
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 4, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 4, 2024
Язык: Английский
Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9
Опубликована: Янв. 1, 2025
Studies have shown that gamma (40 Hz) audiovisual stimulation can enhance oscillations and improve cognitive functioning in patients with Alzheimer's disease. However, despite promising long-term results, the efficacy of short-duration or single-session 40 Hz entrainment humans has been questioned by behavioral studies fail to find observable aftereffects, for two possible reasons: 1) lack validated entrainment, as most lacked concurrent electroencephalography (EEG) data verify neural did take place, 2) diverse tests, not test a wide range factors. This study aimed increase sensitivity detecting entrainment. We employed mid- post-stimulation EEG monitoring ensure worked, comprehensive battery probes perception, attention, working memory, memory. Participants received 30 min synchronized light sound stimulation, followed visual perceptual task, attentional network change detection memory picture EEG. observed robust during but no significant oscillation after improvements. Despite online sensory requires consistent exposure induce neurological changes. Future research should determine optimal duration frequency maximize its therapeutic potential.
Язык: Английский
Процитировано
0PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0321633 - e0321633
Опубликована: Май 20, 2025
With recent advances in the potential usage of visual gamma stimulation at 40 Hz for treatment Alzheimer’s disease, there is motivation to evaluate adjacent frequencies ensure that specifically optimal. As with luminance flicker may affect adherence clinical trials due its inherent perceived flickering, invisible spectral (ISF) was proposed as a more comfortable alternative entraining Hz. Based on current understanding mechanism action stimulation, exact frequency debatable. This study investigates ability ISF evoke acute responses several range 36–44 Twenty healthy volunteers were included an electroencephalography (EEG) experiment nine different (36–44 Hz, 1 interval). Estimated signal-to-noise ratios (SNR) showed cortical power significantly increased all compared baseline, but no significant difference SNR between frequencies. There subject effect, suggesting higher variability subjects than alone. Our results indicate can steady-state potentials low Across population participants, preference or trend any specific tested found. While subject-stimulus interaction significant, it described little variance and patterns individual frequency.
Язык: Английский
Процитировано
0Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
Background Multi-luminaire light stimulation is a novel technique based on luminance flicker with low modulation depth created by two spatially adjacent sources aimed to deliver 40 Hz neural while reducing discomfort, offering potential non-pharmacological, noninvasive, and in-home interventions for Alzheimer's disease dementia. However, these cognitive effects have never been validated electroencephalography (EEG). Objective In this study we aim assess the ability of multi-luminaire evoke EEG response under conditions: direct viewing indirect viewing. Methods The M + BrainCare Delta Electronics was used in study. Participants were stimulated either directly looking at (direct condition), or off reflection from piece paper mimic everyday reading (indirect condition). power conditions compared positive control 100% (stroboscopic flicker). Results both conditions, there no significant oscillations. contrast, stroboscopic elicited robust entrainment all participants, propagating frontal regions. Conclusions Our results question efficacy technology, specifically light, evoking responses. Future studies involving technology should pay special attention validation prior making claims about oscillation brain health.
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 4, 2024
Язык: Английский
Процитировано
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