Pharmacological Approaches to Hearing Loss
Pharmacological Reviews,
Год журнала:
2024,
Номер
76(6), С. 1063 - 1088
Опубликована: Окт. 16, 2024
Hearing
disorders
pose
significant
challenges
to
individuals
experiencing
them
and
their
overall
quality
of
life,
emphasizing
the
critical
need
for
advanced
pharmacological
approaches
address
these
conditions.
Current
treatment
options
often
focus
on
amplification
devices,
cochlear
implants,
or
other
rehabilitative
therapies,
leaving
a
substantial
gap
regarding
effective
interventions.
Advancements
in
our
understanding
molecular
cellular
mechanisms
involved
hearing
induced
by
noise,
aging,
ototoxicity
have
opened
new
avenues
drug
development,
some
which
led
numerous
clinical
trials,
with
promising
results.
The
development
optimal
delivery
solutions
animals
humans
can
also
enhance
targeted
medications
ear.
Moreover,
large
genome
studies
contributing
genetic
loss
combined
technologies
animal
shown
great
potential
increase
etiologies
loss.
auditory
system
exhibits
circadian
rhythms
temporal
variations
its
physiology,
vulnerability
insults,
responsiveness
treatments.
clock
are
under
control
glucocorticoid
system,
preclinical
evidence
suggests
that
risk/benefit
profile
disorder
treatments
using
chronopharmacological
would
be
beneficial.
If
translatable
bedside,
such
may
improve
outcome
trials.
Ongoing
research
into
basis
disorders,
coupled
advancements
formulation
as
well
optimized
timing
administration,
holds
promise
more
SIGNIFICANCE
STATEMENT:
procedures
Язык: Английский
Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics
Development,
Год журнала:
2024,
Номер
151(23)
Опубликована: Ноя. 29, 2024
ABSTRACT
Human
inner
ear
organoids
are
three-dimensional
tissular
structures
grown
in
vitro
that
recapitulate
some
aspects
of
the
fetal
and
allow
differentiation
cell
types.
These
offer
a
system
which
to
study
human
development,
mutations
causing
hearing
loss
vertigo,
new
therapeutic
drugs.
However,
extent
such
mimic
vivo
development
cellular
composition
remains
unclear.
Several
recent
studies
have
performed
single-cell
transcriptomics
on
interrogate
heterogeneity,
reveal
developmental
trajectories
sensory
lineages
compare
organoid-derived
vesicles
developing
ear.
Here,
we
discuss
insights
provided
by
these
analyses
help
define
paths
investigation
understand
development.
Язык: Английский
Synthetically programming natural cell-cell communication pathways for tissue engineering
Leah A. Wallach,
Connor D. Thomas,
Pulin Li
и другие.
Current Opinion in Biomedical Engineering,
Год журнала:
2024,
Номер
32, С. 100554 - 100554
Опубликована: Авг. 24, 2024
Язык: Английский
The Rise of Cochlear Gene Therapy
Molecular Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Recent
evidence
provides
strong
support
for
the
safe
and
effective
use
of
gene
therapy
in
humans
with
hearing
loss.
By
means
a
single
local
injection
set
adeno-associated
virus
(AAV)
vectors,
was
partially
restored
several
children
neurosensory
nonsyndromic
autosomal
recessive
deafness
9
(DFNB9),
harboring
variants
OTOF
gene.
Current
research
focuses
on
refining
endoscopic
transmastoid
procedures
to
reduce
risks
side
effects,
as
emerging
suggests
bidirectional
fluid
exchanges
between
ear
brain.
Moreover,
editing
approaches
novel
AAV
capsids
are
successfully
tested
animal
models
will
likely
lead
enhanced
targeting
cochlea.
Here,
we
cover
recent
advances
cochlear
therapy,
provide
an
overview
translational
potential
these
new
existing
future
clinical
trials,
highlight
implications
that
remain
be
determined
their
application
humans.Graphical
abstract
Язык: Английский