Impact of Physiological and Psychological Stress on Glaucoma Development and Progression: A Narrative Review
Medicina,
Год журнала:
2025,
Номер
61(3), С. 418 - 418
Опубликована: Фев. 27, 2025
Glaucoma
is
a
leading
cause
of
irreversible
blindness
worldwide.
Presently,
elevated
intraocular
pressure
(IOP)
the
only
approved
modifiable
risk
factor.
A
consensus
current
literature
suggests
that
both
physiological
and
psychological
stress
may
also
impact
lifelong
course
glaucoma.
Specifically,
known
to
influence
sympathetic
nervous
system
activity.
An
increase
in
activity
elevate
person’s
blood
(BP)
IOP,
are
strongly
associated
with
glaucomatous
disease.
Anxiety
depression
have
more
conflicting
evidence
relation
Socioeconomic
environmental
worsen
adherence
therapy
disease
outcomes
due
lack
financial
resources
related
access
healthcare.
Neighborhood
quality
conditions,
particularly
urban
environments,
been
glaucoma
factors,
higher
prevalence,
delayed
surgical
interventions.
Racial
differences
identified,
Black
patients
being
stressed
likely
present
increased
severity
faster
progression
than
White
patients.
Mindfulness,
meditation,
other
forms
relaxation
shown
reduce
IOP
biomarkers
result
improved
life
(QOL).
Larger
studies
diverse
populations
needed
clarify
identify
best
therapeutic
approaches
as
method
improve
clinical
QOL
for
Язык: Английский
Survivorship Considerations and Management in the Adolescent and Young Adult Sarcoma Population: A Review
Current Oncology,
Год журнала:
2025,
Номер
32(4), С. 214 - 214
Опубликована: Апрель 3, 2025
Soft
tissue
sarcoma
(STS)
has
an
2–8%
incidence
for
all
malignant
tumors
in
the
adolescent
and
young
adult
(AYA)
population,
which
are
patients
from
ages
15
to
39.
As
most
STS
aggressive,
they
require
multimodal
management
with
surgery,
radiation
chemotherapy.
This
article
discusses
survivorship
considerations
this
population
of
cancer
who
complete
therapy.
The
lasting
side
effects
include
surgical
radiation-related
morbidity,
chemotherapy
toxicity,
early
late
secondary
on
other
organ
systems,
such
as
cardiac
endocrine
dysfunction,
development
cancers.
long-term
psychologic
practical
impacts
those
have
received
a
diagnosis
prime
their
life
fertility,
mental
health,
relationship,
education
career
implications.
Although
there
is
paucity
data
some
these
areas,
we
present
existing
guidelines
available.
serves
comprehensive
review
wide
array
treatment
intended
providers
participating
care
AYA
survivors,
oncologists,
primary
therapists.
Язык: Английский
The role of tea in managing cardiovascular risk factors: potential benefits, mechanisms, and interventional strategies
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 24, 2025
Traditional
major
cardiovascular
disease
(CVD)
risk
factors
include
dyslipidemia,
hypertension,
smoking,
diabetes,
and
obesity.
Tea
is
rich
in
various
bioactive
substances
such
as
tea
polyphenols,
theaflavins,
polysaccharides.
Due
to
the
regulatory
effects
on
multiple
pathways
its
anti-inflammatory
antioxidant
properties,
these
active
have
shown
significant
efficacy
regulating
obesity,
cardiac
autonomic
function.
Additionally,
possesses
antithrombotic
making
it
a
promising
dietary
supplement
for
nutritional
interventions
primary
secondary
prevention
of
CVDs.
However,
complex
composition
tea,
although
certain
vivo,
does
not
fully
elucidate
specific
mechanisms
action.
Moreover,
varying
application
methods
across
different
studies
lead
differences
intervention
dose-response
relationships,
sometimes
resulting
contradictory
findings.
This
article
reviews
potential
benefits,
action,
factors,
elucidating
intervention.
Язык: Английский
Enhancing Heart Attack Prediction: Feature Identification from Multiparametric Cardiac Data Using Explainable AI
Algorithms,
Год журнала:
2025,
Номер
18(6), С. 333 - 333
Опубликована: Июнь 2, 2025
Heart
attack
is
a
leading
cause
of
mortality,
necessitating
timely
and
precise
diagnosis
to
improve
patient
outcomes.
However,
remains
challenge
due
the
complex
nonlinear
relationships
between
clinical
indicators.
Machine
learning
(ML)
deep
(DL)
models
have
potential
predict
cardiac
conditions
by
identifying
patterns
within
data,
but
their
“black-box”
nature
restricts
interpretability,
making
it
challenging
for
healthcare
professionals
comprehend
reasoning
behind
predictions.
This
lack
interpretability
limits
trust
adoption.
The
proposed
approach
addresses
this
limitation
integrating
predictive
modeling
with
Explainable
AI
(XAI)
ensure
both
accuracy
transparency
in
decision-making.
study
enhances
heart
prediction
using
University
California,
Irvine
(UCI)
dataset,
which
includes
various
analysis
parameters
collected
through
electrocardiogram
(ECG)
sensors,
blood
pressure
monitors,
biochemical
analyzers.
Due
class
imbalance,
Synthetic
Minority
Over-sampling
Technique
(SMOTE)
was
applied
enhance
representation
minority
class.
After
preprocessing,
ML
algorithms
were
employed,
among
Artificial
Neural
Networks
(ANN)
achieved
highest
performance
96.1%
accuracy,
95.7%
recall,
F1-score.
To
ANN,
two
XAI
techniques,
specifically
SHapley
Additive
Explanations
(SHAP)
Local
Interpretable
Model-Agnostic
(LIME),
utilized.
incrementally
benchmarks
SMOTE,
techniques
such
as
SHAP
LIME
on
standardized
datasets,
emphasizing
providing
reproducible
framework
practical
implementation.
These
enable
practitioners
understand
model’s
decisions,
identify
key
features,
judgment.
By
bridging
gap
AI-driven
medical
implementation,
work
contributes
highly
accurate
interpretable,
facilitating
its
adoption
real-world
settings.
Язык: Английский
Influence of Brainstem’s Area A5 on Sympathetic Outflow and Cardiorespiratory Dynamics
Biology,
Год журнала:
2024,
Номер
13(3), С. 161 - 161
Опубликована: Март 2, 2024
Area
A5
is
a
noradrenergic
cell
group
in
the
brain
stem
characterised
by
its
important
role
triggering
sympathetic
activity,
exerting
profound
influence
on
outflow,
which
instrumental
modulation
of
cardiovascular
functions,
stress
responses
and
various
other
physiological
processes
that
are
crucial
for
adaptation
survival
mechanisms.
Understanding
area
A5,
therefore,
not
only
provides
insights
into
basic
functioning
nervous
system
but
also
sheds
light
neuronal
basis
number
autonomic
responses.
In
this
review,
we
look
deeper
specifics
exploring
anatomical
connections,
neurochemical
properties
mechanisms
it
influences
activity
cardiorespiratory
regulation
and,
thus,
contributes
to
overall
dynamics
function
regulating
body
homeostasis.
Язык: Английский
Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin
International Immunopharmacology,
Год журнала:
2024,
Номер
145, С. 113711 - 113711
Опубликована: Дек. 7, 2024
Язык: Английский