Noncoding
RNAs
(ncRNAs)
including
circular
(circRNAs)
and
N6-methyladenosine
(m6A)
have
been
shown
to
play
a
critical
role
in
the
development
of
various
diseases
obesity
metabolic
disorder-associated
fatty
liver
disease
(MAFLD).
Obesity
is
chronic
considered
by
excessive
fat
accumulation
body,
which
has
increased
lately
foremost
risk
factor
for
MAFLD.
Causes
may
involve
interaction
genetic,
behavioral,
social
factors.
The
m6A
RNA
methylation
might
add
novel
inspiration
understanding
MAFLD
with
post-transcriptional
regulation
gene
expression.
In
particular,
circRNAs,
microRNAs
(miRNAs)
be
implicated
progression
Interestingly,
modification
could
modulate
translation,
degradation,
other
functions
ncRNAs.
miRNAs/circRNAs
also
modifications
affecting
writers,
erasers,
readers.
turn,
ncRNAs
expression
regulators
different
ways.
However,
there
limited
evidence
on
how
these
interact
affect
promotion
diseases.
M6A
appeared
occur
DNA,
proteins,
associated
several
biological
properties.
This
study
would
provide
mechanistic
association
diseases,
especially
Comprehension
between
contribute
treatment
tactics
Science China Life Sciences,
Год журнала:
2024,
Номер
67(10), С. 2105 - 2119
Опубликована: Май 27, 2024
Abstract
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
emerged
as
a
prominent
global
health
concern
associated
with
high
risk
of
metabolic
syndrome,
and
impacted
substantial
segment
the
population.
The
spectrum
ranges
from
simple
to
non-alcoholic
steatohepatitis
(NASH),
which
can
progress
cirrhosis
hepatocellular
carcinoma
(HCC)
is
increasingly
becoming
prevalent
indication
for
transplantation.
existing
therapeutic
options
NAFLD,
NASH,
HCC
are
limited,
underscoring
urgent
need
innovative
treatment
strategies.
Insights
into
gene
expression,
particularly
RNA
modifications
such
N
6
methyladenosine
(m
A),
hold
promising
avenues
interventions.
These
play
integral
roles
in
metabolism
cellular
functions,
encompassing
entire
NAFLD-NASH-HCC
progression.
This
review
will
encompass
recent
insights
on
diverse
modifications,
including
m
A,
pseudouridine
(ψ),
1
-methyladenosine
5-methylcytidine
5
C)
across
various
species.
It
uncover
their
significance
crucial
aspects
steatosis,
inflammation,
fibrosis,
tumorigenesis.
Furthermore,
prospective
research
directions
implications
be
explored,
advancing
our
comprehensive
understanding
intricate
interconnected
nature
these
pathological
conditions.
Hepatocellular
carcinoma
is
a
fatal
malignancy
that
lacking
specific
therapies.
Homeobox
B4
(HOXB4)
was
negatively
correlated
with
poor
prognosis
in
cancers,
but
its
role
hepatocellular
has
not
been
elucidated.
We
confirmed
HOXB4
downregulated
tissues
and
lower
expression
associated
prognosis.
Gain-
loss-of
function
experiments
were
performed
to
understand
the
functional
consequences.
revealed
overexpression
inhibited
proliferation
metastasis
of
cells,
accompanied
decrease
epithelial-mesenchymal
transition
increase
cell
apoptosis.
Database
analysis
showed
positively
immune
infiltration.
PD-L1
decreased
overexpressed
cells.
inhibit
progression
promote
T
infiltration
vivo.
N6-methyladenosine
(m6A)
modification
implicated
tumorigenesis.
RNA-seq
modulated
METTL7B
expression.
With
performance
dual-luciferase
reporter,
ChIP,
DNA
pulldown
assays,
we
binding
promoter
mRNA
The
increased
aggressiveness
cells
enhanced
escape,
triggered
by
knockdown,
via
downregulation.
Methylated
RNA
immunoprecipitation
assay
displayed
controlled
decay
TKT
m6A
methylation.
TKT,
ultimately
promoting
evasion.
mediated
malignant
phenotypes
evasion
METTL7B/TKT
axis.
HOXB4/METTL7B
cascade
downstream
changes
might
be
novel
targets
for
blocking
progression.
ABSTRACT
Epigenetic
regulation
in
disease
development
has
been
witnessed
within
this
decade.
RNA
methylation
is
the
predominant
form
of
epigenetic
regulation,
and
most
prevalent
modification
N6‐methyladenosine
(m
6
A).
Recently,
emerged
as
a
potential
target
for
treatment.
posttranscriptional
gene
expression
that
involved
both
physiological
pathological
processes.
Evidence
suggests
m
A
significantly
affects
metabolism,
its
abnormal
changes
have
observed
variety
diseases.
Metabolic
diseases
are
series
caused
by
metabolic
processes
body,
common
include
diabetes
mellitus,
obesity,
nonalcoholic
fatty
liver
disease,
etc.;
although
pathogenesis
these
differs
from
each
other
to
current
understanding,
recent
studies
suggested
pivotal
role
modulating
diseases,
A‐based
drug
on
agenda.
This
paper
reviewed
understanding
hoping
provide
systematic
information
those
area.
