COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

Pathology - Research and Practice, Год журнала: 2023, Номер 246, С. 154497 - 154497

Опубликована: Май 3, 2023

Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-19) cases, and 13 billion COVID-19 vaccine doses administered as of April 2023, according to the World Health Organization. An infection with severe acute respiratory syndrome 2 (SARS-CoV-2) can lead an disease, i.e. COVID-19, but also a post-acute (PACS, "long COVID"). Currently, side effects vaccines are increasingly being noted studied. Here, we summarise currently available indications discuss our conclusions that (i) these specific similarities differences PACS, (ii) new term should be used refer (post-COVID-19 vaccination syndrome, PCVS, colloquially "post-COVIDvac-syndrome"), (iii) is need distinguish between (ACVS) (PACVS) - in analogy PACS ("long Moreover, address mixed forms caused by natural SARS-CoV-2 vaccination. We explain why it important for medical diagnosis, care research use terms (PCVS, ACVS PACVS) order avoid confusion misinterpretation underlying causes enable optimal therapy. do not recommend "Post-Vac-Syndrome" imprecise. The article serves current problem "medical gaslighting" relation PCVS raising awareness among professionals supplying appropriate terminology disease.

Язык: Английский

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023

Autoimmunity Reviews, Год журнала: 2023, Номер 22(5), С. 103287 - 103287

Опубликована: Фев. 3, 2023

In 2011, a syndrome entitled ASIA (Autoimmune/inflammatory Syndrome Induced by Adjuvants; Shoenfeld's syndrome) was first described. aimed to organize under single umbrella, the existing evidence regarding certain environmental factors which possess immune stimulatory properties, in order shed light on common pathway of autoimmune pathogenesis. Such stimulators, or adjuvants, include among others: aluminum salts as vaccines, various medical implants, well infectious agents. After launch syndrome, expansion and recognition this different researchers from countries began. During past decades, had been accumulating that (auto)immune symptoms can be triggered exposure act an adjuvant genetically susceptible individuals. A panoply unexplained subjective autonomic-related has reported patients with syndrome. The current review summarizes updates accumulated knowledge describing new adjuvants- (e.g. polypropylene meshes) vaccine- HPV COVID vaccines) induced ASIA. Furthermore, direct association between inflammatory/autoimmune diseases will discussed. Recent cases strengthen some criteria depicted such clear improvement removal adjuvants silicone breast implants) body patients. Finally, we introduce additional included for as: (1) dysregulated non-classical autoantibodies directed against G-protein coupled receptors (GPCRs) autonomic nervous system (2)) small fiber neuropathy (SFN), both might explain, at least part, development 'dysautonomia' many

Язык: Английский

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New-onset autoimmune disease after COVID-19

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 8, 2024

Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may trigger autoimmune disease (AD) through initial innate immune activation with subsequent aberrations in adaptive cells leading to AD. While there are multiple reports of incident AD diagnosed after COVID-19, the risk context key circulating strains is unknown. Methods TriNetX, a global, federated, health research network providing access electronic medical records across 74 healthcare organizations, was utilized define an adult cohort between January 1, 2020, and March 3, 2023. Exposure defined as COVID-19 diagnosis (ICD-10 code or positive laboratory test). Age- sex-propensity score-matched controls never had diagnosed. Outcomes were assessed 1 month year index date. Patients prior within date excluded from primary analysis. Incidence ratios each assessed. Results A total 3,908,592 patients included. Of 24 assessed, adjusted for eight who higher compared those no COVID-19. Cutaneous vasculitis (adjusted hazard ratio (aHR): 1.82; 95% CI 1.55–2.13), polyarteritis nodosa (aHR: 1.76; 1.15–2.70), hypersensitivity angiitis 1.64; 1.12–2.38) highest ratios. Overall, psoriasis (0.15%), rheumatoid arthritis (0.14%), type diabetes (0.13%) incidence during study period, these, more likely The any lower if when Omicron variants predominant strains. antinuclear antibody predictive Discussion SARS-CoV-2 be potential some AD, but decrease time given apparent infection variants.

