Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3322 - 3322

Published: March 15, 2024

The highly conserved Notch signaling pathway affects embryonic development, neurogenesis, homeostasis, tissue repair, immunity, and numerous other essential processes. Although previous studies have demonstrated the location function of core components in various animal phyla, a more comprehensive summary lower organisms is still required. In this review, we objectively summarize molecular features constituents, their current expression profiles, functions invertebrates, with emphasis on effects neurogenesis regeneration. We also analyze evolution facets hope that contents review will be useful to interested researchers.

Language: Английский

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Self-organization of an organizer: Whole-body regeneration from reaggregated cells in cnidarians

Cells and Development, Journal Year: 2025, Volume and Issue: unknown, P. 204024 - 204024

Published: April 1, 2025

Language: Английский

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Form, function, mind: what doesn’t compute (and what might)

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 721, P. 150141 - 150141

Published: May 18, 2024

The applicability of computational and dynamical systems models to organisms is scrutinized, using examples from developmental biology cognition. Developmental morphogenesis dependent on the inherent material properties developing animal (metazoan) tissues, a non-computational modality, but cell differentiation, which utilizes chromatin-based revisable memory banks program-like function-calling, via gene co-expression system unique metazoans, has quasi-computational basis. Multi-attractor are argued be misapplied global development, it suggested that along with computationalism, classic forms dynamicism similarly unsuitable accounting for cognitive phenomena. Proposals made treating brains other nervous tissues as novel excitable matter enable intensification cell-based basal cognition capabilities present throughout tree life. Finally, some connections drawn between viewpoint described here active inference cognition, such Free Energy Principle.

Language: Английский

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Piezo proteins, mechano reception and behaviour in Hydra

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Cells are constantly exposed to mechanical forces. These stimuli must be detected and transduced maintain homeostasis. Due that reason, mechano-sensory systems (MS) present in all the organisms generate appropriate responses. Piezo proteins a recently discovered family of mechano-gated ion channels responds changes plasma membrane, allowing influx cations, mainly Ca2+. MS widely represented Metazoa, acting several physiological systems. Hydra sp. is freshwater member phylum Cnidaria which assumed as sister group Bilateria. Despite existence known, their roles remain unknown. In this work we delve into relevance responses associated We analysed effects Jedi1 (a specific agonist Piezo1) on contractile behaviours, cnidocyst discharge, compared them with caused by natural stimuli. The results show activation increases behaviour, stimulating occurrence contraction burst, sudden kind retraction observed response touch osmotic stress. Cnidocyst discharge was also induced Jedi1, resembling contact prey. both were avoided presence inhibitor GdCl3. bioinformatic analysis shows protein predicted genome has characteristic motifs proteins. consistent Hydra, unveiling roles. Because pathological conditions high level conservation metazoans, could provide significative experimental model assay biological pharmacological issues.

Language: Английский

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Parallel evolution of gravity sensing

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 7, 2024

Omnipresent gravity affects all living organisms; it was a vital factor in the past and current bottleneck for future space exploration. However, little is known about evolution of sensing comparative biology reception. Here, by tracing parallel sensing, we encounter situations when assemblies homologous modules result emergence non-homologous structures with similar systemic properties. This perfect example to study homoplasy at levels biological organization. Apart from numerous practical implementations bioengineering astrobiology, diversity signaling presents unique reference paradigms understand hierarchical homology transitions convergent integrative systems. Second, comparing gravisensory systems major superclades basal metazoans (ctenophores, sponges, placozoans, cnidarians, bilaterians), illuminate alternative solutions implemented toward spatial orientation, focusing on gravitational sensitivity locomotory

Language: Английский

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Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals

Animal Cognition, Journal Year: 2023, Volume and Issue: 26(6), P. 1851 - 1864

Published: Nov. 1, 2023

Language: Английский

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A functional network model for body column neural connectivity in Hydra

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Abstract Hydra is a non-senescent animal with relatively small number of cell types and overall low structural complexity, but surprisingly rich behavioral repertoire. The main drivers ’s behavior are neurons that arranged in two nerve nets comprising several distinct neuronal populations. Among these populations the ectodermal net N3 which located throughout animal. It has been shown necessary sufficient for complex somersaulting also involved feeding behavior. Despite being jack-of-all-trades, there insufficient knowledge on coupling structure N3, its connectome, role activity propagation function. We construct model connectome part body column. Using experimental data placement somata spatial dimensions column, we show generative network combining non-random preferred orientation primary neurites yields good agreement experimentally observed distributions connection distances, angles, per neuron. Having validated this fashion, place simple excitable dynamical each node column it generates directed, short-lived, fast propagating patterns activity. In addition, by slightly changing parameters model, same can generate persistent Finally, use neuromorphic circuit based Morris-Lecar to can, addition through-conductance biologically plausible time scales, host pattern related somersaulting. speculate such different regimes act as substrates functional roles allowing exhibit complexity nervous system does not possess modules or hubs.

Language: Английский

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Piezo Proteins, Mechano Reception and Behaviour in Hydra

Published: Nov. 7, 2024

Cells are constantly exposed to mechanical forces. These stimuli must be detected and transduced maintain homeostasis. Due that reason, mechano-sensory systems (MS) present in all the organisms generate appropriate responses. Piezo proteins a recently discovered family of mechano-gated ion channels respond changes plasma membrane, allowing influx cations, mainly Ca²⁺. MS widely represented Metazoa, acting several physiological systems. Hydra sp. is freshwater member phylum Cnidaria which assumed as sister group Bilateria. Despite existence known, their roles remain unknown. In this work we delve into relevance responses associated We analysed effects Jedi1 (a specific agonist Piezo1) on contractile behaviours, cnidocyst discharge, compared them with caused by natural stimuli. The results show activation increases behaviour, stimulating occurrence contraction burst, sudden kind retraction observed response touch osmotic stress. Cnidocyst discharge was also induced Jedi1, resembling contact prey. both were avoided presence inhibitor GdCl3. bioinformatic analysis shows protein predicted genome has characteristic motifs proteins. confirm Hydra, unveiling roles. Because pathological conditions high level conservation metazoans, could provide significative experimental model assay biological pharmacological issues.

Language: Английский

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Behavioural, Teratogenic and Genotoxic Effects of Antibacterial Compounds, Triclocarban and Triclosan, in Hydra vulgaris

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

ABSTRACT Triclocarban (TCC) and triclosan (TCS) are antibacterial compounds used in household, veterinary, industrial personal care products, which known to be environmental pollutants also toxic organisms. The toxicological effects of these chemicals on higher organisms have been studied detail. But lower invertebrates like hydra, it is still rare yet explored. In this study, the two Hydra vulgaris was performed clearly understand organismal, developmental, molecular behavioural changes. Both TCC TCS with respective LC 50 values 0.09 0.25 mg/L, whereas comparatively more than TCS. structural damage battery cell complexes (BCCs) tentacles observed ultimately made prey capturing difficult. It evident that exposure caused developmental toxicity by affecting reproduction regeneration H. at sublethal doses (0.045 0.125 respectively). DNA resulting apoptosis. This study further reveals teratogenic genotoxic

Language: Английский

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