Thyroid,
Год журнала:
2024,
Номер
34(10), С. 1280 - 1291
Опубликована: Авг. 27, 2024
Background:
It
has
long
been
known
that
thyroid
disease
can
lead
to
changes
in
energy
metabolism,
thermoregulation,
and
anxiety
behavior.
While
these
actions
have
partially
attributed
hormone
receptor
α1
(TRα1)
action
brain,
the
precise
neuroanatomical
substrates
remained
elusive.
Methods:
We
used
PET-CT
scans
identify
brain
regions
affected
by
hormone.
Then
we
inhibited
TRα1
signaling
specifically
most
region,
zona
incerta,
a
still
mysterious
region
previously
implicated
thermogenesis
anxiety.
To
this
end
an
adeno-associated
virus
(AAV)
expressing
dominant-negative
TRα1R384C
wild-type
mice
phenotyped
animals.
Finally,
tyrosine
hydroxylase-Cre
test
contribution
of
incerta
dopaminergic
neurons.
Results:
Our
data
showed
AAV-mediated
inhibition
increased
expenditure
at
thermoneutrality,
while
body
temperature
regulation
unaffected.
Moreover,
circulating
glucocorticoid
levels
were
increased,
mild
habituation
problem
was
observed
open
field
test.
No
effects
when
selectively
Conclusions:
findings
suggest
altered
is
not
involved
regulation,
but
affect
basal
metabolism
modulates
stress
responses.
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 1054 - 1054
Опубликована: Апрель 4, 2024
The
microbiota-gut-brain
(MGB)
axis
is
a
complex
communication
network
linking
the
gut,
microbiota,
and
brain,
influencing
various
aspects
of
health
disease.
Dysbiosis,
disturbance
in
gut
microbiome
equilibrium,
can
significantly
impact
MGB
axis,
leading
to
alterations
microbial
composition
function.
Emerging
evidence
highlights
connection
between
microbiota
neurological
psychiatric
disorders,
including
depression.
This
review
explores
potential
psychobiotics
managing
depressive
emphasizing
their
role
restoring
balance
axis.
Psychobiotics
exhibit
positive
effects
on
intestinal
barrier,
immune
response,
cortisol
levels,
hypothalamic-pituitary-adrenal
(HPA)
Studies
suggest
that
probiotics
may
serve
as
an
adjunct
therapy
for
depression,
especially
treatment-resistant
cases.
discusses
key
findings
from
studies
interventions,
gut-brain
mental
health.
increasing
acceptance
expanded
concept
underscores
importance
microorganisms
well-being.
As
our
understanding
microbiome's
disease
grows,
emerge
promising
agents
addressing
issues,
providing
new
avenues
therapeutic
interventions
disorders.
Journal of Molecular and Cellular Cardiology,
Год журнала:
2025,
Номер
201, С. 32 - 43
Опубликована: Фев. 18, 2025
Post-traumatic
stress
disorder
(PTSD)
is
a
disabling
psychological
characterized
by
chronic
symptoms
of
intrusiveness,
avoidance,
and
hyperarousal
after
traumatic
event.
Retrospective
studies
have
indicated
PTSD
increases
the
risk
for
cardiovascular
disease
(CVD)
including
arrhythmia,
hypertension,
myocardial
infarction.
The
goal
this
study
was
to:
1)
use
murine
model
cued
fear
conditioning
(inescapable
foot
shock,
IFS)
to
develop
scoring
method
distinguish
PTSD-like
phenotype,
2)
system
characterize
cardiac
phenotype
function
in
mice
with
extreme
behaviors.
We
compared
3
groups,
controls,
non-responders
(NR),
at
2
time
points
[4-weeks
8-weeks
post-IFS]
compare
left
ventricular
structure
function.
Assessment
showed
both
male
female
had
increased
isovolumetric
relaxation
post-IFS,
whereas
only
females
demonstrated
E/e',
atrial
diameter,
decreased
ejection
fraction
control
mice.
Female
also
interstitial
fibrosis
through
picrosirius
red
staining
expression
fibrotic
genes
Col3a1
Lox.
Overall,
our
data
that
displaying
behavioral
characteristics
associated
present
sex-dependent
diastolic
dysfunction
likely
due,
least
part,
an
activation
fibrosis.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Март 1, 2024
Introduction:
Depression
is
a
complex
psychiatric
disorder
with
substantial
societal
impact.
While
current
antidepressants
offer
moderate
efficacy,
their
adverse
effects
and
limited
understanding
of
depression’s
pathophysiology
hinder
the
development
more
effective
treatments.
Amidst
this
complexity,
role
neuroinflammation,
recognized
but
poorly
understood
associate
depression,
has
gained
increasing
attention.
This
study
investigates
hydroxytyrosol
(HT),
an
olive-derived
phenolic
antioxidant,
for
its
antidepressant
anti-neuroinflammatory
properties
based
on
mitochondrial
protection.
Methods:
In
vitro
studies
neuronal
injury
models,
protective
effect
HT
ultrastructure
from
inflammatory
damage
was
investigated
in
combination
high-resolution
imaging
substructures.
animal
depressive-like
behaviors
chronic
restraint
stress
(CRS)
mice
unpredictable
mild
(CUMS)
rats
were
examined
to
investigate
alleviating
HT.
