Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome

Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 3004 - 3004

Published: May 31, 2023

This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, evaluate influence different factors. The department's database medical records from 2022 were searched for a confirmed diagnosis OLP based on both clinical histological parameters. A total 100 (59 females 41 males) found mean age 64.03 years. In considered period, percentage was 1.6%, while squamous cell carcinoma (OSCC) 0.18%. statistically significant difference (p = 0.038), tobacco status 0.022), radiotherapy 0.041). analysis revealed presence ex-smokers (>20 pack-years), an odds ratio (OR) 10.0000 (95% confidence interval CI) 1.5793-63.3186); alcohol-drinker patients, OR 4.0519 CI 1.0182-16.1253); ex-smoker 17.6250 2.2464-138.2808); who had undergone radiotherapy, 6.3000 1.2661-31.3484). slightly higher than thought, results possible association age, alcohol status, history radiotherapy. An elevated observed heavy smoking (ex-smokers). Persuading patient quit consumption periodic follow-ups are recommended general, but particularly these

Language: Английский

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Exploring the Relationship between Psychoneuroimmunology and Oral Diseases: A Comprehensive Review and Analysis

Journal of Lifestyle Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 13 - 19

Published: Feb. 29, 2024

The relationship between psychoneuroimmunology (PNI) and oral health has recently garnered increasing attention due to the intricate interaction among psychological factors, nervous system, immune responses, diseases. This comprehensive review aims elucidate multifaceted connections PNI various conditions conduct an in-depth analysis. Psychological such as stress, anxiety, depression, have been linked microbiome alterations function development progression of diseases, periodontal disorders, ulcers, temporomandibular disorders. Conversely, conditions, particularly chronic periodontitis, associated with systemic inflammation, affecting mental overall well-being through neuroendocrine-immune pathways. Moreover, neural mechanisms, including brain-gut axis autonomic significantly influenced modulation inflammatory responses. Understanding these complex interactions implications for therapeutic interventions that target both outcomes. synthesizes current research findings from disciplines, immunology, neuroscience, dentistry, psychology, offer a understanding bidirectional on treatment strategies, preventive measures, interdisciplinary approaches underscore need integrated healthcare models address aspects improve outcomes quality life in patients.

Language: Английский

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Dermatology Quality of Life and Depressıon Anxiety and Stress-42 Scale in Scabies Patients

Dermatology Practical & Conceptual, Journal Year: 2024, Volume and Issue: 14(2), P. e2024112 - e2024112

Published: April 30, 2024

Introduction: Scabies is a pruritic skin infestation with globally increasing prevalance. Sleep problems, dispaired social and personal interactions, mainly due to itching, have been reported. Objectives: We aimed determine the influence of scabies on quality life psychosocial health using Dermatology Quality Life Index (DQOL) Depression Anxiety Stress-42 (DASS-42) Scale analyse whether there correlation between two scales any sociodemographic clinical characteristics. Methods: patients (>16 years) who presented our Outpatient Clinics were enrolled. Age, gender, occupation, marital status education level features recorded. DQOL DASS-42 used. Possible demographic characteristics total scores analysed. The Spearman coefficient analysis was performed these scores. Results: Of 92 (mean age:37.76±15.355, Female/Male: 1.09/1) 63% married 35.9% high-school graduates; 27.2% 23.9% housewives officer-proffesionals. Disease generalized in 57.6% duration disease mostly <4 weeks. Mean 13,16±7,638 42.10±30.644, respectively. Symptoms/feelings affected predominantly. ‘severely’ 41.3% patients. Conclusions: Impairment significant predictive parameter for higher DASS levels. not only associated impairment but may also lead problems. All should be evalauted consulted –if needed- possible problems including depression, anxiety stress as well symptoms secondary complications.

Language: Английский

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On the Role of Psychoneuroimmunology in Oral Medicine

International Dental Journal, Journal Year: 2022, Volume and Issue: 72(6), P. 765 - 772

Published: Sept. 30, 2022

Psychoneuroimmunology (PNI) is an area of interdisciplinary research exploring the complex interactions within immuno-neuro-endocrine system in response to psychosocial influences. Such influences can trigger neurological changes, leading immunological effects related emergence and course various diseases. This concise clinical review explores role PNI oral medicine three exemplary models disease: periodontitis, herpes labialis, lichen planus. Previous literature has shown that stress exacerbations these diseases poorer overall health. The presumed biological mechanisms affect activity axes, i.e. hypothalamus-pituitary-adrenal (HPA) axis sympathetic nervous (SNS), subsequent immune dysregulation. Although remain poorly understood, several reduction interventions have already yielded promising results. In future work, elucidation pathways networks will require carefully designed studies with sensitive methodology, e.g. integrative single-case design. A biopsychosocial approach potential move disease from simple connections rooted empirical dualism reductionism establishment network-based models. Further on should lead novel approaches preventive strategies medicine.

Language: Английский

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Analysis of oral lichen planus severity on micro‐RNA linked with malignant transformation risks

Oral Diseases, Journal Year: 2023, Volume and Issue: 30(5), P. 2918 - 2928

Published: Oct. 13, 2023

Abstract Objective The present study evaluated the oral tissue expression of micro‐RNA (miRNAs) linked to potential malignant evolution lichen planus (OLP). Furthermore, correlation between OLP severity and miRNAs was assessed, possible predictors in patients were identified. Methods enrolled 41 with (median age 58 years) 42 healthy controls 59 years). In each patient, miRNA levels (miR‐7a‐3p,‐7a2‐3p,‐7a‐5p,‐21‐3p,‐21‐5p,‐100‐3p,‐100‐5p,‐125b‐2‐3p,‐125b‐5p,‐200b‐3p,‐200b‐5p) assessed analyzed through reverse transcription polymerase chain reaction. Clinical parameters eventual presence symptoms, signs, disease scores patient reported using an anamnestic questionnaire. Results comparison controls, showed significantly higher miR‐7a‐3p,‐7a‐2‐3p,‐21‐3p, miR‐21‐5p miR‐100‐5p ( p < 0.05) lower miR‐125b‐2‐3p,‐125b‐5p,‐200b‐3p, ‐200b‐5p 0.05). symptoms signs correlated also all Conclusions subjects, exhibited unbalanced risk OLP. some extent significant scores.

