The
study
of
the
human
microbiome
has
been
a
hot
topic
during
last
decades
and
more
recently
skin
aroused
great
interest
as
well.
So
that,
scientists
have
turned
their
attention
to
role
in
health,
its
relationship
with
different
disorders
atopic
dermatitis,
psoriasis,
acne,
rosacea,
among
others.
Numerous
studies
investigations
performed
pre
probiotics
nutraceuticals
treatment
diseases,
growing
evidence
along
ten
years.
This
review
gathers
information
on
use
“nutribiotics”
care
focus
main
dermatological
diseases
other
conditions.
Clinical
show
that
nutribiotics
could
be
new
tool
improve
health
pre,
pro,
syn,
post
para-probiotics
seem
beneficial
several
disorders,
well
repairing
barrier,
or
promoting
wound
healing.
In
conclusion,
emerged
field
high
potential
develop
disruptive
solutions
manage
disease.
Future
advances
this
may
facilitate
dysbiosis
being
suitable
method
for
care.
Foods,
Год журнала:
2025,
Номер
14(3), С. 495 - 495
Опубликована: Фев. 4, 2025
Lactic
acid
bacteria
(LAB)
constitute
a
heterogeneous
group
of
isolated
from
fermented
foods,
animals,
plants,
and
mammalian
guts,
with
many
health-promoting
properties.
Probiotics
antagonistic
properties
against
human
pathogens
foodborne
have
garnered
significant
attention
the
scientific
fraternity.
A
dedicated
review
focusing
on
plant-derived
probiotic
their
has
not
been
comprehensively
reviewed.
Thus,
this
aimed
at
providing
an
overview
LAB
isolates
derived
several
unconventional
sources
such
as
fruits,
seeds,
fruit
pulp,
leaves,
roots,
vegetables,
grasses,
flowers
antibacterial,
antifungal,
antiviral
This
paper
reviewed
antimicrobial
different
genera,
Lactobacillus,
Leuconostoc,
Weissella,
Enterococcus,
Pediococcus,
Bacillus,
Fructobacillus,
postbiotics,
paraprobiotics.
Several
important
mechanisms,
including
secretion
bacteriocins,
bacteriocin-like
substances,
reuterin,
organic
acids
(lactic
acetic),
peptides,
exopolysaccharides,
hydrogen
peroxide,
attributed
to
actions
pathogens.
However,
precise
mode
action
is
poorly
understood;
hence,
further
research
should
be
conducted
reveal
detailed
mechanisms.
Finally,
discusses
summary
future
implications.
Given
significance,
compounds
can
potentially
exploited
in
food
preservation
safety
or
for
medicinal
applications
after
evaluating
safety.
Probiotics and Antimicrobial Proteins,
Год журнала:
2024,
Номер
16(4), С. 1440 - 1464
Опубликована: Янв. 31, 2024
Abstract
Neuropsychiatric
disorders
are
clinical
conditions
that
affect
cognitive
function
and
emotional
stability,
often
resulting
from
damage
or
disease
in
the
central
nervous
system
(CNS).
These
a
worldwide
concern,
impacting
approximately
12.5%
of
global
population.
The
gut
microbiota
has
been
linked
to
neurological
development
function,
implicating
its
involvement
neuropsychiatric
conditions.
Due
their
interaction
with
microbial
communities,
probiotics
offer
natural
alternative
traditional
treatments
such
as
therapeutic
drugs
interventions
for
alleviating
symptoms.
Introduced
by
Metchnikoff
early
1900s,
live
microorganisms
provide
various
health
benefits,
including
improved
digestion,
enhanced
sleep
quality,
reduced
mental
problems.
However,
concerns
about
safety,
particularly
immunocompromised
patients,
warrant
further
investigation;
this
led
concept
“paraprobiotics”,
inactivated
forms
beneficial
safer
alternative.
This
review
begins
exploring
different
methods
inactivation,
each
targeting
specific
cellular
components
like
DNA
proteins.
choice
inactivation
method
is
crucial,
benefits
may
vary
depending
on
employed
inactivation.
subsequent
sections
focus
potential
mechanisms
action
applications
paraprobiotics
therapy.
Probiotics
interact
microbes,
modulating
composition
dysbiosis.
primarily
stem
gut-brain
axis,
bidirectional
communication
channel
involving
pathways
discussed
review.
While
research
needed,
promising
agents
management
disorders.
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 22, 2025
Paraprobiotics
are
inactivated
microbial
cells
or
cell
fractions
that
confer
health
benefits
to
the
consumer,
and
possess
ability
regulate
both
adaptive
innate
immune
systems.
They
exhibit
anti-inflammatory,
antiproliferative,
antioxidant
properties,
antimicrobial
activities.