Targeted
metabolomics
RNA-Seq
CUMS
used
analyze
potential
pathways
Results:
protected
damage,
thus
exerting
neuroprotective
models.
Moreover,
reduced
exposed
CRS
CUMS,
respectively.
HT’s
influence
model
included
hippocampal
modulating
cytokine
production,
dysfunction,
brain-derived
neurotrophic
factor
(BDNF)
signaling.
revealed
neurotransmitter
levels
tryptophan-kynurenine
metabolism.
data
underscored
mechanism
through
BDNF/TrkB
signaling
pathways,
key
nerve
fiber
functions,
myelin
formation,
microglial
differentiation,
neural
regeneration.
Discussion:
The
findings
underscore
as
treatment
shedding
light
relevance
nutritional
psychiatry.
Further
investigations
are
warranted
comprehensively
delineate
mechanisms
optimize
clinical
application
depression
treatment.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 8, 2024
Impaired
motivational
drive
is
a
key
feature
of
depression.
Chronic
stress
known
antecedent
to
the
development
depression
in
humans
and
depressive-like
states
animals.
Whilst
there
clear
relationship
between
drive,
mechanisms
underpinning
this
association
remain
unclear.
One
hypothesis
that
endocrine
system,
via
corticotropin-releasing
hormone
(CRH)
paraventricular
nucleus
hypothalamus
(PVN;
PVN
Negative
memories
engage
a
brain
and
body-wide
stress
response
in
humans
that
can
alter
cognition
behavior.
Prolonged
responses
induce
maladaptive
cellular,
circuit,
systems-level
changes
lead
to
pathological
states
corresponding
disorders
which
mood
memory
are
affected.
However,
it
is
unclear
if
repeated
activation
of
cells
processing
negative
induces
similar
phenotypes
mice.
In
this
study,
we
used
an
activity-dependent
tagging
method
access
neuronal
ensembles
assess
their
molecular
characteristics.
Sequencing
engrams
mice
revealed
positive
(male-to-female
exposure)
(foot
shock)
upregulated
genes
linked
anti-
pro-inflammatory
responses,
respectively.
To
investigate
the
impact
persistent
engrams,
chemogenetically
activated
them
ventral
hippocampus
over
3
months
conducted
anxiety
memory-related
tests.
engram
increased
behaviors
both
6-
14-month-old
mice,
reduced
spatial
working
older
impaired
fear
extinction
younger
heightened
generalization
age
groups.
Immunohistochemistry
microglial
astrocytic
structure
number
hippocampus.
summary,
lasting
cellular
behavioral
abnormalities
offering
insights
into
effects
chronic
thinking-like
on
human
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11315 - 11315
Опубликована: Окт. 21, 2024
Compromised
mitochondrial
electron
transport
chain
(ETC)
activities
are
associated
with
depression
in
humans
and
rodents.
However,
the
effects
of
enhancement
ETC
on
remain
elusive.
We
recently
reported
that
an
extremely
low-frequency
electromagnetic
field
(ELF-EMF)
as
low
10
μT
induced
hormetic
activation
complexes
human/mouse
cultured
cells
mouse
livers.
Chronic
social
defeat
stress
(CSDS)
for
consecutive
days
caused
behavioral
defects
mimicking
mice,
using
ELF-EMF
two
to
six
weeks
ameliorated
them.
CSDS
variably
decreased
proteins
prefrontal
cortex
(PFC)
days,
which
were
increased
by
weeks.
had
no
effect
oxygen
consumption
rate
PFC
but
enhanced
it.
inactivated
SOD2
enhancing
its
acetylation
lipid
peroxidation
PFC.
In
contrast,
activated
Sirt3-FoxO3a-SOD2
pathway
suppressed
peroxidation.
Furthermore,
markers
mitophagy,
was
The
exerted
beneficial
energy
production,
antioxidation,
dynamics
a
model
depression.
envisage
is
promising
therapeutic
option
Journal of Functional Morphology and Kinesiology,
Год журнала:
2025,
Номер
10(1), С. 21 - 21
Опубликована: Янв. 4, 2025
Background/Objectives:
Chronic
exposure
to
stress
has
been
considered
a
risk
factor
for
hypertension,
which
is
also
associated
with
increased
bone
resorption.
This
review
aimed
investigate
the
effect
of
acute
and
chronic
stress,
on
skeletal
system.
Methods:
A
comprehensive
search
was
conducted
across
multiple
databases,
focusing
peer-reviewed
articles
published
in
English.
We
include
experimental,
clinical,
studies
focused
relationship
between
Searches
were
MEDLINE
via
PubMed,
Embase
Scopus,
last
completed
10
September
2024.
Results:
The
main
topics
situations
that
favor
loss,
such
as
psychological
can
lead
osteoporotic
fractures
through
immunological
endocrine
mechanisms.
loss
density,
osteoporosis,
occurs
due
reduction
number
osteoblasts
balance
physiological
formation/resorption.
Conclusions:
significantly
affects
cardiovascular
health
narrative
study
highlights
vulnerability
system,
along
prolonged
emphasizing
need
multidisciplinary
strategies
preventing
stress-related
conditions.
Effective
management
help
reduce
risks
disease
resorption,
their
role
care.
