Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Analytical Chemistry, Год журнала: 2024, Номер 96(21), С. 8837 - 8843

Опубликована: Май 17, 2024

Breast cancer poses the significance of early diagnosis and treatment. Here, we developed an innovative photoelectrochemical (PEC) immunosensor characterized by high-level dual photocurrent signals exceptional sensitivity. The PEC sensor, denoted as MIL&Ag2S, was constructed incorporating Ag2S into a metal–organic framework MIL-101(Cr). This composite not only enhanced electron–hole separation conductivity but also yielded robust stable signals. Through implementation signal switching, achieved combined detection antigen 15-3 (CA15-3) carcinoembryonic (CEA) with outstanding stability, reproducibility, specificity. results revealed linear range for CEA spanning 0.01–32 ng/mL, remarkably low limit 0.0023 ng/mL. Similarly, CA15-3 detection, extended from 0.1 to 320 U/mL, 0.014 U/mL. proposed strategy introduces new avenues development highly efficient, cost-effective, user-friendly sensors. Furthermore, it holds promising prospects clinical diagnosis, contributing potential breakthroughs in medical ultimately improving patient outcomes.

Язык: Английский

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Aptamer-based electrochemical analysis platform for tumor cells and biomarkers detection

Journal of Electroanalytical Chemistry, Год журнала: 2024, Номер 960, С. 118194 - 118194

Опубликована: Март 15, 2024

Язык: Английский

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CA 15-3-specific molecularly imprinted polymer nanoparticles-based voltammetric sensor for breast cancer monitoring

Talanta, Год журнала: 2025, Номер 288, С. 127746 - 127746

Опубликована: Фев. 16, 2025

Язык: Английский

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Molybdenum-Based Electrochemical Sensors for Breast Cancer Biomarker Detection: Advances and Challenges

Critical Reviews in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 21

Опубликована: Апрель 21, 2025

Breast cancer, which is considered the most common type of cancer among women worldwide, estimated to reach 4.4 million cases in 2070. Early diagnosis has become very important prevent this expected increase. Various traditional methods, such as mammography, biopsy, enzyme immunoassay (EI), liquid immunohistochemistry (IGH), fluorescence situ hybridization (FISH) are used diagnose breast but fact that these methods expensive, have low sensitivity, and cause mutations tissues due X-rays led researchers discover faster, more cost-effective, easily detectable methods. In particular, increased levels new blood-based biomarkers circulation can be detected sensitively selectively by electrochemical facilitate early disease screening rapid diagnosis. This comprehensive review focuses on prevalence pathology clinical sensors molybdenum-based compounds for detection various recent years. Electrochemical analysis studies carried out field years compiled aptamer-based, nucleotide-based, immunosensors. The chemical properties molybdenum discussed, modifications electrode surface discussed under 4 headings: drop casting, electrodeposition, atomic layer deposition, electrophoretic deposition.

Язык: Английский

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Highly efficient electrochemical biosensing platform in breast cancer detection based on MOF-COF@Au core-shell like nanostructure

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 2, 2024

Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite Au nanoparticles for the detection CA15-3. Herein, metal clusters MIL-156 as a Metal organic frameworks (MOF) were coated crystalline covalent (COF) through bonding created core-shell-like structures. The active part working electrode modified in two consecutive steps. First, then electrodeposited on glassy carbon (GCE). porosity significantly increased surface area improved conductivity. also form acceptable substrate antibodies due to their affinity amino groups. addition, amplify EC signal undeniable Nanocomposite characterized XRD, SEM, EDAX techniques. To investigate proposed biosensor, differential pulse voltammetry (DPV) used analytical technique. CA15-3 calibration provided linear range between concentrations 30 100 nU/mL, thus expressing powerful diagnostic potential designed biosensor. Furthermore, suggested been serum samples discriminate breast sufferers from healthy individuals confidence levels.

Язык: Английский

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Sponge-like Au@Ru nanozyme-labeled electrochemical immunosensor platform on the trimetallic Au@Pt@Ag NPs decorated surface for the sensitive detection of HER2

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 112538 - 112538

Опубликована: Дек. 1, 2024

Язык: Английский

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