Bidirectional Association between Periodontitis and Thyroid Disease: A Scoping Review

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(7), С. 860 - 860

Опубликована: Июнь 30, 2024

Periodontitis is a chronic inflammatory disease of the tissues surrounding and supporting teeth. Due to development inflammation, periodontitis can contribute several systemic diseases, including thyroid disease. Thyroid pathology includes benign, malignant, autoimmune conditions leading hypothyroidism, hyperthyroidism, or euthyroidism. Alterations in hormones, especially reveal significant oral manifestations, periodontitis. This scoping review aims explore probable causal relationship between disease, terms epidemiology, pathogenesis, treatment. The search strategy follows PRISMA-ScR guidelines. PubMed, Scopus, Web Science, Cochrane were searched from January 2014 2024, entering MESH “periodontitis” “thyroid”. Of 153 initial records, 20 articles selected discussed. There high prevalence among patients with cancer. causes at basis this association are genetic factors, microbiome, proinflammatory cytokines. Periodontal treatment, specifically scaling root planning, ameliorate parameters. Although there few randomized controlled studies literature, lays foundation for bidirectional link which is, once again, inflammation.

Язык: Английский

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A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis

International Dental Journal, Год журнала: 2024, Номер 74(4), С. 705 - 712

Опубликована: Март 2, 2024

Growing evidence appears to intimate a profound connection between periodontitis and coronary atherosclerosis (CA), yet the existence of causal relationship remains unclear. Through implementation Mendelian randomization analysis, we further evaluated potential link chronic/acute (CP/AP) CA.

Язык: Английский

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Exploring the molecular mechanisms underlying intervertebral disc degeneration by analysing multiple datasets

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 28, 2025

The purpose of this study was to explore the genetic characteristics and immune cell infiltration related intervertebral disc degeneration through multidataset analysis, predict potential therapeutic drugs, provide a theoretical basis for clinical treatment. gene expression profile data GSE70362, GSE186542, GSE245147 datasets were downloaded from Gene Expression Omnibus (GEO) database, hub genes identified differentially expressed Ontology (GO) Kyoto Encyclopaedia Genes Genomes (KEGG) functional annotation Mendelian randomization analysis performed. Hub cells identified. Infiltration status determined GSEA GSVA clarify specific signalling pathways associated with key molecular mechanisms by which affect disease progression. reversely predicted using miRNA grid construction transcription factor regulation, regulation obtained GeneCards database. Finally, used drug prediction Connectivity Map database identify drugs treatment degeneration. feasibility tested docking technology. Real-time quantitative PCR confirm in tissue samples.A total 126 GEO 4 (COL6A2, DCXR, GLRX, PDGFRB) bioinformatics methods. Immune revealed that NK cells, macrophages, eosinophils activated during IVDD, whereas mast T suppressed. GO KEGG analyses are involved development such as glycolysis pathway, oxidative phosphorylation cholesterol regulatory haem metabolism pathway. Analysis constructed jointly regulated multiple factors, among most important motif is cisbp_M5578. Disease regulation-related correlation performed, levels two mRNA significantly correlated. performed Abt-751, LY-2183240, podophyllotoxin, vindesine can alleviate or even reverse state. we collected 10 IVDD healthy samples, RT‒qPCR results consistent results. We COL6A2, PDGFRB IVDD. In addition, Abt-751 expected control progression disease. future, these may new directions further mechanistic studies well therapies patients.

Язык: Английский

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Unraveling the role of histone acetylation in sepsis biomarker discovery

Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 12

Опубликована: Апрель 30, 2025

Sepsis is a life-threatening condition caused by dysregulated immune response to infection. Despite advances in clinical care, effective biomarkers for early diagnosis and prognosis remain lacking. Emerging evidence suggests that histone acetylation plays crucial role the pathophysiology of sepsis. Transcriptomic single-cell RNA sequencing data were used identify acetylation-related genes. Differential expression analysis weighted gene co-expression network (WGCNA) performed, followed machine learning algorithms (LASSO, SVM-RFE, Boruta) screen potential biomarkers. Mendelian randomization (MR), RT-qPCR, functional assays conducted validation. BLOC1S1, NDUFA1, SFT2D1 identified as key A predictive nomogram demonstrated strong diagnostic potential. Immune infiltration analyses linked macrophage activity. MR confirmed causal factor Functional showed knockdown suppressed CXCL10 IL-6 expression, indicating its pro-inflammatory role. This study identifies novel associated with dysregulation These findings deepen our understanding sepsis pathogenesis may facilitate development improved therapeutic strategies.

Язык: Английский

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Unraveling the Genetic Link: Exploring the Causal Relationship Between Periodontitis and Allergic Rhinitis

International Journal of Rheumatic Diseases, Год журнала: 2025, Номер 28(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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Breast Cancer and Meningioma Risk: A Mendelian Randomization Study

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Background The exact nature of the link between breast cancer and meningiomas is unknown, although observational studies have shown a correlation two. Using two‐sample Mendelian randomization (MR) strategy, we aimed to investigate effect on meningiomas. Methods Three sets genetic instruments were utilized in this study based publicly available summary data. For cancer, selected 62 strongly associated SNPs; separate datasets curated for HER2‐positive HER2‐negative subtypes. MR analyses included outlier testing, MR‐Egger regression, MR‐PRESSO, weighted median, inverse variance approaches. Results analysis demonstrated significant evidence cancer's meningioma risk (OR = 1.213, 95% CI 1.054–1.396, p 0.007), supported by 1.456, 1.066–1.988, 0.021) though not median method 1.095, 0.914–1.311, 0.326). Inverse weighting specifically revealed association incidence 1.203, 1.048–1.381, 0.009). Furthermore, was with an increased malignant 1.64, 1.12–2.40, 0.011). Conclusions This represents first investigating causal relationship Our findings support hypothesis that may increase risk.

