The role of tRF5-20-AlaAGC-2 in colorectal cancer progression DOI Creative Commons
Chun Wang, Jing Ren, Hui Dai

и другие.

Asian Journal of Surgery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Hypoxia Promotes Malignant Progression of Colorectal Cancer by Inducing POSTN+ Cancer‐Associated Fibroblast Formation DOI Open Access
Jian Qin, Shangshang Hu, Yuhan Chen

и другие.

Molecular Carcinogenesis, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies. Hypoxia can promote occurrence and development CRC. However, how hypoxia regulates CRC immune microenvironment needs to be further explored. The bulk RNA sequencing data clinicopathological information patients were enrolled from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. single‐cell (scRNA‐seq) datasets collected analyzed GEO database ArrayExpress database. score gene set was estimated using “ssGSEA” algorithm in “GSVA” R package. functional characteristics CAF subtypes studied by bioinformatics analysis vitro experiments, a prognostic model constructed based on machine learning correlation. associated with poor prognosis patients. Periostin (POSTN) + Fib cancer‐associated fibroblast (CAF) closely hypoxia, high infiltration POSTN adverse outcomes overall survival (OS) relapse‐free (RFS) induce expression secretion CAFs. Hypoxia‐induced increase CAFs significantly migration proliferation cells. Hypoxia‐Related Risk Model (PFHRM) predict immunotherapy response Our study identified cell subpopulation which promotes malignant progression PFHRM provides theoretical basis for improving patient prognosis.

Язык: Английский

Процитировано

2

A Novel Approach for Predicting the Survival of Colorectal Cancer Patients Using Machine Learning Techniques and Advanced Parameter Optimization Methods DOI Open Access

Andrzej Woźniacki,

Wojciech Książek, Patrycja Mrowczyk

и другие.

Cancers, Год журнала: 2024, Номер 16(18), С. 3205 - 3205

Опубликована: Сен. 20, 2024

Background: Colorectal cancer is one of the most prevalent forms and associated with a high mortality rate. Additionally, an increasing number adults under 50 are being diagnosed disease. This underscores importance leveraging modern technologies, such as artificial intelligence, for early diagnosis treatment support. Methods: Eight classifiers were utilized in this research: Random Forest, XGBoost, CatBoost, LightGBM, Gradient Boosting, Extra Trees, k-nearest neighbor algorithm (KNN), decision trees. These algorithms optimized using frameworks Optuna, RayTune, HyperOpt. study was conducted on public dataset from Brazil, containing information tens thousands patients. Results: The models developed demonstrated classification accuracy predicting one-, three-, five-year survival, well overall cancer-specific mortality. Forest delivered best performance, achieving approximately 80% across all evaluated tasks. Conclusions: research enabled development effective that can be applied clinical practice.

Язык: Английский

Процитировано

10

Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture DOI Creative Commons

Joanna Słoka,

Barbara Strzałka‐Mrozik, Sebastian Kubica

и другие.

Biomedicines, Год журнала: 2025, Номер 13(1), С. 219 - 219

Опубликована: Янв. 16, 2025

Background/Objectives: Colorectal cancer (CRC) is one of the most common oncological disorders. Its fundamental treatments include surgery and chemotherapy, predominantly utilizing 5-fluorouracil (5-FU). Despite medical advances, CRC continues to present a high risk recurrence, metastasis low survival rates. Consequently, significant emphasis has been directed towards exploring novel types cell death, particularly ferroptosis. Ferroptosis characterized by iron imbalance accumulation lipid peroxides reactive oxygen species (ROS), leading cellular damage death. Thus, discovery safe inducers ferroptosis, offering new hope in struggle against CRC, remains crucial. In this study, we applied concept drug repositioning, selecting mesalazine (MES), non-steroidal anti-inflammatory (NSAID), for investigation. Methods: The study was conducted on colon line DLD-1 normal intestinal epithelial cells from CCD 841 CoN line. Both lines were treated with MES solutions at concentrations 10, 20, 30, 40, 50 mM. Cytotoxicity assessed using MTT assay, while ferroptosis-related gene expression analysis performed oligonucleotide microarrays, RT-qPCR used validation. Results: effectively reduces viability minimally affecting cells. Subsequent microarray revealed that significantly alters 56 genes associated Conclusions: Our results suggest may induce ferroptosis providing foundation further research area.

