Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3322 - 3322
Опубликована: Март 15, 2024
The
highly
conserved
Notch
signaling
pathway
affects
embryonic
development,
neurogenesis,
homeostasis,
tissue
repair,
immunity,
and
numerous
other
essential
processes.
Although
previous
studies
have
demonstrated
the
location
function
of
core
components
in
various
animal
phyla,
a
more
comprehensive
summary
lower
organisms
is
still
required.
In
this
review,
we
objectively
summarize
molecular
features
constituents,
their
current
expression
profiles,
functions
invertebrates,
with
emphasis
on
effects
neurogenesis
regeneration.
We
also
analyze
evolution
facets
hope
that
contents
review
will
be
useful
to
interested
researchers.
Язык: Английский
Self-organization of an organizer: Whole-body regeneration from reaggregated cells in cnidarians
Cells and Development,
Год журнала:
2025,
Номер
unknown, С. 204024 - 204024
Опубликована: Апрель 1, 2025
Язык: Английский
Form, function, mind: what doesn’t compute (and what might)
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
721, С. 150141 - 150141
Опубликована: Май 18, 2024
The
applicability
of
computational
and
dynamical
systems
models
to
organisms
is
scrutinized,
using
examples
from
developmental
biology
cognition.
Developmental
morphogenesis
dependent
on
the
inherent
material
properties
developing
animal
(metazoan)
tissues,
a
non-computational
modality,
but
cell
differentiation,
which
utilizes
chromatin-based
revisable
memory
banks
program-like
function-calling,
via
gene
co-expression
system
unique
metazoans,
has
quasi-computational
basis.
Multi-attractor
are
argued
be
misapplied
global
development,
it
suggested
that
along
with
computationalism,
classic
forms
dynamicism
similarly
unsuitable
accounting
for
cognitive
phenomena.
Proposals
made
treating
brains
other
nervous
tissues
as
novel
excitable
matter
enable
intensification
cell-based
basal
cognition
capabilities
present
throughout
tree
life.
Finally,
some
connections
drawn
between
viewpoint
described
here
active
inference
cognition,
such
Free
Energy
Principle.
Язык: Английский
Piezo proteins, mechano reception and behaviour in Hydra
María Eugenia Alzugaray,
María Victoria Gavazzi,
Lucía Griffo
и другие.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 22, 2025
Cells
are
constantly
exposed
to
mechanical
forces.
These
stimuli
must
be
detected
and
transduced
maintain
homeostasis.
Due
that
reason,
mechano-sensory
systems
(MS)
present
in
all
the
organisms
generate
appropriate
responses.
Piezo
proteins
a
recently
discovered
family
of
mechano-gated
ion
channels
responds
changes
plasma
membrane,
allowing
influx
cations,
mainly
Ca2+.
MS
widely
represented
Metazoa,
acting
several
physiological
systems.
Hydra
sp.
is
freshwater
member
phylum
Cnidaria
which
assumed
as
sister
group
Bilateria.
Despite
existence
known,
their
roles
remain
unknown.
In
this
work
we
delve
into
relevance
responses
associated
We
analysed
effects
Jedi1
(a
specific
agonist
Piezo1)
on
contractile
behaviours,
cnidocyst
discharge,
compared
them
with
caused
by
natural
stimuli.
The
results
show
activation
increases
behaviour,
stimulating
occurrence
contraction
burst,
sudden
kind
retraction
observed
response
touch
osmotic
stress.
Cnidocyst
discharge
was
also
induced
Jedi1,
resembling
contact
prey.
both
were
avoided
presence
inhibitor
GdCl3.
bioinformatic
analysis
shows
protein
predicted
genome
has
characteristic
motifs
proteins.
consistent
Hydra,
unveiling
roles.
Because
pathological
conditions
high
level
conservation
metazoans,
could
provide
significative
experimental
model
assay
biological
pharmacological
issues.
Язык: Английский
Parallel evolution of gravity sensing
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Март 7, 2024
Omnipresent
gravity
affects
all
living
organisms;
it
was
a
vital
factor
in
the
past
and
current
bottleneck
for
future
space
exploration.
However,
little
is
known
about
evolution
of
sensing
comparative
biology
reception.
Here,
by
tracing
parallel
sensing,
we
encounter
situations
when
assemblies
homologous
modules
result
emergence
non-homologous
structures
with
similar
systemic
properties.
This
perfect
example
to
study
homoplasy
at
levels
biological
organization.
Apart
from
numerous
practical
implementations
bioengineering
astrobiology,
diversity
signaling
presents
unique
reference
paradigms
understand
hierarchical
homology
transitions
convergent
integrative
systems.
