Re-evaluating the choice of gamma stimulation frequency for the potential treatment of Alzheimer’s disease DOI Creative Commons
Mark Alexander Henney, Bianca L. Hansen, Luna Skytte Hansen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Abstract With recent advances in the potential usage of visual gamma stimulation at 40 Hz for treatment Alzheimer’s disease, there is motivation to evaluate adjacent frequencies ensure that specifically optimal.The choice based on studies over several decades describe "40 Hz" oscillations with considerable frequency variability.As luminance flicker may affect adherence clinical trials due its inherent perceived flickering, invisible spectral (ISF) was proposed as a more comfortable alternative entraining Hz. This study investigates ability ISF evoke acute responses range 36-44 Twenty healthy volunteers were included an electroencephalography (EEG) experiment initial eyes-open baseline recording followed by paradigm using nine different (36-44 Hz, 1 interval). The evaluated signal-to-noise ratio (SNR) averaged occipital electrodes and analysed mixed-effect models. Evoked compared between frequencies. estimated SNR values showed EEG power significantly increased all baseline, but no significant difference There subject effect, even when disregarding one who responded 1-2 orders magnitude higher than others. These results suggest variability subjects alone. Our indicate can induce steady-state visually evoked potentials low Across population participants, preference or trend any specific tested found. While subject-stimulus interaction significant, it described little variance patterns individual frequency.

Language: Английский

Single-session gamma sensory stimulation entrains real-time electroencephalography but does not enhance perception, attention, short-term memory, or long-term memory DOI Creative Commons

Chi-Chen Wu,

Ting Yin Lin,

Yu‐Hui Lo

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Studies have shown that gamma (40 Hz) audiovisual stimulation can enhance oscillations and improve cognitive functioning in patients with Alzheimer's disease. However, despite promising long-term results, the efficacy of short-duration or single-session 40 Hz entrainment humans has been questioned by behavioral studies fail to find observable aftereffects, for two possible reasons: 1) lack validated entrainment, as most lacked concurrent electroencephalography (EEG) data verify neural did take place, 2) diverse tests, not test a wide range factors. This study aimed increase sensitivity detecting entrainment. We employed mid- post-stimulation EEG monitoring ensure worked, comprehensive battery probes perception, attention, working memory, memory. Participants received 30 min synchronized light sound stimulation, followed visual perceptual task, attentional network change detection memory picture EEG. observed robust during but no significant oscillation after improvements. Despite online sensory requires consistent exposure induce neurological changes. Future research should determine optimal duration frequency maximize its therapeutic potential.

Language: Английский

Citations

0
Re-evaluating the choice of gamma stimulation frequency for the potential treatment of Alzheimer’s disease DOI Creative Commons
Mark Alexander Henney, Bianca L. Hansen, Luna Skytte Hansen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Abstract With recent advances in the potential usage of visual gamma stimulation at 40 Hz for treatment Alzheimer’s disease, there is motivation to evaluate adjacent frequencies ensure that specifically optimal.The choice based on studies over several decades describe "40 Hz" oscillations with considerable frequency variability.As luminance flicker may affect adherence clinical trials due its inherent perceived flickering, invisible spectral (ISF) was proposed as a more comfortable alternative entraining Hz. This study investigates ability ISF evoke acute responses range 36-44 Twenty healthy volunteers were included an electroencephalography (EEG) experiment initial eyes-open baseline recording followed by paradigm using nine different (36-44 Hz, 1 interval). The evaluated signal-to-noise ratio (SNR) averaged occipital electrodes and analysed mixed-effect models. Evoked compared between frequencies. estimated SNR values showed EEG power significantly increased all baseline, but no significant difference There subject effect, even when disregarding one who responded 1-2 orders magnitude higher than others. These results suggest variability subjects alone. Our indicate can induce steady-state visually evoked potentials low Across population participants, preference or trend any specific tested found. While subject-stimulus interaction significant, it described little variance patterns individual frequency.

Language: Английский

Citations

0