OTORHINOLARYNGOLOGY,
Год журнала:
2023,
Номер
unknown, С. 91 - 100
Опубликована: Янв. 1, 2023
The
structure
of
the
hearing
organ
combines
simplicity
and
depth,
remaining
in
many
issues
subject
active
scientific
research.
ontogenesis
this
exquisite
mechanism
is
regulated
by
complex
still
incompletely
understood
mechanisms.
technological
tools
modern
biomedical
science
allow
not
only
to
study,
but
also
work
at
cellular
molecular
level.
In
article,
we
review
data
on
realism
restoring
population
human
auditory
receptors
promising
ways
solve
problem.
addition,
offer
an
answer
a
fundamental
question
–
why,
with
small
number
relatively
simply
arranged
receptor
cells
inner
ear,
their
self-restored.
Key
words:
spiral
organ,
stem
cells,
progenitors,
impairments,
regeneration,
bioprosthetics,
bioengineering.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 22, 2024
Cochlear
implants
(CI)
have
revolutionized
the
treatment
of
patients
with
severe
to
profound
sensory
hearing
loss
by
providing
a
method
bypassing
normal
directly
stimulate
auditory
nerve.
A
further
advance
in
field
has
been
introduction
“hearing
preservation”
surgery,
whereby
CI
electrode
array
(EA)
is
carefully
inserted
spare
damage
delicate
anatomy
and
function
cochlea.
Preserving
residual
inner
ear
allows
receive
maximal
benefit
from
combine
electric
stimulation
acoustic
hearing,
offering
improved
postoperative
speech,
quality
life
outcomes.
However,
under
current
paradigm
implant
where
EAs
are
hand,
cochlea
cannot
be
reliably
spared
damage.
Robotics-assisted
EA
insertion
an
emerging
technology
that
may
overcome
fundamental
human
kinetic
limitations
prevent
consistency
achieving
steady
slow
insertion.
This
review
begins
describing
relationship
between
speed
generation
intracochlear
forces
pressures.
The
various
mechanisms
which
these
can
lead
worsened
outcomes
discussed.
constraints
manual
technique
compared
robotics-assisted
methods,
followed
overview
future
state
Sensors,
Год журнала:
2024,
Номер
24(11), С. 3307 - 3307
Опубликована: Май 22, 2024
Cochlear
implants
are
crucial
for
addressing
severe-to-profound
hearing
loss,
with
the
success
of
procedure
requiring
careful
electrode
placement.
This
scoping
review
synthesizes
findings
from
125
studies
examining
factors
influencing
insertion
forces
(IFs)
and
intracochlear
pressure
(IP),
which
optimizing
implantation
techniques
enhancing
patient
outcomes.
The
highlights
impact
variables,
including
depth,
speed,
use
robotic
assistance
on
IFs
IP.
Results
indicate
that
higher
speeds
generally
increase
IP
in
artificial
models,
a
pattern
not
consistently
observed
cadaveric
due
to
variations
methodology
sample
size.
study
also
explores
minimal
reducing
compared
manual
methods.
Importantly,
this
underscores
need
standardized
approach
cochlear
implant
research
address
inconsistencies
improve
clinical
practices
aimed
at
preserving
during
implantation.
Frontiers in Materials,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 23, 2024
Sensorineural
hearing
loss
(SNHL)
occurs
when
the
sound
transduction
mechanism
in
inner
ear
is
compromised,
because
of
impairments
affecting
sensory
hair
cells—the
actual
biological
transducers
(90%
cases)—or
neurons.
SNHL
results
a
broad
spectrum
developmental,
cognitive
and
psycho-social
damages.
To
date,
only
cochlear
implants
(CIs)
can
offer
therapeutic
solution
to
patients.
They
are
multi-component
electronic
devices,
surgically
implanted,
which
capture,
elaborate
convert
into
electric
stimuli
delivered
cochlea.
Due
inherent
limitations
current
electronic-based
CIs,
new
class
devices
has
been
envisioned,
based
on
piezoelectric
materials.
However,
using
membranes,
obtained
sensitivity
was
not
enough.
The
frontiers
for
material-based
CI
aim
at
synergizing
micro/nanofabrication
aided
by
multiscale
materials
modeling
with
an
vivo
tissue
engineering
approach
provide
implantable
biomaterial-based
system
SNHL,
acting
as
next-generation
CI.
