Effect of repeated HPA axis stimulation on hair cortisol concentration, growth, and behavior in preweaned dairy cattle DOI

J. Kern,

Matthew W. Jorgensen, Jacquelyn P. Boerman

et al.

Journal of Animal Science, Journal Year: 2024, Volume and Issue: 102

Published: Jan. 1, 2024

Abstract The study objective was to investigate the effect of repeated hypothalamic–pituitary–adrenal (HPA) axis stimulation using synthetic adrenocorticotropic hormone (ACTH) intramuscular injections on hair cortisol concentration, growth, and behavior in preweaned dairy calves. Twenty-seven Holstein calves were assigned nine triads (based sex birth order) randomly 1 3 treatments: 1) control (CON; 2 mL saline weekly); 2) moderate (MOD; alternating Cosyntropin [2 mcg/kg body weight (BW)] or 3) frequent (FREQ; BW] weekly). Calves received their first injection day 0 (7 ± d age). Hair collected from tail switch between days −5 −3 (baseline), 21, 49 analyzed for concentration. To verify endogenous release by during treatment period, saliva 0, 14, 28, 42 before every 15 min h after analysis salivary fitted with accelerometers continuously monitor lying time, number bouts, bout duration throughout study. Growth measures (BW, hip height, width) recorded weekly. Data ANOVA (SAS, Version 9.4), models included fixed effects treatment, time (min day), interaction time. Temperature humidity index as a continuous covariate all models. We observed × (P < 0.0001), whereby concentration lower CON compared MOD FREQ 120 postinjection. While not influenced decreased 21 (1.28 0.03 ng/mL) (0.93 ng/mL). Average BW similar across treatments (CON [59.4 1.09 kg], [58.6 0.98 [57.6 0.96 kg]; P = 0.50). There no evidence suggest difference average daily [18.5 0.23 h/d], [18.6 h/d]; 0.99). These results that HPA through administration increased but did influence

Language: Английский

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review DOI Open Access
Angela Dziedzic, Karina Maciak, Katarzyna Bliźniewska-Kowalska

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1054 - 1054

Published: April 4, 2024

The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health disease. Dysbiosis, disturbance in gut microbiome equilibrium, can significantly impact MGB axis, leading to alterations microbial composition function. Emerging evidence highlights connection between microbiota neurological psychiatric disorders, including depression. This review explores potential psychobiotics managing depressive emphasizing their role restoring balance axis. Psychobiotics exhibit positive effects on intestinal barrier, immune response, cortisol levels, hypothalamic-pituitary-adrenal (HPA) Studies suggest that probiotics may serve as an adjunct therapy for depression, especially treatment-resistant cases. discusses key findings from studies interventions, gut-brain mental health. increasing acceptance expanded concept underscores importance microorganisms well-being. As our understanding microbiome's disease grows, emerge promising agents addressing issues, providing new avenues therapeutic interventions disorders.

Language: Английский

Citations

16
Differential effects of chronic unpredictable stress on behavioral and molecular (cortisol and microglia-related neurotranscriptomic) responses in adult leopard (leo) zebrafish DOI
Tatiana O. Kolesnikova,

Nikita O. Prokhorenko,

S. V. Amikishiev

et al.

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(1)

Published: Jan. 15, 2025

Language: Английский

Citations

1
Mouse model of post-traumatic stress disorder negatively impacts cardiac homeostasis DOI Creative Commons
Alexa Corker,

Miguel Troncoso,

Maya Learmonth

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: 201, P. 32 - 43

Published: Feb. 18, 2025

Post-traumatic stress disorder (PTSD) is a disabling psychological characterized by chronic symptoms of intrusiveness, avoidance, and hyperarousal after traumatic event. Retrospective studies have indicated PTSD increases the risk for cardiovascular disease (CVD) including arrhythmia, hypertension, myocardial infarction. The goal this study was to: 1) use murine model cued fear conditioning (inescapable foot shock, IFS) to develop scoring method distinguish PTSD-like phenotype, 2) system characterize cardiac phenotype function in mice with extreme behaviors. We compared 3 groups, controls, non-responders (NR), at 2 time points [4-weeks 8-weeks post-IFS] compare left ventricular structure function. Assessment showed both male female had increased isovolumetric relaxation post-IFS, whereas only females demonstrated E/e', atrial diameter, decreased ejection fraction control mice. Female also interstitial fibrosis through picrosirius red staining expression fibrotic genes Col3a1 Lox. Overall, our data that displaying behavioral characteristics associated present sex-dependent diastolic dysfunction likely due, least part, an activation fibrosis.