Язык: Английский

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Autoimmune inflammatory rheumatic diseases post-COVID‐19 vaccination

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 109061 - 109061

Опубликована: Июль 15, 2022

Язык: Английский

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Overview of autoantibodies in COVID‐19 convalescents

Journal of Medical Virology, Год журнала: 2023, Номер 95(6)

Опубликована: Июнь 1, 2023

Abstract Accumulating evidence shows that SARS‐CoV‐2 can potentially trigger autoimmune processes, which be responsible for the long‐term consequences of COVID‐19. Therefore, this paper aims to review autoantibodies reported in COVID‐19 convalescents. Six main groups were distinguished: (i) against components immune system, (ii) cardiovascular (iii) thyroid autoantibodies, (iv) specific rheumatoid diseases, (v) antibodies G‐protein coupled receptors, and (vi) other autoantibodies. The reviewed here clearly highlights infection may induce humoral responses. However, available studies share number limitations, such as: (1) sole presence does not necessarily implicate clinically‐relevant risks, (2) functional investigations rarely performed it is often unknown whether observed are pathogenic, (3) control seroprevalence, healthy, noninfected individuals was reported; thus sometimes detected result or accidental post‐COVID‐19 detection, (4) correlated with symptoms syndrome, (5) size studied small, (6) focused predominantly on adult populations, (7) age‐ sex‐related differences seroprevalence explored, (8) genetic predispositions involved generation during infections investigated, (9) reactions following variants vary clinical course remain unexplored. Further longitudinal advocated assess link between identified particular outcomes

Язык: Английский

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Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review

American Journal of Medicine Open, Год журнала: 2024, Номер 11, С. 100068 - 100068

Опубликована: Фев. 14, 2024

The virus called SARS-CoV-2 emerged in 2019 and quickly spread worldwide, causing COVID-19. It has greatly impacted on everyday life, healthcare systems, the global economy. In order to save as many lives possible, precautions such social distancing, quarantine, testing policies were implemented, effective vaccines developed. A growing amount of data collected worldwide allowed characterization this new disease, which turned out be more complex than other common respiratory tract infections. An increasing number convalescents presented with a variety non-specific symptoms emerging after acute infection. This possible health problem was identified labelled long COVID. Since then, great effort been made by clinicians scientific community understand underlying mechanisms develop preventive measures treatment. role autoimmunity induced infection development COVID is discussed review. We aim deliver description several conditions an autoimmune background observed COVID-19 convalescents, including Guillain-Barré syndrome, antiphospholipid syndrome related thrombosis, Kawasaki disease highlighting relationship between autoimmunity. However, further studies are required determine its true clinical significance.

Язык: Английский

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Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters

Vaccines, Год журнала: 2024, Номер 12(2), С. 178 - 178

Опубликована: Фев. 9, 2024

The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model exposome research. This scenario explores fine balance between protective exacerbating factors, providing insights into complex relationship environmental exposure immunopathogenesis when a trigger appears, such as that hyperinflammatory state induced by COVID-19 vaccine. Analyzing interactions vaccine-induced phenomena parameters may provide clinically relevant information important for personalized medicine decision-making. We performed literature review seeking patients with plaque flares or new onset change another subtype, pustular erythrodermic flare, focusing on inner external traits patients. identified 71 flares, 12 new-onset psoriasis, 17 subtype change, assessed terms clinical presentation, post-vaccination flare period treatment status, well (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) (UV, infectomics). Novel data following are primarily obtained combining episode features characteristics comparing them similar unrelated vaccination.

Язык: Английский

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Efgartigimod as a novel FcRn inhibitor for autoimmune disease

Neurological Sciences, Год журнала: 2024, Номер 45(9), С. 4229 - 4241

Опубликована: Апрель 22, 2024

Язык: Английский

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Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

Vaccines, Год журнала: 2023, Номер 11(2), С. 208 - 208

Опубликована: Янв. 17, 2023

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 deaths from COVID-19 have been reported worldwide. Currently, death rate has reduced due decreased pathogenicity new SARS-CoV-2 variants, but major factor in rates is administration 12.8 billion vaccine doses globally. While vaccines are saving lives, serious side effects after vaccinations for several premature non-communicable diseases (NCDs). However, adverse events low number. The scientific community must investigate entire spectrum COVID-19-vaccine-induced complications so that necessary safety measures can be taken, current re-engineered avoid or minimize their effects. We describe depth severe metabolic, mental, neurological disorders; cardiovascular, renal, autoimmune diseases, reproductive health issues detected whether these causal incidental. In any case, it become clear benefits outweigh risks by a large margin. pre-existing conditions vaccinated individuals need taken into account prevention treatment events.

Язык: Английский

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COVID-19 vaccination and thyroiditis

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101759 - 101759

Опубликована: Март 3, 2023

Язык: Английский

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