Journal of Orthopaedic Surgery and Research,
Год журнала:
2023,
Номер
18(1)
Опубликована: Март 15, 2023
Abstract
Background
Immune-mediated
conditions
associated
to
Corona
Virus
Disease-19
(COVID-19)
have
been
reported,
including
vasculitis,
antiphospholipid
antibody
syndrome,
myositis,
and
lupus.
Emerging
studies
reported
the
potential
occurrence
of
reactive
arthritis
in
patients
previously
infected
with
COVID-19.
This
systematic
review
summarised
current
evidence
on
by
Methods
study
was
conducted
according
2020
PRISMA
guidelines.
All
clinical
investigations
describing
following
COVID-19
were
accessed.
In
September
2022,
databases
accessed:
PubMed,
Web
Science,
Google
Scholar,
Embase.
The
generalities
extracted:
author,
year
journal
publication,
country
main
design,
sample
size,
mean
age,
number
women,
results
study.
data
severity
management
retrieved:
type
treatment,
hospitalization
regimes
(inpatient
or
outpatient),
admission
intensive
care
unit,
need
mechanical
ventilation,
pharmacological
management.
collected:
time
elapsed
between
infection
onset
symptoms
(days),
management,
(mono-
bilateral,
mono-
polyarticular),
extra-articular
manifestations,
presence
tenosynovitis
enthesitis,
synovial
examination
at
microscopic
polarised
light,
imaging
(radiography,
magnetic
resonance,
sonography),
examination,
laboratory
findings.
Results
Data
from
27
case
reports
(54
patients)
retrieved,
a
age
49.8
±
14.5
years.
54%
(29
54
women.
span
22.3
10.7
days.
Between
diagnosis
heterogeneous.
Symptoms
resolved
within
few
days
all
considered.
At
last
follow-up,
minimally
symptomatic
asymptomatic,
no
additional
therapy
attentions
required
any
patient.
Conclusion
Poor
suggests
that
could
target
musculoskeletal
system
causing
its
post
infectious
stage.
can
act
as
causative
agent
trigger
for
development
even
without
antibodies
rheumatological
disorders.
Treating
physicians
should
high
index
suspicion
while
treating
patient
arthralgia.
Level
IV,
review.
Annals of Medicine,
Год журнала:
2022,
Номер
54(1), С. 1473 - 1487
Опубликована: Май 20, 2022
After
almost
2
years
of
fighting
against
SARS-CoV-2
pandemic,
the
number
patients
enduring
persistent
symptoms
long
after
acute
infection
is
a
matter
concern.
This
set
was
referred
to
as
"long
COVID",
and
it
defined
more
recently
"Post
COVID-19
condition"
by
World
health
Organization
(WHO).
Although
studies
have
revealed
that
COVID
can
manifest
whatever
severity
inaugural
illness,
underlying
pathophysiology
still
enigmatic.To
conduct
comprehensive
review
address
putative
persisting
COVID.We
searched
11
bibliographic
databases
(Cochrane
Library,
JBI
EBP
Database,
Medline,
Embase,
PsycInfo,
CINHAL,
Ovid
Nursing
Journals@Ovid,
SciLit,
EuropePMC,
CoronaCentral).
We
selected
put
forward
hypotheses
on
pathophysiology,
well
those
encompassed
in
their
research
investigation.A
total
98
articles
were
included
systematic
review,
54
which
exclusively
addressed
while
44
involved
patients.
Studies
displayed
heterogeneity
with
respect
initial
timing
analysis,
or
presence
control
group.
likely
results
from
long-term
organ
damage
due
acute-phase
infection,
specific
mechanisms
following
illness
could
contribute
later
possibly
affecting
many
organs.
As
such,
autonomic
nervous
system
account
for
without
clear
evidence
damage.
Immune
dysregulation,
auto-immunity,
endothelial
dysfunction,
occult
viral
persistence,
coagulation
activation
are
main
pathophysiological
so
far.Evidence
why
occur
limited,
available
heterogeneous.
Apart
damage,
hints
suggest
be
symptoms.
KEY
MESSAGESLong-COVID
multisystem
disease
develops
regardless
severity.
Its
clinical
spectrum
comprises
wide
range
symptoms.The
its
unclear.
phase
accounts
symptoms,
long-lasting
inflammatory
been
proposed,
well.Existing
involving
Long-COVID
highly
heterogeneous,
they
include
various
levels
different
time
frame
well.
Frontiers in Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Март 31, 2023
The
Long
COVID/Post
Acute
Sequelae
of
COVID-19
(PASC)
group
includes
patients
with
initial
mild-to-moderate
symptoms
during
the
acute
phase
illness,
in
whom
recovery
is
prolonged,
or
new
are
developed
over
months.
Here,
we
propose
a
description
pathophysiology
COVID
presentation
based
on
inflammatory
cytokine
cascades
and
p38
MAP
kinase
signaling
pathways
that
regulate
production.
In
this
model,
SARS-CoV-2
viral
infection
hypothesized
to
trigger
dysregulated
peripheral
immune
system
activation
subsequent
release.
