Aging Clinical and Experimental Research,
Год журнала:
2022,
Номер
35(2), С. 253 - 269
Опубликована: Дек. 30, 2022
Throughout
the
course
of
life,
there
are
age-related
changes
in
sleep.
Despite
these
normal
changes,
is
a
high
percentage
older
adults
that
report
sleep
dissatisfaction
with
pervasiveness
chronic
insomnia,
most
common
disorder
worldwide,
its
prevalence
being
expected
to
continuously
increase
due
growing
rates
aging
and
obesity.
This
can
have
different
adverse
health
outcomes,
especially
by
promoting
both
physical
cognitive
decline,
which
ultimately
may
aggravate
frailty
adults.
Moreover,
dysfunction
mechanism
related
hallmarks
cellular
aging.
Cellular
was
categorized
into
nine
hallmarks,
such
as
DNA
damage,
telomere
attrition
epigenetic
changes.
In
context
geriatric
insomnia
research,
this
review
aims
at
discussing
current
evidence
from
animal
models
human
cohorts
addressing
link
between
their
impact
on
frailty.
recent
research
about
putative
effect
therapeutic
approaches
will
be
also
highlighted.
Aging,
Год журнала:
2022,
Номер
14(16), С. 6829 - 6839
Опубликована: Авг. 29, 2022
Aging
|
doi:10.18632/aging.204248.
Tomas
Schmauck-Medina,
Adrian
Molière,
Sofie
Lautrup,
Jianying
Zhang,
Stefan
Chlopicki,
Helena
Borland
Madsen,
Shuqin
Cao,
Casper
Soendenbroe,
Els
Mansell,
Mark
Bitsch
Vestergaard,
Zhiquan
Li,
Yosef
Shiloh,
Patricia
L.
Opresko,
Jean-Marc
Egly,
Thomas
Kirkwood,
Eric
Verdin,
Vilhelm
A.
Bohr,
Lynne
S.
Cox,
Tinna
Stevnsner,
Lene
Juel
Rasmussen,
Evandro
F.
Fang
Nature Aging,
Год журнала:
2022,
Номер
2(7), С. 580 - 591
Опубликована: Июль 20, 2022
Having
made
substantial
progress
understanding
molecules,
cells,
genes
and
pathways,
aging
biology
research
is
now
moving
toward
integration
of
these
parts,
attempting
to
understand
how
their
joint
dynamics
may
contribute
aging.
Such
a
shift
perspective
requires
the
adoption
formal
complex
systems
framework,
transition
being
facilitated
by
large-scale
data
collection
new
analytical
tools.
Here,
we
provide
theoretical
framework
orient
researchers
around
key
concepts
for
this
transition,
notably
emergence,
interaction
networks
resilience.
Drawing
on
evolutionary
theory,
network
theory
principles
homeostasis,
propose
that
organismal
function
accomplished
regulatory
mechanisms
at
multiple
hierarchical
scales,
disruption
ensemble
causes
phenotypic
functional
manifestations
We
present
examples
scales
ranging
from
sub-organismal
clinical
geriatrics,
outlining
approach
can
potentially
enrich
our
The
authors
discuss
adopting
crucial
step
in
advancing
process
fundamental
alteration
questions
asked
methods
used
answer
them.
Molecular Psychiatry,
Год журнала:
2022,
Номер
28(1), С. 242 - 255
Опубликована: Июль 15, 2022
Aging
is
a
major
risk
factor
for
number
of
chronic
diseases,
including
neurodegenerative
and
cerebrovascular
disorders.
processes
have
therefore
been
discussed
as
potential
targets
the
development
novel
broadly
effective
preventatives
or
therapeutics
age-related
those
affecting
brain.
Mechanisms
thought
to
contribute
aging
summarized
under
term
"hallmarks
aging"
include
loss
proteostasis,
mitochondrial
dysfunction,
altered
nutrient
sensing,
telomere
attrition,
genomic
instability,
cellular
senescence,
stem
cell
exhaustion,
epigenetic
alterations
intercellular
communication.
We
here
examine
key
claims
about
aging".
Our
analysis
reveals
important
weaknesses
that
preclude
strong
definitive
conclusions
concerning
possible
role
these
in
shaping
organismal
rate.
Significant
ambiguity
arises
from
overreliance
on
lifespan
proxy
marker
aging,
use
models
with
unclear
relevance
study
designs
do
not
allow
properly
estimate
intervention
effects
also
discuss
future
research
directions
should
be
taken
clarify
if
what
extent
putative
regulators
fact
interact
aging.
These
multidimensional
analytical
frameworks
well
facilitate
proper
assessment
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2022,
Номер
43(1), С. 15 - 29
Опубликована: Ноя. 22, 2022
Cardiovascular
disease
is
the
most
common
cause
of
death
worldwide,
especially
beyond
age
65
years,
with
vast
majority
morbidity
and
mortality
due
to
myocardial
infarction
stroke.
