Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions DOI Creative Commons
Jelena Popović, Tatjana Cvetković, Tanja Džopalić

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 31

Опубликована: Дек. 30, 2024

BACKGROUND Apical periodontitis is caused by infected dental pulp and may be associated with caries or trauma, which can destroy periradicular tissues. This study included periapical tissue of patients chronic apical aimed to evaluate the presence cytomegalovirus (CMV) Epstein-Barr virus (EBV) using polymerase chain reaction (PCR), determine levels inflammatory cytokines enzyme-linked immunoassay (ELISA). MATERIAL AND METHODS A total 79 participated in this study. Periapical lesions were taken from tooth roots indicated for extraction, divided into 2 groups: symptomatic asymptomatic. PCR was used identify HCMV EBV. Interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor beta-1 (TGFß-1) determined ELISA. RESULTS The occurrence (P<0.05) dual HCMV/EBV infection significantly more frequent compared concentrations IL-6, IL-8, TNF-alpha higher virus-positive virus-negative ones (P<0.05); especially high cytokine found (P<0.05). level TGF-ß1 lesions, but difference significant only CONCLUSIONS prevalence herpesviruses asymptomatic indicates their important role pathogenesis lesions. Expression TNF-alpha, IL-8 importance development clinical features herpesvirus-infected while appears no significance.

Язык: Английский

Oral SARS‐CoV‐2 Infection and Risk for Long Covid DOI Creative Commons

Joel Schwartz,

Kristelle J. Capistrano,

Heba Hussein

и другие.

Reviews in Medical Virology, Год журнала: 2025, Номер 35(2)

Опубликована: Март 1, 2025

ABSTRACT SARS‐CoV‐2 is an oral pathogen that infects and replicates in mucosal salivary epithelial cells, contributing to post‐acute sequelae COVID‐19 (PASC) other non‐oral pathologies. While pre‐existing inflammatory diseases provides a conducive environment for the virus, acute infection persistence of can also results microbiome dysbiosis further worsens poor health. Indeed, PASC includes periodontal diseases, dysgeusia, xerostomia, pharyngitis, keratoses, pulpitis suggesting significant bacterial contributions tissue tropism. Dysbiotic microbiome‐induced inflammation promote viral entry via angiotensin‐converting enzyme receptor‐2 (ACE2), serine transmembrane TMPRSS2 possibly non‐canonical pathways. Additionally, metabolites derived from dysbiotic alter physiological biochemical pathways related metabolism lipids, carbohydrates, amino acids. This may pro‐inflammatory microenvironment, leading immune exhaustion, loss tolerance, susceptibility variety pathogens, causing later chronic inflammation. Microbial release mimics host metallopeptidases furin, ADAM17 (A disintegrin metalloproteinase 17), glycoprotein aid attachment T cell immunoglobulin‐like (TIMs), enhancing while simultaneously depressing resistance clearance. Membrane reorganization characterised by neuroproteins, such as neuropilins, functionally assists with extends pathogenesis cavity brain, gut, or tissues. Thus, health, disrupted microbiomes tropism, weaken antiviral resistance, heightens infection. dysfunction increases risk additional infections, exacerbating conditions like endodontic diseases. These persistent health issues contribute systemic inflammation, creating bidirectional effects between tissues, potentially Post‐Acute Sequelae (PASC).

Язык: Английский

Процитировано

1
The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage DOI
Mitra Rostami,

Pouria Farahani,

Samar Esmaelian

и другие.

Stem Cell Reviews and Reports, Год журнала: 2024, Номер 20(8), С. 2062 - 2103

Опубликована: Авг. 16, 2024

Язык: Английский

Процитировано

4
A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial DOI Creative Commons

Georgios Kardaras,

Ruxandra Christodorescu, Marius Boariu

и другие.

Dentistry Journal, Год журнала: 2024, Номер 12(5), С. 144 - 144

Опубликована: Май 15, 2024

In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral bacterial etiology; thus, a mechanical approach alone may not be sufficient eliminate substantial portion subgingival pathogens, especially in deep sites. Background Objectives: This single-blind, randomized clinical trial aimed compare microbiological efficacy low-cost protocol using povidone–iodine sodium hypochlorite formulations as adjuncts non-surgical for patients with stage IV periodontitis when compared chlorhexidine, most commonly employed substance date antimicrobial regimens therapy. Materials Methods: Forty-five were randomly divided into two groups: control (subgingival instrumentation, chlorhexidine-assisted) test (antiviral medication, instrumentation povidone–iodine, rinsing solution, antibiotics). Clinical measurements analyses performed at baseline after three months. Results: After months, notable differences found detection scores Porphyromonas gingivalis (a significant reduction frequency was observed (p = 0.021)), there reductions group Tannerella forsythia Treponema denticola, showing undetectable levels < 0.0001 both). group, pocket probing depth median value reduced significantly 0.0005); similarly, bleeding on showed marked decrease 0.0001). However, changes attachment loss full-mouth plaque score statistically significant. Conclusions: Using proposed protocol, improvements parameters obtained current recommendations.