Язык: Английский

Процитировано

2

Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota DOI
Ali Rahimi,

Zeinab Baghernejadan,

Ali Hazrati

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118014 - 118014

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

1

Unraveling the complexities of colorectal cancer and its promising therapies – An updated review DOI

Sayan Saha,

Shreya Ghosh, Suman Ghosh

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113325 - 113325

Опубликована: Окт. 14, 2024

Язык: Английский

Процитировано

8

A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer DOI Creative Commons
Hongyu Liu,

T.-C. Wu,

Yunjian Yu

и другие.

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

ABSTRACT Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs complex procedures, which are inconvenient large‐scale screening. Given its high prevalence in malignant tissues feces of patients, Fusobacterium nucleatum ( F. ) has emerged as a crucial biomarker CRC. Herein, we propose ‐specific recognition diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between FadA on allows AIE‐Pep NPs to adhere selectively , emits strong red/NIR fluorescence. In model orthotopic CRC, can precisely localize around Moreover, demonstrated limit (LOD) 82.97 CFU/mL could significantly differentiate mice from those normal mice. Overall, this study presents pivotal approach specifically identifying holds immense potential

Язык: Английский

Процитировано

1

Current state and future prospects of spatial biology in colorectal cancer DOI Creative Commons
Francisco Carranza, Fernando C. Diaz, Maria Ninova

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Дек. 3, 2024

Over the past century, colorectal cancer (CRC) has become one of most devastating cancers impacting human population. To gain a deeper understanding molecular mechanisms driving this solid tumor, researchers have increasingly turned their attention to tumor microenvironment (TME). Spatial transcriptomics and proteomics emerged as particularly powerful technology for deciphering complexity CRC tumors, given that TME its spatial organization are critical determinants disease progression treatment response. enables high-resolution mapping whole transcriptome. While maps protein expression function across tissue sections. Together, they provide detailed view landscape cellular interactions within TME. In review, we delve into recent advances in biology technologies applied research, highlighting both methodologies challenges associated with use, such substantial heterogeneity characteristic CRC. We also discuss limitations current approaches need novel computational tools manage interpret these complex datasets. conclude, emphasize importance further developing integrating precision medicine strategies enhance therapeutic targeting improve patient outcomes.

Язык: Английский

Процитировано

6

WTAP/IGF2BP3 Mediated m6A Modification of SOD2 mRNA Aggravates the Tumourigenesis of Colorectal Cancer DOI Open Access

Chengfu Zhou,

Meng Wang, Xinming Du

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(1)

Опубликована: Янв. 1, 2025

Wilms tumor 1-associated protein (WTAP) has been validated to be a crucial regulator in the tumorigenesis and advancement of diverse malignancies. This study intended probe impacts WTAP on colorectal cancer (CRC) progression from perspective N6-methyladenosine (m6A) modification. The differential expression patterns clinical CRC samples cultured cell lines were via qRT-PCR western blot. Cell function tests conducted with colony formation, transwell, CCK-8. MeRIP-qPCR was identify WTAP-mediated SOD2 (Superoxide dismutase 2) mRNA modification cells. Animal experiments adopted evaluate vivo. exhibited high pattern along Silencing potently restrained growth virto Mechanically, identified as an m6A target WTAP. elevated its stability IGF2BP3-dependent manner. Meanwhile, overexpression could reverse suppressive effect induced by silencing. Molecular therapy targeting WTAP-SOD2 may offer novel insights perspectives for treatment CRC.

Язык: Английский

Процитировано

0

Discovery of tetracyclic 1,2,4-triazoline-fused dibenzo[b,f][1,4]oxazepine as a potent anti-colorectal cancer agent with good efficacy and low toxicity DOI
Qiwen Shi, Tao Zhou, Yanting Zhou

и другие.

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер 125, С. 118203 - 118203

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

0

The role of inflammation in colorectal Cancer and the preventive potential of natural compounds DOI
Nasreddine El Omari, Meriem El Fessikh, Sara Aboulaghras

и другие.

Journal of Functional Foods, Год журнала: 2025, Номер 129, С. 106857 - 106857

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0