Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants DOI Creative Commons
Takaki Maekawa, Hamid Kashkar, Núria S. Coll

et al.

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 30(2), P. 258 - 268

Published: Oct. 4, 2022

Abstract Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. can restrict proliferation by depleting their replicative niche and at the same time dying cells alert neighbouring prepare environmental conditions favouring future attacks. As expected, many pathogenic microbes have strategies subvert host promote virulence. The structural lifestyle differences between animals plants been anticipated shape very different defence mechanisms. However, an emerging body evidence indicates that several components host–pathogen interaction machinery are shared two major branches eukaryotic life. Many proteins involved execution or death-associated immunity exert direct effects on endomembrane loss membrane integrity has proposed explain potential immunogenicity cells. In this review we aim provide comparative view how processes linked anti-microbial mechanisms pathogens interfere with these programmes. comparison well-defined animals, immunogenic plant is broadly defined as hypersensitive response. Our overview may help discerning whether specific types exist plants, correspondingly, it new hints for previously undiscovered mechanism animals.

Language: Английский

Pyroptosis: a new paradigm of cell death for fighting against cancer DOI Creative Commons
Yixin Tan,

Quanzhu Chen,

Xiaoling Li

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2021, Volume and Issue: 40(1)

Published: May 3, 2021

Abstract Background Unraveling the mystery of cell death is one most fundamental progresses life sciences during past decades. Regulated (RCD) or programmed (PCD) not only essential in embryonic development, but also plays an important role occurrence and progression diseases, especially cancers. Escaping hallmarks cancer. Main body Pyroptosis inflammatory usually caused by microbial infection, accompanied activation inflammasomes maturation pro-inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18). Gasdermin family proteins are executors pyroptosis. Cytotoxic N-terminal gasdermins generated from caspases granzymes proteases mediated cleavage gasdermin oligomerizes forms pore across membrane, leading to release IL-1β, IL-18. exerts tumor suppression function evokes anti-tumor immune responses. Therapeutic regimens, including chemotherapy, radiotherapy, targeted therapy therapy, induce pyroptosis cancer, which potentiate local systemic immunity. On other hand, normal cells attributes side effects anti-cancer therapies. Conclusion In this review, we focus on regulatory mechanisms suppressive We discuss attribution reprogramming microenvironments restoration immunity its potential application cancer therapy.

Language: Английский

Citations

361
Superoxide Radicals in the Execution of Cell Death DOI Creative Commons
Junichi Fujii, Takujiro Homma, Tsukasa Osaki

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 501 - 501

Published: March 4, 2022

Superoxide is a primary oxygen radical that produced when an molecule receives one electron. dismutase (SOD) plays role in the cellular defense against oxidative insult by ROS. However, resulting hydrogen peroxide still reactive and, presence of free ferrous iron, may produce hydroxyl radicals and exacerbate diseases. Polyunsaturated fatty acids are preferred target radicals. Ferroptosis, type necrotic cell death induced lipid peroxides has attracted considerable interest because its pathogenesis many Radical electrons, namely those released from mitochondrial electron transfer complexes, enzymatic reactions, such as lipoxygenases, appear to cause peroxidation. While GPX4 most potent anti-ferroptotic enzyme known reduce alcohols, other antioxidative enzymes also indirectly involved protection ferroptosis. Moreover, several low molecular weight compounds include α-tocopherol, ascorbate, nitric oxide efficiently neutralize thereby suppressing The removal electrons early stages importance protecting ferroptosis diseases related stress.

Language: Английский

Citations

198
Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response DOI
Mingle Li, Jungryun Kim, Hyeonji Rha

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(11), P. 6007 - 6023

Published: March 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Language: Английский

Citations

91
DAMPs and DAMP-sensing receptors in inflammation and diseases DOI Open Access
Ming Ma, Wei Jiang, Rongbin Zhou

et al.