Vascular
pathology
stems
from
a
combination
genetic
risk,
environmental
factors,
biologic
changes
associated
aging.
The
pathogenesis
underlying
development
vascular
aging,
calcification
in
particular,
still
not
fully
understood.
Accumulating
data
suggests
that
likely
compounded
by
epigenetic
modifications,
including
diabetes
chronic
kidney
disease,
plasticity
smooth
muscle
cells
acquire
an
osteogenic
phenotype
are
major
determinants
age-associated
calcification.
Understanding
molecular
mechanisms
modifiable
risk
factors
regulating
may
inspire
strategies
promote
healthy
This
article
summarizes
current
knowledge
concepts
emphasis
on
Abstract
Ageing
is
inherent
to
all
human
beings,
yet
why
we
age
remains
a
hotly
contested
topic.
Most
mechanistic
explanations
of
ageing
posit
that
caused
by
the
accumulation
one
or
more
forms
molecular
damage.
Here,
I
propose
not
because
inevitable
damage
hardware
but
rather
intrinsic
design
flaws
in
software,
defined
as
DNA
code
orchestrates
how
single
cell
develops
into
an
adult
organism.
As
developmental
software
runs,
its
sequence
events
reflected
shifting
cellular
epigenetic
states.
Overall,
suggest
understand
need
decode
our
and
flow
information
throughout
life
course.
Ageing Research Reviews,
Год журнала:
2024,
Номер
95, С. 102204 - 102204
Опубликована: Янв. 23, 2024
The
pursuit
for
the
fountain
of
youth
has
long
been
a
fascination
amongst
scientists
and
humanity.
Ageing
is
broadly
characterized
by
cellular
decline
with
increased
susceptibility
to
age-related
diseases,
being
intimately
associated
epigenetic
modifications.
Recently,
reprogramming-induced
rejuvenation
strategies
have
begun
greatly
alter
longevity
research
not
only
tackle
defects
but
also
possibly
reverse
ageing
process.
Hence,
in
this
review,
we
highlight
major
changes
during
state-of-art
current
emerging
reprogramming
leveraging
on
transcription
factors.
Notably,
partial
enables
resetting
clock
without
erasing
identity.
Promising
chemical-based
harnessing
small
molecules,
including
DNA
methyltransferase
histone
deacetylase
inhibitors
are
discussed.
Moreover,
parallel
interventions,
foundations
clocks
accurate
assessment
evaluation
approaches
briefly
presented.
Going
further,
such
scientific
breakthroughs,
witnessing
rise
biotech
industry
aiming
extend
health
span
ideally
achieve
human
one
day.
In
context,
overview
main
scenarios
proposed
future
socio-economic
ethical
challenges
an
field.
Ultimately,
review
aims
inspire
interventions
that
promote
healthy
all.
PLoS Biology,
Год журнала:
2024,
Номер
22(2), С. e3002513 - e3002513
Опубликована: Фев. 27, 2024
Why
and
how
we
age
are
2
intertwined
questions
that
have
fascinated
scientists
for
many
decades.
However,
attempts
to
answer
these
remain
compartmentalized,
preventing
a
comprehensive
understanding
of
the
aging
process.
We
argue
current
lack
knowledge
about
evolution
mechanisms
is
due
clarity
regarding
evolutionary
theories
explicitly
involve
physiological
processes:
disposable
soma
theory
(DST)
developmental
(DTA).
In
this
Essay,
propose
new
hierarchical
model
linking
genes
vital
rates,
enabling
us
critically
reevaluate
DST
DTA
in
terms
their
relationship
genetic
(mutation
accumulation
(MA)
antagonistic
pleiotropy
(AP)).
also
demonstrate
can
be
incorporated
unified
framework.
The
framework
will
help
generate
testable
hypotheses
hallmarks
shaped
by
natural
selection.
Abstract
Sex
differences
in
aging
occur
many
animal
species,
and
they
include
sex
lifespan,
the
onset
progression
of
age‐associated
decline,
physiological
molecular
markers
aging.
vary
greatly
across
kingdom.
For
example,
there
are
species
with
longer‐lived
females,
where
males
live
longer,
lacking
lifespan.
The
underlying
causes
remain
mostly
unknown.
Currently,
we
do
not
understand
drivers
aging,
or
whether
related
to
accepted
hallmarks
pillars
linked
other
well‐characterized
processes.
In
particular,
understanding
role
sex‐determination
mechanisms
is
relatively
understudied.
Here,
take
a
comparative,
interdisciplinary
approach
explore
various
hypotheses
about
how
arise.
We
discuss
genomic,
morphological,
environmental
between
sexes
these
relate
Finally,
present
some
suggestions
for
future
research
this
area
provide
recommendations
promising
experimental
designs.
