Survivorship Considerations and Management in the Adolescent and Young Adult Sarcoma Population: A Review

Current Oncology, Journal Year: 2025, Volume and Issue: 32(4), P. 214 - 214

Published: April 3, 2025

Soft tissue sarcoma (STS) has an 2–8% incidence for all malignant tumors in the adolescent and young adult (AYA) population, which are patients from ages 15 to 39. As most STS aggressive, they require multimodal management with surgery, radiation chemotherapy. This article discusses survivorship considerations this population of cancer who complete therapy. The lasting side effects include surgical radiation-related morbidity, chemotherapy toxicity, early late secondary on other organ systems, such as cardiac endocrine dysfunction, development cancers. long-term psychologic practical impacts those have received a diagnosis prime their life fertility, mental health, relationship, education career implications. Although there is paucity data some these areas, we present existing guidelines available. serves comprehensive review wide array treatment intended providers participating care AYA survivors, oncologists, primary therapists.

Language: Английский

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Impact of Physiological and Psychological Stress on Glaucoma Development and Progression: A Narrative Review

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 418 - 418

Published: Feb. 27, 2025

Glaucoma is a leading cause of irreversible blindness worldwide. Presently, elevated intraocular pressure (IOP) the only approved modifiable risk factor. A consensus current literature suggests that both physiological and psychological stress may also impact lifelong course glaucoma. Specifically, known to influence sympathetic nervous system activity. An increase in activity elevate person’s blood (BP) IOP, are strongly associated with glaucomatous disease. Anxiety depression have more conflicting evidence relation Socioeconomic environmental worsen adherence therapy disease outcomes due lack financial resources related access healthcare. Neighborhood quality conditions, particularly urban environments, been glaucoma factors, higher prevalence, delayed surgical interventions. Racial differences identified, Black patients being stressed likely present increased severity faster progression than White patients. Mindfulness, meditation, other forms relaxation shown reduce IOP biomarkers result improved life (QOL). Larger studies diverse populations needed clarify identify best therapeutic approaches as method improve clinical QOL for

Language: Английский

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The role of tea in managing cardiovascular risk factors: potential benefits, mechanisms, and interventional strategies

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 24, 2025

Traditional major cardiovascular disease (CVD) risk factors include dyslipidemia, hypertension, smoking, diabetes, and obesity. Tea is rich in various bioactive substances such as tea polyphenols, theaflavins, polysaccharides. Due to the regulatory effects on multiple pathways its anti-inflammatory antioxidant properties, these active have shown significant efficacy regulating obesity, cardiac autonomic function. Additionally, possesses antithrombotic making it a promising dietary supplement for nutritional interventions primary secondary prevention of CVDs. However, complex composition tea, although certain vivo, does not fully elucidate specific mechanisms action. Moreover, varying application methods across different studies lead differences intervention dose-response relationships, sometimes resulting contradictory findings. This article reviews potential benefits, action, factors, elucidating intervention.

Language: Английский

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Influence of Brainstem’s Area A5 on Sympathetic Outflow and Cardiorespiratory Dynamics

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 161 - 161

Published: March 2, 2024

Area A5 is a noradrenergic cell group in the brain stem characterised by its important role triggering sympathetic activity, exerting profound influence on outflow, which instrumental modulation of cardiovascular functions, stress responses and various other physiological processes that are crucial for adaptation survival mechanisms. Understanding area A5, therefore, not only provides insights into basic functioning nervous system but also sheds light neuronal basis number autonomic responses. In this review, we look deeper specifics exploring anatomical connections, neurochemical properties mechanisms it influences activity cardiorespiratory regulation and, thus, contributes to overall dynamics function regulating body homeostasis.

Language: Английский

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Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113711 - 113711

Published: Dec. 7, 2024

Language: Английский

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