Specifically,
envisioned
device
will
move
forward
primitive
concept
bulk-structured
CIs
designing
nanostructured
material
(e.g.,
nanofibers)
be
precisely
intimately
efficiently
integrated
microenvironment.
Piezoelectric
indeed
hypothesized
have
much
higher
resolution
electrical
stimulation
more
than
hundreds
channels,
compared
maximum
22
stimulating
elements
present
CIs.
Moreover,
site
closest
peripheral
nerve
fiber
endings
maximal
resolution.
This
would
first
implant
feedback
micrometer
scale.
Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(15), С. 155010 - 155010
Опубликована: Июль 22, 2024
Abstract
Objective.
Despite
the
widespread
use
and
technical
improvement
of
cochlear
implant
(CI)
devices
over
past
decades,
further
research
into
bioelectric
bases
CI
stimulation
is
still
needed.
Various
modes
implemented
by
different
manufacturers
coexist,
but
their
true
clinical
benefit
remains
unclear,
probably
due
to
high
inter-subject
variability
reported,
which
makes
prediction
outcomes
optimal
fitting
parameters
challenging.
A
highly
detailed
full-head
model
that
includes
a
cochlea
an
electrode
array
developed
in
this
study
emulate
intracochlear
voltages
extracochlear
current
pathways
through
head
stimulation.
Approach.
Simulations
based
on
finite
element
method
were
conducted
under
monopolar,
bipolar,
tripolar
(TP),
partial
TP
modes,
as
well
for
apical,
medial,
basal
electrodes.
Variables
simulated
included:
voltages,
electric
field
(EF)
decay,
potentials
at
scalp
currents
head.
To
better
understand
side
effects
such
facial
nerve
stimulation,
caused
spurious
leakage
out
from
cochlea,
special
emphasis
given
analysis
EF
nerve.
Main
results.
The
reasonably
predicts
magnitudes
trends
previously
reported
users.
New
relevant
brain
tissues
have
been
identified.
Simulated
results
also
show
differences
magnitude
distribution
segments
upon
electrodes,
dependent
bone
tissue
conductivities.
Significance.
Full-head
models
prove
useful
tools
intra
EFs
Our
findings
could
design
future
experimental
studies
contrast
FNS
mechanisms
electrodes
modes.
freely
available
community
use.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Despite
the
significant
advantages
of
Shape
Memory
Polymers
(SMPs),
material
processing
and
production
challenges
have
limited
their
applications.
Recent
advances
in
fiber
manufacturing
offer
a
novel
approach
to
polymers,
broadening
functions
fibers
beyond
optical
In
this
study,
thermal
drawing
technique
for
SMPs
fabricate
Polymer
Fibers
(SMPFs)
tailored
medical
applications,
featuring
programmable
stiffness
shape
control
is
developed.
Rheological
differential
scanning
calorimetry
analyses
are
conducted
assess
SMP's
compatibility
with
proposed
process
leading
multilumen,
multimaterial
SMPFs
activated
at
body
temperature.
Different
properties
investigated
three
devices:
stiffness-adjustable
catheters,
softening
neural
interface,
shape-programmable
cochlear
implants.
Comprehensive
characterization
these
devices
demonstrates
potential
thermally
drawn
be
employed
wide
range
applications
demanding
mechanical
properties.
Applied Sciences,
Год журнала:
2024,
Номер
14(22), С. 10408 - 10408
Опубликована: Ноя. 12, 2024
The
cochlear
neuromodulator
provides
substantial
auditory
perception
to
those
with
impaired
hearing.
accurate
insertion
of
electrodes
into
the
cochlea
is
an
important
factor,
as
misplaced
may
lead
further
damage.
impedance
measurement
be
used
a
marker
electrode
guidance.
It
feasible
investigate
impact
dielectric
properties
tissue
layers
on
guidance
using
sophisticated
bio-computational
methods
that
are
impractical
or
impossible
perform
in
implant
(CI)
patients.
Although
previous
modeling
approaches
argued
capacitive
layer
can
neglected
quasi-static
(QS)
approximation
method,
it
widely
accepted
acts
frequency
filter.
Thus,
QS
method
not
always
appropriate
due
short-duration
pulses.
This
study
aimed
frequency-dependent
variation
by
following
systematic
approach.
volume
conductor
model
was
developed,
each
were
attained,
and
settings
applied
obtain
results
based
both
transient
solution
(TS)
methods.
TS
compared
define
what
extent
these
parameters
affect
outcome.
suggested
should
considered
after
certain
level.
