Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities DOI Creative Commons
Ping Jin, Xudong Feng, Chongan Huang

и другие.

MedComm – Oncology, Год журнала: 2024, Номер 3(4)

Опубликована: Дек. 1, 2024

Abstract Oxidative stress results from an imbalance between the production and neutralization of reactive oxygen species. It induces oxidative damage to cellular components including proteins, lipids, nucleic acids, membranes, therefore intrinsically linking aging‐related diseases such as cancer, cardiovascular disease, neurological disorders. Emerging evidence suggests that may promote tumor development by influencing various aspects senescence, its onset, pro‐inflammatory secretion, alteration function structure. Modulating target senescence offers a novel strategy for cancer prevention treatment. However, thorough grasp specific mechanisms at play is lacking. This review will present association their regulatory role in progression treatment, with emphasis on senescence‐associated secretory phenotype, immunosenescence therapy‐induced senescence. Current agents strategies remove side effects via killing senescent cells or modulating improve antitumor efficacy be summarized. help readers better understand complex relationship also provide basis further research this area.

Язык: Английский

Immunosenescence promotes cancer development: from mechanisms to treatment strategies DOI Creative Commons

Leihan Wang,

Tang Dong

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 10, 2025

The body's innate immune system plays a pivotal role in identifying and eliminating cancer cells. However, as the ages, its functionality can deteriorate, becoming dysfunctional, inefficient, or even inactive—a condition referred to immunosenescence. This decline significantly increases risk of malignancies. While pro-cancer effects T-cell aging have been widely explored, there remains notable gap literature regarding impact on cells, such macrophages neutrophils. review seeks address this gap, with emphasis these cell types. Furthermore, although certain immunotherapies, including checkpoint inhibitors (ICIs), demonstrated efficacy across broad spectrum cancers, elderly patients are less likely derive clinical benefit from treatments. In some cases, they may experience immune-related adverse events (irAEs). senolytic strategies shown promise exerting anti-cancer effects, their reactions potential off-target present significant challenges. aims elucidate immunosenescence, implications for safety ICIs, anti-aging treatment strategies. addition, optimizing therapies minimize enhance therapeutic outcomes critical focus future research endeavors. Senescence is an inevitable phenomenon human body, scientists explored specific mechanisms by which immunosenescence advances development cancer. summarizes characteristics be used level surveillance cancers due "Targeting immunosenescence" new idea strategy therapy.

Язык: Английский

Процитировано

2

Light-activated photosensitizer/quercetin co-loaded extracellular vesicles for precise oral squamous cell carcinoma therapy DOI
Qian Liu, Dandan Jiang, Shasha Zhang

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер 671, С. 125224 - 125224

Опубликована: Янв. 15, 2025

Язык: Английский

Процитировано

0

Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases DOI
Peili Cen

Advances in pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Lung Epithelial Cell Membrane-Camouflaged ROS-Activatable Berberine Nanoparticles for Targeted Treatment in Acute Lung Injury DOI Creative Commons

Chengkang Jin,

Yingjie Zhang, Lin Chen

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6163 - 6183

Опубликована: Май 1, 2025

Acute lung injury (ALI) seriously threatens human health and is induced by multiple factors. When ALI occurs, lesions affect gas exchange may trigger respiratory failure. Current clinical treatments are limited, traditional drug delivery has drawbacks. Berberine, a natural with anti-inflammatory effects, difficulty in effectively exerting its efficacy. The study designed nano-micelle. Hydrophobic berberine was encapsulated diselenide bonds as the linker. Then, epithelial cell membranes were extracted to encapsulate disguise These nanoparticles injected intravenously. Thanks membrane's specificity, they could bind tissue, achieving targeted delivery. In inflamed area of acute injury, significantly increased reactive oxygen species level used break bonds, enabling precise release at site. nano-drug (MM-NPs) successfully prepared, encapsulation efficiency micelles reaching 68.2%. ROS environment, nano-micelles quickly over 80% berberine. inflammatory MLE-12 cells, MM-NPs responded well ROS, cellular factor levels improved after treatment. lipopolysaccharide (LPS)-induced pneumonia mouse model, achieved targeting. Further studies showed that administration alleviated LPS-induced mice. Additionally, evaluation indicated had good in-vivo safety no obvious adverse reactions. This developed novel system, MM-NPs, overcoming berberine's low bioavailability problem treating injury. system excellent physicochemical properties, biocompatibility, metabolic safety. vitro animal experiments verified it can enhance therapeutic effect, offering new ideas hopes for future, trials be advanced, targeting strategies explored more breakthroughs.

Язык: Английский

Процитировано

0

Advances in Nanotherapy for Targeting Senescent Cells DOI Creative Commons

Yurou Shi,

Yingjie Zhang,

Yaxuan Zhang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 8797 - 8813

Опубликована: Авг. 1, 2024

Aging is an inevitable process in the human body, and cellular senescence refers to irreversible cell cycle arrest caused by external aging-promoting mechanisms. Moreover, as age increases, accumulation of senescent cells limits both health body lifespan even accelerates occurrence progression age-related diseases. Therefore, it crucial delay periodic continuous address issue aging. The fundamental solution targeted therapy focused on eliminating or reducing senescence-associated secretory phenotype. Over past few decades, remarkable development nanomaterials has revolutionized clinical drug delivery pathways. Their unique optical, magnetic, electrical properties effectively compensate for shortcomings traditional drugs, such low stability short half-life, thereby maximizing bioavailability minimizing toxicity delivery. This article provides overview how nanomedicine systems control release achieve effective diagnosis. By presenting analyzing recent advances nanotherapy targeting cells, underlying mechanisms senolytic senomorphic are clarified, providing great potential cells.

Язык: Английский

Процитировано

2

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications DOI Creative Commons
Timur Saliev, Prim B. Singh

Cells, Год журнала: 2024, Номер 13(24), С. 2052 - 2052

Опубликована: Дек. 12, 2024

Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.

Язык: Английский

Процитировано

1

Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities DOI Creative Commons
Ping Jin, Xudong Feng, Chongan Huang

и другие.

MedComm – Oncology, Год журнала: 2024, Номер 3(4)

Опубликована: Дек. 1, 2024

Abstract Oxidative stress results from an imbalance between the production and neutralization of reactive oxygen species. It induces oxidative damage to cellular components including proteins, lipids, nucleic acids, membranes, therefore intrinsically linking aging‐related diseases such as cancer, cardiovascular disease, neurological disorders. Emerging evidence suggests that may promote tumor development by influencing various aspects senescence, its onset, pro‐inflammatory secretion, alteration function structure. Modulating target senescence offers a novel strategy for cancer prevention treatment. However, thorough grasp specific mechanisms at play is lacking. This review will present association their regulatory role in progression treatment, with emphasis on senescence‐associated secretory phenotype, immunosenescence therapy‐induced senescence. Current agents strategies remove side effects via killing senescent cells or modulating improve antitumor efficacy be summarized. help readers better understand complex relationship also provide basis further research this area.

Язык: Английский

Процитировано

1