
These
findings
suggest
that
can
serve
biomarkers
predicting
opening
new
avenues
targeted
therapies
early
detection
strategies.
Chemotherapy‑induced
nausea
and
vomiting
(CINV)
is
a
common
distressing
adverse
effect
in
elderly
patients
with
gynecological
cancer
undergoing
paclitaxel
carboplatin
therapy.
The
present
study
aimed
to
identify
predictors
of
CINV
this
population.
A
retrospective
analysis
was
conducted
209
treated
chemotherapy
at
Affiliated
Hospital,
Southwest
Medical
University
(Luzhou,
China)
between
May
2019
July
2023.
Multinational
Association
Supportive
Care
Cancer
Antiemesis
Tool
(MAT)
used
assess
the
presence,
frequency,
severity
CINV.
Patients
were
categorized
into
group
(n=76)
non‑CINV
(n=133)
based
on
MAT
results.
Age,
hypertension,
pre‑chemotherapy
sleep
duration
anxiety
level
identified
as
significant
univariate
analysis.
In
multivariate
analysis,
age,
remained
predictors.
conclusion,
are
These
findings
could
help
tailoring
preventative
strategies
for
