Cell Death and Differentiation,
Год журнала:
2022,
Номер
30(2), С. 258 - 268
Опубликована: Окт. 4, 2022
Abstract
Host
organisms
utilise
a
range
of
genetically
encoded
cell
death
programmes
in
response
to
pathogen
challenge.
can
restrict
proliferation
by
depleting
their
replicative
niche
and
at
the
same
time
dying
cells
alert
neighbouring
prepare
environmental
conditions
favouring
future
attacks.
As
expected,
many
pathogenic
microbes
have
strategies
subvert
host
promote
virulence.
The
structural
lifestyle
differences
between
animals
plants
been
anticipated
shape
very
different
defence
mechanisms.
However,
an
emerging
body
evidence
indicates
that
several
components
host–pathogen
interaction
machinery
are
shared
two
major
branches
eukaryotic
life.
Many
proteins
involved
execution
or
death-associated
immunity
exert
direct
effects
on
endomembrane
loss
membrane
integrity
has
proposed
explain
potential
immunogenicity
cells.
In
this
review
we
aim
provide
comparative
view
how
processes
linked
anti-microbial
mechanisms
pathogens
interfere
with
these
programmes.
comparison
well-defined
animals,
immunogenic
plant
is
broadly
defined
as
hypersensitive
response.
Our
overview
may
help
discerning
whether
specific
types
exist
plants,
correspondingly,
it
new
hints
for
previously
undiscovered
mechanism
animals.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2021,
Номер
40(1)
Опубликована: Май 3, 2021
Abstract
Background
Unraveling
the
mystery
of
cell
death
is
one
most
fundamental
progresses
life
sciences
during
past
decades.
Regulated
(RCD)
or
programmed
(PCD)
not
only
essential
in
embryonic
development,
but
also
plays
an
important
role
occurrence
and
progression
diseases,
especially
cancers.
Escaping
hallmarks
cancer.
Main
body
Pyroptosis
inflammatory
usually
caused
by
microbial
infection,
accompanied
activation
inflammasomes
maturation
pro-inflammatory
cytokines
interleukin-1β
(IL-1β)
interleukin-18
(IL-18).
Gasdermin
family
proteins
are
executors
pyroptosis.
Cytotoxic
N-terminal
gasdermins
generated
from
caspases
granzymes
proteases
mediated
cleavage
gasdermin
oligomerizes
forms
pore
across
membrane,
leading
to
release
IL-1β,
IL-18.
exerts
tumor
suppression
function
evokes
anti-tumor
immune
responses.
Therapeutic
regimens,
including
chemotherapy,
radiotherapy,
targeted
therapy
therapy,
induce
pyroptosis
cancer,
which
potentiate
local
systemic
immunity.
On
other
hand,
normal
cells
attributes
side
effects
anti-cancer
therapies.
Conclusion
In
this
review,
we
focus
on
regulatory
mechanisms
suppressive
We
discuss
attribution
reprogramming
microenvironments
restoration
immunity
its
potential
application
cancer
therapy.
Antioxidants,
Год журнала:
2022,
Номер
11(3), С. 501 - 501
Опубликована: Март 4, 2022
Superoxide
is
a
primary
oxygen
radical
that
produced
when
an
molecule
receives
one
electron.
dismutase
(SOD)
plays
role
in
the
cellular
defense
against
oxidative
insult
by
ROS.
However,
resulting
hydrogen
peroxide
still
reactive
and,
presence
of
free
ferrous
iron,
may
produce
hydroxyl
radicals
and
exacerbate
diseases.
Polyunsaturated
fatty
acids
are
preferred
target
radicals.
Ferroptosis,
type
necrotic
cell
death
induced
lipid
peroxides
has
attracted
considerable
interest
because
its
pathogenesis
many
Radical
electrons,
namely
those
released
from
mitochondrial
electron
transfer
complexes,
enzymatic
reactions,
such
as
lipoxygenases,
appear
to
cause
peroxidation.
While
GPX4
most
potent
anti-ferroptotic
enzyme
known
reduce
alcohols,
other
antioxidative
enzymes
also
indirectly
involved
protection
ferroptosis.
Moreover,
several
low
molecular
weight
compounds
include
α-tocopherol,
ascorbate,
nitric
oxide
efficiently
neutralize
thereby
suppressing
The
removal
electrons
early
stages
importance
protecting
ferroptosis
diseases
related
stress.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(11), С. 6007 - 6023
Опубликована: Март 7, 2023
Pyroptosis
refers
to
the
process
of
gasdermin-mediated
lytic
programmed
cell
death
(PCD)
characterized
by
release
pro-inflammatory
cytokines.
Our
knowledge
pyroptosis
has
expanded
beyond
cellular
level
and
now
includes
extracellular
responses.
In
recent
years,
attracted
considerable
attention
due
its
potential
induce
host
immunity.
For
instance,
at
2022
International
Medicinal
Chemistry
Natural
Active
Ligand
Metal-Based
Drugs
(MCNALMD)
conference,
numerous
researchers
demonstrated
an
interest
in
photon-controlled
activation
("PhotoPyro"),
emerging
pyroptosis-engineered
approach
for
activating
systemic
immunity
via
photoirradiation.
