Minerva Dental and Oral Science, Год журнала: 2023, Номер 73(5)
Опубликована: Окт. 25, 2023
The aim of this study was to investigate oral mucosal changes in patients with confirmed moderate-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Язык: Английский
Pathogens, Год журнала: 2024, Номер 13(1), С. 58 - 58
Опубликована: Янв. 7, 2024
The oral cavity is a niche for diverse microbes, including viruses. Members of the Herpesviridae family, comprised dsDNA viruses, as well severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an ssRNA virus, are among most prevalent viruses infecting cavity, and they exhibit clinical manifestations unique to tissues. Viral infection mucosal epithelia triggers immune response that results in prolonged inflammation. systemic disease HHV have been researched extensively, several recent studies illuminated relationship between inflammatory diseases. Burgeoning evidence suggests manifestation SARS-CoV-2 includes xerostomia, dysgeusia, periodontal disease, mucositis, opportunistic viral bacterial infections, collectively described post-acute sequelae COVID-19 (PASC). These could be result intensified responses initially due copious production proinflammatory cytokines: so-called "cytokine storm syndrome", facilitating widespread non-oral tissue damage. This review explores interplay HHV, SARS-CoV-2, diseases such periodontitis, endodontic peri-implantitis. Additionally, discusses proper diagnostic techniques identifying how diagnostics can lead improved overall patient health.
Язык: Английский
Процитировано
7
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 15, 2025
Globally, periodontal diseases, mainly driven by polymicrobial biofilms, are a widespread concern of social medicine due to their considerable incidence and tie-up systemic disorders like diabetes, cardiovascular complications during pregnancy. Traditional treatments focus on mechanical debridement antimicrobial therapies, but these approaches have limitations, including recurrence antibiotic resistance. Periodontal vaccines offer promising alternative targeting the immunological mechanisms underlying disease. This review explores current state vaccine development, highlighting key antigens, delivery systems, preclinical clinical advancements. Special emphasis is placed antigen selection, host variability, immune tolerance, future directions overcome barriers. article highlights advancements challenges in research, offering insights into capability immunoprophylaxis as groundbreaking way manage diseases.
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 26, 2025
In the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in innate immune response, possess ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, well resulting damage-associated patterns (DAMPs), endogenous molecules released after cellular damage. A developing perspective suggests that TLRs central neuroinflammation, fundamental factor neurodegenerative conditions like Alzheimer’s Parkinson’s disease (PD). comprehensive review consolidates current research investigating potential interplay TLRs, their signaling mechanisms, processes neurodegeneration following SARS-CoV-2 infection with an aim elucidate involvement long-term neurological complications COVID-19 explore targeting means implementing intervention strategies for prevention or treatment COVID-19-associated brain outcomes.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(10), С. e31061 - e31061
Опубликована: Май 1, 2024
Human Papilloma Virus (HPV) is considered one of the most common sexually transmitted infections and has been shown to play an important role in pathogenesis squamous cell carcinomas (SCC) cervix head neck. Manifestations HPV can be manifold, ranging from asymptomatic benign or potentially malignant lesions intraepithelial neoplasms invasive carcinomas. The heterogeneity clinical manifestations infection depends on interactions between viral agent host, a direct consequence ability part remain silent evade convey action host immune system. oral mucosa represents tissues for which distinct tropism frequently affected by infection. While much information available that plays development SCC cavity, there less HPV-induced lesions. Therefore, purpose this review analyze, light current knowledge, early bio-humoral prognostic features related risk transformation, focusing subclinical conditions, lesions, correlation other districts. data show main associated with transformation Although HPV-driven OPSCC better prognosis than non-HPV-driven OPSCC, primary prevention detection genotype are essential reduce neoplastic complications improve prognosis.
Язык: Английский
Процитировано
3
International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Bioaerosols generated during dental treatment are considered to be potentially carriers of infectious respiratory pathogens. The use preprocedural mouthwashes has been suggested reduce microbial load prior surgery procedures. However, limited evidence on the effectiveness regarding mitigating pathogens exists. aim this clinical trial is determine and compare 3 recommended by Department Health Hong Kong Special Administrative Region in mitigation care pandemic times.
Язык: Английский
Процитировано
2
PLoS ONE, Год журнала: 2024, Номер 19(2), С. e0297291 - e0297291
Опубликована: Фев. 16, 2024
Background The oral cavity is the site of entry and replication for many respiratory viruses. Furthermore, it source droplets aerosols that facilitate viral transmission. It thought appropriate hygiene alters infectivity might reduce spread viruses contribute to infection control. Materials methods Here, we analyzed antiviral activity cetylpyridinium chloride (CPC), chlorhexidine (CHX), three commercial CPC CHX-containing mouthwash preparations against Influenza A virus Respiratory syncytial virus. To do so aforementioned compounds were incubated with or Next, viability treated particles. Results Our results indicate CHX decrease both Syncytial in vitro between 90 99.9% depending on concentration. Likewise, up 99.99% effective decreasing . Conclusion use a containing alone combination represent cost-effective measure limit enveloped infecting cavity, aiding reducing findings may stimulate future clinical studies evaluate effects transmissions.
Язык: Английский
Процитировано
1
Medical alphabet, Год журнала: 2024, Номер 11, С. 7 - 13
Опубликована: Май 11, 2024
Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated critical importance of understanding mechanisms transmission and finding effective methods prevention. Particular attention been paid to role oral hygiene, as cavity serves a major route transmission. Studies show that composition microbiota can influence course outcome disease. Therefore, there is need study effects antiseptics on microbiome, which may offer new opportunities for prevention treatment this Objective. aim evaluate effectiveness cleansing foam «Parodontol PROF» in reducing pathogenic microflora patients with assess its effect risk secondary infections. Materials methods. was conducted basis Clinical Medical Centre «Kuskovo» Russian University Medicine. It included 450 confirmed diagnosis COVID-19. participants were divided into two groups: test group used foam, while control no additional hygiene. Comparative analyses taxonomic oropharyngeal dental plaque before after use performed. Results . showed who regularly had significant decrease representation pathogens, including Mycoplasma, an increase number beneficial commensals such Lactococcus Lactobacillus. These changes indicate potential efficacy product improve hygiene reduce Conclusion. supports hypothesis improving specialised antiseptic agents, help This, turn, pathogen migration lower respiratory tract development findings emphasise further research area comprehensive approaches management context infectious diseases.
Язык: Английский
Процитировано
1
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Март 13, 2024
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(19), С. e37928 - e37928
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
0
Clinical Oral Investigations, Год журнала: 2023, Номер 27(S1), С. 1 - 2
Опубликована: Май 10, 2023
Язык: Английский
Процитировано
0