Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies DOI Creative Commons
Martin Heil

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Фев. 19, 2024

The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling nuclear factor kappa light chain enhancer in B-cells (NF-κB)-driven interleukin (IL)-1β, IL-6, IL-18 secretion causing cytokine storms. translation the how resulting systemic inflammation can lead life-threatening complications into novel treatments vaccine technologies is underway. Nevertheless, previously existing role cytoplasmatic or circulating self-DNA as a pro-inflammatory damage-associated molecular pattern (DAMP) was largely ignored. Pathologies reported ‘ de novo ’ for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 be outcomes self-DNA-driven fact had been linked earlier different contexts, e.g., infection Human Immunodeficiency Virus (HIV)-1, sterile inflammation, autoimmune diseases. highlight particularly synergies other DAMPs render immunogenic properties normally non-immunogenic extracellular self-DNA, discuss shared features gp41 unit HIV-1 envelope protein SARS-CoV 2 Spike that enable SARS-CoV-2 interact cell membranes, trigger syncytia formation, inflict damage their host’s DNA, – likely own benefit. These similarities motivate speculations similar mechanisms those driven by explain inflammatory contributes some most frequent adverse events after vaccination BNT162b2 mRNA (Pfizer/BioNTech) mRNA-1273 (Moderna) vaccine, i.e., myocarditis, herpes zoster, rheumatoid arthritis, nephritis hepatitis, new-onset lupus erythematosus, flare-ups psoriasis lupus. hope wider application lessons learned from experiences COVID-19 new vaccines combat future non-COVID-19

Язык: Английский

Central diabetes insipidus revealing a hypophysitis induced by SARS-CoV-2 vaccine DOI Open Access
Taïeb Ach,

Fatma Kammoun,

Hamza El Fekih

и другие.

Therapies, Год журнала: 2022, Номер 78(4), С. 453 - 455

Опубликована: Окт. 6, 2022

Язык: Английский

Процитировано

18
Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population DOI Creative Commons
Loredana Frasca, Giuseppe Ocone,

Raffaella Palazzo

и другие.

Pathogens, Год журнала: 2023, Номер 12(2), С. 233 - 233

Опубликована: Фев. 2, 2023

The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since beginning of 2020, and COVID-19 vaccines were considered crucial eradication. Instead producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into host, production antigenic protein SARS-CoV-2 called Spike, injecting an instruction based on RNA or DNA sequence. Here, we aim give overview safety profile actual known adverse effects these in relationship with their mechanism action. We discuss use at-risk people, especially those autoimmune diseases previously reported myocarditis, but also general population. debate real necessity administering unclear long-term people conditions, as well healthy at time omicron variants. This, considering existence therapeutic interventions, much more clearly assessed present compared past, relatively lower aggressive nature new viral

Язык: Английский

Процитировано

11
Postural Orthostatic Tachycardia Syndrome in COVID-19: A Contemporary Review of Mechanisms, Clinical Course and Management DOI Creative Commons
Bharat Narasimhan, Arundhati Calambur, Errol Moras

и другие.

Vascular Health and Risk Management, Год журнала: 2023, Номер Volume 19, С. 303 - 316

Опубликована: Май 1, 2023

Abstract: The long-term implications of COVID-19 have garnered increasing interest in recent months, with Long-COVID impacting over 65 million individuals worldwide. Postural orthostatic tachycardia syndrome (POTS) has emerged as an important component the umbrella, estimated to affect between 2 and 14% survivors. POTS remains very challenging diagnose manage – this review aims provide a brief overview whole goes on summarize available literature pertaining setting COVID-19. We clinical reports, outline proposed pathophysiological mechanisms end note management considerations. Keywords: POTS, COVID-19, long COVID,

Язык: Английский

Процитировано

11
Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens DOI Creative Commons
Aaron Lerner, Carina Benzvi, Aristo Vojdani

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 16, 2023

Microbial transglutaminase (mTG) is a bacterial survival factor, frequently used as food additive to glue processed nutrients. As result, new immunogenic epitopes are generated that might drive autoimmunity. Presently, its contribution autoimmunity through epitope similarity and cross-reactivity was investigated. Emboss Matcher perform sequence alignment between mTG various antigens implicated in many autoimmune diseases. Monoclonal polyclonal antibodies made specifically against were applied 77 different human tissue using ELISA. Six detected share significant homology with sequences, representing major targets of common conditions. Polyclonal antibody reacted significantly 17 out antigens. This reaction most pronounced mitochondrial M2, ANA, extractable nuclear The results indicate possible, supporting the relationship development disorders 150W.

Язык: Английский

Процитировано

10
Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies DOI Creative Commons
Martin Heil

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Фев. 19, 2024

The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling nuclear factor kappa light chain enhancer in B-cells (NF-κB)-driven interleukin (IL)-1β, IL-6, IL-18 secretion causing cytokine storms. translation the how resulting systemic inflammation can lead life-threatening complications into novel treatments vaccine technologies is underway. Nevertheless, previously existing role cytoplasmatic or circulating self-DNA as a pro-inflammatory damage-associated molecular pattern (DAMP) was largely ignored. Pathologies reported ‘ de novo ’ for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 be outcomes self-DNA-driven fact had been linked earlier different contexts, e.g., infection Human Immunodeficiency Virus (HIV)-1, sterile inflammation, autoimmune diseases. highlight particularly synergies other DAMPs render immunogenic properties normally non-immunogenic extracellular self-DNA, discuss shared features gp41 unit HIV-1 envelope protein SARS-CoV 2 Spike that enable SARS-CoV-2 interact cell membranes, trigger syncytia formation, inflict damage their host’s DNA, – likely own benefit. These similarities motivate speculations similar mechanisms those driven by explain inflammatory contributes some most frequent adverse events after vaccination BNT162b2 mRNA (Pfizer/BioNTech) mRNA-1273 (Moderna) vaccine, i.e., myocarditis, herpes zoster, rheumatoid arthritis, nephritis hepatitis, new-onset lupus erythematosus, flare-ups psoriasis lupus. hope wider application lessons learned from experiences COVID-19 new vaccines combat future non-COVID-19

Язык: Английский

Процитировано

4