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 752 - 771

Published: April 1, 2024

Language: Английский

Citations

90
Activation of immune signals during organ transplantation DOI Creative Commons
Qingwen Li, Peixiang Lan

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 11, 2023

Abstract The activation of host’s innate and adaptive immune systems can lead to acute chronic graft rejection, which seriously impacts survival. Thus, it is particularly significant clarify the signals, are critical initiation maintenance rejection generated after transplantation. response dependent on sensing danger stranger molecules. ischemia reperfusion grafts cell stress or death, followed by releasing a variety damage-associated molecular patterns (DAMPs), recognized pattern recognition receptors (PRRs) host cells activate intracellular signals induce sterile inflammation. In addition DAMPs, exposed ‘non-self’ antigens (stranger molecules) system, stimulating more intense further aggravating damage. polymorphism MHC genes between different individuals key for donor identify heterologous components in allogeneic xenogeneic organ antigen mediates host, resulting memory immunity trained graft, poses challenge long-term survival graft. This review focuses receptor patterns, alloantigens xenoantigens, described as model model. this review, we also discuss

Language: Английский

Citations

71
The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis DOI Creative Commons
Runzhi Guo, Jiayu Duan, Shaokang Pan

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 13, 2023

Abstract Acute kidney injury (AKI) is a prevalent pathological condition that characterized by precipitous decline in renal function. In recent years, growing body of studies have demonstrated maladaptation following AKI results chronic disease (CKD). Therefore, targeting the transition to CKD displays excellent therapeutic potential. However, mechanism mediated multifactor, and there still lack effective treatments. Ferroptosis, novel nonapoptotic form cell death, believed role progression. this study, we retrospectively examined history characteristics ferroptosis, summarized ferroptosis’s research progress CKD, discussed how ferroptosis participates regulating progression CKD. Furthermore, highlighted limitations present projected future evolution ferroptosis. We hope work will provide clues for further contribute study targets prevent diseases.

Language: Английский

Citations

48
Paraptosis Inducer to Effectively Trigger Immunogenic Cell Death for Metastatic Tumor Immunotherapy with IDO Inhibition DOI
Rongrong Zheng, Linping Zhao, Chu‐Yu Huang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 9972 - 9986

Published: May 18, 2023

Paraptosis is characterized by the extensive vacuolization of endoplasmic reticulum (ER) and mitochondria, which will cause release damage-associated molecular patterns to promote immunogenic cell death (ICD). However, tumor can develop an immunosuppressive microenvironment affect ICD activation for purpose immune escape. Herein, a paraptosis inducer (CMN) constructed amplify effect efficient immunotherapy inhibiting activity indoleamine 2,3-dioxygenase (IDO). Initially, CMN prepared assembly copper ions (Cu2+), morusin (MR), IDO inhibitor (NLG919) through noncovalent interactions. Without need extra drug carriers, possesses very high contents exhibits favorable GSH responsiveness disassembly. Subsequently, released MR trigger ER contributing activating immunotherapy. Moreover, NLG919 would inhibit remodel cytotoxic T cells, leading intensive antitumor immunity. Abundant in vivo studies indicate that superior suppressing proliferations not only primary but also metastatic rechallenged tumors. Such GSH-responsive might provide promising strategy enhance

Language: Английский

Citations

47
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways DOI
Yi Huang, Wei Jiang, Rongbin Zhou

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(10), P. 703 - 719

Published: April 29, 2024

Language: Английский

Citations

33
PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications DOI Open Access
Sara Cicchinelli, Giulia Pignataro, Stefania Gemma

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 962 - 962

Published: Jan. 12, 2024

Sepsis is a serious organ dysfunction caused by dysregulated immune host reaction to pathogen. The innate immunity programmed react immediately conserved molecules, released the pathogens (PAMPs), and (DAMPs). We aimed review molecular mechanisms of early phases sepsis, focusing on PAMPs, DAMPs, their related pathways, identify potential biomarkers. included studies published in English searched PubMed® Cochrane®. After detailed discussion actual knowledge PAMPs/DAMPs, we analyzed role different organs affected trying elucidate basis some most-used prognostic scores for sepsis. Furthermore, described chronological trend release PAMPs/DAMPs that may be useful subsets septic patients, who benefit from targeted therapies. These findings are preliminary since these pathways seem strongly influenced peculiar characteristics features. Due reasons, while initial promising, additional necessary clarify involvement patterns natural evolution sepsis facilitate transition into clinical setting.

Language: Английский

Citations

29
Innate immune activation in neurodegenerative diseases DOI
Sergio Castro‐Gomez, Michael T. Heneka

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 790 - 814

Published: April 1, 2024

Language: Английский

Citations

29