Chronic
low-grade
inflammation
leads
brain
microglia
an
exaggerated
release
central
cytokines,
producing
neuroinflammation.
Immunothrombosis
linked
chronic
microclot
formation
decreased
tissue
perfusion
ischemia.
Intermittent
fatigue,
Post
Exertional
Malaise
(PEM),
CNS
"brain
fog,"
arthralgias,
paresthesias,
dysautonomia,
GI
ophthalmic
problems
can
consequently
arise
as
result
elevated
cytokines.
There
abundant
similarities
between
myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS).
DNA
polymorphisms
viral-induced
epigenetic
changes
gene
expression
may
lead
patients,
predisposing
some
develop
autoimmunity,
which
be
gateway
ME/CFS.
Rheumatology International,
Год журнала:
2021,
Номер
unknown
Опубликована: Май 12, 2021
To
describe
the
rheumatic
and
musculoskeletal
symptoms
at
hospitalization
as
well
their
persistence/severity
after
discharge
with
coronavirus
disease
2019
(COVID-19)
to
identify
whether
age,
sex,
body
mass
index
(BMI),
length
of
hospital
stay
are
associated
persistence
these
symptoms.
In
this
single-center
cohort
study,
comprising
300
participants,
two
phone
interviews
were
conducted
(2-week
1-month
hospitalization)
queried
a
standardized
form.
This
form
included
other
COVID-19
Considering
all
(musculoskeletal
other),
100.0%,
86.7%,
72.0%
patients
reported
one
or
more
symptoms,
hospitalization,
2-week,
1-month,
respectively.
only
92.3%,
72.7%,
56.3%
any
symptom
The
fatigue
(44.3%
reported),
back
pain
(22.7%),
arthralgia
(22.0%),
myalgia
(21.0%),
low
(16.3%),
neck
(10.3%);
shortness
breath
(26.3%),
loss
taste
(15.0%),
cough
(14.0%),
smell
(12.3%),
appetite
(10.3%),
headache
(8.7%),
sore
throat
(3.0%),
diarrhea
(1.3%),
dizziness
fever
(0.3%)
1-month.
Increasing
BMI
was
higher
odds
(OR:
1.08,
1.03
1.13),
1.01
1.14),
1.07,
1.02
1.14,
p
=
0.012)
Nearly
three-quarters
than
half
1
month.
most
common
fatigue,
followed
by
pain,
arthralgia,
myalgia,
pain.
related
BMI.
study
results
increase
our
understanding
spectrum
COVID-19,
which,
in
turn,
may
lead
efficient
better
care
for
survivors.
Diagnostics,
Год журнала:
2023,
Номер
13(11), С. 1850 - 1850
Опубликована: Май 25, 2023
As
the
number
of
reports
post-acute
COVID-19
musculoskeletal
manifestations
is
rapidly
rising,
it
important
to
summarize
current
available
literature
in
order
shed
light
on
this
new
and
not
fully
understood
phenomenon.
Therefore,
we
conducted
a
systematic
review
provide
an
updated
picture
potential
rheumatological
interest,
with
particular
focus
joint
pain,
onset
rheumatic
diseases
presence
autoantibodies
related
inflammatory
arthritis
such
as
rheumatoid
factor
anti-citrullinated
protein
antibodies.
We
included
54
original
papers
our
review.
The
prevalence
arthralgia
was
found
range
from
2%
65%
within
time
frame
varying
4
weeks
12
months
after
acute
SARS-CoV-2
infection.
Inflammatory
also
reported
various
clinical
phenotypes
symmetrical
polyarthritis
RA-like
pattern
similar
other
prototypical
viral
arthritis,
polymyalgia-like
symptoms,
or
monoarthritis
oligoarthritis
large
joints
resembling
reactive
arthritis.
Moreover,
high
figures
post-COVID-19
patients
fulfilling
classification
criteria
for
fibromyalgia
were
found,
ranging
31%
40%.
Finally,
about
antibodies
largely
inconsistent.
In
conclusion,
interest
new-onset
are
frequently
COVID-19,
highlighting
role
trigger
development
autoimmune
conditions
diseases.
Eosinophilic
granulomatosis
with
polyangiitis
is
a
type
of
medium
and
small-vessel
vasculitis
that
characterized
by
asthma,
polyneuropathy,
peripheral
eosinophilia,
rhinosinusitis,
other
organ
involvement,
such
as
the
lung
skin.
Here,
we
present
an
interesting
case
eosinophilic
after
mRNA-1273
(Moderna)
vaccine
against
coronavirus
disease
2019
(COVID-19).
The
patient
presented
progressive
weakness
paresthesia
in
upper
lower
extremities.
She
was
found
to
have
eosinophilia
elevated
anti-myeloperoxidase
antibodies.
Nerve
muscle
biopsies
showed
focal
infiltration
eosinophils.
started
on
steroids
steroid-sparing
agent
shortly
had
marked
improvement
her
symptoms.