Second,
comparing
gravisensory
systems
major
superclades
basal
metazoans
(ctenophores,
sponges,
placozoans,
cnidarians,
bilaterians),
illuminate
alternative
solutions
implemented
toward
spatial
orientation,
focusing
on
gravitational
sensitivity
locomotory
Язык: Английский
Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals
Animal Cognition,
Год журнала:
2023,
Номер
26(6), С. 1851 - 1864
Опубликована: Ноя. 1, 2023
Язык: Английский
A functional network model for body column neural connectivity in Hydra
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Abstract
Hydra
is
a
non-senescent
animal
with
relatively
small
number
of
cell
types
and
overall
low
structural
complexity,
but
surprisingly
rich
behavioral
repertoire.
The
main
drivers
’s
behavior
are
neurons
that
arranged
in
two
nerve
nets
comprising
several
distinct
neuronal
populations.
Among
these
populations
the
ectodermal
net
N3
which
located
throughout
animal.
It
has
been
shown
necessary
sufficient
for
complex
somersaulting
also
involved
feeding
behavior.
Despite
being
jack-of-all-trades,
there
insufficient
knowledge
on
coupling
structure
N3,
its
connectome,
role
activity
propagation
function.
We
construct
model
connectome
part
body
column.
Using
experimental
data
placement
somata
spatial
dimensions
column,
we
show
generative
network
combining
non-random
preferred
orientation
primary
neurites
yields
good
agreement
experimentally
observed
distributions
connection
distances,
angles,
per
neuron.
Having
validated
this
fashion,
place
simple
excitable
dynamical
each
node
column
it
generates
directed,
short-lived,
fast
propagating
patterns
activity.
In
addition,
by
slightly
changing
parameters
model,
same
can
generate
persistent
Finally,
use
neuromorphic
circuit
based
Morris-Lecar
to
can,
addition
through-conductance
biologically
plausible
time
scales,
host
pattern
related
somersaulting.
speculate
such
different
regimes
act
as
substrates
functional
roles
allowing
exhibit
complexity
nervous
system
does
not
possess
modules
or
hubs.
Язык: Английский
Piezo Proteins, Mechano Reception and Behaviour in Hydra
María Eugenia Alzugaray,
María Victoria Gavazzi,
Lucía Griffo
и другие.
Опубликована: Ноя. 7, 2024
Abstract
Cells
are
constantly
exposed
to
mechanical
forces.
These
stimuli
must
be
detected
and
transduced
maintain
homeostasis.
Due
that
reason,
mechano-sensory
systems
(MS)
present
in
all
the
organisms
generate
appropriate
responses.
Piezo
proteins
a
recently
discovered
family
of
mechano-gated
ion
channels
respond
changes
plasma
membrane,
allowing
influx
cations,
mainly
Ca
2+.
MS
widely
represented
Metazoa,
acting
several
physiological
systems.
Hydra
sp.
is
freshwater
member
phylum
Cnidaria
which
assumed
as
sister
group
Bilateria.
Despite
existence
known,
their
roles
remain
unknown.
In
this
work
we
delve
into
relevance
responses
associated
We
analysed
effects
Jedi1
(a
specific
agonist
Piezo1)
on
contractile
behaviours,
cnidocyst
discharge,
compared
them
with
caused
by
natural
stimuli.
The
results
show
activation
increases
behaviour,
stimulating
occurrence
contraction
burst,
sudden
kind
retraction
observed
response
touch
osmotic
stress.
Cnidocyst
discharge
was
also
induced
Jedi1,
resembling
contact
prey.
both
were
avoided
presence
inhibitor
GdCl3.
bioinformatic
analysis
shows
protein
predicted
genome
has
characteristic
motifs
proteins.
confirm
Hydra,
unveiling
roles.
Because
pathological
conditions
high
level
conservation
metazoans,
could
provide
significative
experimental
model
assay
biological
pharmacological
issues.
Язык: Английский
Behavioural, Teratogenic and Genotoxic Effects of Antibacterial Compounds, Triclocarban and Triclosan, in Hydra vulgaris
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 23, 2024
ABSTRACT
Triclocarban
(TCC)
and
triclosan
(TCS)
are
antibacterial
compounds
used
in
household,
veterinary,
industrial
personal
care
products,
which
known
to
be
environmental
pollutants
also
toxic
organisms.
The
toxicological
effects
of
these
chemicals
on
higher
organisms
have
been
studied
detail.
But
lower
invertebrates
like
hydra,
it
is
still
rare
yet
explored.
In
this
study,
the
two
Hydra
vulgaris
was
performed
clearly
understand
organismal,
developmental,
molecular
behavioural
changes.
Both
TCC
TCS
with
respective
LC
50
values
0.09
0.25
mg/L,
whereas
comparatively
more
than
TCS.
structural
damage
battery
cell
complexes
(BCCs)
tentacles
observed
ultimately
made
prey
capturing
difficult.
It
evident
that
exposure
caused
developmental
toxicity
by
affecting
reproduction
regeneration
H.
at
sublethal
doses
(0.045
0.125
respectively).
DNA
resulting
apoptosis.
This
study
further
reveals
teratogenic
genotoxic
Язык: Английский