Immunosenescence promotes cancer development: from mechanisms to treatment strategies
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 10, 2025
The
body's
innate
immune
system
plays
a
pivotal
role
in
identifying
and
eliminating
cancer
cells.
However,
as
the
ages,
its
functionality
can
deteriorate,
becoming
dysfunctional,
inefficient,
or
even
inactive—a
condition
referred
to
immunosenescence.
This
decline
significantly
increases
risk
of
malignancies.
While
pro-cancer
effects
T-cell
aging
have
been
widely
explored,
there
remains
notable
gap
literature
regarding
impact
on
cells,
such
macrophages
neutrophils.
review
seeks
address
this
gap,
with
emphasis
these
cell
types.
Furthermore,
although
certain
immunotherapies,
including
checkpoint
inhibitors
(ICIs),
demonstrated
efficacy
across
broad
spectrum
cancers,
elderly
patients
are
less
likely
derive
clinical
benefit
from
treatments.
In
some
cases,
they
may
experience
immune-related
adverse
events
(irAEs).
senolytic
strategies
shown
promise
exerting
anti-cancer
effects,
their
reactions
potential
off-target
present
significant
challenges.
aims
elucidate
immunosenescence,
implications
for
safety
ICIs,
anti-aging
treatment
strategies.
addition,
optimizing
therapies
minimize
enhance
therapeutic
outcomes
critical
focus
future
research
endeavors.
Senescence
is
an
inevitable
phenomenon
human
body,
scientists
explored
specific
mechanisms
by
which
immunosenescence
advances
development
cancer.
summarizes
characteristics
be
used
level
surveillance
cancers
due
"Targeting
immunosenescence"
new
idea
strategy
therapy.
Язык: Английский
Light-activated photosensitizer/quercetin co-loaded extracellular vesicles for precise oral squamous cell carcinoma therapy
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
671, С. 125224 - 125224
Опубликована: Янв. 15, 2025
Язык: Английский
Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases
Advances in pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Lung Epithelial Cell Membrane-Camouflaged ROS-Activatable Berberine Nanoparticles for Targeted Treatment in Acute Lung Injury
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6163 - 6183
Опубликована: Май 1, 2025
Acute
lung
injury
(ALI)
seriously
threatens
human
health
and
is
induced
by
multiple
factors.
When
ALI
occurs,
lesions
affect
gas
exchange
may
trigger
respiratory
failure.
Current
clinical
treatments
are
limited,
traditional
drug
delivery
has
drawbacks.
Berberine,
a
natural
with
anti-inflammatory
effects,
difficulty
in
effectively
exerting
its
efficacy.
The
study
designed
nano-micelle.
Hydrophobic
berberine
was
encapsulated
diselenide
bonds
as
the
linker.
Then,
epithelial
cell
membranes
were
extracted
to
encapsulate
disguise
These
nanoparticles
injected
intravenously.
Thanks
membrane's
specificity,
they
could
bind
tissue,
achieving
targeted
delivery.
In
inflamed
area
of
acute
injury,
significantly
increased
reactive
oxygen
species
level
used
break
bonds,
enabling
precise
release
at
site.
nano-drug
(MM-NPs)
successfully
prepared,
encapsulation
efficiency
micelles
reaching
68.2%.
ROS
environment,
nano-micelles
quickly
over
80%
berberine.
inflammatory
MLE-12
cells,
MM-NPs
responded
well
ROS,
cellular
factor
levels
improved
after
treatment.
lipopolysaccharide
(LPS)-induced
pneumonia
mouse
model,
achieved
targeting.
Further
studies
showed
that
administration
alleviated
LPS-induced
mice.
Additionally,
evaluation
indicated
had
good
in-vivo
safety
no
obvious
adverse
reactions.
This
developed
novel
system,
MM-NPs,
overcoming
berberine's
low
bioavailability
problem
treating
injury.
system
excellent
physicochemical
properties,
biocompatibility,
metabolic
safety.
vitro
animal
experiments
verified
it
can
enhance
therapeutic
effect,
offering
new
ideas
hopes
for
future,
trials
be
advanced,
targeting
strategies
explored
more
breakthroughs.
