Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 27, 2023
Abstract
Objectives
Growing
evidence
appears
to
intimate
a
profound
connection
between
periodontitis
and
coronary
atherosclerosis
(CA),
yet
the
existence
of
causal
relationship
remains
unclear.
Through
implementation
Mendelian
randomization
analysis,
We
further
evaluated
potential
link
chronic/acute
(CP/AP)
CA.
Utilizing
genome-wide
association
study
(GWAS)
summary
statistics,
we
incorporated
data
derived
from
European
samples
(n1
=
198,441;
n2
195,762)
CA
61,194
cases.
conducted
two
sample,
bidirectional
(MR)
analysis
using
inverse-variance
weighted
(IVW)
method
as
main
analytical
approach.
Supplementary
analyses
were
executed
through
MR
Egger,
Weighted
median
(WM),
IVW,
Simple
mode,
mode
approaches.
Results
The
IVW
revealed
no
significant
(CA-CP:
OR
2.110,
95%
CI
1.483–3.003,
P
0.527;
CA-AP:
0.414,
0.051–3.384,
0.644).
Similarly,
did
not
identify
impact
on
(OR
1.000,
0.999–1.001,
0.953).
supplementary
corroborated
these
findings.
Conclusions
While
studies
highlighting
correlation
CA,
our
comprehensive
does
corroborate
Further
research
is
needed
elucidate
other
shared
mechanisms
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(7), С. 860 - 860
Опубликована: Июнь 30, 2024
Periodontitis
is
a
chronic
inflammatory
disease
of
the
tissues
surrounding
and
supporting
teeth.
Due
to
development
inflammation,
periodontitis
can
contribute
several
systemic
diseases,
including
thyroid
disease.
Thyroid
pathology
includes
benign,
malignant,
autoimmune
conditions
leading
hypothyroidism,
hyperthyroidism,
or
euthyroidism.
Alterations
in
hormones,
especially
reveal
significant
oral
manifestations,
periodontitis.
This
scoping
review
aims
explore
probable
causal
relationship
between
disease,
terms
epidemiology,
pathogenesis,
treatment.
The
search
strategy
follows
PRISMA-ScR
guidelines.
PubMed,
Scopus,
Web
Science,
Cochrane
were
searched
from
January
2014
2024,
entering
MESH
“periodontitis”
“thyroid”.
Of
153
initial
records,
20
articles
selected
discussed.
There
high
prevalence
among
patients
with
cancer.
causes
at
basis
this
association
are
genetic
factors,
microbiome,
proinflammatory
cytokines.
Periodontal
treatment,
specifically
scaling
root
planning,
ameliorate
parameters.
Although
there
few
randomized
controlled
studies
literature,
lays
foundation
for
bidirectional
link
which
is,
once
again,
inflammation.
International Dental Journal,
Год журнала:
2024,
Номер
74(4), С. 705 - 712
Опубликована: Март 2, 2024
Growing
evidence
appears
to
intimate
a
profound
connection
between
periodontitis
and
coronary
atherosclerosis
(CA),
yet
the
existence
of
causal
relationship
remains
unclear.
Through
implementation
Mendelian
randomization
analysis,
we
further
evaluated
potential
link
chronic/acute
(CP/AP)
CA.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 28, 2025
The
purpose
of
this
study
was
to
explore
the
genetic
characteristics
and
immune
cell
infiltration
related
intervertebral
disc
degeneration
through
multidataset
analysis,
predict
potential
therapeutic
drugs,
provide
a
theoretical
basis
for
clinical
treatment.
gene
expression
profile
data
GSE70362,
GSE186542,
GSE245147
datasets
were
downloaded
from
Gene
Expression
Omnibus
(GEO)
database,
hub
genes
identified
differentially
expressed
Ontology
(GO)
Kyoto
Encyclopaedia
Genes
Genomes
(KEGG)
functional
annotation
Mendelian
randomization
analysis
performed.
Hub
cells
identified.
Infiltration
status
determined
GSEA
GSVA
clarify
specific
signalling
pathways
associated
with
key
molecular
mechanisms
by
which
affect
disease
progression.
reversely
predicted
using
miRNA
grid
construction
transcription
factor
regulation,
regulation
obtained
GeneCards
database.
Finally,
used
drug
prediction
Connectivity
Map
database
identify
drugs
treatment
degeneration.
feasibility
tested
docking
technology.
Real-time
quantitative
PCR
confirm
in
tissue
samples.A
total
126
GEO
4
(COL6A2,
DCXR,
GLRX,
PDGFRB)
bioinformatics
methods.
Immune
revealed
that
NK
cells,
macrophages,
eosinophils
activated
during
IVDD,
whereas
mast
T
suppressed.
