ACS Applied Nano Materials,
Год журнала:
2022,
Номер
5(3), С. 3065 - 3086
Опубликована: Март 10, 2022
As
one
of
the
two
nucleic
acids
used
by
extant
biochemistry,
RNA
is
great
importance
for
cellular
function
and
development,
its
expression
can
affect
cell
homeostasis.
Therefore,
accurate
detection
key
contributor
to
disease
diagnosis,
including
tumor
detection.
Compared
with
conventional
methods,
molecular
beacons
(MBs)
have
high
selectivity
target
molecules
detection,
which
been
widely
in
However,
background
fluorescence
typical
MBs
will
seriously
sensitivity
accuracy.
In
addition,
poor
affinity
weak
resistance
nuclease
digestion
also
limit
applications.
With
development
nanotechnology,
many
nanomaterials
quenching
ability
as
quenchers
carriers
construct
nanoprobes
(Nano-MBs).
this
review,
we
summarize
recent
developments
Nano-MBs
imaging
over
past
decade.
First,
structure,
working
principle,
classification
are
discussed.
Then,
introduce
several
based
on
gold
nanoparticles,
polydopamine,
graphene
oxide,
molybdenum
disulfide,
quantum
dots.
Particular
emphasis
placed
application
mRNA
miRNA
diagnosis
treatment
diseases,
well
cancer.
Finally,
current
challenges
future
perspectives
Cell Reports,
Год журнала:
2023,
Номер
42(1), С. 111982 - 111982
Опубликована: Янв. 1, 2023
Cellular
circadian
clocks
direct
a
daily
transcriptional
program
that
supports
homeostasis
and
resilience.
Emerging
evidence
has
demonstrated
age-associated
changes
in
functions.
To
define
age-dependent
at
the
systems
level,
we
profile
transcriptome
hypothalamus,
lung,
heart,
kidney,
skeletal
muscle,
adrenal
gland
three
age
groups.
We
find
tissue-specific
clock
output
changes.
Aging
reduces
number
of
rhythmically
expressed
genes
(REGs),
indicative
weakened
control.
REGs
are
enriched
for
hallmarks
aging,
adding
another
dimension
to
our
understanding
aging.
Analyzing
differential
gene
expression
within
tissue
four
different
times
day
identifies
distinct
clusters
differentially
(DEGs).
Increased
variability
across
is
common
feature
aged
tissues.
This
analysis
extends
landscape
aging
highlights
impact
on
function
temporal
expression.
Acta Neuropathologica,
Год журнала:
2024,
Номер
147(1)
Опубликована: Май 9, 2024
Abstract
Aging
affects
all
cell
types
in
the
CNS
and
plays
an
important
role
diseases.
However,
underlying
molecular
mechanisms
driving
these
age-associated
changes
their
contribution
to
diseases
are
only
poorly
understood.
The
white
matter
aging
brain
as
well
diseases,
such
Multiple
sclerosis
is
characterized
by
subtle
abnormalities
myelin
sheaths
paranodes,
suggesting
that
oligodendrocytes,
myelin-maintaining
cells
of
CNS,
lose
capacity
preserve
a
proper
structure
potentially
function
age
certain
Here,
we
made
use
directly
converted
oligodendrocytes
(dchiOL)
from
young,
adult
old
human
donors
study
changes.
dchiOL
three
groups
differentiated
comparable
manner
into
O4
+
immature
but
proportion
MBP
mature
decreased
with
increasing
donor
age.
This
was
associated
increased
ROS
production
upregulation
cellular
senescence
markers
CDKN1A,
CDKN2A
dchiOL.
Comparison
transcriptomic
profiles
revealed
1324
differentially
regulated
genes
limited
overlap
donors’
fibroblasts
or
published
data
sets
neurons
primary
rodent
oligodendroglial
lineage
cells.
Methylome
analyses
tissue
samples
demonstrate
chronological
epigenetic
correlate
resulted
identification
age-specific
signature.
Furthermore,
observed
accelerated
myelinated,
normal
appearing
multiple
(MS)
patients
compared
healthy
individuals.
Impaired
differentiation
could
be
induced
young
vitro
using
supernatants
pro-inflammatory
microglia.
In
summary,
our
suggest
physiological
inflammation-induced
contribute
pathology
inflammatory
demyelinating
MS.
Trends in Genetics,
Год журнала:
2024,
Номер
40(4), С. 299 - 312
Опубликована: Март 21, 2024
Recent
studies
of
aging
organisms
have
identified
a
systematic
phenomenon,
characterized
by
negative
correlation
between
gene
length
and
their
expression
in
various
cell
types,
species,
diseases.
We
term
this
phenomenon
gene-length-dependent
transcription
decline
(GLTD)
suggest
that
it
may
represent
bottleneck
the
machinery
thereby
significantly
contribute
to
as
an
etiological
factor.
review
potential
links
GLTD
key
processes
such
DNA
damage
explore
identifying
disease
modification
targets.
Notably,
Alzheimer's
disease,
spotlights
extremely
long
synaptic
genes
at
chromosomal
fragile
sites
(CFSs)
vulnerability
postmitotic
damage.
is
integral
element
biological
aging.
Aging Medicine,
Год журнала:
2018,
Номер
1(2), С. 158 - 175
Опубликована: Июль 30, 2018
Abstract
Aging
is
progressive
physiological
degeneration
and
consequently
declined
function,
which
linked
to
senescence
on
both
cellular
organ
levels.
Accumulating
studies
indicate
that
long
noncoding
RNA
s
(lnc
s)
play
important
roles
in
at
all
levels—transcriptional,
post‐transcriptional,
translational,
post‐translational.
Understanding
the
molecular
mechanism
of
lnc
underlying
could
facilitate
interpretation
intervention
aging
age‐related
diseases.
In
this
review,
we
describe
categories
known
novel
have
been
involved
progression
senescence.
We
also
identify
implicated
diseases
arising
from
age‐driven
or
dysfunction
some
representative
organs
systems
(brains,
liver,
muscle,
cardiovascular
system,
bone
pancreatic
islets,
immune
system).
Improved
comprehension
process
levels,
cell
organismal,
may
provide
new
insights
into
amelioration
pathologies
prolonged
healthspan.
Annual Review of Vision Science,
Год журнала:
2021,
Номер
7(1), С. 633 - 664
Опубликована: Июнь 1, 2021
Multifaceted
and
divergent
manifestations
across
tissues
cell
types
have
curtailed
advances
in
deciphering
the
cellular
events
that
accompany
advanced
age
contribute
to
morbidities
mortalities.
Increase
human
lifespan
during
past
century
has
heightened
awareness
of
need
prevent
age-associated
frailty
neuronal
sensory
systems
allow
a
healthy
productive
life.
In
this
review,
we
discuss
molecular
physiological
attributes
aging
retina,
with
goal
understanding
age-related
impairment
visual
function.
We
highlight
epigenome–metabolism
nexus
proteostasis
as
key
contributors
retinal
lifestyle
changes
potential
modulators
Finally,
deliberate
promising
intervention
strategies
for
promoting
retina
improved
vision.
