Clinical significance of serum CXCL9, CXCL10, and CXCL11 in patients with lupus nephritis DOI Creative Commons
Shuo Wang, Yanhui Cui

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(8)

Опубликована: Авг. 1, 2024

Lupus nephritis (LN) is an autoimmune disease as a complication of systemic lupus erythematosus (SLE). LN typically diagnosed through combination clinical evaluation index scoring, and kidney biopsy more accurate but invasive examination. In the current study, we assessed serological markers including IFN-γ-inducible chemokines C-X-C motif chemokine ligand (CXCL)9, CXCL10, CXCL11 in diagnosing LN.

Язык: Английский

Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes DOI Creative Commons
Zhang Li, Yang Luo, Haili Shen

и другие.

Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 23, 2025

Rheumatoid arthritis (RA) is a prevalent autoimmune disorder primarily targeting the diarthrodial joints. During progression of RA, fibroblast-like synoviocytes (FLSs) exhibit tumor-like behavior, including increased proliferation, inflammation mediation, and aggressive phenotypes, leading to bone erosion. Additionally, T cells in RA acquire pro-inflammatory characteristics, exacerbating inflammatory environment affected joints associated tissues. Notably, senescent contribute inflammation, further accelerating disease process. Metabolic changes rheumatoid FLSs not only maintain their properties but also trigger cascades, particularly affecting lymphocytes. This review examines molecular alterations context systemic immune aging, with focus on thymic insufficiency-associated cell senescence, explores potential therapeutic avenues.

Язык: Английский

Процитировано

0
The role of CXCL9, CXCL10, and CXCL13 chemokines in patients with Sjögren’s syndrome DOI
Selda Hakbilen, Dilek Tezcan, Duygu Eryavuz Onmaz

и другие.

Clinical Rheumatology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Язык: Английский

Процитировано

0
Unveiling the Crucial Role of CD8+ T Cell and Endothelial Cell Interaction in Rheumatoid Arthritis through the Integrated Analysis of Spatial Transcriptomics and Bulk/Single-Cell RNA-Seq DOI Creative Commons

Yu Lai,

Zishao Zhong, Runze Li

и другие.

Journal of Translational Autoimmunity, Год журнала: 2025, Номер 10, С. 100285 - 100285

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0
Establishment of immortalized human minor salivary gland cells and chemokine expression induced by IFN-γ, TNF-α, and IL-1β DOI

Takako Naruse,

Kouji Ohta, Misaki Akagi

и другие.

Odontology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary Sjögren's syndrome DOI Creative Commons
Jun Huang,

Jia Tang,

Chen Zhang

и другие.

Journal of Translational Autoimmunity, Год журнала: 2024, Номер 9, С. 100248 - 100248

Опубликована: Июль 16, 2024

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder with an unclear pathogenetic mechanism in the labial gland. This study aims to investigate cellular and molecular mechanisms contributing development of this disease.

Язык: Английский

Процитировано

1
Clinical significance of serum CXCL9, CXCL10, and CXCL11 in patients with lupus nephritis DOI Creative Commons
Shuo Wang, Yanhui Cui

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(8)

Опубликована: Авг. 1, 2024

Lupus nephritis (LN) is an autoimmune disease as a complication of systemic lupus erythematosus (SLE). LN typically diagnosed through combination clinical evaluation index scoring, and kidney biopsy more accurate but invasive examination. In the current study, we assessed serological markers including IFN-γ-inducible chemokines C-X-C motif chemokine ligand (CXCL)9, CXCL10, CXCL11 in diagnosing LN.

Язык: Английский

Процитировано

0