GO
KEGG
analyses
are
involved
development
such
as
glycolysis
pathway,
oxidative
phosphorylation
cholesterol
regulatory
haem
metabolism
pathway.
Analysis
constructed
jointly
regulated
multiple
factors,
among
most
important
motif
is
cisbp_M5578.
Disease
regulation-related
correlation
performed,
levels
two
mRNA
significantly
correlated.
performed
Abt-751,
LY-2183240,
podophyllotoxin,
vindesine
can
alleviate
or
even
reverse
state.
we
collected
10
IVDD
healthy
samples,
RT‒qPCR
results
consistent
results.
We
COL6A2,
PDGFRB
IVDD.
In
addition,
Abt-751
expected
control
progression
disease.
future,
these
may
new
directions
further
mechanistic
studies
well
therapies
patients.
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 30, 2025
Sepsis
is
a
life-threatening
condition
caused
by
dysregulated
immune
response
to
infection.
Despite
advances
in
clinical
care,
effective
biomarkers
for
early
diagnosis
and
prognosis
remain
lacking.
Emerging
evidence
suggests
that
histone
acetylation
plays
crucial
role
the
pathophysiology
of
sepsis.
Transcriptomic
single-cell
RNA
sequencing
data
were
used
identify
acetylation-related
genes.
Differential
expression
analysis
weighted
gene
co-expression
network
(WGCNA)
performed,
followed
machine
learning
algorithms
(LASSO,
SVM-RFE,
Boruta)
screen
potential
biomarkers.
Mendelian
randomization
(MR),
RT-qPCR,
functional
assays
conducted
validation.
BLOC1S1,
NDUFA1,
SFT2D1
identified
as
key
A
predictive
nomogram
demonstrated
strong
diagnostic
potential.
Immune
infiltration
analyses
linked
macrophage
activity.
MR
confirmed
causal
factor
Functional
showed
knockdown
suppressed
CXCL10
IL-6
expression,
indicating
its
pro-inflammatory
role.
This
study
identifies
novel
associated
with
dysregulation
These
findings
deepen
our
understanding
sepsis
pathogenesis
may
facilitate
development
improved
therapeutic
strategies.
Brain and Behavior,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
ABSTRACT
Background
The
exact
nature
of
the
link
between
breast
cancer
and
meningiomas
is
unknown,
although
observational
studies
have
shown
a
correlation
two.
Using
two‐sample
Mendelian
randomization
(MR)
strategy,
we
aimed
to
investigate
effect
on
meningiomas.
Methods
Three
sets
genetic
instruments
were
utilized
in
this
study
based
publicly
available
summary
data.
For
cancer,
selected
62
strongly
associated
SNPs;
separate
datasets
curated
for
HER2‐positive
HER2‐negative
subtypes.
MR
analyses
included
outlier
testing,
MR‐Egger
regression,
MR‐PRESSO,
weighted
median,
inverse
variance
approaches.
Results
analysis
demonstrated
significant
evidence
cancer's
meningioma
risk
(OR
=
1.213,
95%
CI
1.054–1.396,
p
0.007),
supported
by
1.456,
1.066–1.988,
0.021)
though
not
median
method
1.095,
0.914–1.311,
0.326).
Inverse
weighting
specifically
revealed
association
incidence
1.203,
1.048–1.381,
0.009).
Furthermore,
was
with
an
increased
malignant
1.64,
1.12–2.40,
0.011).
Conclusions
This
represents
first
investigating
causal
relationship
Our
findings
support
hypothesis
that
may
increase
risk.
Brain and Behavior,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
Research
on
osteoarthritis
(OA)
and
Alzheimer's
disease
(AD)
is
currently
highly
controversial,
the
upstream
downstream
relationships
between
them
remain
unclear.
This
study
aimed
to
assess
association
OA
AD
using
Mendelian
randomization
(MR).
Summary
data
from
genome-wide
studies
(GWAS)
were
obtained
for
AD.
Single
nucleotide
polymorphisms
(SNPs)
selected
as
instrumental
variables
(IVs),
significant
(p
<
5.0
×
10-8)
independent
(r2
0.001)
SNPs
extracted
two-sample
MR
analyses.
Inverse
variance
weighting
(IVW)
was
used
these
causal
relationships,
meta-analysis
combine
results
multiple
IVWs.
Confounders
assessed
by
multivariate
(MVMR).
Results
reported
odds
ratios
(OR).
Heterogeneity
then
tested
Cochran's
Q
test,
multiplicity
MR-Egger
intercept
MR-PRESSO,
sensitivity
analyses
performed
leave-one-out
test.
