Depressive Disorder and Dermatological Autoimmune Diseases

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(11), С. 3224 - 3224

Опубликована: Май 30, 2024

Depressive disorders are a growing problem worldwide. They also characterized by high comorbidity, including from the circle of dermatological diseases. Autoimmune diseases seem to be particularly correlated with depressive raising question their possible common pathomechanism. The PubMed database was searched, focusing on results published after 2016. A particular reciprocal correlation psoriasis, atopic dermatitis, alopecia areata, impetigo, lupus and systemic scleroderma found. One explanation for co-occurrence above is that inflammatory theory may applicable depression, various elements which apply autoimmune

Язык: Английский

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Dermatology Quality of Life and Depressıon Anxiety and Stress-42 Scale in Scabies Patients

Dermatology Practical & Conceptual, Год журнала: 2024, Номер 14(2), С. e2024112 - e2024112

Опубликована: Апрель 30, 2024

Introduction: Scabies is a pruritic skin infestation with globally increasing prevalance. Sleep problems, dispaired social and personal interactions, mainly due to itching, have been reported. Objectives: We aimed determine the influence of scabies on quality life psychosocial health using Dermatology Quality Life Index (DQOL) Depression Anxiety Stress-42 (DASS-42) Scale analyse whether there correlation between two scales any sociodemographic clinical characteristics. Methods: patients (>16 years) who presented our Outpatient Clinics were enrolled. Age, gender, occupation, marital status education level features recorded. DQOL DASS-42 used. Possible demographic characteristics total scores analysed. The Spearman coefficient analysis was performed these scores. Results: Of 92 (mean age:37.76±15.355, Female/Male: 1.09/1) 63% married 35.9% high-school graduates; 27.2% 23.9% housewives officer-proffesionals. Disease generalized in 57.6% duration disease mostly <4 weeks. Mean 13,16±7,638 42.10±30.644, respectively. Symptoms/feelings affected predominantly. ‘severely’ 41.3% patients. Conclusions: Impairment significant predictive parameter for higher DASS levels. not only associated impairment but may also lead problems. All should be evalauted consulted –if needed- possible problems including depression, anxiety stress as well symptoms secondary complications.

Язык: Английский

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On the Role of Psychoneuroimmunology in Oral Medicine

International Dental Journal, Год журнала: 2022, Номер 72(6), С. 765 - 772

Опубликована: Сен. 30, 2022

Psychoneuroimmunology (PNI) is an area of interdisciplinary research exploring the complex interactions within immuno-neuro-endocrine system in response to psychosocial influences. Such influences can trigger neurological changes, leading immunological effects related emergence and course various diseases. This concise clinical review explores role PNI oral medicine three exemplary models disease: periodontitis, herpes labialis, lichen planus. Previous literature has shown that stress exacerbations these diseases poorer overall health. The presumed biological mechanisms affect activity axes, i.e. hypothalamus-pituitary-adrenal (HPA) axis sympathetic nervous (SNS), subsequent immune dysregulation. Although remain poorly understood, several reduction interventions have already yielded promising results. In future work, elucidation pathways networks will require carefully designed studies with sensitive methodology, e.g. integrative single-case design. A biopsychosocial approach potential move disease from simple connections rooted empirical dualism reductionism establishment network-based models. Further on should lead novel approaches preventive strategies medicine.

Язык: Английский

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Impacts of Heavy Metal Pollution on Ethiopian Agriculture: A Review on the Safety and Quality of Vegetable Crops

Advances in Agriculture, Год журнала: 2023, Номер 2023, С. 1 - 11

Опубликована: Май 3, 2023

Lack of nutritive and consumption polluted food sources are the main health implications in African countries. Vegetable production is an optional balanced source easily grown urban rural areas. However, levels contaminant heavy metals cultivated vegetables have not yet been identified. This review scrutinizes contamination route, sources, effects, environmental problems, safety complications, remedial activities vegetable Ethiopian agriculture. Informal settlement, rapid rate urbanization, lack community-based industrial expansion lead to massive increases toxic ecosystems. They supplied with diets unrestrictedly, mainly for consumption. Among assessed metals, Zn (112.7 mg/kg), Cr (47.7 Pb (17.76 Cd (0.25 mg/kg) existed vegetables, highest concentrations Ethiopia. negative effects on public safety, security, nutrient horticultural crops. Hence, Ethiopia has no permissible standards hazard analysis, critical control point, or system. Additionally, physical, biological, natural strategies such as phytoremediation, phytoextraction, phytostabilization, rhizofiltration, bioremediation, phytovolatilization applied curtail deadly substance contents Despite this, some mitigation strategies, waste treatment activities, underway Ethiopia’s universities beer sugar factories. found that use integrated could help improve efficiency a sustainable manner, solid metal management Ethiopia, should begin local solutions.