Language: Английский

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The efficacy of henna (Lawsonia inermis L.) mouthwash versus chlorhexidine gluconate 0.2% mouthwash as adjuvant therapy of oral lichen planus: A randomized double-blind clinical trial

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 290, P. 115037 - 115037

Published: Feb. 5, 2022

Language: Английский

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Impacts of Heavy Metal Pollution on Ethiopian Agriculture: A Review on the Safety and Quality of Vegetable Crops

Advances in Agriculture, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 11

Published: May 3, 2023

Lack of nutritive and consumption polluted food sources are the main health implications in African countries. Vegetable production is an optional balanced source easily grown urban rural areas. However, levels contaminant heavy metals cultivated vegetables have not yet been identified. This review scrutinizes contamination route, sources, effects, environmental problems, safety complications, remedial activities vegetable Ethiopian agriculture. Informal settlement, rapid rate urbanization, lack community-based industrial expansion lead to massive increases toxic ecosystems. They supplied with diets unrestrictedly, mainly for consumption. Among assessed metals, Zn (112.7 mg/kg), Cr (47.7 Pb (17.76 Cd (0.25 mg/kg) existed vegetables, highest concentrations Ethiopia. negative effects on public safety, security, nutrient horticultural crops. Hence, Ethiopia has no permissible standards hazard analysis, critical control point, or system. Additionally, physical, biological, natural strategies such as phytoremediation, phytoextraction, phytostabilization, rhizofiltration, bioremediation, phytovolatilization applied curtail deadly substance contents Despite this, some mitigation strategies, waste treatment activities, underway Ethiopia’s universities beer sugar factories. found that use integrated could help improve efficiency a sustainable manner, solid metal management Ethiopia, should begin local solutions.

Language: Английский

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Hypertension in oral lichen planus: A systematic review and meta‐analysis

Oral Diseases, Journal Year: 2023, Volume and Issue: 30(4), P. 1793 - 1805

Published: Sept. 19, 2023

Abstract Objectives To perform a systematic review and meta‐analysis in order to qualitatively quantitatively evaluate the prevalence magnitude of association hypertension patients with oral lichen planus (OLP). Methods MEDLINE, Embase, Scopus, Web Science databases were searched for studies published before May 2022, not restricted by publication language or date. The methodological quality risk bias primary‐level critically assessed. Meta‐analyses performed, as well meta‐regression, stratified, sensitivity small‐study effects analyses, Galbraith (radial) plot, trial sequential analysis. Quality evidence was evaluated using GRADE system. Results 104 studies, including 16,587 patients, met inclusion criteria. results show that who suffer from OLP have high (PP = 24.17%, 95% CI 21.45–27.00), low evidence. A significant between also reported (OR 1.28, 1.01–1.63, p 0.04), showing moderate Conclusions Patients could be at an increased suffering which is probably due multiple factors. Healthcare practitioners involved management should aware this comorbidity apply suitable measures make referrals if suspected, although further research needed.

Language: Английский

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Characteristics of Oral Mucosal Lesions and Their Association With Socioeconomic Status and Systemic Health: A Cross-Sectional Study of Consecutively Collected Oral Medicine Clinic Data in a Remote Rural Area of China

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: May 23, 2022

Objectives Epidemiological data of oral mucosal lesions (OMLs) are required to develop practical care policies. However, limited available for rural areas in China. We aimed estimate the spectrum and frequency OMLs identify their associated socioeconomic status (SES) systemic health a remote area Yunnan, Methods screened patients an medicine clinic China, from August 2020 February 2021. were documented. SES, including highest education level achieved previous month's household income, as well patient's health, history smoking, alcohol use, chronic disease, obtained Medical History/Health Questionnaire Form patient medical records. Results A total 146 found have OMLs. The most frequent OML was aphthous ulcer ( n = 41, 28.1%), followed by burning mouth syndrome (BMS) 16, 11.0%), viral 14, 9.6%), lichen planus (OLP) 9, 6.2%). In these patients, common diseases sleep apnea 35, 24.0%), hypertension 23, 15.8%), bronchitis reflux (including gastroesophageal disease) 12, 8.2%), arthritis 11, 7.5%). On adjusted regression, without had lower risk BMS than those with [odds ratio (OR), 0.2; 95% confidence interval (CI), 0.03–0.9]. Age independent protective factor ulcers (OR, 1.0; CI, 0.9–1.0). Patients low-income levels OLP high-income 0.05–0.9). Conclusions Our showed ulcer, which BMS, OLP. Oral policies should be prioritized among ulcer. Preventive strategy targeted people disease equalities. Therefore, individualized interventions might optimal, based on specific epidemiologic characteristics settings.

Language: Английский

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Significant efficacy of short-course, low-concentration betamethasone mouthwash therapy for severe erosive oral lichen planus: a randomized controlled trial

Clinical Oral Investigations, Journal Year: 2023, Volume and Issue: 27(8), P. 4323 - 4334

Published: June 6, 2023

Language: Английский

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