Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐senolytics
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 26, 2024
Cellular
senescence
is
a
significant
risk
factor
for
aging
and
age-related
diseases
(ARD).
The
canonical
senolytics
Dasatinib
Quercetin
(DQ)
have
shown
promise
in
clearing
senescent
cells
(SnCs);
however,
the
lack
of
selectivity
poses
challenge
achieving
optimal
outcomes.
Despite
recent
occurrence
nanomaterial-based
approaches
targeting
SnCs,
limited
therapeutic
effects,
potential
toxicity
still
remain
major
concern.
Herein,
"double
locks-like"
nanoplatform
developed
that
integrated
Galactan
coating
mesoporous
polydopamine
to
encase
senolytic
drug
DQ.
By
this
way,
DQ
only
released
SnCs
are
featured
with
higher
levels
β-galactosidase
(β-gal)
low
PH.
Additionally,
nanoparticles
equipped
2,2,6,6-Tetramethylpiperidine-1-oxyl
(Tempo)
gain
enhanced
photothermal
converting
potential.
Consequently,
synthesized
nanosenolytics
demonstrate
remarkable
specificity
efficacy
eradicating
accordingly
reverse
pulmonary
fibrosis
mice
without
affecting
normal
tissues.
Upon
exposure
near-infrared
(NIR)
light,
efficiently
remove
tumor
inducted
by
chemotherapy,
thereby
hindering
outgrowth
metastasis
or
breast
cancer.
Collectively,
present
study
develops
an
"On/Off"
switchable
response
produces
more
safe,
efficient,
feasible
way
delay
alleviate
age-associated
diseases.
Язык: Английский
Peripheral neuropathy: from guidelines to clinical practise
Current Opinion in Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Purpose
of
review
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
is
a
substantial
adverse
effect
anticancer
therapy.
No
effective
preventive
strategies
are
established
in
clinical
routine,
although
some
forms
cryotherapy
or
compression
therapy
seem
to
be
promising.
CIPN
difficult
grade
objectively
and
has
mostly
relied
on
clinician-
patient-based
rating
that
subjective
not
easily
reproducible.
Recent
findings
preclinical
studies
showed
an
indicative
hint
serum
neurofilaments
for
axonal
damage
as
biomarker
might
introduced
practice
the
future.
Axonal
degeneration
toxic
triggered
by
molecular
pathways
including
SARM1.
Presence
certain
genotypes
predispose
developing
severe
vincristine
neuropathy.
Still,
treatment
focused
treating
neuropathic
pain
primarily
based
physicians
experience.
A
positive
membrane
stabilizers
such
gabapentinoids
could
shown
systematic
due
inconsistent
study
populations.
In
prevention
functional
disability,
physical
exercise
sensorimotor-training
whole-body
vibration
seems
Summary
More
research
needed
quantification
biomarkers
prior
symptom
expression.
All
these
recent
should
support
health-care
team
patient
centred
approach.
Язык: Английский
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms
Neurotoxicity Research,
Год журнала:
2025,
Номер
43(2)
Опубликована: Март 18, 2025
Язык: Английский
Therapy-induced senescence is finally escapable, what is next?
Cell Cycle,
Год журнала:
2024,
Номер
23(6), С. 713 - 721
Опубликована: Март 18, 2024
Several
breakthrough
articles
have
recently
confirmed
the
ability
of
tumor
cells
to
escape
stable
cell
cycle
arrest
imposed
by
Therapy-Induced
Senescence
(TIS).
Subsequently,
accepting
hypothesis
that
TIS
is
escapable
should
encourage
serious
reassessments
fundamental
roles
senescence
in
cancer
treatment.
The
potential
for
from
undermines
well-established
suppressor
function
senescence,
proposes
it
as
a
mechanism
dormancy
leading
disease
recurrence
and
invites
further
investigation
its
unfavorable
contribution
therapy
outcomes.
Moreover,
escaping
strongly
indicates
elimination
senescent
cells,
primarily
through
pharmacological
means,
suitable
approach
increasing
efficacy
treatment,
one
still
requires
exploration.
This
commentary
provides
an
overview
recent
evidence
unequivocally
demonstrated
therapy-induced
overcoming
terminal
growth
fate
future
perspectives
on
biology.
Язык: Английский
Can senolysis be used to overcome tumor immune evasion?
Wally Veklych,
Thomas E. Ichim,
Robert Reznik
и другие.
Journal of Stem Cell Research & Therapeutics,
Год журнала:
2024,
Номер
9(1), С. 26 - 32
Опубликована: Янв. 1, 2024
Tumor
escape
from
immunologically
mediated
destruction
is
a
well-studied
phenomena
and
has
been
shown
to
utilize
several
pathways
in
common
with
physiological
conditions
such
as
pregnancy,
well
ocular
or
testicular
immune
privilege.
Recent
interest
senescence
revealed
that
senescent
cells
surrounding
tumors
contribute
development
of
specific
microenvironment
may
allow
for
escape.
Senescent
have
reported
possess
“senescence
associated
secretory
phenotype”
(SASP)
which
produces
inflammatory
agents
directly
indirectly
suppression
T
cell
NK
function.
Exosomes
secreted
by
can
suppress
activation,
downregulate
activity
dendritic
cells,
are
needed
initiation
immunity.
Studies
demonstrated
reduction
load
increases
tumor
sensitivity
variety
therapies.
We
will
overview
supportive
evidence
use
senolytics
potentiate
the
efficacy
immunotherapy
cancer,
discuss
our
preliminary
findings
regarding
SenoVax™
(IND
#30745),
an
autologous,
polyvalent
senolytic
vaccine
being
developed
treatment
advanced
non-small
lung
cancer.
Язык: Английский