Meteorin-like levels of oral fluids in periodontal health and diseases: a comparative cross-sectional study

Clinical Oral Investigations, Год журнала: 2025, Номер 29(2)

Опубликована: Фев. 18, 2025

Cytokines are critical role in the pathogenesis of periodontal diseases. Meteorin-like (Metrnl), a protein released oral mucosa, is novel cytokine associated with various inflammatory This study aimed to evaluate levels salivary and gingival crevicular fluid (GCF), interleukin - 1 beta (IL-1β), 10 (IL-10), Metrnl disease. It was formed three groups 20 individuals each: healthy, gingivitis, periodontitis (Stage III, Grades A B) groups. The enzyme-linked immunosorbent assay method measured IL-1β, IL-10, GCF samples. Clinical measurement including probing pocket depth (PD), clinical attachment loss (CAL), plaque index (PI), (GI) percentage bleeding on (%BOP); biochemical parameters were evaluated using statistical analysis. Salivary concentrations total amount IL-1β significantly higher disease (p < 0.001). There no significant difference among either or IL-10 > 0.05). lower group = 0.002). had negative correlations %BOP, PD, CAL 0.03). receiver operating characteristics curve showed: area under (AUC) 0.731 for discriminate from health gingivitis. Based findings this study, Metrnl, as an immunoregulatory cytokine, may have important relationship periodontitis. Additional studies needed fully elucidate functional effect Background In knock-out experimental studies, it has been reported that acts inflammation-related cytokine. relating diseases support idea play variety Although abundantly secreted authors' knowledge there evaluating gingivitis periodontitis, fluids, such saliva, examined presence different can be useful distinguishing destruction health.

Язык: Английский

---

Host Markers of Periodontal Diseases: Meta‐Analysis of Diagnostic Accuracy Studies

Journal Of Clinical Periodontology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

ABSTRACT Objective To identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction future disease progression and/or resolution. Material Methods Cross‐sectional prospective studies ≥ 20 participants per group, reporting accuracy (e.g., area under curve [AUC]) (focused question 1 [FQ1]), periodontitis progression/relapse (FQ2) or resolution (FQ3) were searched three electronic databases. Meta‐analyses estimating (DA) individual grouped salivary gingival crevicular fluid (GCF) independently performed whenever two more identified. Results Sixty‐one eligible identified, which 13 included meta‐analyses FQ1 (discrimination between health periodontitis). Matrix metalloproteinase‐8 (MMP‐8) was most reported biomarker both saliva GCF, comparable AUC (0.70–0.90), sensitivity (0.49–0.84) specificity (0.62–0.79) sample types. Cytokines had good ability discrimination periodontitis/gingivitis versus health, although they substantially less accurate gingivitis. Combinations cytokines MMPs tended to increase overall but without significant improvement case discrimination. Bone best performing group (AUC = 0.91) when compared 0.86) 0.77). GCF microRNAs (MiRs) a singly meta‐analysed biomarkers demonstrating 0.79. Conclusion Reported on exhibit serious limitations regarding validation standards, being main cause lack progress classification. Disease‐specific such as bone showed better (from limited number studies) MMPs.

Язык: Английский

---

Relationship Between MCP‐1 Levels in GCF and Periodontitis: A Systematic Review With Meta‐Analysis and Analysis of Molecular Interactions

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(9)

Опубликована: Май 1, 2025

ABSTRACT Monocyte chemoattractant protein 1 (MCP‐1) is involved in monocyte chemotaxis, endothelial activation and regulation of leukocyte function biological activities that promote inflammation, such as periodontitis. A systematic review meta‐analysis was conducted with the primary objective investigating roles MCP‐1 gingival crevicular fluid (GCF) subjects chronic periodontitis compared to periodontally healthy subjects. The study protocol adhered PRISMA guidelines. Digital searches were carried out across several databases, including PubMed, Dentistry & Oral Science Source, ScienceDirect, Scopus, Web Google Scholar. quality studies evaluated using JBI tool for cross‐sectional clinical trials. To assess concentration GCF exposure group versus control group, a employing random‐effects model. search strategy yielded 1694 articles, 14 meeting inclusion criteria 10 articles subjected quantitative analysis. total 497 examined, comprising 298 cases 199 controls. indicated significant increase levels individuals (GCF: SMD = 20.29, 95% CI: 10.33–30.25, Z 3.992, p 0.001*). are elevated controls, suggesting its potential future use diagnostic settings.