Language: Английский

Citations

1
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development DOI Creative Commons
Shuaiguang Li,

Huarong Shao,

Ting Sun

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 1, 2024

Introduction: Depression is a complex psychiatric disorder with substantial societal impact. While current antidepressants offer moderate efficacy, their adverse effects and limited understanding of depression’s pathophysiology hinder the development more effective treatments. Amidst this complexity, role neuroinflammation, recognized but poorly understood associate depression, has gained increasing attention. This study investigates hydroxytyrosol (HT), an olive-derived phenolic antioxidant, for its antidepressant anti-neuroinflammatory properties based on mitochondrial protection. Methods: In vitro studies neuronal injury models, protective effect HT ultrastructure from inflammatory damage was investigated in combination high-resolution imaging substructures. animal depressive-like behaviors chronic restraint stress (CRS) mice unpredictable mild (CUMS) rats were examined to investigate alleviating HT. Targeted metabolomics RNA-Seq CUMS used analyze potential pathways Results: protected damage, thus exerting neuroprotective models. Moreover, reduced exposed CRS CUMS, respectively. HT’s influence model included hippocampal modulating cytokine production, dysfunction, brain-derived neurotrophic factor (BDNF) signaling. revealed neurotransmitter levels tryptophan-kynurenine metabolism. data underscored mechanism through BDNF/TrkB signaling pathways, key nerve fiber functions, myelin formation, microglial differentiation, neural regeneration. Discussion: The findings underscore as treatment shedding light relevance nutritional psychiatry. Further investigations are warranted comprehensively delineate mechanisms optimize clinical application depression treatment.

Language: Английский

Citations

7
Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive DOI Creative Commons
Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 8, 2024

Impaired motivational drive is a key feature of depression. Chronic stress known antecedent to the development depression in humans and depressive-like states animals. Whilst there clear relationship between drive, mechanisms underpinning this association remain unclear. One hypothesis that endocrine system, via corticotropin-releasing hormone (CRH) paraventricular nucleus hypothalamus (PVN; PVN

Language: Английский

Citations

6
Relationship of Chronic Stress and Hypertension with Bone Resorption DOI Creative Commons
M. Paulini,

Mariangeles Aimone,

Sara Feldman

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 21 - 21

Published: Jan. 4, 2025

Background/Objectives: Chronic exposure to stress has been considered a risk factor for hypertension, which is also associated with increased bone resorption. This review aimed investigate the effect of acute and chronic stress, on skeletal system. Methods: A comprehensive search was conducted across multiple databases, focusing peer-reviewed articles published in English. We include experimental, clinical, studies focused relationship between Searches were MEDLINE via PubMed, Embase Scopus, last completed 10 September 2024. Results: The main topics situations that favor loss, such as psychological can lead osteoporotic fractures through immunological endocrine mechanisms. loss density, osteoporosis, occurs due reduction number osteoblasts balance physiological formation/resorption. Conclusions: significantly affects cardiovascular health narrative study highlights vulnerability system, along prolonged emphasizing need multidisciplinary strategies preventing stress-related conditions. Effective management help reduce risks disease resorption, their role care.

Language: Английский

Citations

0
Environmental enrichment induces depressive- and anxiety-like behaviors in male Balb/C mice DOI

Malcon Carneiro de Brito,

Beatriz Yamada Costa,

Thiago Amorim de Souza Lima

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115462 - 115462

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models DOI Creative Commons
Raül Andero

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Most of the fear literature on humans and animals tests healthy individuals. However, memories can differ between individuals those previously exposed to traumatic stress, such as a car accident, sexual abuse, military combat personal assault. Traumatic stress lead post-traumatic disorder (PTSD) which presents alterations in memories, an impairment extinction recall. PTSD-like animal models are single highly stressful experience laboratory, immobilization or single-prolonged stress. Some days later, model be tested procedures that help uncover molecular mechanisms memories. In this review, there discussed stress-induced patients with PTSD models. The focus is effects estradiol cortisol/corticosterone hormones different genes, FKBP prolyl isomerase 5 gene (FKBP5) - FK506 binding protein 51 (FKBP51), pituitary adenylate cyclase-activating peptide (PACAP) polypeptide type I receptor (PAC1R), endocannabinoid (eCB) system tropomyosin kinase B (TrkB) brain-derived neurotrophic factor (BDNF). conclusion greater emphasis should placed investigating PTSD, through direct testing use relevant

Language: Английский

Citations

0
Antidepressant Effect of Crossopteryx Febrifuga Trunk Bark Aqueous Extract on Chronic Stress-Induced Depression in Rodents: A Sex-Based Approach DOI

Daniel Ndavoumta,

Harquin Simplice Foyet, Camdi Woumitna Guillaume

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Models developed to explain the effects of stress on brain and behavior DOI
Adejoke Elizabeth Memudu, Baliqis Adejoke Olukade,

Kenechukwu Emmanuel Nwanama

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0