International Journal of Medical Sciences,
Journal Year:
2025,
Volume and Issue:
22(5), P. 1158 - 1166
Published: Feb. 11, 2025
Cholangiocarcinoma
(CCA)
is
a
highly
lethal
malignancy
and
the
most
common
adenocarcinoma
of
hepatobiliary
system.
PGM2L1
belongs
to
α-D-phosphohexomutase
superfamily
functions
as
glucose
1,6-bisphosphate
(G16BP)
synthase.
There
growing
evidence
provide
an
association
its
function
cancer
metabolism
progression.
However,
molecular
mechanisms
in
CCA
development
remain
lacking
evidence.
In
this
study,
we
found
that
patients
with
high
expression
had
poorest
prognosis.
We
identified
two
methylation
sites
(cg15214137
cg03699633)
within
gene
their
prognostic
relevance.
further
investigated
relationship
between
tumor-infiltrating
immune
cells,
particular
focus
on
neutrophils
CCA.
Functional
enrichment
analyses
revealed
was
associated
Wnt
signaling
pathway,
glycolytic
metabolism,
recruitment
neutrophils.
Collectively,
these
findings
suggest
may
serve
independent
biomarker
closely
linked
tumor
infiltration
metabolic
reprogramming
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 7, 2025
Gastric
cancer
patients
are
prone
to
lower
extremity
deep
vein
thrombosis
(DVT)
after
surgery,
which
is
an
important
cause
of
death
in
postoperative
patients.
Therefore,
it
particularly
find
a
suitable
way
predict
the
risk
occurrence
DVT
GC
This
study
aims
explore
effectiveness
using
machine
learning
(ML)
assisted
radiomics
build
imaging
models
for
prediction
surgery.
Included
this
retrospective
were
eligible
who
underwent
surgery
GC.
CT
data
from
these
collected
and
divided
into
training
set
validation
set.
The
least
absolute
shrinkage
selection
operator
(LASSO)
algorithm
was
applied
reduce
dimensionality
variables
Four
algorithms,
known
as
random
forest
(RF),
extreme
gradient
boosting
(XGBoost),
support
vector
(SVM)
naive
Bayes
(NB),
used
develop
predicting
These
subsequently
validated
internal
external
cohort.
LASSO
analysis
identified
10
variables,
based
on
four
ML
established,
then
incorporated
with
clinical
characteristics
Among
models,
RF
NB
demonstrated
highest
predictive
performance,
achieving
AUC
0.928,
while
SVM
XGBoost
achieved
slightly
0.915
0.869,
respectively.
algorithms
information
may
prove
be
novel
non-invasive
World Journal of Surgical Oncology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 10, 2025
This
study
aimed
to
investigate
the
knowledge,
attitudes,
and
practices
(KAP)
regarding
whole-course
management
among
patients
with
gastrointestinal
(GI)
cancers.
cross-sectional
enrolled
GI
cancers
at
Inner
Mongolia
Hospital
of
Peking
University
Cancer
between
November
2023
April
2024.
Data
were
collected
through
a
self-administered
questionnaire,
which
captured
demographic
information
scores
on
KAP.
A
total
408
participants
included
in
this
study.
The
mean
KAP
10.62
±
3.14
(out
maximum
15),
39.11
4.94
50),
31.35
5.60
40),
respectively.
Knowledge
was
positively
correlated
attitudes
(r
=
0.307,
P
<
0.001)
0.417,
0.001),
while
0.383,
0.001).
structural
equation
model
indicated
that
knowledge
influenced
(β
0.573,
0.466,
0.525,
Patients
demonstrated
insufficient
moderate
suboptimal
management.
Improvements
practice
could
be
achieved
by
enhancing
specialized
health
education.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 18, 2025
The
administration
of
second-line
or
subsequent
immune
checkpoint
inhibitors
(ICIs)
in
previously
treated
patients
with
advanced
solid
cancers
has
been
clinically
investigated.
However,
previous
clinical
trials
lacked
an
appropriate
primary
endpoint
for
efficacy
assessment.
This
systematic
review
aimed
to
explore
the
most
optimal
early
such
trials.
Phase
2
3
involving
disease
progression
following
standard
first-line
therapy
receiving
ICI
administration,
adequate
survival
outcome
data,
were
included
from
PubMed,
Embase,
Web
Science,
and
Cochrane
Library
databases
before
February
2023.
Quality
assessment
was
conducted
using
tool
Newcastle–Ottawa
Assessment
Scale
Cohort
Studies
randomized
controlled
(RCTs)
non-randomized
trials,
respectively.
Objective
response
rate
(ORR)
progression-free
(PFS)
at
3,
6,
9
months
investigated
as
potential
candidates
12-month
overall
(OS),
a
strong
correlation
defined
Pearson's
coefficient
r
≥
0.8.
A
total
64
RCTs
comprising
22,725
106
prospective
10,608
participants
eligible
modeling
external
validation,
examined
15
different
cancer
types,
predominantly
non-small-cell
lung
(NSCLC)
(17,
28%),
melanoma
(9,
14%),
esophageal
squamous
cell
carcinoma
(5,
8%).
median
sample
size
124
patients,
follow-up
time
3.2–57.7
months.
ORR
(r
=
0.38;
95%
confidence
interval
[CI],
0.18–0.54)
PFS
0.42;
CI,
0.14–0.64)
exhibited
weak
trial-level
correlations
OS.
Within
treatment
arms,
values
3-,
6-,
9-month
OS
0.61
(95%
0.37–0.79),
0.78
0.62–0.88),
0.84
0.77–0.90),
0.86
0.79–0.90),
External
validation
6-month
indicated
acceptable
discrepancy
between
actual
predicted
In
phase
on
cancers,
could
serve
endpoint.
endpoints
are
not
recommended
replace
International Journal of Medical Sciences,
Journal Year:
2025,
Volume and Issue:
22(5), P. 1158 - 1166
Published: Feb. 11, 2025
Cholangiocarcinoma
(CCA)
is
a
highly
lethal
malignancy
and
the
most
common
adenocarcinoma
of
hepatobiliary
system.
PGM2L1
belongs
to
α-D-phosphohexomutase
superfamily
functions
as
glucose
1,6-bisphosphate
(G16BP)
synthase.
There
growing
evidence
provide
an
association
its
function
cancer
metabolism
progression.
However,
molecular
mechanisms
in
CCA
development
remain
lacking
evidence.
In
this
study,
we
found
that
patients
with
high
expression
had
poorest
prognosis.
We
identified
two
methylation
sites
(cg15214137
cg03699633)
within
gene
their
prognostic
relevance.
further
investigated
relationship
between
tumor-infiltrating
immune
cells,
particular
focus
on
neutrophils
CCA.
Functional
enrichment
analyses
revealed
was
associated
Wnt
signaling
pathway,
glycolytic
metabolism,
recruitment
neutrophils.
Collectively,
these
findings
suggest
may
serve
independent
biomarker
closely
linked
tumor
infiltration
metabolic
reprogramming