Given
this
enthusiasm,
we
share
Perspective
our
views
on
area
expound
how
why
"PhotoPyro"
could
trigger
antitumor
(i.e.,
turning
so-called
"cold"
tumors
"hot").
doing
so,
have
tried
highlight
cutting-edge
breakthroughs
PhotoPyro
while
suggesting
areas
future
contributions.
By
providing
insights
into
current
state
art
serving
as
a
resource
individuals
interested
working
area,
it
is
hoped
that
will
set
stage
evolve
broadly
applicable
cancer
treatment
strategy.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 11, 2023
Abstract
The
activation
of
host’s
innate
and
adaptive
immune
systems
can
lead
to
acute
chronic
graft
rejection,
which
seriously
impacts
survival.
Thus,
it
is
particularly
significant
clarify
the
signals,
are
critical
initiation
maintenance
rejection
generated
after
transplantation.
response
dependent
on
sensing
danger
stranger
molecules.
ischemia
reperfusion
grafts
cell
stress
or
death,
followed
by
releasing
a
variety
damage-associated
molecular
patterns
(DAMPs),
recognized
pattern
recognition
receptors
(PRRs)
host
cells
activate
intracellular
signals
induce
sterile
inflammation.
In
addition
DAMPs,
exposed
‘non-self’
antigens
(stranger
molecules)
system,
stimulating
more
intense
further
aggravating
damage.
polymorphism
MHC
genes
between
different
individuals
key
for
donor
identify
heterologous
components
in
allogeneic
xenogeneic
organ
antigen
mediates
host,
resulting
memory
immunity
trained
graft,
poses
challenge
long-term
survival
graft.
This
review
focuses
receptor
patterns,
alloantigens
xenoantigens,
described
as
model
model.
this
review,
we
also
discuss
Cell Death and Disease,
Год журнала:
2023,
Номер
14(7)
Опубликована: Июль 13, 2023
Abstract
Acute
kidney
injury
(AKI)
is
a
prevalent
pathological
condition
that
characterized
by
precipitous
decline
in
renal
function.
In
recent
years,
growing
body
of
studies
have
demonstrated
maladaptation
following
AKI
results
chronic
disease
(CKD).
Therefore,
targeting
the
transition
to
CKD
displays
excellent
therapeutic
potential.
However,
mechanism
mediated
multifactor,
and
there
still
lack
effective
treatments.
Ferroptosis,
novel
nonapoptotic
form
cell
death,
believed
role
progression.
this
study,
we
retrospectively
examined
history
characteristics
ferroptosis,
summarized
ferroptosis’s
research
progress
CKD,
discussed
how
ferroptosis
participates
regulating
progression
CKD.
Furthermore,
highlighted
limitations
present
projected
future
evolution
ferroptosis.
We
hope
work
will
provide
clues
for
further
contribute
study
targets
prevent
diseases.
ACS Nano,
Год журнала:
2023,
Номер
17(11), С. 9972 - 9986
Опубликована: Май 18, 2023
Paraptosis
is
characterized
by
the
extensive
vacuolization
of
endoplasmic
reticulum
(ER)
and
mitochondria,
which
will
cause
release
damage-associated
molecular
patterns
to
promote
immunogenic
cell
death
(ICD).
However,
tumor
can
develop
an
immunosuppressive
microenvironment
affect
ICD
activation
for
purpose
immune
escape.
Herein,
a
paraptosis
inducer
(CMN)
constructed
amplify
effect
efficient
immunotherapy
inhibiting
activity
indoleamine
2,3-dioxygenase
(IDO).
Initially,
CMN
prepared
assembly
copper
ions
(Cu2+),
morusin
(MR),
IDO
inhibitor
(NLG919)
through
noncovalent
interactions.
Without
need
extra
drug
carriers,
possesses
very
high
contents
exhibits
favorable
GSH
responsiveness
disassembly.
Subsequently,
released
MR
trigger
ER
contributing
activating
immunotherapy.
Moreover,
NLG919
would
inhibit
remodel
cytotoxic
T
cells,
leading
intensive
antitumor
immunity.
Abundant
in
vivo
studies
indicate
that
superior
suppressing
proliferations
not
only
primary
but
also
metastatic
rechallenged
tumors.
Such
GSH-responsive
might
provide
promising
strategy
enhance
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 962 - 962
Опубликована: Янв. 12, 2024
Sepsis
is
a
serious
organ
dysfunction
caused
by
dysregulated
immune
host
reaction
to
pathogen.
The
innate
immunity
programmed
react
immediately
conserved
molecules,
released
the
pathogens
(PAMPs),
and
(DAMPs).
We
aimed
review
molecular
mechanisms
of
early
phases
sepsis,
focusing
on
PAMPs,
DAMPs,
their
related
pathways,
identify
potential
biomarkers.
included
studies
published
in
English
searched
PubMed®
Cochrane®.
After
detailed
discussion
actual
knowledge
PAMPs/DAMPs,
we
analyzed
role
different
organs
affected
trying
elucidate
basis
some
most-used
prognostic
scores
for
sepsis.
Furthermore,
described
chronological
trend
release
PAMPs/DAMPs
that
may
be
useful
subsets
septic
patients,
who
benefit
from
targeted
therapies.
These
findings
are
preliminary
since
these
pathways
seem
strongly
influenced
peculiar
characteristics
features.
Due
reasons,
while
initial
promising,
additional
necessary
clarify
involvement
patterns
natural
evolution
sepsis
facilitate
transition
into
clinical
setting.