Non-Coding RNA,
Год журнала:
2024,
Номер
10(1), С. 11 - 11
Опубликована: Фев. 5, 2024
Noncoding
RNAs
(ncRNAs),
including
circular
(circRNAs)
and
N6-methyladenosine
(m6A),
have
been
shown
to
play
a
critical
role
in
the
development
of
various
diseases
obesity
metabolic
disorder-associated
fatty
liver
disease
(MAFLD).
Obesity
is
chronic
caused
by
excessive
fat
accumulation
body,
which
has
recently
become
more
prevalent
foremost
risk
factor
for
MAFLD.
Causes
may
involve
interaction
genetic,
behavioral,
social
factors.
m6A
RNA
methylation
might
add
novel
inspiration
understanding
MAFLD
with
post-transcriptional
regulation
gene
expression.
In
particular,
circRNAs,
microRNAs
(miRNAs),
be
implicated
progression
Interestingly,
modification
can
modulate
translation,
degradation,
other
functions
ncRNAs.
miRNAs/circRNAs
also
modifications
affecting
writers,
erasers,
readers.
turn,
ncRNAs
could
expression
regulators
different
ways.
However,
there
limited
evidence
on
how
these
interact
affect
promotion
diseases.
It
seems
that
occur
DNA,
RNA,
proteins
associated
several
biological
properties.
This
study
provides
mechanistic
association
diseases,
especially
Comprehension
between
contribute
treatment
tactics
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116966 - 116966
Опубликована: Июнь 20, 2024
In
recent
years,
there
has
been
a
significant
increase
in
the
incidence
of
metabolic-associated
fatty
liver
disease
(MAFLD),
which
attributed
to
increasing
prevalence
type
2
diabetes
mellitus
(T2DM)
and
obesity.
MAFLD
affects
more
than
one-third
adults
worldwide,
making
it
most
prevalent
globally.
Moreover,
is
considered
risk
factor
for
hepatocellular
carcinoma
(HCC),
with
MAFLD-related
HCC
cases
increasing.
Approximately
1
6
patients
are
believed
have
MAFLD,
nearly
40
%
these
do
not
progress
cirrhosis,
indicating
direct
transformation
from
HCC.
N6-methyladenosine
(m
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 981 - 981
Опубликована: Янв. 12, 2024
Hepatocellular
carcinoma
(HCC)
is
a
highly
lethal
malignant
neoplasm,
and
the
involvement
of
bone
morphogenetic
protein
9
(BMP9)
has
been
implicated
in
pathogenesis
liver
diseases
HCC.
Our
goal
was
to
investigate
role
BMP9
signaling
regulating
N6-methyladenosine
(m
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 2, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
primary
liver
malignancy
with
high
mortality
rates
and
poor
prognosis.
Recent
advances
in
high-throughput
sequencing
bioinformatic
technologies
have
greatly
enhanced
the
understanding
of
genetic
epigenetic
changes
cancer.
Among
these
changes,
RNA
methylation,
most
prevalent
internal
modification,
has
emerged
as
significant
contributor
development
progression
HCC.
Growing
evidence
reported
significantly
abnormal
levels
methylation
dysregulation
RNA-methylation-related
enzymes
HCC
tissues
cell
lines.
These
alterations
play
crucial
role
regulation
various
genes
signaling
pathways
involved
HCC,
thereby
promoting
tumor
progression.
Understanding
pathogenesis
would
help
developing
prognostic
biomarkers
targeted
therapies
for
Targeting
molecules
shown
promising
potential
management
terms
novel
Exploring
clinical
application
may
provide
new
insights
approaches
Further
research
this
field
warranted
to
fully
understand
functional
roles
underlying
mechanisms
In
review,
we
described
multifaceted
Moreover,
prospects
are
discussed,
which
basis
subsequent
in-depth
on
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 13, 2024
Liver
cancer
is
a
significant
global
health
challenge,
with
hepatocellular
carcinoma
(HCC)
being
the
most
prevalent
form,
characterized
by
high
incidence
and
mortality
rates.
Despite
advances
in
targeted
therapies
immunotherapies,
prognosis
for
advanced
liver
remains
poor.
This
underscores
urgent
need
deeper
understanding
of
molecular
mechanisms
underlying
HCC
to
enable
early
detection
development
novel
therapeutic
strategies.
Post-translational
modifications
(PTMs)
are
crucial
regulatory
cellular
biology,
affecting
protein
functionality,
interactions,
localization.
These
modifications,
including
phosphorylation,
acetylation,
methylation,
ubiquitination,
glycosylation,
occur
after
synthesis
play
vital
roles
various
processes.
Recent
proteomics
biology
have
highlighted
complex
networks
PTMs,
emphasizing
their
critical
role
maintaining
homeostasis
disease
pathogenesis.
Dysregulation
PTMs
has
been
associated
several
malignant
processes
HCC,
such
as
altered
cell
proliferation,
migration,
immune
evasion,
metabolic
reprogramming,
contributing
tumor
growth
metastasis.
review
aims
provide
comprehensive
pathological
clinical
implications
cancer.
By
exploring
multifaceted
interactions
impact
on
progression,
we
highlight
potential
biomarkers
targets.
The
significance
this
lies
its
inform
approaches
improve
prognostic
tools
intervention
fight
against