Язык: Английский

---

Clinical Periodontal Evaluation and Assessment of Dipeptidyl-Peptidase-4 and Galectin-3 in Gingival Crevicular Fluid of Periodontitis Patients with Heart Failure and Diabetes

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(10), С. 3345 - 3345

Опубликована: Май 12, 2025

Background/Objectives: Periodontitis, a prevalent chronic inflammatory disease affecting tooth-supporting structures, has been increasingly linked to systemic conditions such as diabetes mellitus (DM) and cardiovascular diseases (CVDs). This study aimed evaluate the periodontal status levels of dipeptidyl peptidase-4 (DPP-4) galectin-3 (Gal-3) in gingival crevicular fluid (GCF) patients with periodontitis, heart failure (HF), diabetes, exploring their potential biomarkers for association. Methods: A cross-sectional was conducted on 88 categorized into four groups: periodontally systemically healthy (control, C); periodontitis (P); HF (P+HF); HF, (P+HF+D). Periodontal assessed using probing pocket depth (PPD) Gingival Index (GI). GCF samples were collected analyzed DPP-4 Gal-3 ELISA. Statistical analyses performed assess differences between groups correlations. Results: Results indicated significantly higher all test compared controls (p < 0.0001), highest P+HF+D group. Similarly, elevated patients, particularly those there no significant difference P+HF groups. No observed smokers non-smokers regarding these markers. Positive correlations found parameters immunological markers Conclusions: The findings suggest that may serve association being more upregulated failure.

Язык: Английский

---

“Outcome of non-surgical periodontal treatment on Gal-1 and Gal-3 GCF levels in periodontitis patients: a case-control study”

Clinical Oral Investigations, Год журнала: 2024, Номер 28(6)

Опубликована: Май 14, 2024

This study aimed to explore the effect of nonsurgical periodontal treatment on Galectin-1 and -3 GCF levels in gingivitis periodontitis stage III compared periodontally healthy individuals, determine whether they could serve as diagnostic markers / therapeutic targets for revealing their possible role disease.

Язык: Английский

---

Wnt signaling in periodontitis

Clinical Oral Investigations, Год журнала: 2023, Номер 27(11), С. 6801 - 6812

Опубликована: Окт. 10, 2023

Язык: Английский

---

Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions

Biomarkers, Год журнала: 2024, Номер 29(3), С. 118 - 126

Опубликована: Фев. 12, 2024

The study aimed to analyze cytokine levels, including interleukin (IL)-1β, IL-10, and IL-36γ, investigate the link between pro- anti-inflammatory responses in periodontal conditions assess their potential as diagnostic biomarkers for distinguishing different types of conditions.

Язык: Английский

---

Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment

Journal Of Clinical Periodontology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 15, 2024

To identify gingival crevicular fluid (GCF)-derived inflammatory markers of periodontitis progression and periodontal treatment impact.

Язык: Английский

---

Gingival Crevicular Fluid and Salivary Levels of Galectin-3 in Patient with Gingivitis and Patient with Stage III Periodontitis: An Observational Study

Advanced Dental Journal, Год журнала: 2023, Номер 5(4), С. 742 - 751

Опубликована: Окт. 1, 2023

Aim:The study was aimed at assessing the levels of Galectin-3 in GCF and Saliva gingivitis stage III periodontitis patients.Subjects methods: The present cross-sectional conducted on 66 participants including periodontal healthy, gingivitis, as well individuals.Periodontal examination continued outpatient clinic, Department Oral Medicine Periodontology, Faculty Dentistry, Cairo University.Pocket depth, clinical attachment level, bleeding probing, plaque index were measured using a manual UNC probe.GCF samples collected from deepest site by inserting absorbent paper strips into gingival sulcus for 30 seconds.Five ml saliva sample each subject Eppendorf tubes which immediately frozen & stored -70 °C.GCF Salivary quantified commercial Enzyme-Linked Immunosorbent Assay Kit.All these parameters subjected to statistical analysis.Results: There statistically significant higher than healthy.also, group had compared healthy group, while there no difference between periodontitis.Conclusion: is proinflammatory protein that might play essential roles disease pathogenesis.

Язык: Английский

---

EVALUATION OF INFLAMMASOMES AS BIOMARKER FOLLOWING NON-SURGICAL PERIODONTAL TREATMENT

Archives of Oral Biology, Год журнала: 2024, Номер 164, С. 105987 - 105987

Опубликована: Май 4, 2024

Язык: Английский

---