The
showed
a
positive
effect
of
(IVW
OR
=
19.89,
95%
CI
2.90-136.57,
p
0.002;
1.28,
1.11-1.47,
0.017;
1.27,
1.11-1.46,
0.017)
no
significance
reverse
>
0.05).
Meta-analysis
confirmed
this
finding
in
all
population
subgroups
(OR
1.29,
1.18-1.40).
findings
maintained
after
controlling
confounders
MVMR
6.75,
1.50-30.44,
0.013).
These
be
reliable
stable
testing.
Our
found
AD,
which
highest
levels
evidence-based
medicine.
It
may
provide
meaningful
evidence
current
controversy.
ABSTRACT
Background
Intervertebral
disc
degeneration
(IDD)
is
a
major
cause
of
cervical
and
lumbar
diseases,
significantly
impacting
patients'
quality
life.
Mitochondria
cell
death
have
been
implicated
in
IDD,
but
the
key
related
genes
remain
unknown.
Methods
Differentially
expressed
(DEGs)
between
IDD
control
samples
were
identified
using
GSE70362.
Mitochondria‐related
(MRGs)
programmed
death‐related
(PCDRGs)
intersected
with
DEGs
to
find
DE‐MRGs
DE‐PCDRGs.
Weighted
gene
co‐expression
network
analysis
(WGCNA)
module
genes,
overlap
revealed
candidate
genes.
Mendelian
randomization
(MR)
was
used
determine
causally
linked
IDD.
Machine
learning
expression
validation
further
refined
which
then
build
nomogram
predict
risk.
Additionally,
set
enrichment
(GSEA),
immune
infiltration,
single‐cell
performed.
Results
A
total
515
224
yielding
31
Six
genes—BCKDHB,
BID,
TNFAIP6,
VRK1,
CAB39L,
TMTC1—showed
causal
relationship
TMTC1
as
through
machine
validation.
developed
based
on
these
GSEA
BID
enriched
N‐glycan
biosynthesis,
TNFAIP6
aminoacyl
tRNA
ribosomal
pathways.
Activated
dendritic
cells,
CD56dim
natural
killer
monocytes,
other
cells
elevated
strongly
correlating
activated
cells.
Key
at
higher
levels
degraded
samples.
Conclusion
TMTC1,
mitochondria
offering
new
insights
for
diagnosis
treatment.
Frontiers in Genetics,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 23, 2023
Objective:
According
to
the
2020
data
from
World
Health
Organization
(WHO),
cancers
stand
as
one
of
foremost
contributors
global
mortality.
Revealing
novel
cancer
risk
factors
and
protective
is
paramount
importance
in
prevention
disease
occurrence.
Studies
on
relationship
between
chemokines
are
ongoing;
however,
due
coordination
multiple
potential
mechanisms,
specific
causal
association
remains
unclear.
Methods:
We
performed
a
bidirectional
Mendelian
randomization
analysis
explore
serum
pan-carcinoma.
All
GWAS
catalog
IEU
Open
database.
The
inverse-variance
weighted
(IVW)
method
primarily
employed
for
assessing
statistical
significance
findings.
In
addition,
threshold
after
hypothesis
test
(Bonferroni)
was
0.0013,
evidence
considered
if
p
-value
<
0.05,
but
remained
greater
than
Bonferroni’s
threshold.
Results:
results
indicate
that
CCL1
(odds
ratio,
OR
=
1.18),
CCL2
(OR
1.04),
CCL8
1.36),
CCL14
(Colorectal,
1.08,
Small
intestine,
0.77,
Lung,
1.11),
CCL15
0.85),
CCL18
(Breast,
0.95,
Prostate,
0.96),
CCL19
(Lung,
0.66,
0.92),
CCL20
0.53,
Thyroid,
0.76),
CCL21
0.62),
CCL22
2.05),
CCL23
1.31),
CCL24
1.06),
CCL27
1.49),
CCL28
0.74),
CXCL5
0.95),
CXCL9
3.60),
CXCL12
0.87,
0.58),
CXCL13
0.93,
1.29),
CXCL14
(Colon,
1.40)
CXCL17
1.07)
cancers.
there
reverse
0.94)
breast
cancer.
Sensitivity
were
similar.
other
four
MR
Methods
consistent
with
main
results,
leave-one-out
showed
not
driven
by
Single
nucleotide
polymorphism
(SNP).
Moreover,
no
heterogeneity
pleiotropy
our
analysis.
Conclusion:
Based
two-sample
Analysis
method,
we
found
might
be
upstream
pathogenesis.
These
provide
new
insights
into
future
use
targets
treatment.
Our
also
important
clues
tumor
prevention,
changes
chemokine
concentration
may
recognized
features
precancerous
lesions
clinical
trials.