Язык: Английский

Процитировано

2
SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19 DOI Creative Commons
Joel Schwartz, Kristelle J. Capistrano,

Joseph L. Gluck

и другие.

Reviews in Medical Virology, Год журнала: 2024, Номер 34(3)

Опубликована: Май 1, 2024

Abstract COVID‐19 as a pan‐epidemic is waning but there it imperative to understand virus interaction with oral tissues and inflammatory diseases. We review periodontal disease (PD), common disease, driver of post‐acute‐sequelae conditions (PASC). Oral PASC identifies PD, loss teeth, dysgeusia, xerostomia, sialolitis‐sialolith, mucositis. contend that PD‐associated microbial dysbiosis involving higher burden periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. These pathogens interact epithelial cells activate molecular or biochemical pathways promote viral adherence, entry, persistence in the cavity. A repertoire diverse molecules this relationship including lipids, carbohydrates enzymes. The S protein SARS‐CoV‐2 binds ACE2 receptor activated by protease activity host furin TRMPSS2 cleave subunits entry. However, PD additional enzymatic assistance mimicking augment adherence inducing entry receptors ACE2/TRMPSS, which are poorly expressed on cells. discuss mechanisms periodontopathogens factors facilitate infection immune resistance resulting incomplete clearance risk ‘long‐haul’ health issues characterising PASC. Finally, we suggest potential diagnostic markers treatment avenues mitigate

Язык: Английский

Процитировано

2
The Role of Viruses in Pulpal and Apical Disease: A Systematic Review DOI Creative Commons

Katia Hermosilla Hermosilla,

Paula Soto Cárdenas,

Manuel Donoso Zúñiga

и другие.

Viruses, Год журнала: 2024, Номер 16(10), С. 1537 - 1537

Опубликована: Сен. 28, 2024

Apical lesions are diseases of infectious origin that can cause destruction the surrounding periapical tissue, including bone tissue and periodontal ligaments, resulting in loss affected teeth. Currently, microorganisms present pulp apical disease mostly studied as bacteria. However, recent years, interest has been aroused study viruses could be lesions, how these affect progression disease. In study, we conducted a systematic review literature to evaluate synthesize scientific evidence on presence their possible role pulpal This was performed according PRISMA reporting guidelines. The search for studies PubMed Web Science databases. A total seven published last 10 years were included. types samples used virus analysis varied from one another. all included studies, any found, either or tissue. Herpesviridae family, Epstein-Barr (EBV) Human cytomegalovirus (HCMV) stood out most commonly lesions. Further required clarify understand pathogenic

Язык: Английский

Процитировано

2
The effect of artificial saliva on the control of dry mouth: a semi-experimental study on COVID-19 patients under Non-invasive mechanical ventilation DOI Creative Commons
Ladan Sedighi, Sorour Khari, Morteza Hasheminik

и другие.

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Май 31, 2024

Since maintaining oral hygiene is essential in nursing care, the present study was conducted to determine effect of care using Mucosamin artificial saliva spray control dry mouth ICU patients with COVID-19.

Язык: Английский

Процитировано

1
Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions DOI Creative Commons
Jelena Popović, Tatjana Cvetković, Tanja Džopalić

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 31

Опубликована: Дек. 30, 2024

BACKGROUND Apical periodontitis is caused by infected dental pulp and may be associated with caries or trauma, which can destroy periradicular tissues. This study included periapical tissue of patients chronic apical aimed to evaluate the presence cytomegalovirus (CMV) Epstein-Barr virus (EBV) using polymerase chain reaction (PCR), determine levels inflammatory cytokines enzyme-linked immunoassay (ELISA). MATERIAL AND METHODS A total 79 participated in this study. Periapical lesions were taken from tooth roots indicated for extraction, divided into 2 groups: symptomatic asymptomatic. PCR was used identify HCMV EBV. Interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor beta-1 (TGFß-1) determined ELISA. RESULTS The occurrence (P<0.05) dual HCMV/EBV infection significantly more frequent compared concentrations IL-6, IL-8, TNF-alpha higher virus-positive virus-negative ones (P<0.05); especially high cytokine found (P<0.05). level TGF-ß1 lesions, but difference significant only CONCLUSIONS prevalence herpesviruses asymptomatic indicates their important role pathogenesis lesions. Expression TNF-alpha, IL-8 importance development clinical features herpesvirus-infected while appears no significance.

Язык: Английский

Процитировано

0