Язык: Английский
Advances in Nanotherapy for Targeting Senescent Cells
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8797 - 8813
Опубликована: Авг. 1, 2024
Aging
is
an
inevitable
process
in
the
human
body,
and
cellular
senescence
refers
to
irreversible
cell
cycle
arrest
caused
by
external
aging-promoting
mechanisms.
Moreover,
as
age
increases,
accumulation
of
senescent
cells
limits
both
health
body
lifespan
even
accelerates
occurrence
progression
age-related
diseases.
Therefore,
it
crucial
delay
periodic
continuous
address
issue
aging.
The
fundamental
solution
targeted
therapy
focused
on
eliminating
or
reducing
senescence-associated
secretory
phenotype.
Over
past
few
decades,
remarkable
development
nanomaterials
has
revolutionized
clinical
drug
delivery
pathways.
Their
unique
optical,
magnetic,
electrical
properties
effectively
compensate
for
shortcomings
traditional
drugs,
such
low
stability
short
half-life,
thereby
maximizing
bioavailability
minimizing
toxicity
delivery.
This
article
provides
overview
how
nanomedicine
systems
control
release
achieve
effective
diagnosis.
By
presenting
analyzing
recent
advances
nanotherapy
targeting
cells,
underlying
mechanisms
senolytic
senomorphic
are
clarified,
providing
great
potential
cells.
Язык: Английский
From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications
Cells,
Год журнала:
2024,
Номер
13(24), С. 2052 - 2052
Опубликована: Дек. 12, 2024
Cellular
rejuvenation
therapies
represent
a
transformative
frontier
in
addressing
age-related
decline
and
extending
human
health
span.
By
targeting
fundamental
hallmarks
of
aging—such
as
genomic
instability,
epigenetic
alterations,
mitochondrial
dysfunction,
cellular
senescence—these
aim
to
restore
youthful
functionality
cells
tissues,
offering
new
hope
for
treating
degenerative
diseases.
Recent
advancements
have
showcased
range
strategies,
including
reprogramming,
senolytic
interventions,
restoration,
stem
cell-based
approaches,
gene-editing
technologies
like
CRISPR.
Each
modality
has
demonstrated
substantial
potential
preclinical
models
is
now
being
cautiously
explored
early-stage
clinical
trials.
However,
translating
these
from
the
laboratory
practice
presents
unique
challenges:
safety
concerns,
delivery
precision,
complex
regulatory
requirements,
ethical
considerations,
high
costs
impede
widespread
adoption.
This
review
examines
current
landscape
rejuvenation,
highlighting
key
advancements,
risks,
strategies
needed
overcome
hurdles.
Язык: Английский
Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities
MedComm – Oncology,
Год журнала:
2024,
Номер
3(4)
Опубликована: Дек. 1, 2024
Abstract
Oxidative
stress
results
from
an
imbalance
between
the
production
and
neutralization
of
reactive
oxygen
species.
It
induces
oxidative
damage
to
cellular
components
including
proteins,
lipids,
nucleic
acids,
membranes,
therefore
intrinsically
linking
aging‐related
diseases
such
as
cancer,
cardiovascular
disease,
neurological
disorders.
Emerging
evidence
suggests
that
may
promote
tumor
development
by
influencing
various
aspects
senescence,
its
onset,
pro‐inflammatory
secretion,
alteration
function
structure.
Modulating
target
senescence
offers
a
novel
strategy
for
cancer
prevention
treatment.
However,
thorough
grasp
specific
mechanisms
at
play
is
lacking.
This
review
will
present
association
their
regulatory
role
in
progression
treatment,
with
emphasis
on
senescence‐associated
secretory
phenotype,
immunosenescence
therapy‐induced
senescence.
Current
agents
strategies
remove
side
effects
via
killing
senescent
cells
or
modulating
improve
antitumor
efficacy
be
summarized.
help
readers
better
understand
complex
relationship
also
provide
basis
further
research
this
area.
Язык: Английский