Язык: Английский

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Unraveling the Controversy: The Causal Link Between Osteoarthritis and Alzheimer's Disease

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

Research on osteoarthritis (OA) and Alzheimer's disease (AD) is currently highly controversial, the upstream downstream relationships between them remain unclear. This study aimed to assess association OA AD using Mendelian randomization (MR). Summary data from genome-wide studies (GWAS) were obtained for AD. Single nucleotide polymorphisms (SNPs) selected as instrumental variables (IVs), significant (p < 5.0 × 10-8) independent (r2 0.001) SNPs extracted two-sample MR analyses. Inverse variance weighting (IVW) was used these causal relationships, meta-analysis combine results multiple IVWs. Confounders assessed by multivariate (MVMR). Results reported odds ratios (OR). Heterogeneity then tested Cochran's Q test, multiplicity MR-Egger intercept MR-PRESSO, sensitivity analyses performed leave-one-out test. The showed a positive effect of (IVW OR = 19.89, 95% CI 2.90-136.57, p 0.002; 1.28, 1.11-1.47, 0.017; 1.27, 1.11-1.46, 0.017) no significance reverse > 0.05). Meta-analysis confirmed this finding in all population subgroups (OR 1.29, 1.18-1.40). findings maintained after controlling confounders MVMR 6.75, 1.50-30.44, 0.013). These be reliable stable testing. Our found AD, which highest levels evidence-based medicine. It may provide meaningful evidence current controversy.

Язык: Английский

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Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration

JOR Spine, Год журнала: 2025, Номер 8(1)

Опубликована: Март 1, 2025

ABSTRACT Background Intervertebral disc degeneration (IDD) is a major cause of cervical and lumbar diseases, significantly impacting patients' quality life. Mitochondria cell death have been implicated in IDD, but the key related genes remain unknown. Methods Differentially expressed (DEGs) between IDD control samples were identified using GSE70362. Mitochondria‐related (MRGs) programmed death‐related (PCDRGs) intersected with DEGs to find DE‐MRGs DE‐PCDRGs. Weighted gene co‐expression network analysis (WGCNA) module genes, overlap revealed candidate genes. Mendelian randomization (MR) was used determine causally linked IDD. Machine learning expression validation further refined which then build nomogram predict risk. Additionally, set enrichment (GSEA), immune infiltration, single‐cell performed. Results A total 515 224 yielding 31 Six genes—BCKDHB, BID, TNFAIP6, VRK1, CAB39L, TMTC1—showed causal relationship TMTC1 as through machine validation. developed based on these GSEA BID enriched N‐glycan biosynthesis, TNFAIP6 aminoacyl tRNA ribosomal pathways. Activated dendritic cells, CD56dim natural killer monocytes, other cells elevated strongly correlating activated cells. Key at higher levels degraded samples. Conclusion TMTC1, mitochondria offering new insights for diagnosis treatment.

Язык: Английский

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Association between stable angina pectoris and gastric cancer: two-sample bidirectional mendelian randomization study

Journal of Thrombosis and Thrombolysis, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

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A two-sample Mendelian randomization analysis: causal association between chemokines and pan-carcinoma

Frontiers in Genetics, Год журнала: 2023, Номер 14

Опубликована: Ноя. 23, 2023

Objective: According to the 2020 data from World Health Organization (WHO), cancers stand as one of foremost contributors global mortality. Revealing novel cancer risk factors and protective is paramount importance in prevention disease occurrence. Studies on relationship between chemokines are ongoing; however, due coordination multiple potential mechanisms, specific causal association remains unclear. Methods: We performed a bidirectional Mendelian randomization analysis explore serum pan-carcinoma. All GWAS catalog IEU Open database. The inverse-variance weighted (IVW) method primarily employed for assessing statistical significance findings. In addition, threshold after hypothesis test (Bonferroni) was 0.0013, evidence considered if p -value &lt; 0.05, but remained greater than Bonferroni’s threshold. Results: results indicate that CCL1 (odds ratio, OR = 1.18), CCL2 (OR 1.04), CCL8 1.36), CCL14 (Colorectal, 1.08, Small intestine, 0.77, Lung, 1.11), CCL15 0.85), CCL18 (Breast, 0.95, Prostate, 0.96), CCL19 (Lung, 0.66, 0.92), CCL20 0.53, Thyroid, 0.76), CCL21 0.62), CCL22 2.05), CCL23 1.31), CCL24 1.06), CCL27 1.49), CCL28 0.74), CXCL5 0.95), CXCL9 3.60), CXCL12 0.87, 0.58), CXCL13 0.93, 1.29), CXCL14 (Colon, 1.40) CXCL17 1.07) cancers. there reverse 0.94) breast cancer. Sensitivity were similar. other four MR Methods consistent with main results, leave-one-out showed not driven by Single nucleotide polymorphism (SNP). Moreover, no heterogeneity pleiotropy our analysis. Conclusion: Based two-sample Analysis method, we found might be upstream pathogenesis. These provide new insights into future use targets treatment. Our also important clues tumor prevention, changes chemokine concentration may recognized features precancerous lesions clinical trials.

Язык: Английский

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