Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies

Lab on a Chip, Год журнала: 2024, Номер 24(7), С. 1867 - 1874

Опубликована: Янв. 1, 2024

In this perspective article, we present the state of microfluidic field regarding current limitations and propose future directions new approaches for to advance lab-on-a-chip technologies closer translation clinical use.

Язык: Английский

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Tailoring drug delivery systems by microfluidics for tumor therapy

Materials Today, Год журнала: 2024, Номер 73, С. 151 - 178

Опубликована: Янв. 30, 2024

Язык: Английский

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Fundamentals and Applications of Surface Wetting

Langmuir, Год журнала: 2024, Номер 40(16), С. 8293 - 8326

Опубликована: Апрель 8, 2024

In an era defined by insatiable thirst for sustainable energy solutions, responsible water management, and cutting-edge lab-on-a-chip diagnostics, surface wettability plays a pivotal role in these fields. The seamless integration of fundamental research the following demonstration applications on groundbreaking technologies hinges manipulating fluid through wettability, significantly optimizing performance, enhancing efficiency, advancing overall sustainability. This Review explores behavior liquids when they engage with engineered surfaces, delving into far-reaching implications interactions various applications. Specifically, we explore wetting, dissecting it three distinctive facets. First, delve principles that underpin wetting. Next, navigate intricate liquid–surface interactions, unraveling complex interplay dynamics, as well heat- mass-transport mechanisms. Finally, report practical realm, where scrutinize myriad everyday processes real-world scenarios.

Язык: Английский

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Trends in Aptasensing and the Enhancement of Diagnostic Efficiency and Accuracy

ACS Synthetic Biology, Год журнала: 2025, Номер 14(1), С. 21 - 40

Опубликована: Янв. 6, 2025

The field of healthcare diagnostics is navigating complex challenges driven by evolving patient demographics and the rapid advancement new technologies worldwide. In response to these challenges, biosensors offer distinctive advantages over traditional diagnostic methods, such as cost-effectiveness, enhanced specificity, adaptability, making their integration with point-of-care (POC) platforms more feasible. recent years, aptasensors have significantly evolved in capabilities through emerging microfluidics, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems, wearable devices, machine learning (ML), driving progress precision medicine global solutions. Moreover, advancements not only improve accuracy but also hold potential revolutionize early detection, reduce costs, outcomes, especially resource-limited settings. This Account examines key advancements, focusing on how scientific breakthroughs, including artificial intelligence (AI), improved sensitivity precision. Additionally, has enabled real-time monitoring data analysis, fostering advances personalized healthcare. Furthermore, commercialization aptasensor could increase availability clinical settings support use widespread solutions for health challenges. Hence, this review discusses technological improvements, practical uses, prospects while surrounding standardization, validation, interdisciplinary collaboration application. Finally, ongoing efforts address are ensure that can be effectively implemented diverse systems.

Язык: Английский

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Trends of respiratory virus detection in point-of-care testing: A review

Analytica Chimica Acta, Год журнала: 2023, Номер 1264, С. 341283 - 341283

Опубликована: Май 3, 2023

Язык: Английский

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A roadmap to high-speed polymerase chain reaction (PCR): COVID-19 as a technology accelerator

Biosensors and Bioelectronics, Год журнала: 2023, Номер 246, С. 115830 - 115830

Опубликована: Ноя. 16, 2023

The limit of detection (LOD), speed, and cost crucial COVID-19 diagnostic tools, including lateral flow assays (LFA), enzyme-linked immunosorbent (ELISA), polymerase chain reactions (PCR), have all improved because the financial governmental support for epidemic. most notable improvement in overall efficiency among them has been seen with PCR. Its significance human health increased during pandemic, when it emerged as commonly used approach identifying virus. However, problems complexity, expense, PCR deployment point-of-care settings continues to be difficult. Microfluidic platforms offer a promising solution by enabling development smaller, more affordable, faster systems. In this review, we delve into engineering challenges associated advancement high-speed microfluidic equipment. We introduce criteria that facilitate evaluation comparison factors such LOD, cycling efficiency, multiplexing capacity, considering sample volume, fluidics, reactor geometry materials, well heating/cooling methods. also provide comprehensive list commercially available devices conclude projections discussion regarding current obstacles need addressed order progress further field.

Язык: Английский

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Advancements and emerging technologies in biosensors for rapid and accurate virus detection

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 172, С. 117609 - 117609

Опубликована: Фев. 20, 2024

Язык: Английский

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Advances in microfluidic technologies for antibody separation and detection: toward enhanced diagnostics and therapeutic applications

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 114061 - 114061

Опубликована: Май 1, 2025

Язык: Английский

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The Taylor flow characteristic and mass transfer in curved T-microchannels

Physics of Fluids, Год журнала: 2025, Номер 37(3)

Опубликована: Март 1, 2025

Mass transfer processes in curved microchannels are challenging to measure due the complex flow structures induced by geometries. This study systematically investigates Taylor and mass mechanisms T-microchannels using visualization experiments numerical simulations. Three primary patterns—slug flow, long slug columnar flow—are observed. A length prediction model is developed based on dispersed phase Reynolds number continuous capillary number. Comparisons of fields different reveal that curvature effectively disrupts symmetric internal circulation within slug, shifting it toward head splitting into multiple secondary circulations. disruption enhances radial mixing slug. By introducing efficiency Dean number, this quantifies influence channel radius, bends, two-phase velocity enhancement transfer. Results indicate smaller radii, a greater higher volume fractions intensify cross section, thereby promoting Additionally, pressure drop measurement demonstrates with more bends radii correspond energy dissipation. Based comprehensive experimental results, broadly applicable highly accurate established provides theoretical guidance for optimizing microchannel designs furthering application reactors fine chemical related fields.

Язык: Английский

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Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 18, 2023

Increased human activities around the globe and rapid development of once rural regions have increased probability contact between humans wild animals. A majority bunyaviruses are zoonotic origin, outbreaks may result in substantial loss lives, economy contraction, social instability. Many require manipulation highest levels biocontainment, such as Biosafety Level 4 (BSL-4) laboratories, scarcity this resource has limited speed vaccines for these pathogens. Meanwhile, new technologies been created, used to innovate vaccines, like mRNA vaccine platform bioinformatics-based antigen design. Here, we summarize current developments three different requiring work biocontainment: Crimean-Congo Hemorrhagic Fever Virus (CCHFV), Rift Valley (RVFV), Hantaan virus (HTNV), provide perspectives potential future directions that can be further explored advance specific livestock.

Язык: Английский

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