Язык: Английский

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Exploring the Relationship between Psychoneuroimmunology and Oral Diseases: A Comprehensive Review and Analysis

Journal of Lifestyle Medicine, Год журнала: 2024, Номер 14(1), С. 13 - 19

Опубликована: Фев. 29, 2024

The relationship between psychoneuroimmunology (PNI) and oral health has recently garnered increasing attention due to the intricate interaction among psychological factors, nervous system, immune responses, diseases. This comprehensive review aims elucidate multifaceted connections PNI various conditions conduct an in-depth analysis. Psychological such as stress, anxiety, depression, have been linked microbiome alterations function development progression of diseases, periodontal disorders, ulcers, temporomandibular disorders. Conversely, conditions, particularly chronic periodontitis, associated with systemic inflammation, affecting mental overall well-being through neuroendocrine-immune pathways. Moreover, neural mechanisms, including brain-gut axis autonomic significantly influenced modulation inflammatory responses. Understanding these complex interactions implications for therapeutic interventions that target both outcomes. synthesizes current research findings from disciplines, immunology, neuroscience, dentistry, psychology, offer a understanding bidirectional on treatment strategies, preventive measures, interdisciplinary approaches underscore need integrated healthcare models address aspects improve outcomes quality life in patients.

Язык: Английский

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Oraler Lichen planus

wissen kompakt, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

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The role of vitamin D deficiency in the development and severity of oral lichen planus: a case-control study

Clinical Oral Investigations, Год журнала: 2025, Номер 29(6)

Опубликована: Май 30, 2025

Abstract Objectives Examine the responsibility of Vitamin D (VD) deficit as a risk element in development and severity oral lichen planus (OLP) considering dietary habits, sex, sun exposure, socioeconomic class psychological factors. Materials methods Blood samples from 35 OLP patients healthy controls were collected for analysis serum VD level (SVDL) by ELISA. deficiency was considered when SVDL ≤ 20 ng/ml. Additionally, structured questionnaire used to analyze other possible confounders. Results statistically significant greater control group than ( P 0.001). There difference between 3 types with statistical significance which least values erosive type Furthermore, no found dysplastic non-dysplastic lesions. In terms deficiency, distinction noticed two research sets 0.001) more pronounced atrophic reticular types. Depression well exposure significantly affected number having = 0.001, 0.027). revealed direct relation (odds ratio 1.38; 95%CI 1.18–1.617). Conclusion plays vital role severe forms. Clinical relevance It corroborates that is probable factor forms many

Язык: Английский

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The efficacy of henna (Lawsonia inermis L.) mouthwash versus chlorhexidine gluconate 0.2% mouthwash as adjuvant therapy of oral lichen planus: A randomized double-blind clinical trial

Journal of Ethnopharmacology, Год журнала: 2022, Номер 290, С. 115037 - 115037

Опубликована: Фев. 5, 2022

Язык: Английский

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Analysis of oral lichen planus severity on micro‐RNA linked with malignant transformation risks

Oral Diseases, Год журнала: 2023, Номер 30(5), С. 2918 - 2928

Опубликована: Окт. 13, 2023

Abstract Objective The present study evaluated the oral tissue expression of micro‐RNA (miRNAs) linked to potential malignant evolution lichen planus (OLP). Furthermore, correlation between OLP severity and miRNAs was assessed, possible predictors in patients were identified. Methods enrolled 41 with (median age 58 years) 42 healthy controls 59 years). In each patient, miRNA levels (miR‐7a‐3p,‐7a2‐3p,‐7a‐5p,‐21‐3p,‐21‐5p,‐100‐3p,‐100‐5p,‐125b‐2‐3p,‐125b‐5p,‐200b‐3p,‐200b‐5p) assessed analyzed through reverse transcription polymerase chain reaction. Clinical parameters eventual presence symptoms, signs, disease scores patient reported using an anamnestic questionnaire. Results comparison controls, showed significantly higher miR‐7a‐3p,‐7a‐2‐3p,‐21‐3p, miR‐21‐5p miR‐100‐5p ( p < 0.05) lower miR‐125b‐2‐3p,‐125b‐5p,‐200b‐3p, ‐200b‐5p 0.05). symptoms signs correlated also all Conclusions subjects, exhibited unbalanced risk OLP. some extent significant scores.

Язык: Английский

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Characteristics of Oral Mucosal Lesions and Their Association With Socioeconomic Status and Systemic Health: A Cross-Sectional Study of Consecutively Collected Oral Medicine Clinic Data in a Remote Rural Area of China

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Май 23, 2022

Objectives Epidemiological data of oral mucosal lesions (OMLs) are required to develop practical care policies. However, limited available for rural areas in China. We aimed estimate the spectrum and frequency OMLs identify their associated socioeconomic status (SES) systemic health a remote area Yunnan, Methods screened patients an medicine clinic China, from August 2020 February 2021. were documented. SES, including highest education level achieved previous month's household income, as well patient's health, history smoking, alcohol use, chronic disease, obtained Medical History/Health Questionnaire Form patient medical records. Results A total 146 found have OMLs. The most frequent OML was aphthous ulcer ( n = 41, 28.1%), followed by burning mouth syndrome (BMS) 16, 11.0%), viral 14, 9.6%), lichen planus (OLP) 9, 6.2%). In these patients, common diseases sleep apnea 35, 24.0%), hypertension 23, 15.8%), bronchitis reflux (including gastroesophageal disease) 12, 8.2%), arthritis 11, 7.5%). On adjusted regression, without had lower risk BMS than those with [odds ratio (OR), 0.2; 95% confidence interval (CI), 0.03–0.9]. Age independent protective factor ulcers (OR, 1.0; CI, 0.9–1.0). Patients low-income levels OLP high-income 0.05–0.9). Conclusions Our showed ulcer, which BMS, OLP. Oral policies should be prioritized among ulcer. Preventive strategy targeted people disease equalities. Therefore, individualized interventions might optimal, based on specific epidemiologic characteristics settings.

Язык: Английский

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