The
aim
of
this
study
is
evaluate
these
activities
Lacticaseibacillus
paracasei
lysates
isolated
from
fermented
palm
sap.
bacterial
were
prepared
via
sonication,
their
antibacterial
activity
was
assessed
against
three
pathogens
using
agar
well
diffusion
assay.
Antioxidant
evaluated
DPPH
ABTS
radical
scavenging
assays.
Cytotoxicity
anti-inflammatory
determined
in
LPS-stimulated
RAW
264.7
by
measuring
nitric
oxide
production,
secretion,
mRNA
level
cytokines
(IL-1β,
IL-6,
IL-10).
Among
lysates,
L.
T1901
demonstrated
strongest
Escherichia
coli,
Bacillus
cereus,
Acinetobacter
baumannii.
Most
exhibited
potent
activity,
especially
T0601
showed
highest
In
cells,
effectively
reduced
levels
suppressed
production
pro-inflammatory
(IL-1β
IL-6);
simultaneously,
enhanced
immunosuppressive
cytokine
IL-10
secretion.
Furthermore,
no
cytotoxic
effect
observed
lysate-treated
cells.
highlights
potential
as
multifunctional
agents
with
antibacterial,
antioxidant,
properties.
These
findings
support
application
developing
functional
foods
therapeutic
for
managing
oxidative
stress
inflammatory
diseases.
Frontiers in Marine Science,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 10, 2024
This
review
delves
into
the
increasing
interest
in
probiotics
and
paraprobiotics
as
a
viable
alternative
to
antibiotics
aquaculture,
highlighting
their
potential
enhance
fish
health
prevent
diseases.
As
aquaculture
industry
continues
its
global
expansion,
addressing
challenges
associated
with
disease
outbreaks
high-density
populations
becomes
imperative.
The
underscores
promising
role
of
sustainable
strategy
mitigate
these
challenges.
diverse
positive
impacts
various
probiotic
strains
such
Arthrobacter
,
Bacillus
Lactobacillus
Bifidobacterium
Clostridium
others
emphasize
roles
enhancing
growth,
resistance
diseases
(including
bacterial,
viral,
parasitic
infections),
stress
reduction,
water
quality
management,
environmental
sustainability.
Challenges
stability,
host
specificity,
regulatory
considerations
must
be
addressed
optimize
use
aquaculture.
Additionally,
paraprobiotics,
or
non-viable
microbial
cells,
present
safer
criticized
even
live
environments
where
viability
poses
risk.
These
inactivated
cells
retain
ability
modulate
immune
system
improve
gut
health,
offering
complementary
approach
prevention.
advocates
for
systematic
combining
research,
innovation,
collaboration
effectively
integrate
farming
practices.
Furthermore,
mechanisms
by
which
microbiota,
produce
antimicrobial
compounds,
strengthen
fish’s
have
been
elucidated.
Moreover,
practical
applications
farming,
including
optimal
administration
methods
limitations
faced
industry,
discussed.
Emphasis
on
importance
continued
research
explore
new
paraprobiotic
develop
innovative
delivery
systems
ensure
sustainability
has
By
reducing
need
antibiotics,
improving
quality,
probiotics,
contribute
more
environmentally
responsible
operations.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Introduction
The
increasing
stress
of
modern
life
has
led
to
a
decline
in
immunity,
sparking
widespread
interest
new
strategies
boost
immune
function.
Lactiplantibacillus
plantarum
and
stachyose
have
gained
attention
for
their
immune-regulating
effects,
but
the
mechanisms
combined
application
remain
unclear.
This
study
aims
investigate
immunoregulatory
effects
CCFM8661
with
cyclophosphamide-induced
immunocompromised
mice.
Methods
Mice
were
divided
into
normal
control
group,
model
group
(normal
saline),
positive
drug
(levamisole
hydrochloride,
10
mg/kg),
low,
medium,
high-dose
groups
(1.5×10
5
,
1.5×10
6
7
CFU
+
1.5
mg
stachyose).
Each
treatment
received
continuous
oral
gavage
administration
28
days.
On
days
23
24,
except
all
other
intraperitoneally
injected
cyclophosphamide
(40
mg/kg)
establish
an
immunosuppressed
model.
day
28,
30
minutes
after
final
administration,
mice
euthanized
collect
thymus,
spleen,
serum,
ileum,
feces
subsequent
analysis
indicators,
intestinal
barrier
function,
serum
cytokines,
microbiota.
Results
combination
significantly
improved
organ
atrophy,
restored
morphology,
normalized
cytokine
levels
mice,
indicating
enhanced
Additionally,
it
microbiota
diversity
by
abundance
Muribaculaceae
while
reducing
Lachnospiraceae
potentially
promoting
homeostasis.
Discussion
immune-enhancing
achieved
regulating
inflammation
maintaining
